Huang Qi Jian Zhong Tang

Astragalus Decoction to Construct the Middle · 黃芪建中湯

Also known as: Huang Qi Jian Zhong Tang, Astragalus Combination, 黄耆建中汤

A warming, strengthening formula for people with chronic weakness, fatigue, and digestive discomfort marked by abdominal cramping, poor appetite, and spontaneous sweating. It gently rebuilds the body's core digestive strength and Qi, making it especially well suited for long-standing stomach problems with cold sensitivity and general exhaustion.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing — Hàn dynasty, ~200 CE
Composition 7 herbs
Huang Qi
King
Huang Qi
Yi Tang
King
Yi Tang
Gui Zhi
Deputy
Gui Zhi
Bai Shao
Deputy
Bai Shao
Sheng Jiang
Assistant
Sheng Jiang
Da Zao
Assistant
Da Zao
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huang Qi Jian Zhong Tang is designed to correct these specific patterns.

Why Huang Qi Jian Zhong Tang addresses this pattern

When the Spleen and Stomach Qi are chronically depleted, they can no longer transform food into Qi and Blood effectively. This leads to fatigue, poor appetite, loose stools, and a pale complexion. Huang Qi Jian Zhong Tang directly builds the Qi of the Middle Burner through the combined action of Huang Qi, Yi Tang, Da Zao, and Zhi Gan Cao, all of which are sweet and warm and enter the Spleen and Stomach. Gui Zhi warms the Yang to support the Spleen's transforming function, while Bai Shao prevents the warming herbs from consuming Yin.

A practitioner would look for one or more of these signs

Eye Fatigue

Chronic tiredness worsened by exertion

Poor Appetite

Reduced desire to eat

Abdominal Pain

Cramping pain relieved by warmth and pressure

Spontaneous Sweat

Sweating without exertion, indicating weak Wei Qi

Dull Pale Complexion

Sallow, yellowish face colour

Shortness Of Breath

Breathlessness on mild activity

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Huang Qi Jian Zhong Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, gastric ulcers of the cold-deficiency type arise when the Spleen and Stomach Yang are too weak to maintain the warmth and protective function of the stomach lining. The Middle Burner loses its ability to 'ripen and rot' food properly, and internal Cold accumulates, causing cramping pain that characteristically improves with warmth and pressure. The weakness of the Spleen's holding function means the stomach lining cannot repair itself, allowing the ulcer to persist. This is a pattern of insufficiency rather than excess, which is why warming, tonifying treatment is appropriate rather than clearing or draining approaches.

Why Huang Qi Jian Zhong Tang Helps

Huang Qi Jian Zhong Tang addresses gastric ulcers on multiple levels. Huang Qi tonifies the Spleen Qi that drives tissue repair and is traditionally recognized for its 'flesh-generating' (生肌) action, which supports healing of the damaged stomach lining. Yi Tang and Zhi Gan Cao provide sweet, coating nourishment that soothes and protects irritated tissue while relaxing the spasms that cause pain. Gui Zhi and Sheng Jiang warm the Middle Burner to dispel the Cold that underlies the condition. Clinical studies have shown this formula can inhibit gastric acid secretion and promote ulcer healing, with one trial reporting a 97.78% total effectiveness rate in treating Spleen-Stomach deficiency Cold type gastric ulcers.

Also commonly used for

Duodenal Ulcers

Deficiency-Cold type peptic ulcers

Gastroesophageal Reflux Disease

Spleen-Stomach deficiency Cold pattern with reflux symptoms

Irritable Bowel Syndrome

Cold-deficiency type with cramping abdominal pain

Anemia

Aplastic anaemia or chronic anaemia from deficiency

Chronic Hepatitis

When presenting with Spleen-Stomach deficiency

Ulcerative Colitis

Cold-deficiency type

Dysmenorrhoea

Primary dysmenorrhoea from cold deficiency

Spontaneous Sweat

From Qi deficiency with weak exterior defence

What This Formula Does

Every TCM formula has a specific set of actions — here's what Huang Qi Jian Zhong Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Huang Qi Jian Zhong Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Huang Qi Jian Zhong Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Huang Qi Jian Zhong Tang works at the root level.

