Chuan Xin Lian Kang Tang

Andrographis Anti-Inflammatory Decoction · 穿心莲抗汤

Also known as: Chuan Xin Lian Kang Yan Pian (穿心莲抗炎片, Andrographis Anti-Inflammatory Tablet), Chuan Xin Lian Kang Yan Wan (穿心莲抗炎丸, Andrographis Anti-Inflammatory Pill), InflamClear

A simple but powerful heat-clearing formula used to fight infections and inflammation throughout the body. It is commonly taken at the onset of colds, sore throats, and other conditions caused by excessive heat and toxins, working as a natural anti-inflammatory that targets the lungs, throat, and digestive system.

Origin Modern Chinese patent medicine formula (现代中成药方剂), widely standardized in Chinese Pharmacopoeia — Modern era (People's Republic of China), mid-20th century
Composition 3 herbs
Chuan Xin Lian
King
Chuan Xin Lian
Ban Lan Gen
Deputy
Ban Lan Gen
Pu Gong Ying
Assistant
Pu Gong Ying
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chuan Xin Lian Kang Tang is designed to correct these specific patterns.

Why Chuan Xin Lian Kang Tang addresses this pattern

Toxic heat (热毒, re du) refers to a particularly intense and virulent form of heat pathogen that causes severe inflammation, infection, and tissue damage. This formula is designed precisely for this pattern: Chuan Xin Lian is one of the strongest toxin-resolving herbs available, directly neutralizing toxic heat in the Lung, Heart, and Large Intestine. Ban Lan Gen reinforces this by cooling the blood and clearing epidemic toxins that cause acute throat swelling and fever. Pu Gong Ying adds the ability to disperse the swollen, inflamed tissue that results from toxic heat accumulation. All three herbs share the core action of clearing heat and resolving toxins, creating a concentrated, focused attack on this pattern.

A practitioner would look for one or more of these signs

Sore Throat

Severe, with redness and swelling

Fever

High fever with thirst and restlessness

Sore

Oral ulcers from accumulated heat

Dysentery

Acute bacterial dysentery with bloody stool

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Chuan Xin Lian Kang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acute sore throat is most often caused by wind-heat or toxic heat invading the Lung system. The throat is considered the "gateway of the Lung" and the "door of the Stomach," making it vulnerable when external heat pathogens enter the body. When toxic heat flares upward and lodges in the throat, it causes redness, swelling, pain, and difficulty swallowing. In more severe cases (such as with tonsillitis), the heat can become particularly concentrated and may produce pus. The condition primarily involves the Lung channel, though the Stomach channel also passes through the throat.

Why Chuan Xin Lian Kang Tang Helps

Chuan Xin Lian Kang Yan Tang directly targets throat inflammation through its powerful heat-clearing and toxin-resolving ingredients. Chuan Xin Lian enters the Lung channel and clears the toxic heat that is the root cause of the throat inflammation. Ban Lan Gen has a special affinity for the throat, cooling the blood and reducing pharyngeal swelling. Pu Gong Ying's ability to disperse swelling and scatter nodulations helps reduce the physical swelling of inflamed tonsils and pharyngeal tissue. The formula is often taken at the first sign of a sore throat for best results.

Also commonly used for

Bronchitis

Acute bronchitis with yellow phlegm

Gastroenteritis

Acute bacterial gastroenteritis

Dysentery

Bacterial dysentery

Pneumonia

As adjunctive support

Sore

Oral ulcers and stomatitis from heat

Sinusitis

Acute sinusitis with yellow discharge

Tonsillitis

Acute tonsillitis with swelling and pain

Lumps

Epidemic parotitis

What This Formula Does

Every TCM formula has a specific set of actions — here's what Chuan Xin Lian Kang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Chuan Xin Lian Kang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Chuan Xin Lian Kang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Chuan Xin Lian Kang Tang works at the root level.

