Xin Yi San

Magnolia Flower Powder · 辛夷散

Also known as: Hsin I San, Magnolia Flower Formula

A classical formula for nasal congestion, runny nose, loss of smell, and sinus headaches caused by Wind-Cold blocking the nasal passages. It uses aromatic, upward-moving herbs to open the nose and restore normal breathing. Originally designed as a fine powder taken with green tea, it is one of the most widely used traditional formulas for chronic and acute nasal conditions.

Origin Yan Shi Ji Sheng Fang (严氏济生方, Yan's Formulas to Aid the Living) by Yan Yonghe — Sòng dynasty, 1253 CE
Composition 10 herbs
Xin Yi Hua
King
Xin Yi Hua
Xi Xin
Deputy
Xi Xin
Bai Zhi
Deputy
Bai Zhi
Sheng Ma
Deputy
Sheng Ma
Gao Ben
Assistant
Gao Ben
Fang Feng
Assistant
Fang Feng
Qiang Huo
Assistant
Qiang Huo
Chuan Xiong
Assistant
Chuan Xiong
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xin Yi San is designed to correct these specific patterns.

Why Xin Yi San addresses this pattern

When Wind-Cold invades the Lung system, it can lodge in the nasal passages, which are the 'opening' of the Lungs. The pathogenic factor obstructs the free flow of Lung Qi through the nose, causing congestion, copious clear or white nasal discharge, loss of smell, and headache. The tongue coating is typically thin and white, and the pulse is floating. Xin Yi San directly targets this mechanism: Xin Yi Hua, Xi Xin, Bai Zhi, Fang Feng, and Qiang Huo disperse Wind-Cold from the exterior and head region, while Sheng Ma and Gao Ben raise clear Yang to restore Lung Qi's normal descending and dispersing function through the nasal passages. The formula is especially appropriate when the Wind-Cold has settled specifically in the nose rather than causing generalized body aches and fever.

A practitioner would look for one or more of these signs

Nasal Congestion

Persistent nasal stuffiness, often alternating sides or bilateral

Runny Nose

Copious clear or white watery nasal discharge

Loss Of Smell

Inability to smell or diminished sense of smell

Headaches

Frontal or vertex headache accompanying nasal congestion

Sneezing

Frequent sneezing triggered by Wind exposure or temperature changes

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xin Yi San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, allergic rhinitis (鼻鼽, bí qiú) is understood as a condition where the Lung system's defensive function is impaired, leaving the nasal passages vulnerable to Wind invasion. The nose is the 'opening' of the Lungs, and when Lung Qi is weak or when Wind-Cold invades, the nose loses its ability to function properly. The hallmark symptoms of sneezing, itching, watery discharge, and congestion reflect Wind (the sudden, changeable nature of attacks) combining with Cold (the clear, watery quality of the discharge). The underlying root is often Lung Qi deficiency, sometimes involving the Spleen and Kidneys, which fail to support the Lung's defensive capacity.

Why Xin Yi San Helps

Xin Yi San directly addresses the acute Wind-Cold obstruction that triggers allergic rhinitis episodes. Xin Yi Hua and Xi Xin powerfully open the nasal passages, while Bai Zhi and Fang Feng disperse Wind and relieve itching and sneezing. Sheng Ma raises clear Yang to the head, helping restore the Lung's governance of the nose. For patients with frequent recurrences suggesting Lung Qi deficiency, practitioners often add Huang Qi and Bai Zhu to strengthen the defensive Qi alongside this formula's Wind-dispersing action.

Also commonly used for

Nasal Congestion

Persistent nasal obstruction from various causes

Loss Of Smell

Anosmia or hyposmia accompanying nasal obstruction

Headaches

Sinus headaches, frontal or vertex headache from nasal congestion

Common Cold

Wind-Cold type common cold with predominant nasal symptoms

Chronic Rhinitis

Chronic rhinitis with persistent congestion and discharge

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xin Yi San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xin Yi San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xin Yi San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xin Yi San works at the root level.

In Chinese medicine, the nose is the sensory opening of the Lungs. When the Lungs are functioning well, the nasal passages remain clear, breathing is unobstructed, and the sense of smell is sharp. However, when the Lung's defensive Qi is weak or insufficient, external pathogenic factors (especially Wind-Cold and Dampness) can invade and lodge in the nasal passages.

