Huai Hua San

Sophorae Flower Powder · 槐花散

Also known as: Sophora Japonica Flower Powder, Pagoda Flower Powder, Sophora Flower Formula

A classical four-herb formula used to cool the intestines and stop rectal bleeding caused by heat in the bowels. It is commonly applied for hemorrhoid bleeding, blood in the stool, and inflammatory bowel conditions where the blood is bright red and the underlying cause is heat or dampness obstructing the intestinal blood vessels.

Origin Pǔ Jì Běn Shì Fāng (普济本事方, Formulas for Universal Benefit from My Practice) by Xǔ Shūwēi (许叔微) — Sòng dynasty, 1132 CE
Composition 4 herbs
Huai Hua
King
Huai Hua
Ce Bo Ye
Deputy
Ce Bo Ye
Jing Jie
Assistant
Jing Jie
Zh
Assistant
Zhi Qiao (枳壳, Fructus Aurantii)
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huai Hua San is designed to correct these specific patterns.

Why Huai Hua San addresses this pattern

When Wind-Heat invades the Large Intestine, it enters the blood level and damages the intestinal blood vessels, causing what classical texts call 'intestinal Wind' (肠风). The blood escapes the vessels and appears as bright red bleeding before or during bowel movements. Huai Hua and Ce Bai Ye directly clear intestinal heat and cool the blood to seal the damaged vessels, while Jing Jie Sui disperses the Wind component and Zhi Qiao restores Qi circulation in the intestines. The formula addresses both the Heat (which damages vessels) and the Wind (which drives the pathogenic process).

A practitioner would look for one or more of these signs

Bleeding

Bright red blood appearing before defecation

Dark Blood In Stool

Fresh blood mixed with or coating the stool

Hemorrhoids

Hemorrhoid bleeding with bright red blood

Red Tongue

Red tongue with yellow coating

Rapid Pulse

Rapid (数) or wiry-rapid pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Huai Hua San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, hemorrhoids are closely related to damp-heat accumulating in the Large Intestine and the downward flow of turbid Qi. Prolonged sitting, spicy or rich diets, and emotional stress can generate internal heat that damages the blood vessels in the rectal area. When Wind is also involved, the bleeding tends to be sudden and bright red, while damp-heat predominance produces more swelling, pain, and darker blood. The Liver and Spleen also play supporting roles: Liver heat can intensify blood movement, while Spleen deficiency may fail to hold blood in the vessels.

Why Huai Hua San Helps

Huai Hua San addresses hemorrhoid bleeding by cooling the Large Intestine and stanching blood with Huai Hua and Ce Bai Ye, while Jing Jie disperses the Wind that agitates the bleeding and Zhi Qiao relaxes the intestinal Qi to reduce local congestion. Modern research shows the formula has anti-inflammatory effects and can reduce vascular permeability in the intestines, which directly relates to the swelling and fragility of hemorrhoidal blood vessels. The formula is best suited for acute bleeding episodes with heat signs rather than chronic hemorrhoids with prolapse or deficiency.

Also commonly used for

Bleeding

Hematochezia from various intestinal heat conditions

Anal Fissure

With bleeding due to local heat and dryness

Colitis

Including radiation-induced colitis with intestinal bleeding

Bloody Stool

Functional lower GI bleeding attributed to heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Huai Hua San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Huai Hua San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Huai Hua San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Huai Hua San works at the root level.

Huai Hua San addresses a condition that classical texts call "intestinal Wind" (肠风 cháng fēng) and "visceral toxin" (脏毒 zàng dú), both of which cause blood in the stool. The underlying problem is an accumulation of Wind-Heat or Damp-Heat that becomes lodged in the Large Intestine, damaging the blood vessels within the intestinal wall and forcing blood to leak out of its proper pathways.

In the "intestinal Wind" pattern, Wind and Heat combine and injure the more superficial blood vessels of the intestine. The blood that appears tends to be bright red and often comes before the stool. In the "visceral toxin" pattern, Dampness and Heat stagnate more deeply, and the resulting blood is typically darker, sometimes mixed into the stool. In both scenarios, the pathological heat agitates the Blood and drives it recklessly out of the vessels (a process TCM calls "Heat forcing Blood to move recklessly," 血热妄行). At the same time, Wind stirs movement in the bowels, and when Qi flow in the Large Intestine is obstructed by the accumulation of these pathogenic factors, the normal downward passage of waste becomes disordered, further aggravating the bleeding.