Chuan Xin Lian Kang Tang addresses acute conditions caused by the invasion of external Wind-Heat or the accumulation of toxic Heat (热毒, re du) in the body. In TCM terms, when external pathogenic Wind and Heat enter the body, they first affect the Lung system and the body's exterior. The Lungs govern the throat and nose, so when Heat lodges there, it produces sore throat, swollen tonsils, cough, fever, and headache. If the Heat is strong or not expelled promptly, it can deepen and transform into toxic Heat, causing more severe inflammation such as high fever, purulent throat infections, or skin eruptions.

The Heat may also descend along the channels into the Stomach and Large Intestine, producing symptoms such as diarrhea with burning sensations, painful urination, or mouth and tongue sores. In some cases, toxic Heat congests locally, leading to abscesses, swollen glands, or red, hot skin lesions. The Liver channel can also be affected, with Liver Fire rising to cause red eyes, irritability, and headache.

The formula works by directly clearing this accumulated Heat and Toxin from multiple organ systems simultaneously, especially the Lungs, Stomach, Large Intestine, and Liver. Its strongly bitter and cold nature drains pathogenic Heat downward and outward, while its detoxifying action neutralizes the toxic quality of the pathogen. This addresses the root mechanism of acute infectious and inflammatory conditions viewed through the TCM lens.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and cold, with the intensely bitter quality driving its Heat-clearing and detoxifying actions and a secondary sweet element from Pu Gong Ying providing mild nourishing balance.

Ingredients

3 herbs

The herbs that make up Chuan Xin Lian Kang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Chuan Xin Lian

Chuan Xin Lian

Andrographis

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, Large Intestine, Urinary Bladder

Role in Chuan Xin Lian Kang Tang

The chief herb and namesake of the formula. Chuan Xin Lian powerfully clears heat and resolves toxins, with a particular affinity for the Lung and Large Intestine channels. It addresses the core pathomechanism of toxic heat invading the body, directly combating infection and inflammation in the upper respiratory tract, throat, and intestines.
Deputy — Assists and enhances the King
Ban Lan Gen

Ban Lan Gen

Isatis root

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Stomach

Role in Chuan Xin Lian Kang Tang

Reinforces the King herb's heat-clearing and toxin-resolving action. Ban Lan Gen has a special affinity for the throat, cooling the blood and relieving swelling in the pharynx. It also has broad anti-viral properties that complement Chuan Xin Lian's antibacterial strength, broadening the formula's range against epidemic pathogens.
Assistant — Supports or moderates other herbs
Pu Gong Ying

Pu Gong Ying

Dandelion

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Stomach

Role in Chuan Xin Lian Kang Tang

Clears heat, resolves toxins, and disperses swelling and nodulations. Pu Gong Ying adds a dampness-draining quality and helps reduce abscesses and inflammatory swellings. It also gently supports Liver Qi flow and has a milder nature that softens the intense bitterness and cold of the other two herbs.

Why This Combination Works

How the herbs in Chuan Xin Lian Kang Tang complement each other

Overall strategy

This formula assembles three potent heat-clearing and toxin-resolving herbs to directly attack toxic heat that has invaded the body, particularly the Lung, throat, and intestines. The strategy is straightforward: concentrate maximum fire-clearing and detoxifying power in a small, focused composition.

King herbs

Chuan Xin Lian (Andrographis) is the King and namesake of the formula. Bitter and cold, it enters the Heart, Lung, Large Intestine, and Bladder channels. It is one of the most powerful heat-clearing herbs in the materia medica, sometimes called the "Chinese antibiotic" for its broad antimicrobial action. It clears heat from all three burners, resolves toxic fire, and reduces inflammatory swelling, making it the primary agent against the full spectrum of toxic heat conditions this formula targets.

Deputy herbs

Ban Lan Gen (Isatis Root) serves as Deputy, reinforcing the heat-clearing and toxin-resolving action with particular strength in cooling the blood and soothing the throat. Where Chuan Xin Lian excels at clearing heat in the Lung and Large Intestine, Ban Lan Gen brings special skill in addressing epidemic toxins and relieving pharyngeal swelling and pain, making the pair more effective against upper respiratory infections than either herb alone.