When Wind-Cold blocks the nasal orifices, the Lung's ability to disperse and descend its Qi is impaired. Clear Yang, the light, ascending force that should nourish the head and sensory organs, fails to rise properly. Meanwhile, turbid Yin (heavy, cloudy substances) accumulates and cannot descend. This blockage produces the hallmark symptoms: stuffed nose, copious clear or white nasal discharge, inability to smell, and a heavy sensation in the head. In chronic or severe cases, the stagnation of Qi and fluids can congeal into nasal polyps, which classical commentators compared to "mushrooms growing on damp ground exposed to warmth."

Xin Yi San addresses this by powerfully dispersing the Wind-Cold lodged in the nasal passages while simultaneously restoring the proper ascending of clear Yang to the head. The formula also incorporates a descending component (Mu Tong and green tea as the vehicle) to drain turbidity downward through urination, creating a balanced dynamic of "ascending the clear and descending the turbid" that restores normal Lung function and reopens the nasal orifices.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid (pungent) with a sweet undertone. The acrid taste disperses Wind-Cold and opens the orifices; the mild sweetness from Gan Cao harmonizes and moderates the formula's strong dispersing action.

Target Organs

Channels Entered

Lung Stomach Bladder

Ingredients

10 herbs

The herbs that make up Xin Yi San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Xin Yi Hua

Xin Yi Hua

Biond’s magnolia flowers

Dosage 3 - 9g
Temperature Warm
Taste Pungent
Organ Affinity Stomach, Lungs
Preparation Remove the outer fuzzy hairs before use (去毛) as they can irritate the throat.

Role in Xin Yi San

The chief herb and namesake of the formula. Warm and acrid, it enters the Lung and Stomach channels and is the premier herb in the Chinese materia medica for unblocking the nasal passages. It disperses Wind-Cold from the head and face, opens the nose, and relieves nasal congestion and headache.
Deputies — Assists and enhances the King
Xi Xin

Xi Xin

Wild ginger

Dosage 1 - 3g
Temperature Warm
Taste Pungent
Organ Affinity Heart, Kidneys, Lungs

Role in Xin Yi San

Strongly acrid and warming, Xi Xin disperses Wind-Cold and penetrates all nine orifices. It powerfully opens the nasal passages and is classically described as able to 'break through congestion and move Qi through the orifices.' It enhances the King herb's ability to unblock the nose.
Bai Zhi

Bai Zhi

Angelica roots

Dosage 3 - 6g
Temperature Warm
Taste Pungent
Organ Affinity Spleen, Stomach, Lungs

Role in Xin Yi San

Acrid and warm, Bai Zhi enters the Lung and Stomach channels. It relieves the exterior, disperses Wind from the Yangming channel, opens the nasal passages, expels Dampness, and alleviates frontal headache and sinus pain. Together with Xin Yi Hua and Sheng Ma, it raises clear Qi upward to the head.
Sheng Ma

Sheng Ma

Bugbane rhizomes

Dosage 3 - 6g
Temperature Cool
Taste Pungent, Sweet
Organ Affinity Large Intestine, Lungs, Spleen, Stomach

Role in Xin Yi San

Ascending in nature, Sheng Ma lifts the clear Yang of the Stomach upward toward the head, directing the other herbs to the nasal region. It also clears Heat and releases toxins from the skin and muscle layer, helping to resolve congestion in the upper body.
Assistants — Supports or moderates other herbs
Gao Ben

Gao Ben

Chinese lovage roots

Dosage 3 - 6g
Temperature Warm
Taste Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Xin Yi San

Acrid and warm, Gao Ben enters the Bladder channel and ascends to the vertex of the head. It disperses Wind-Cold-Dampness from the upper body, overcomes Dampness, and relieves vertex headache. It reinforces the overall ascending, opening strategy of the formula.
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 3 - 6g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Xin Yi San

A gentle Wind-dispersing herb that releases the exterior and overcomes Dampness. Fang Feng works broadly across multiple channels to expel Wind and is often called the 'master of Wind treatment.' It reinforces the exterior-releasing action of the formula while being milder than Xi Xin.
Qiang Huo

Qiang Huo

Notopterygium roots

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Kidneys

Role in Xin Yi San

Acrid, bitter, and warm, Qiang Huo releases the exterior, disperses Cold and Dampness, and directs Qi along the Taiyang (Greater Yang) channel and the Governing Vessel toward the upper back and head. It reinforces the overall Wind-Cold dispersing and Dampness-overcoming action of the formula.
Chuan Xiong