The formula works because it directly targets this combination of problems: it cools the intestinal Heat that is the root driver of the bleeding, calms the reckless movement of Blood, disperses the Wind component, and restores normal Qi flow through the intestines. Once Heat is cleared and Qi movement is restored, the blood vessels are no longer damaged, and the bleeding resolves naturally.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter with some acrid notes — bitter to clear Heat and drain downward, acrid to disperse Wind and move Qi.

Ingredients

4 herbs

The herbs that make up Huai Hua San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Huai Hua

Huai Hua

Pagoda tree flowers

Dosage 10 - 15g
Temperature Cool
Taste Bitter
Organ Affinity Large Intestine, Liver
Preparation Stir-fried (炒) to enhance its hemostatic action

Role in Huai Hua San

The principal herb of the formula. Huai Hua is bitter and slightly cold, entering the Liver and Large Intestine channels. It excels at clearing damp-heat from the Large Intestine, cooling the Blood, and stopping bleeding. It directly addresses the core pathomechanism of heat damaging the intestinal blood vessels.
Deputy — Assists and enhances the King
Ce Bo Ye

Ce Bo Ye

Biota twigs and leaves

Dosage 10 - 15g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Large Intestine, Liver, Lungs
Preparation Pounded and baked (杵烂焙)

Role in Huai Hua San

Assists the King herb by also cooling the Blood and stopping bleeding. Ce Bai Ye is bitter, astringent, and slightly cold. It enters the blood level to clear heat and dry dampness without injuring Yin, reinforcing the hemostatic and heat-clearing power of Huai Hua.
Assistants — Supports or moderates other herbs
Jing Jie

Jing Jie

Japanese catnip

Dosage 6 - 10g
Temperature Neutral
Taste Pungent
Organ Affinity Liver, Lungs

Role in Huai Hua San

Disperses Wind and enters the blood level to stop bleeding. Although Jing Jie is mildly warm and acrid, when charred or used as the spike (穗), it acts on the blood level to resolve bleeding caused by Wind-Heat lodged in the intestines. It prevents the cool herbs from over-congealing the blood.
Zh

Zhi Qiao (枳壳, Fructus Aurantii)

Dosage 6 - 10g
Preparation Remove seeds, slice thinly, bran stir-fried (去瓤麸炒黄)

Role in Huai Hua San

Moves Qi and widens the intestines. Since Wind-Heat and damp-heat obstruct the Qi mechanism of the Large Intestine, Zhi Qiao restores proper Qi flow, embodying the principle that 'when Qi is regulated, Blood is regulated' (气调则血调). Its downward-directing action complements the upward-lifting quality of Jing Jie.

Why This Combination Works

How the herbs in Huai Hua San complement each other

Overall strategy

The formula targets intestinal bleeding caused by Wind-Heat or damp-heat accumulating in the Large Intestine and damaging blood vessels. The strategy is to cool the blood and stop bleeding as the primary approach, while simultaneously dispersing Wind and promoting Qi flow to address the root cause of the obstruction.

King herbs

Huai Hua (Sophorae Flower) is the sole King. Bitter and slightly cold, it has a specific affinity for the Large Intestine channel, where it clears damp-heat and cools the blood to stop bleeding. It directly targets the core mechanism of heat forcing blood out of the vessels in the intestines.

Deputy herbs

Ce Bai Ye (Biota Leaves) reinforces the King by also cooling the blood and stopping bleeding. As noted in classical commentary, it "enters the blood level, nourishes Yin and dries dampness, best at cooling heat in the blood level." Its astringent quality adds a gentle containing action that complements the clearing action of Huai Hua.

Assistant herbs

Two herbs serve as Assistants, each addressing a different dimension of the pathology. Jing Jie Sui (Schizonepeta Spike) is a reinforcing assistant that disperses Wind from the blood level. Wind is one of the pathogenic factors driving the intestinal bleeding, and Jing Jie addresses it while also helping to stop bleeding by entering the blood level. Its mild warmth prevents the formula from becoming excessively cold. Zhi Qiao (Bitter Orange) is also a reinforcing assistant that moves Qi and relaxes the intestines. Because damp-heat and Wind obstruct the intestinal Qi mechanism, restoring Qi circulation is essential to resolving the bleeding. This reflects the classical principle that regulating Qi helps regulate Blood.