Assistant herbs

Pu Gong Ying (Dandelion) serves as a reinforcing Assistant. It adds its own heat-clearing and toxin-resolving properties while also dispersing swollen, inflamed tissue and draining dampness. This dampness-clearing action extends the formula's reach to damp-heat conditions in the lower burner such as urinary tract infections. Pu Gong Ying's gentler nature also helps balance the intense cold bitterness of the other two herbs.

Notable synergies

The pairing of Chuan Xin Lian with Ban Lan Gen creates a broad-spectrum anti-infective combination: Chuan Xin Lian's strength lies in clearing heat and dampness from the Lung and intestines, while Ban Lan Gen targets viral epidemic toxins and soothes the blood level. Together, they cover bacterial and viral infections simultaneously. Pu Gong Ying's ability to scatter nodulations complements both herbs by addressing the physical swelling and accumulation that toxic heat produces in tissues.

How to Prepare

Traditional preparation instructions for Chuan Xin Lian Kang Tang

Place the herbs in a ceramic or glass pot. Add approximately 600 ml (about 2.5 cups) of water and soak for 20 to 30 minutes. Bring to a boil over high heat, then reduce to a gentle simmer and cook for 20 to 25 minutes until the liquid reduces to roughly 200 to 250 ml. Strain and divide into two portions to be taken warm, once in the morning and once in the evening. A second decoction can be prepared by adding 400 ml of water to the dregs and simmering for 15 minutes.

Note: Chuan Xin Lian (Andrographis) is extremely bitter. When the formula is prepared as a decoction, some patients may experience nausea. For this reason, the formula is more commonly taken in tablet (Pian) or pill (Wan) form in clinical practice.

Common Modifications

How practitioners adapt Chuan Xin Lian Kang Tang for specific situations

Added
She Gan

6-9g, clears heat from the throat and disperses swelling

Shan Dou Gen

6-9g, powerfully clears toxic heat from the throat

She Gan and Shan Dou Gen are both strong throat-specific heat-clearing herbs that reinforce the formula's action on pharyngeal and tonsillar inflammation.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Chuan Xin Lian Kang Tang should not be used or requires extra caution

Avoid

Spleen and Stomach deficiency Cold (脾胃虚寒): The formula is strongly bitter and cold, which can further injure an already weak digestive system. People who experience chronic loose stools, poor appetite, or cold sensations in the abdomen should avoid this formula.

Avoid

Pregnancy: Chuan Xin Lian (Andrographis) has demonstrated anti-fertility and possible uterine-stimulating effects in preclinical research. This formula should not be used during pregnancy.

Avoid

Wind-Cold patterns: This formula is designed exclusively for Heat-pattern conditions. Using it for common colds caused by Wind-Cold invasion (chills predominating over fever, clear nasal discharge, absence of sore throat) may worsen the condition by further introducing Cold into the body.

Caution

Yin deficiency with false Heat: People with underlying Yin deficiency who present with low-grade, lingering heat signs (such as afternoon flushing, night sweats, dry mouth) should use this formula cautiously or not at all, as bitter-cold herbs can further deplete Yin fluids.

Caution

Concurrent use with anticoagulant or antiplatelet medications: Andrographolide has been shown in preclinical studies to potentially inhibit CYP3A4 and CYP2C9, which could increase the systemic exposure of warfarin and similar drugs. Close monitoring is required.

Caution

Long-term or excessive use: Prolonged use of strongly bitter-cold formulas can damage Spleen Yang and impair digestion. This formula is intended for short-term, acute use only.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Chuan Xin Lian (Andrographis paniculata), the chief herb in this formula, has demonstrated anti-fertility effects in animal studies and may have uterine-stimulating properties. Its strongly bitter and cold nature also poses a risk of disrupting the stability needed to support pregnancy. Additionally, Xia Ku Cao (Prunella) and Bai Hua She She Cao (Oldenlandia) are cold-natured herbs that may further compromise the delicate balance required during gestation. Women who are pregnant or trying to conceive should not use this formula.