This formula addresses a condition where the middle burner (Spleen and Stomach) has become chronically deficient and cold, and Qi is significantly depleted. The Spleen is the source of Qi and Blood for the whole body. When Middle Qi is weak, it can no longer properly transform food and drink into nourishment, leading to widespread deficiency. The body lacks the warmth and motive force to keep all systems functioning, resulting in fatigue, a wan complexion, shortness of breath, spontaneous sweating, and a weak pulse.

Cold accumulates in the abdomen because the weakened Spleen Yang cannot warm the interior, causing cramping or spasmodic abdominal pain that is relieved by warmth and pressure. When the Spleen is this weak, the Liver (Wood) easily overacts on the Spleen (Earth), adding to the cramping and tension. The classical text describes this as "internal urgency" (li ji, 里急), a tight, pulling sensation in the abdomen. Because the fundamental source of nourishment is impaired, both Yin and Yang become deficient, which is why the original text simply says "all kinds of deficiencies" (zhu bu zu, 诸不足).

Crucially, this is a dual deficiency where neither Yin nor Yang can be aggressively tonified alone. As the Ling Shu teaches, supplementing Yang too strongly risks exhausting Yin, while draining Yin risks collapsing Yang. The only safe approach is gentle, sweet medicines that rebuild the center. Once the middle burner is restored, Qi and Blood are generated naturally, Yang rises and Yin follows, and the body's many deficiency symptoms resolve on their own.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet with mild pungent and sour notes. Sweet to tonify the middle and relax tension, pungent to warm Yang and move Qi, sour to restrain Yin and ease spasm.

Ingredients

7 herbs

The herbs that make up Huang Qi Jian Zhong Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Huang Qi Jian Zhong Tang

The defining addition to the base Xiao Jian Zhong Tang formula. Huang Qi powerfully tonifies Qi, strengthens the Spleen, and raises Yang. It also secures the exterior to stop spontaneous sweating, and its tissue-regenerating properties support healing of damaged mucous membranes. Combined with Yi Tang, it forms the core Qi-tonifying axis of the formula.
Yi Tang

Yi Tang

Maltose (Barley Malt Sugar)

Dosage 30 - 60g
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Lungs
Preparation Dissolved into the strained decoction over low heat at the end; not boiled with the other herbs.

Role in Huang Qi Jian Zhong Tang

Maltose is the sweet, warming core of the Jian Zhong formula family. It tonifies the Middle Burner, nourishes Qi and Blood, and is the primary herb for relieving cramping abdominal pain through its sweet, relaxing nature (甘以缓急). As the essence of grain, it directly supplements the Spleen and Stomach.
Deputies — Assists and enhances the King
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Huang Qi Jian Zhong Tang

Warms the Yang of the Middle Burner and disperses Cold. Combined with Bai Shao, it harmonizes the Ying (nutritive) and Wei (defensive) Qi. Its pungent warmth paired with the sweetness of Yi Tang and Gan Cao creates the 'pungent-sweet transforms into Yang' (辛甘化阳) dynamic that is essential to building central Yang.
Bai Shao

Bai Shao

White peony root

Dosage 12 - 18g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Huang Qi Jian Zhong Tang

Used at double the dose of Gui Zhi (the defining ratio change from Gui Zhi Tang), Bai Shao nourishes Ying Blood and Yin, softens the Liver, and relieves abdominal cramping. Its sour-sweet nature paired with Gan Cao creates the 'sour-sweet transforms into Yin' (酸甘化阴) dynamic, ensuring that both Yin and Yang are replenished.
Assistants — Supports or moderates other herbs
Sheng Jiang

Sheng Jiang

Fresh ginger rhizome

Dosage 6 - 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach

Role in Huang Qi Jian Zhong Tang

Warms the Stomach, aids digestion, and assists Gui Zhi in dispersing Cold from the Middle Burner. It also harmonizes the Stomach to prevent nausea and promotes the movement of Wei Qi.
Da Zao

Da Zao

Chinese date (Jujube fruit)

Dosage 4 - 6 pieces
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Preparation Split open (擘) before decocting.