Notable synergies

The pairing of Jing Jie and Zhi Qiao is particularly noteworthy. Jing Jie has an upward, outward dispersing quality, while Zhi Qiao directs Qi downward. Together they restore the normal ascending and descending of the Qi mechanism, relieving the stagnation that underlies the heat and bleeding. The combination of cooling and blood-stanching herbs (Huai Hua + Ce Bai Ye) with Qi-moving and Wind-dispersing herbs (Jing Jie + Zhi Qiao) exemplifies the formula's distinctive strategy of embedding Qi regulation within hemostasis, and Wind-dispersal within intestinal cooling.

How to Prepare

Traditional preparation instructions for Huai Hua San

In the original text, all four herbs are processed as specified (Huai Hua stir-fried, Ce Bai Ye pounded and baked, Zhi Qiao sliced and bran-fried), then ground together into a fine powder. Take 6g of the powder mixed into plain rice water (米饮, mǐ yǐn), on an empty stomach before meals.

In modern practice, the formula may also be prepared as a decoction: combine the herbs in proportional dosages, add approximately 400ml of water, bring to a boil, then simmer for 20–30 minutes. Strain and take warm in two divided doses on an empty stomach.

Common Modifications

How practitioners adapt Huai Hua San for specific situations

Added
Di yu

Di Yu (地榆) 10–15g, cools blood and astringes to stop bleeding

Zong Lu

Zong Lu Tan (棕榈炭) 6–10g, charred palm fiber to astringently stop bleeding

When bleeding is profuse, Jing Jie should be replaced with Jing Jie charcoal (荆芥炭) to enhance hemostasis, and Di Yu and Zong Lu Tan are added for their strong astringent and blood-stanching properties.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Huai Hua San should not be used or requires extra caution

Avoid

Intestinal bleeding due to Spleen Qi deficiency failing to hold Blood (deficiency-cold pattern). This formula is cold in nature and designed for Heat patterns. Using it for deficiency bleeding without Heat signs could worsen the condition.

Avoid

Chronic Blood in the stool with signs of Yin deficiency (night sweats, dry mouth, thin rapid pulse). The cold, bitter nature of this formula may further damage Yin fluids without addressing the root deficiency.

Caution

Cold from deficiency of the Middle Burner (Spleen and Stomach Yang deficiency) with symptoms like cold limbs, loose stools, and pale tongue. Use with extreme caution or avoid entirely.

Caution

Long-term use. As a predominantly cold formula, prolonged administration may injure Spleen and Stomach Yang. It should be discontinued once bleeding stops and Heat signs resolve.

Caution

Patients on anticoagulant or antiplatelet medications. The bleeding-stopping herbs may complicate the management of bleeding when combined with blood-thinning drugs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered low-risk in pregnancy but should be used with caution. The formula contains no strongly abortifacient or uterine-stimulating herbs. However, its overall cold nature could potentially affect Spleen and Stomach function if used for extended periods, which is undesirable during pregnancy. Jing Jie (Schizonepeta) is sometimes noted for mild blood-moving properties when charred, though it is generally regarded as safe. Zhi Qiao (Bitter Orange, Fructus Aurantii) has mild Qi-moving and downward-directing properties that warrant caution in pregnancy. Use only under practitioner guidance, at the lowest effective dose, and for the shortest duration necessary.

Breastfeeding

No specific contraindication during breastfeeding has been documented for this formula. The herbs are generally mild and unlikely to produce significant effects through breast milk. However, the formula's cold nature could theoretically affect maternal digestion if used long-term, which could indirectly affect milk quality or quantity. Short-term use for acute intestinal bleeding under practitioner supervision is considered acceptable. If the nursing infant develops any digestive disturbance (loose stools, decreased appetite), the formula should be discontinued and the practitioner consulted.

