Formula Pill (Wan)

Huai Jiao Wan

Sophora Fruit Pill · 槐角丸

Also known as: Sophora Japonica Fruit Pill, Fructus Sophora Pills

A classical formula for rectal and hemorrhoidal bleeding caused by heat accumulating in the intestines. It cools the blood, stops bleeding, and clears heat from the lower bowel while gently regulating bowel movement and Qi flow. Commonly used for hemorrhoids with bright red bleeding, as well as rectal prolapse associated with constipation and heat signs.

Origin Tài Píng Huì Mín Hé Jì Jú Fāng (太平惠民和剂局方) — Sòng dynasty, ~1107–1110 CE (Bǎoqìng supplement edition)
Composition 6 herbs
Huai Jiao
King
Huai Jiao
Di Yu
Deputy
Di Yu
Huang Qin
Deputy
Huang Qin
Dang Gui
Assistant
Dang Gui
Zhi Ke
Assistant
Zhi Ke
Fang Feng
Envoy
Fang Feng
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huai Jiao Wan is designed to correct these specific patterns.

Why Huai Jiao Wan addresses this pattern

Intestinal wind (肠风) is a classical pattern describing rectal bleeding caused by wind-heat invading the Large Intestine and forcing blood out of the intestinal vessels. In this pattern, heat accumulates in the blood level of the intestines, causing the blood to move recklessly outside its normal pathways. Huai Jiao Wan directly addresses this by cooling the blood (Huai Jiao, Di Yu, Huang Qin), stopping the reckless bleeding, and dispersing the wind component (Fang Feng). The formula simultaneously regulates intestinal Qi (Zhi Ke) and prevents blood stasis from the cold, astringent approach (Dang Gui), making it a well-rounded treatment for this pattern.

A practitioner would look for one or more of these signs

Bleeding

Bright red blood in the stool, either before or after the bowel movement

Hemorrhoids

Swollen, painful hemorrhoids with bleeding

Constipation

Dry, difficult stools that worsen bleeding

Rectal Prolapse

Mild prolapse of the rectum, especially with dry stools

Ankle Pain

Burning or stinging pain around the anus

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Huai Jiao Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Intestinal Wind due to Blood-Heat Damp-Heat in the Large Intestine

TCM Interpretation

In TCM, hemorrhoids (痔) are understood as a disorder of Qi and blood circulation in the anal region. Several factors contribute: prolonged sitting or standing, overindulgence in rich, spicy, or greasy foods, emotional stress, and chronic constipation. These factors generate heat in the Large Intestine and cause Qi to stagnate in the lower body. When heat enters the blood level of the intestines, it forces blood out of the vessels, producing bleeding. Meanwhile, the local accumulation of damp-heat causes the tissue to swell, creating the hemorrhoidal masses. The condition is worsened when dry, hard stools scrape against inflamed tissue, creating a cycle of constipation, straining, and bleeding.

Why Huai Jiao Wan Helps

Huai Jiao Wan breaks this cycle from multiple directions. Huai Jiao, Di Yu, and Huang Qin cool the intestinal heat that drives the bleeding, with Huai Jiao and Di Yu specifically chosen because they also moisten the intestines and soften stools, preventing the dry bowel movements that aggravate hemorrhoids. Dang Gui further supports smooth bowel function while nourishing the blood that has been lost. Zhi Ke promotes normal intestinal peristalsis, relieving the straining that worsens hemorrhoidal pressure. Fang Feng addresses the wind component that classical texts associate with intestinal bleeding and provides an upward-lifting action that counteracts the prolapsing tendency of hemorrhoids. The formula is best suited for hemorrhoids presenting with bright red bleeding and heat signs, rather than for pale bleeding from Qi deficiency.

Also commonly used for

Rectal Prolapse

Mild prolapse associated with constipation and heat, not Qi deficiency

Anal Fissure

When accompanied by heat signs and bleeding

Ulcerative Colitis

Bloody stools with damp-heat pattern

Dysentery

Bloody dysentery with tenesmus and heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Huai Jiao Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Huai Jiao Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Huai Jiao Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Huai Jiao Wan works at the root level.