Role in Huang Qi Jian Zhong Tang

Tonifies the Spleen and nourishes Blood and Qi. Working with Sheng Jiang, it harmonizes the nutritive and defensive layers. Its sweet nature supports the overall Middle Burner-tonifying strategy of the formula.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Huang Qi Jian Zhong Tang

Honey-prepared Licorice tonifies the Spleen Qi, relieves spasmodic abdominal pain in combination with Bai Shao (the classic Shao Yao Gan Cao Tang pairing), and harmonizes all the herbs in the formula. It is the envoy that ties the prescription together.

Why This Combination Works

How the herbs in Huang Qi Jian Zhong Tang complement each other

Overall strategy

This formula addresses a state where prolonged illness or overwork has depleted the body's central Qi and weakened both the Yin and Yang of the Spleen and Stomach. The prescription strategy is to 'build the centre' (建中) by warming and tonifying the Middle Burner with sweet, warm substances while simultaneously nourishing Yin to prevent the warmth from drying out the body. A classical teaching states: 'When all five organs are deficient, treat from the centre' (五脏皆虚从中治), because the Spleen and Stomach are the root source of Qi and Blood for the entire body.

King herbs

Huang Qi and Yi Tang (maltose) together form the core of this formula. Yi Tang is the quintessential sweet, warm substance for nourishing the Middle Burner and relaxing abdominal cramping. Huang Qi, famous for its ability to tonify Qi and raise Yang, reinforces the Spleen's capacity to generate Qi and Blood while also securing the exterior to stop spontaneous sweating. The Jin Gui Yao Lue Xin Dian states: "not enough must be supplemented with warmth, and for filling emptiness, Huang Qi has a special strength."

Deputy herbs

Gui Zhi and Bai Shao form a carefully balanced pair that addresses both sides of the Yin-Yang equation. Gui Zhi warms Yang and unblocks the channels, while Bai Shao nourishes Yin and Blood and relaxes muscle spasm. Critically, Bai Shao is used at double the dose of Gui Zhi, which shifts the formula's emphasis from exterior release (as in Gui Zhi Tang) toward interior nourishment. Gui Zhi combined with the sweet herbs generates Yang through the 'pungent-sweet transforms into Yang' principle, while Bai Shao combined with Gan Cao generates Yin through the 'sour-sweet transforms into Yin' principle.

Assistant herbs

Sheng Jiang (reinforcing assistant) warms the Stomach and assists Gui Zhi in dispersing interior Cold while also preventing nausea. Da Zao (reinforcing assistant) nourishes the Spleen and Blood, and together with Sheng Jiang harmonizes the nutritive and defensive layers of the body.

Envoy herbs

Zhi Gan Cao (honey-prepared Licorice) tonifies Spleen Qi, moderates the formula's actions, and directs the other herbs toward the Middle Burner. Paired with Bai Shao, it forms the famous antispasmodic combination (Shao Yao Gan Cao Tang) embedded within the formula.

Notable synergies

The Gui Zhi and Bai Shao pairing simultaneously generates both Yang and Yin when each is combined with the sweet herbs. The Bai Shao and Zhi Gan Cao pairing specifically targets cramping abdominal pain. Huang Qi and Yi Tang together amplify the Qi-tonifying effect far beyond what either achieves alone, creating a powerful yet gentle rebuilding of central Qi.

How to Prepare

Traditional preparation instructions for Huang Qi Jian Zhong Tang

Decoct the six solid herbs (Huang Qi, Gui Zhi, Bai Shao, Sheng Jiang, Zhi Gan Cao, Da Zao) in approximately 1400 mL of water. Bring to a boil, then simmer until reduced to about 600 mL. Strain out the dregs. Add the Yi Tang (maltose/malt sugar) to the strained decoction and return to a gentle flame, stirring until the maltose is fully dissolved.