Breastfeeding

Use with caution during breastfeeding. While there is no direct evidence of harm to nursing infants, the strongly bitter and cold properties of the formula's herbs (particularly Chuan Xin Lian and Bai Hua She She Cao) may theoretically transfer through breast milk and affect the infant's immature digestive system, potentially causing loose stools or decreased appetite. There is also limited safety data on andrographolide transfer into human breast milk. If acute treatment is needed, short-term use under professional supervision may be acceptable, but the infant should be monitored for any digestive changes. Prolonged use should be avoided.

Children

This formula may be used in children under professional guidance, but requires significant dosage reduction due to its strongly bitter and cold nature. General guidelines: children under 3 years should generally avoid this formula; children aged 3 to 6 may take approximately one-quarter to one-third of the adult dose; children aged 7 to 12 may take approximately half the adult dose; adolescents over 12 may take two-thirds to the full adult dose. The bitter taste can be challenging for children, so tablet or teapill forms are often preferred. Duration should be kept short (3 to 5 days). Monitor closely for signs of digestive upset such as loose stools, nausea, or decreased appetite, which indicate the cold nature is affecting the child's Spleen. Discontinue immediately if these signs appear.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Chuan Xin Lian Kang Tang

Anticoagulant and antiplatelet medications (e.g. warfarin, heparin, aspirin, clopidogrel): Andrographolide, the main active compound in Chuan Xin Lian, has been shown in preclinical studies to potentially increase warfarin levels by inhibiting CYP3A4 and CYP2C9 enzyme activity. Lab studies also suggest possible inhibition of platelet aggregation. Patients on blood-thinning medications should use this formula only under medical supervision with appropriate monitoring of coagulation parameters.

CYP450 substrate medications: Andrographis extract has been shown in laboratory studies to inhibit CYP1A2, CYP2C9, and CYP3A4. While the clinical significance in humans has not been fully established, this could theoretically alter the metabolism of many commonly prescribed drugs including certain statins, calcium channel blockers, benzodiazepines, and immunosuppressants. Caution is warranted when combining this formula with any medication metabolized by these enzymes.

Antihypertensive medications: Andrographis may have mild blood pressure-lowering effects. Concurrent use with antihypertensive drugs could theoretically produce additive hypotensive effects. Blood pressure should be monitored.

Immunosuppressant medications: Because Andrographis has immune-stimulating properties, long-term use may theoretically reduce the effectiveness of immunosuppressant drugs used after organ transplant or for autoimmune conditions.

Hypoglycemic medications: Some evidence suggests andrographolide may influence blood sugar regulation. People taking diabetes medications should monitor blood glucose levels more closely if using this formula.

Usage Guidance

Practical advice for getting the most out of Chuan Xin Lian Kang Tang

Best time to take

30 minutes after meals, 2 to 3 times daily, to reduce potential gastrointestinal irritation from the formula's bitter-cold nature.

Typical duration

Acute use: 3 to 7 days. Not intended for prolonged use due to its strongly bitter and cold nature.

Dietary advice

While taking this formula, avoid spicy, fried, greasy, and heavily seasoned foods, as these generate internal Heat and counteract the formula's cooling action. Avoid alcohol and smoking, which add Heat and Toxin to the body. Avoid rich, heavy, or tonifying foods (such as lamb, ginger tea, or strong herbal tonics) that may trap the pathogen inside. Favor light, easily digestible foods such as congee, steamed vegetables, pear, mung bean soup, and chrysanthemum tea, which support the body's Heat-clearing process. Stay well hydrated with room-temperature or slightly warm water. Because the formula is very cold in nature, avoid simultaneously eating cold or raw foods (such as ice cream or cold salads) to prevent excessive strain on digestion.