Huai Jiao Wan addresses a pattern where Wind and Heat accumulate in the Large Intestine, forcing Blood to move recklessly out of the vessels. In TCM theory, the Liver stores Blood and governs the free flow of Qi. When the Liver becomes overheated (often from dietary excess of rich, spicy, or greasy foods, or from emotional stress and long periods of sitting), that Heat can transfer downward along its channel relationship with the Large Intestine. The Heat "scorches" the intestinal vessels, causing Blood to leak from its normal pathways, which manifests as bloody stool, hemorrhoidal bleeding, or anal swelling and pain.

At the same time, Wind (a pathogenic force associated with movement and change) can invade the Yang Ming (Stomach/Large Intestine) level and combine with this internal Heat. Wind-Heat in the intestinal collaterals destabilizes the blood vessels further, and the result is what classical texts call "intestinal Wind" (肠风). When Qi also sinks downward and fails to hold tissues in place, rectal prolapse can occur alongside the bleeding. The blood is characteristically bright red because it is driven out by Heat rather than by cold or deficiency. The formula works by directly cooling the Liver and intestinal Heat that is the root cause, while simultaneously addressing the Wind component, supporting proper Qi movement so that the sinking tendency is corrected, and gently nourishing Blood so that the bleeding stops without creating stagnation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter with secondary astringent and acrid notes. The bitter taste clears Heat and dries Dampness, astringency helps restrain bleeding, and the mild acrid quality from Fang Feng disperses Wind.

Ingredients

6 herbs

The herbs that make up Huai Jiao Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Huai Jiao

Huai Jiao

Sophora fruit

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Large Intestine
Preparation Dry-fried (清炒) to moderate its cold nature and enhance its astringent hemostatic effect

Role in Huai Jiao Wan

The principal herb, used at double the dosage of all other ingredients. Clears heat from the Large Intestine, cools the blood, stops bleeding, and gently moistens the intestines to ease bowel movements. Its bitter, cold nature directly targets the root cause of intestinal heat forcing blood out of the vessels.
Deputies — Assists and enhances the King
Di Yu

Di Yu

Sanguisorba root

Dosage 6 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Large Intestine, Stomach
Preparation Charred (地榆炭) to enhance hemostatic action

Role in Huai Jiao Wan

Strongly cools the blood and stops bleeding, with a particular affinity for the lower body and lower digestive tract. Works in concert with Huai Jiao to powerfully arrest rectal bleeding. Also has a mild laxative effect that helps keep stools soft, preventing further damage to hemorrhoidal tissue.
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 6 - 12g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Huai Jiao Wan

Clears heat and dries dampness, particularly in the intestines. Reinforces the blood-cooling and bleeding-stopping effects of Huai Jiao and Di Yu. Its ability to clear damp-heat from the Large Intestine addresses the underlying pathogenic environment that produces hemorrhoidal bleeding.
Assistants — Supports or moderates other herbs
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Huai Jiao Wan

Nourishes and invigorates the blood, ensuring that bleeding is stopped without causing blood stasis. Moistens the intestines and promotes smooth bowel movements. Prevents the cold, astringent nature of the other herbs from causing unwanted blood stagnation.
Zhi Ke

Zhi Ke

Bitter orange fruit

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine, Lungs
Preparation Bran-fried (麸炒) to moderate its harsh dispersing nature and better focus its action on the middle and lower digestive tract

Role in Huai Jiao Wan

Regulates Qi movement and relieves distension in the intestines. Promotes intestinal peristalsis, which has an indirect compressive hemostatic effect on bleeding vessels. Addresses the Qi stagnation component that often accompanies hemorrhoids.
Envoy — Directs the formula to its target
Fang Feng

Fang Feng

Siler root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Huai Jiao Wan

Disperses wind and lifts the clear Yang Qi, counterbalancing the heavily descending nature of the other herbs. In the context of intestinal wind bleeding, it addresses the wind component of the pathology. Its upward-lifting quality helps prevent rectal prolapse and guides the formula to regulate the intestines.

Why This Combination Works

How the herbs in Huai Jiao Wan complement each other

Overall strategy

This formula targets heat accumulating in the Large Intestine that forces blood out of the intestinal vessels, causing hemorrhoidal and rectal bleeding. The prescription combines strong blood-cooling and bleeding-stopping herbs with Qi-regulating and wind-dispersing herbs to address both the bleeding itself and the underlying Qi dynamics that contribute to it.