Divide into three portions and take warm, three times daily. The maltose must not be boiled vigorously, only gently melted into the finished decoction over low heat (微火消解).

Common Modifications

How practitioners adapt Huang Qi Jian Zhong Tang for specific situations

Added
Sheng Jiang

Increase the dose of Sheng Jiang

This modification comes directly from the Jin Gui Yao Lue original text (气短胸满者加生姜). Additional Sheng Jiang warms the Middle Burner and promotes the descent of rebellious Qi to relieve chest oppression.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Huang Qi Jian Zhong Tang should not be used or requires extra caution

Avoid

Yin Deficiency with Empty Heat (signs such as red tongue with little coating, night sweats with five-palm heat from true Yin depletion). This warm, sweet formula can further injure Yin and aggravate Heat.

Avoid

Excess Heat patterns or Damp-Heat accumulation in the Stomach and intestines. The warming and tonifying nature of this formula will worsen these conditions.

Caution

Patients with vomiting (the classical text states 'those who vomit should not use Jian Zhong Tang because it is sweet'). The heavy sweetness of Yi Tang (maltose) can worsen nausea and vomiting.

Caution

Patients with roundworm (intestinal parasites). Sweet substances can aggravate parasitic conditions and may worsen symptoms.

Caution

Patients with acid reflux or hyperacidity. If used, Yi Tang (maltose) should be removed and appropriate modifications made (e.g. adding Wu Zhu Yu or calcined Wa Leng Zi).

Caution

Patients with significant Dampness or Phlegm accumulation. The heavy sweetness of this formula can generate or worsen Dampness.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy, as it contains no known teratogenic or uterine-stimulating herbs. The formula is mild and tonifying in nature. However, Zhi Gan Cao (prepared licorice) has documented pseudo-aldosterone effects that can promote fluid retention and raise blood pressure. In large doses or with prolonged use, licorice may increase the risk of preterm birth due to its corticosteroid-like and mild estrogenic activity. Pregnant women should use this formula only under practitioner supervision, with attention to appropriate dosing and duration.

Breastfeeding

Generally considered safe during breastfeeding. All ingredients are food-grade or commonly used tonifying herbs with no documented toxicity concerns for nursing infants. The formula's Qi-tonifying and middle-warming properties may actually support postpartum recovery and milk production by strengthening the Spleen. Zhi Gan Cao (prepared licorice) in typical formula doses is unlikely to cause problems, but prolonged use at high doses could theoretically affect fluid balance. No specific contraindications for breastfeeding are noted in classical or modern sources.

Children

Huang Qi Jian Zhong Tang is one of the most frequently used formulas in pediatric practice, both in China and in Japanese Kampo medicine. It is well suited for children with weak constitutions, poor appetite, thin body habitus, pallid complexion, recurrent abdominal pain, and susceptibility to colds. Dosage should be adjusted by age and body weight: typically one-quarter to one-third of the adult dose for children under 6, and one-half to two-thirds for children aged 6 to 12. Yi Tang (maltose) makes the formula naturally palatable for children. For very young children (under 3), smaller doses and shorter courses are appropriate, with close monitoring. This formula is particularly valued for children with recurrent functional abdominal pain or failure to thrive linked to Spleen Qi deficiency.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Huang Qi Jian Zhong Tang

Zhi Gan Cao (Glycyrrhiza/Licorice) interactions: This is the primary herb of concern for drug interactions in this formula.