Children

Huai Hua San can be used in children but requires dose adjustment based on age and body weight. As a general guide: children under 6 years may take one-quarter to one-third of the adult dose; children 6 to 12 years may take one-half of the adult dose; adolescents over 12 can take two-thirds to the full adult dose. The formula's cold nature means it should be used with particular caution in young children, whose Spleen and Stomach systems are still developing and more vulnerable to cold damage. Duration should be kept short, and the formula should be discontinued as soon as bleeding resolves. If a child has concurrent poor appetite, loose stools, or signs of Spleen deficiency, this formula may not be appropriate. Always use under practitioner guidance in pediatric cases.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Huai Hua San

Anticoagulant and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Huai Hua (Sophora flower) contains rutin (a flavonoid glycoside) that affects vascular permeability and may influence platelet aggregation. Ce Bai Ye (Arborvitae leaf) also has hemostatic properties. The formula's blood-cooling and bleeding-stopping actions could theoretically interact with the mechanisms of anticoagulant therapy in unpredictable ways, either counteracting the intended blood-thinning effect or masking signs of active bleeding. Close monitoring is advised.

Antihypertensive medications: Rutin and quercetin from Huai Hua have documented mild blood-pressure-lowering effects. Concurrent use with antihypertensive drugs could potentially produce additive hypotensive effects. Blood pressure should be monitored.

Cytochrome P450 substrates: Quercetin, a major bioactive compound in Sophora flower, is a known inhibitor of CYP3A4, CYP2C9, and CYP1A2 enzymes. This could theoretically alter the metabolism of drugs processed by these pathways (including some statins, calcium channel blockers, and certain immunosuppressants). Clinical significance at typical formula doses is uncertain but warrants awareness.

Usage Guidance

Practical advice for getting the most out of Huai Hua San

Best time to take

On an empty stomach, before meals (traditionally specified as 空心食前服). The classical method calls for taking it in the morning before breakfast, mixed with rice water or warm water.

Typical duration

Acute use: 3–7 days for active bleeding episodes, then reassess. Should not be continued long-term due to its cold nature.

Dietary advice

While taking this formula, avoid spicy, greasy, and fried foods, as these generate Damp-Heat in the intestines and directly counteract the formula's cooling action. Alcohol should be strictly avoided, as it produces Heat and toxin in the Blood and aggravates intestinal bleeding. Raw, cold foods and iced drinks should also be limited, as the formula is already cooling and excessive cold can injure the Spleen. Favor bland, easily digestible foods such as congee (rice porridge), steamed vegetables, and mung bean soup, which gently support intestinal health and complement the formula's actions. Light, fiber-rich foods can help regulate bowel movements without straining.

Huai Hua San originates from Pǔ Jì Běn Shì Fāng (普济本事方, Formulas for Universal Benefit from My Practice) by Xǔ Shūwēi (许叔微) Sòng dynasty, 1132 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Huai Hua San and its clinical use

Original source text — 《普济本事方》(Pǔ Jì Běn Shì Fāng), by Xǔ Shūwēi (Song Dynasty):

「治肠风脏毒,槐花散。槐花(炒)、柏叶(烂杵,焙)、荆芥穗、枳壳(去瓤,细切,麸炒黄),各等分。上修事了,方秤等分,细末,用清米饮调下二钱,空心食前服。」

Translation: "For treating intestinal Wind and visceral toxin, Huai Hua San. Sophora flower (stir-fried), Arborvitae leaf (pounded and baked), Schizonepeta spike, and Bitter orange shell (deseeded, finely sliced, bran-fried until yellow), in equal parts. After processing, weigh equal portions, grind to a fine powder. Take two qian [approx. 6g] mixed with clear rice water, on an empty stomach before meals."


《成方便读》(Chéng Fāng Biàn Dú), by Zhāng Bǐngchéng (Qing Dynasty):

「槐花禀天地至阴之性,疏肝泻热,能凉大肠;侧柏叶生而向西,禀金兑之气,苦寒芳香,能入血分,养阴燥湿,最凉血分之热;荆芥散瘀搜风;枳壳宽肠利气。四味所入之处,俱可相及,宜乎肠风、脏毒等病,皆可治耳。」

Translation: "Sophora flower, endowed with the most Yin nature between Heaven and Earth, disperses Liver stagnation and drains Heat, effectively cooling the Large Intestine. Arborvitae leaf grows facing west, imbued with the Qi of Metal [the west], bitter-cold and fragrant, able to enter the Blood level, nourish Yin, and dry Dampness — it is the best at cooling Heat in the Blood. Schizonepeta disperses stasis and expels Wind. Bitter orange widens the intestines and moves Qi. The sites that these four herbs enter overlap and complement each other, making them well-suited for treating intestinal Wind, visceral toxin, and similar conditions."