King herb

Huai Jiao is used at double the dosage of all other ingredients and serves as the chief herb. It is bitter, cold, and has a descending nature that specifically targets the Large Intestine. Classical sources describe it as a premier blood-cooling agent that "clears all heat, disperses all stagnation, and drains all fire." It clears intestinal damp-heat, cools recklessly moving blood back into the vessels, and its oily, moistening quality helps keep stools soft to prevent further injury to hemorrhoidal tissue.

Deputy herbs

Di Yu (charred) and Huang Qin reinforce the King herb from complementary angles. Di Yu is especially effective for lower body bleeding and has a proven ability to shorten clotting time and constrict blood vessels. Huang Qin clears damp-heat from the intestines and prevents the reckless movement of blood. Together with Huai Jiao, these three herbs form the core blood-cooling, heat-clearing, and bleeding-stopping team of the formula.

Assistant herbs

Dang Gui serves as a restraining assistant. While the other herbs cool and constrict, Dang Gui nourishes and gently moves the blood, ensuring that stopping the bleeding does not lead to blood stasis. It also moistens the intestines, complementing the laxative effects of Huai Jiao and Di Yu. Zhi Ke (bran-fried) is a reinforcing assistant that regulates Qi flow in the intestines. By promoting intestinal contraction and relieving abdominal distension, it indirectly supports hemostasis through a compressive mechanism and addresses Qi stagnation that worsens hemorrhoidal swelling.

Envoy herb

Fang Feng disperses wind and lifts the clear Yang Qi upward. In a formula dominated by cold, descending herbs, Fang Feng provides essential upward-lifting balance. It addresses the "wind" component of intestinal wind bleeding (肠风), helps prevent rectal prolapse by raising sunken Qi, and harmonizes the overall direction of the formula by ensuring that the intestines are regulated without excessive downward drainage.

Notable synergies

The Huai Jiao and Di Yu pairing is particularly noteworthy: both cool blood and stop bleeding, but they were specifically chosen over other hemostatic herbs because both also moisten the intestines and keep stools soft. Since dry, hard stools are a major aggravating factor for hemorrhoidal bleeding, this dual function of cooling blood while preventing constipation makes them ideally suited for this condition. The Fang Feng and Zhi Ke pairing works on the Qi level: Fang Feng lifts the clear Yang upward while Zhi Ke moves Qi through the intestines, together restoring normal Qi circulation in the lower body and helping prevent prolapse.

How to Prepare

Traditional preparation instructions for Huai Jiao Wan

Grind all herbs into a fine powder. Mix the powder with a wine-based paste (酒糊) to form pills the size of Chinese parasol tree seeds (approximately 8mm diameter). Take 30 pills each time with rice water (米饮), without regard to timing of meals. For prolonged use.

In modern prepared forms, the formula is commonly produced as water-honey pills (水蜜丸) using honey as the binding agent. The standard modern dosage for prepared pills is 6g per dose, taken twice daily with warm water.

Common Modifications

How practitioners adapt Huai Jiao Wan for specific situations

Added
Ce Bo Ye

9 - 12g, charred, to strongly cool blood and stop bleeding

Xian He Cao

9 - 15g, to astringe and stop bleeding

Ce Bai Ye (charred) and Xian He Cao reinforce the hemostatic action when bleeding is heavy and urgent, adding both cooling and astringent mechanisms to arrest blood loss more quickly.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Huai Jiao Wan should not be used or requires extra caution

Avoid

Pregnancy: this formula contains bitter, cold herbs (Huai Jiao, Huang Qin, Di Yu) that may adversely affect the fetus. Dang Gui also promotes Blood circulation, which poses additional risk. Pregnant women should not use this formula.

Avoid

Spleen and Stomach deficiency Cold (脾胃虚寒): the formula is predominantly cold in nature and may further damage the Spleen and Stomach Yang in patients who already have cold-type digestive weakness, loose stools from deficiency, or poor appetite with cold sensations.