  • Cardiac glycosides (digoxin, digitalis): Glycyrrhizic acid in licorice can cause potassium depletion (pseudo-aldosteronism), which increases sensitivity to cardiac glycosides and may precipitate toxicity. Concurrent use should be avoided.
  • Antihypertensive medications: Licorice can cause sodium and water retention and raise blood pressure, potentially counteracting the effects of blood pressure-lowering drugs.
  • Potassium-depleting diuretics (furosemide, thiazides): Combined use with licorice may compound potassium loss, increasing the risk of hypokalemia, muscle weakness, and cardiac arrhythmias.
  • Warfarin and anticoagulants: Some evidence suggests licorice may interact with warfarin metabolism, potentially altering anticoagulant effects. Monitoring is advised.
  • Hypoglycemic agents (insulin, sulfonylureas, metformin): Glycyrrhizic acid has glucocorticoid-like effects that can raise blood sugar, potentially reducing the efficacy of diabetes medications.
  • Corticosteroids: Licorice inhibits the metabolism of hydrocortisone and prednisolone, potentially increasing their blood levels and side effects.

These interactions are dose-dependent and more relevant with prolonged use. In typical short-course prescriptions at standard doses, clinical significance is low but should still be considered.

Usage Guidance

Practical advice for getting the most out of Huang Qi Jian Zhong Tang

Best time to take

30 minutes before meals on an empty stomach, taken warm, 2 to 3 times daily. The classical instruction is to take it warm (温服) to enhance its middle-warming action.

Typical duration

Chronic use: typically prescribed for 2 to 8 weeks, then reassessed. May be taken intermittently over longer periods for constitutional weakness.

Dietary advice

Favor warm, easily digestible, cooked foods such as congee (rice porridge), soups, stewed root vegetables, well-cooked grains, and mild proteins. These support the formula's goal of rebuilding middle burner function. Avoid cold and raw foods (salads, iced drinks, raw fruit), greasy or fried foods, and overly sweet or rich desserts, all of which burden the weakened Spleen and Stomach. Dairy products should be minimized as they tend to generate Dampness. Spicy or acrid foods in excess should also be avoided, as they can scatter the Qi that the formula is trying to consolidate. Eat regular, moderate-sized meals rather than large heavy ones. The classical approach emphasizes gentle nourishment, sometimes described as eating soft foods like porridge on the day of taking the formula.

Huang Qi Jian Zhong Tang originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Huang Qi Jian Zhong Tang and its clinical use

Jin Gui Yao Lue (金匮要略), Blood Impediment and Consumptive Disease chapter:
「虚劳里急,诸不足,黄芪建中汤主之。」
"For consumptive disease with internal urgency and all kinds of deficiencies, Huang Qi Jian Zhong Tang governs."

Shang Han Lun (伤寒论), regarding the parent formula Xiao Jian Zhong Tang:
「呕家不可用建中汤,以甜故也。」
"Those who are prone to vomiting should not use Jian Zhong Tang, because it is sweet."

Jin Gui Yao Lue Xin Dian (金匮要略心典) by You Zai-Jing:
「急者缓之必以甘,不足者补之必以温,而充虚塞空,则黄芪尤有专长也。」
"To relax what is tense one must use sweetness; to supplement what is insufficient one must use warmth; and for filling up emptiness, Huang Qi (Astragalus) has particular expertise."

Ling Shu, Zhong Shi chapter (灵枢·终始):
「阴阳俱不足,补阳则阴竭,泻阴则阳脱。如是者,可将以甘药,不可饮以至剂。」
"When both Yin and Yang are insufficient, supplementing Yang will exhaust Yin, and draining Yin will cause Yang to collapse. In such cases, one should use sweet medicines and must not administer drastic remedies."
This passage from the Nei Jing is considered the theoretical foundation for the entire Jian Zhong Tang family of formulas.