《本事方释义》(Běn Shì Fāng Shì Yì):

「此脏毒肠风下血不止,纯用辛凉苦寒之药,以泄肠胃之热,血得凉而宁静,则病自然减耳。」

Translation: "For visceral toxin and intestinal Wind with incessant bloody stool, one uses purely acrid-cool and bitter-cold medicines to drain Heat from the intestines and Stomach. When the Blood is cooled and made calm, the condition naturally resolves."

Historical Context

How Huai Hua San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Huai Hua San was created by the Song dynasty physician Xǔ Shūwēi (许叔微, c. 1079–1154), also known by his courtesy name Zhīkě (知可). He recorded it in his influential work Pǔ Jì Běn Shì Fāng (《普济本事方》, "Formulas for Universal Benefit from My Practice"), completed around 1143. Xǔ Shūwēi was one of the great Shang Han Lun scholars of the Song dynasty and held the title of Hanlin Academician, which is why he was respectfully called "Xǔ Xuéshì" (许学士, "Academician Xu"). His book title uses "本事" (běn shì, "personal experience") to emphasize that the formulas within were personally tested and verified in clinical practice, not merely theoretical.

Huai Hua San became one of the most enduring formulas from this text. Later physicians across dynasties adopted and modified it. Zhang Yuansu (张元素) of the Jin dynasty created a variant in Jié Gǔ Jiā Zhēn (《洁古家珍》) using Sophora flower, Green Tangerine Peel, and Schizonepeta for chronic bloody dysentery. Zhu Danxi recorded another version in Dān Xī Xīn Fǎ (《丹溪心法》) adding Dampness-drying herbs. The Yī Zōng Jīn Jiàn (《医宗金鉴》) of the Qing dynasty added Huang Lian (Coptis) for stronger Heat-clearing. In 2018, the Chinese government included Huai Hua San in its official list of the "First Hundred Classical Prescriptions" (经典名方100首), recognizing its enduring clinical value. The Qing-era master Ye Tianshi (叶天士) reportedly treasured the Pǔ Jì Běn Shì Fāng as essential reading, calling it a bedside treasure.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Huai Hua San

1

Huai hua san alleviates dextran sulphate sodium-induced colitis and modulates colonic microbiota (Animal study, 2020)

Liu P, Bian Y, Liu T, Zhong J, Zhong Y, Zhuang S, Liu Z. Journal of Ethnopharmacology, 2020, 259:112944.

This preclinical study in rats found that oral administration of Huai Hua San alleviated symptoms of DSS-induced ulcerative colitis, normalized colonic vascular permeability, and positively regulated the composition of colonic mucosal microbiota, reducing the elevated Bacteroidetes/Firmicutes ratio characteristic of colitis.

2

Revealing the mechanism of 'Huai Hua San' in the treatment of ulcerative colitis based on network pharmacology and experimental study (Network pharmacology + in vitro/in vivo study, 2021)

Chen PY, Yuan C, Hong ZC, Zhang Y, Ke XG, Yu B, Wang C, Xiao XC, Wu HZ, Yang YF. Journal of Ethnopharmacology, 2021, 281:114321.

Using network pharmacology combined with molecular docking and cell experiments, this study identified quercetin, luteolin, and nobiletin as key active compounds in Huai Hua San for treating ulcerative colitis. The formula was found to exert anti-inflammatory effects via the PI3K/AKT signaling pathway and inhibition of inflammatory cytokines in RAW264.7 macrophage cells.

PubMed
3

Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of Huai Hua San against ulcerative colitis (Network pharmacology + molecular docking + in vitro, 2021)

Liu J, Liu J, Tong X, Peng W, Wei S, Sun T, Wang Y, Zhang B, Li W. Drug Design, Development and Therapy, 2021, 15:3255-3276.

This study used bioinformatics and molecular docking to predict that Huai Hua San treats ulcerative colitis through multi-target mechanisms, particularly involving the PI3K/AKT signaling pathway and targets including JUN, TP53, and ESR1. In vitro experiments confirmed that quercetin, a key active ingredient, could suppress inflammatory factors in stimulated macrophages.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.