Avoid

Hemorrhoidal bleeding due to Spleen Qi sinking (脾气下陷): if bleeding is pale in color and accompanied by fatigue, weak limbs, and a pale tongue, the pattern is Qi deficiency rather than Blood Heat. Bu Zhong Yi Qi Tang would be more appropriate. Huai Jiao Wan's cold nature could worsen the condition.

Caution

Concurrent use with anticoagulant or antiplatelet medications (such as warfarin, heparin, aspirin, or clopidogrel): the formula contains herbs that affect clotting and Blood movement (Dang Gui, Di Yu, Huang Qin), which may potentiate the anticoagulant effect and increase bleeding risk.

Avoid

Patients with large-volume active hemorrhage requiring emergency intervention: this formula is designed for chronic or moderate intestinal bleeding from Heat patterns, not for acute massive hemorrhage which requires emergency care.

Caution

Prolonged use beyond the recommended course without reassessment: the formula's cold and bitter properties can gradually injure Spleen and Stomach Qi if used for extended periods. It should be discontinued or modified once bleeding stops.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains several bitter, cold herbs (Huai Jiao, Huang Qin, Di Yu) that could injure fetal development by depleting the mother's Spleen and Stomach Yang. Dang Gui (Angelica sinensis) promotes Blood circulation, and Zhi Ke (bitter orange) moves Qi downward, both of which carry a theoretical risk of disturbing the pregnancy. Chinese Pharmacopoeia and clinical references list this formula as prohibited for pregnant women (孕妇禁用). Pregnant women experiencing hemorrhoidal symptoms should seek guidance from a qualified practitioner for safer alternatives.

Breastfeeding

Use with caution during breastfeeding. While there is no explicit prohibition in classical texts for nursing mothers, the formula's predominantly cold and bitter nature raises concerns. Bitter, cold medicinals may transfer through breast milk and potentially cause digestive upset (loose stools, reduced appetite) in the nursing infant. Dang Gui and its active compounds may also pass into breast milk. Some modern Chinese clinical references recommend that breastfeeding women either pause nursing during the course of treatment or use the formula only under close practitioner supervision. If hemorrhoidal bleeding is mild, non-medicinal measures (dietary fiber, sitz baths) should be tried first.

Children

Huai Jiao Wan is not commonly prescribed for young children. Hemorrhoidal conditions are rare in pediatric patients, and the formula's cold, bitter nature can easily injure the still-developing digestive system of children. If used for older children or adolescents (generally over 12 years) with confirmed Blood-Heat intestinal bleeding patterns, the dosage should be reduced to approximately one-third to one-half of the adult dose, depending on body weight and constitution. A qualified practitioner should supervise use. The formula should not be given to infants or toddlers.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Huai Jiao Wan

Anticoagulants and antiplatelet drugs (e.g., warfarin, heparin, aspirin, clopidogrel): This formula contains Dang Gui (Angelica sinensis), which is known to enhance the anticoagulant effect of warfarin by promoting Blood circulation. Huang Qin (Scutellaria) contains baicalin, which has demonstrated antiplatelet activity in pharmacological studies. Di Yu (Sanguisorba) shortens clotting time but the net interaction with pharmaceutical anticoagulants is unpredictable. Concurrent use may increase bleeding risk, and INR should be closely monitored if combined use is unavoidable.

Iron supplements: The tannin content in Di Yu (Sanguisorba) and Huang Qin may bind dietary or supplemental iron, reducing its absorption. If iron supplementation is needed, doses should be separated by at least two hours.

Other hemostatic or Blood-moving Chinese patent medicines: Avoid stacking this formula with other Blood-cooling or Blood-moving preparations (e.g., Yun Nan Bai Yao, Di Yu Huai Jiao Wan) to prevent unpredictable additive effects on coagulation.

Usage Guidance

Practical advice for getting the most out of Huai Jiao Wan

Best time to take

Take on an empty stomach or 30 minutes before meals, twice daily, with warm rice water or warm water as traditionally recommended.

Typical duration

Typically taken for 7–14 days per course, with reassessment if symptoms persist. Not recommended for continuous use beyond 2–3 weeks without practitioner evaluation, as prolonged use of cold-natured formulas may injure the Spleen and Stomach.