Chuan Xin Lian Kang Tang originates from Modern Chinese patent medicine formula (现代中成药方剂), widely standardized in Chinese Pharmacopoeia Modern era (People's Republic of China), mid-20th century

Classical Texts

Key passages from the classical Chinese medical texts that first described Chuan Xin Lian Kang Tang and its clinical use

There are no classical text quotes specifically attributable to this formula, as Chuan Xin Lian Kang Tang is a modern formulation rather than a classical prescription. However, the therapeutic principles it embodies draw from well-established classical teachings:

The herb Chuan Xin Lian (穿心莲, Andrographis) is described in modern Chinese materia medica references as: 「苦,寒。归肺、胃、大肠、小肠经。清热解毒,凉血,消肿,燥湿。」 — "Bitter, cold. Enters the Lung, Stomach, Large Intestine, and Small Intestine channels. Clears Heat and resolves Toxins, cools the Blood, reduces swelling, and dries Dampness." This summarizes the core therapeutic logic of the entire formula.

Historical Context

How Chuan Xin Lian Kang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Chuan Xin Lian Kang Tang is a modern Chinese herbal formula, not found in the classical canonical texts. The herb Chuan Xin Lian (穿心莲, Andrographis paniculata) itself was introduced to Chinese medicine relatively recently. Originally native to South and Southeast Asia, where it has been used for centuries in Ayurvedic and traditional medicine systems, Andrographis was incorporated into the Chinese materia medica primarily during the 20th century. It gained widespread clinical use in China during the mid-20th century, particularly during efforts to develop effective, accessible treatments for infectious diseases.

The formula represents a modern TCM approach to combining multiple Heat-clearing and Toxin-resolving herbs. Its composition of Chuan Xin Lian with Pu Gong Ying (Dandelion), Xia Ku Cao (Prunella), and Bai Hua She She Cao (Oldenlandia) reflects the influence of both traditional herbal pairing principles and modern pharmacological understanding of anti-inflammatory and antimicrobial herbs. It became widely available as a patent medicine (中成药) in tablet form (Chuan Xin Lian Kang Yan Pian) and is now one of the most commonly used over-the-counter Chinese herbal products for upper respiratory infections across East and Southeast Asia.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Chuan Xin Lian Kang Tang

1

Systematic review and meta-analysis of Andrographis paniculata for acute respiratory tract infections (2017)

Hu XY, Wu RH, Logue M, Blondel C, Lai LYW, Stuart B, et al. PLoS One, 2017, 12(8): e0181780

A comprehensive review of 33 randomized controlled trials involving 7,175 patients found that Andrographis paniculata preparations improved cough and sore throat symptoms compared to placebo, and appeared to shorten the time to symptom resolution in acute respiratory infections. The authors concluded the herb appears beneficial and safe but noted that study quality was generally poor.

DOI
2

Systematic review and meta-analysis on safety of Andrographis paniculata (2021)

Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Pharmacoepidemiology and Drug Safety, 2021, 30(6): 727-739

This systematic review and meta-analysis evaluated adverse event incidence from oral Andrographis paniculata monotherapy. The review concluded that while some adverse events can occur (mainly mild gastrointestinal complaints), the herb may be generally safe when used orally in standard preparations. The authors emphasized the need for larger, higher-quality safety studies.

DOI
3

Systematic review on adverse effects of andrographolide derivatives vs. herbal preparations of Andrographis paniculata (2022)

Front Pharmacol, 2022, 13: 773282

A large review of 262 clinical studies found that injectable andrographolide derivative medications can cause serious adverse reactions including rare anaphylaxis, while oral herbal preparations of Andrographis paniculata were found to be essentially safe, with adverse reactions limited mainly to mild gastrointestinal and skin complaints.

DOI
4

Preclinical study on herb-drug interaction between andrographolide and warfarin in rats (2018)

Pharmaceutical Biology, 2018, 56(1): 398-404

This study found that andrographolide pretreatment increased the systemic exposure of warfarin in rats, likely by inhibiting CYP3A4 and CYP2C9 enzymes responsible for warfarin metabolism. The authors cautioned that dose adjustment should be considered when andrographolide and warfarin are used together.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.