Historical Context

How Huang Qi Jian Zhong Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Huang Qi Jian Zhong Tang was first recorded in Zhang Zhongjing's Jin Gui Yao Lue (Synopsis of Prescriptions of the Golden Cabinet), composed during the late Eastern Han Dynasty (circa 200 CE). It is a modification of Xiao Jian Zhong Tang (Minor Construct the Middle Decoction), itself derived from the foundational Gui Zhi Tang (Cinnamon Twig Decoction). The addition of Huang Qi (Astragalus) specifically strengthens the formula's ability to tonify Qi, making it suitable for more severe cases of consumptive disease where Qi deficiency is prominent. The name "Jian Zhong" (建中, "construct the middle") reflects the classical principle that rebuilding the Spleen and Stomach is the foundation for recovering from chronic illness.

The Qing Dynasty Warm Disease master Ye Tianshi (叶天士) later refined the clinical indications for this formula in treating consumptive disease, helping practitioners identify which patients would most benefit from it. In Japan, this formula (known as Ogi-Kenchu-To) became one of the most frequently prescribed Kampo formulas, particularly in pediatrics for children with weak constitutions, poor appetite, and recurrent abdominal pain. The Li Xu Yuan Jian (理虚元鉴) contains a famous commentary describing how Huang Qi acts like a central banner in an army: once this rallying point is established in the middle burner, all the scattered forces of the five organ systems fall back into line.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Huang Qi Jian Zhong Tang

1

Systematic Review: Huangqi Jianzhong Tang for Treatment of Chronic Gastritis (2016)

Wei Y, Ma LX, Yin SJ, An J, Wei Q, et al. Evidence-Based Complementary and Alternative Medicine. 2016; 2016: 9016498.

A systematic review and meta-analysis of 9 randomized controlled trials involving 979 patients evaluated HQJZT for chronic gastritis. The results suggested potential benefit, but the authors noted that the methodological quality of the included trials was generally poor, limiting the strength of conclusions.

PubMed
2

Preclinical Study: HQJZT Ameliorates Indomethacin-Induced Duodenal Ulcers in Rats via NF-κB and STAT Pathways (2022)

Song H, Qiu J, Yu C, Xiong M, Ou C, Ren B, Zhong M, Zeng M, Peng Q. Biomedicine & Pharmacotherapy. 2022; 156: 113866.

This animal study investigated HQJZT's protective effects against indomethacin-induced duodenal ulcers in rats. The formula completely protected the duodenal mucosa from ulceration, as shown by improved tissue appearance, decreased ulcer index, and normalization of duodenal architecture. The mechanism involved anti-inflammatory effects through the NF-κB and STAT signaling pathways.

3

Preclinical Study: HQJZT Accelerates Healing of Indomethacin-Induced Gastric Ulceration via Anti-Inflammatory and Antioxidant Mechanisms (2023)

Song H, Xiong M, Yu C, Ren B, Zhong M, Zhou S, Gao Q, Ou C, Wang X, Lu J, Zeng M, Cai X, Peng Q. Journal of Ethnopharmacology. 2024; 319: 117151.

This rat study explored the gastroprotective potential of HQJZT against indomethacin-induced gastric ulcers. The formula demonstrated significant healing effects through both anti-inflammatory (NF-κB/STAT pathways) and antioxidant mechanisms (improved GSH, CAT, SOD levels and reduced MDA).

PubMed
4

Preclinical Study: HQJZT Pellet Attenuates TNBS-Induced Colitis in Rats via Energy Metabolism Improvement (2013)

Liu DY, Pan CS, Liu YY, et al. Evidence-Based Complementary and Alternative Medicine. 2013; 2013: 574629.

This animal study showed that HQJZT pellets could attenuate experimentally induced colitis in rats, with the mechanism involving improvement of cellular energy metabolism. This supports the formula's traditional use for gastrointestinal inflammation linked to deficiency.

5

Metabolic Profiling of HQJZT and Anti-Inflammatory Activity (2016)

Planta Medica. 2016; 82(S 01): S1-S381.

This study performed chemical profiling of HQJZT to enable standardization of the formula. Pharmacological testing showed that various fractions of the decoction significantly inhibited the expression of pro-inflammatory cytokines TNF-α, IFN-γ, IL-1β, and IL-4 in immune cells, supporting its anti-inflammatory properties.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.