Dietary advice

Avoid spicy, greasy, fried, and heavily seasoned foods (chili peppers, hot pot, fried meats, alcohol), as these generate Heat and Dampness in the intestines and directly worsen hemorrhoidal conditions. Reduce consumption of rich, sweet foods that produce Dampness. Increase dietary fiber from vegetables, whole grains, and fruits to keep bowel movements soft and regular, since constipation and straining aggravate hemorrhoids and bleeding. Drink adequate water. Mung bean soup, pear, lotus root, and bitter melon are supportive foods that gently clear Heat. Avoid cold, raw foods in excess if the person already has a weak digestion, as the formula itself is already cooling.

Huai Jiao Wan originates from Tài Píng Huì Mín Hé Jì Jú Fāng (太平惠民和剂局方) Sòng dynasty, ~1107–1110 CE (Bǎoqìng supplement edition)

Classical Texts

Key passages from the classical Chinese medical texts that first described Huai Jiao Wan and its clinical use

From the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Volume 8, Baoqing Supplementary Formulas (宝庆新增方):

「治五种肠风泻血。粪前有血名外痔,粪后有血名内痔,大肠不收名脱肛,谷道四面胬肉如奶名举痔,头上有乳名瘘;及肠风疮内小虫,里急下脓血。」

Translation: "Treats five types of intestinal Wind bleeding. Blood before the stool is called external hemorrhoids; blood after the stool is called internal hemorrhoids; when the Large Intestine cannot hold itself in, it is called rectal prolapse; fleshy growths around the anus like nipples are called raised hemorrhoids; when there are holes at the top, it is called fistula. Also treats intestinal Wind sores with small worms, and tenesmus with pus and blood in the stool."


From the Ben Cao Jing Shu (本草经疏) by Miao Xiyong, on Huai Jiao:

「槐为苦寒纯阴之药,为凉血要品,故能除一切热,散一切结,清一切火。」

Translation: "Sophora fruit is a bitter, cold, purely Yin medicinal. It is an essential substance for cooling the Blood, and therefore can eliminate all Heat, disperse all accumulations, and clear all Fire."

Historical Context

How Huai Jiao Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Huai Jiao Wan first appeared in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), specifically in the Baoqing Supplementary Formulas (宝庆新增方) section of Volume 8. The He Ji Ju Fang was the Song Dynasty government's official formulary, first compiled around 1078 CE and revised multiple times. The Baoqing supplements were added during the Baoqing era (1225–1227 CE) of the Southern Song, making Huai Jiao Wan a later addition to this already influential text. The formulary itself was described as having such widespread authority that "officials upheld it as law, physicians transmitted it as their trade, the sick relied on it for their lives, and the common people practiced it as custom."

Over the centuries, numerous variants of Huai Jiao Wan appeared in other texts. The Ren Zhai Zhi Zhi Fang Lun (仁斋直指方论) recorded a version adding Huang Bai, Huang Lian, Ce Bai Ye, and Jing Jie Sui for more severe intestinal bleeding. The Yu Yao Yuan Fang (御药院方) added Huang Qi and Mu Xiang for cases with Qi deficiency and poor appetite. The modern proprietary medicine Di Yu Huai Jiao Wan is an expanded derivative that adds herbs like Da Huang, Sheng Di Huang, Chi Shao, and Hong Hua for more pronounced Heat and Blood stasis. The enduring use of Huai Jiao Wan in various forms for nearly 800 years, and its inclusion in the Chinese Pharmacopoeia as a standard patent medicine, testifies to its lasting clinical significance in treating hemorrhoidal conditions.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Huai Jiao Wan

1

A Randomized, Double-Blind, Placebo-Controlled Trial of a Chinese Herbal Sophora Flower Formula in Patients with Symptomatic Haemorrhoids: A Preliminary Study (RCT, 2013)

Gan T, Liu YD, Wang Y, Yang J. BMC Complementary and Alternative Medicine, 2013, 13:199

This double-blind RCT tested a Sophora-based formula (closely related to the Huai Jiao family of formulas) against placebo for symptomatic hemorrhoids. After 14 days, 78.2% of patients in the treatment group were asymptomatic compared to only 40.9% resolution in the placebo group, with improvements in bleeding and other symptoms noted as early as day 7.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.