Chuan Xiong

Szechuan lovage roots

Dosage 3 - 6g
Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium

Role in Xin Yi San

Known as the 'herb that reaches the top of the head,' Chuan Xiong moves Blood, dispels Blood stasis, and relieves pain, especially headache. It invigorates circulation in the head, helping to break through congestion that Wind-Cold stasis causes. It is classically noted as a guiding herb (使药) for Xin Yi.
Mu Tong

Mu Tong

Akebia stems

Dosage 3 - 6g
Temperature Cold
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine

Role in Xin Yi San

Bitter and cold, Mu Tong promotes urination and drains Dampness downward. In this predominantly ascending formula, it provides a crucial counterbalance by directing turbid Dampness and Heat downward through the urinary tract. This 'lowering' action prevents the many warm, upward-moving herbs from being too one-directional.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xin Yi San

Harmonizes all the other herbs in the formula and moderates their acrid, dispersing nature so they do not overly scatter the body's Qi. Its sweet, neutral quality also gently supports the Spleen and Stomach, protecting the middle from the many pungent, drying herbs.

Why This Combination Works

How the herbs in Xin Yi San complement each other

Overall strategy

The formula addresses Wind-Cold obstructing the nasal passages by combining a large group of aromatic, acrid, upward-moving herbs that open the nose and disperse pathogenic factors from the head, balanced by a small number of downward-draining and harmonizing herbs. The design follows the principle of 'raising the clear and lowering the turbid' (升清降浊): the majority of herbs lift clear Yang to the head while Mu Tong and green tea direct turbid Dampness and Heat downward.

King herbs

Xin Yi Hua is the sole King herb and the formula's namesake. It is the single most effective herb in the Chinese materia medica for unblocking nasal congestion. Warm and acrid, it targets the Lung channel and specifically opens the nose, dispersing the Wind-Cold that has lodged in the nasal passages. Its light, ascending nature carries its effects directly to the head and face.

Deputy herbs

Xi Xin powerfully penetrates the orifices, disperses deep-seated Cold, and amplifies Xin Yi Hua's nasal-opening action. Bai Zhi targets the Yangming channel to relieve frontal headache and sinus pain while also expelling Dampness and pus from the nasal area. Sheng Ma lifts the clear Yang of the Stomach upward toward the head, acting as an 'elevator' that directs the formula's therapeutic effects to the correct location.

Assistant herbs

Gao Ben and Qiang Huo are reinforcing assistants that strengthen the Wind-Cold dispersing and Dampness-overcoming actions. Gao Ben targets the vertex of the head via the Bladder channel, while Qiang Huo works through the Taiyang channel and Governing Vessel. Fang Feng broadly disperses Wind. Chuan Xiong is a reinforcing assistant that moves Blood and Qi in the head, breaking through the circulatory stagnation that accompanies nasal obstruction. Mu Tong is a restraining assistant: its bitter, cold nature drains Dampness and Heat downward, preventing the formula's many warm, acrid herbs from generating excess Heat or being too one-directionally upward.

Envoy herbs

Zhi Gan Cao harmonizes the formula, moderating the strong dispersing actions of the acrid herbs so they do not excessively scatter Qi. The green tea used to take the powder is also functionally an Envoy: its bitter, cool properties direct turbid Heat downward and clear the head.

Notable synergies

Xin Yi Hua paired with Chuan Xiong is a classical combination. The Ben Cao Jing Ji Zhu notes that Chuan Xiong is the guiding herb for Xin Yi, and together they open the nasal passages more effectively than either alone. Sheng Ma paired with Bai Zhi lifts Stomach clear Yang to the head and targets the Yangming channel to relieve frontal headache. The ascending group (Xin Yi, Sheng Ma, Bai Zhi, Gao Ben) paired against the descending element (Mu Tong plus green tea) creates the 'raise the clear, lower the turbid' dynamic essential to resolving nasal obstruction.

How to Prepare

Traditional preparation instructions for Xin Yi San

The original preparation from the source text instructs to grind all herbs into a fine powder (细末). Take 6 grams (approximately 2 qián) per dose, mixed with freshly brewed green tea (茶清调服), after meals. Typically taken two to three times daily.

In modern practice, the formula is also commonly prepared as a decoction. When used as a decoction, standard dosages of each herb (typically 3 to 6 grams each) are simmered in water. The use of green tea as the vehicle for the powder is considered therapeutically significant: its bitter, cool nature helps direct turbid Heat downward and moderates the warming, ascending nature of the many acrid herbs.

Common Modifications

How practitioners adapt Xin Yi San for specific situations

Added
Huang Qin

9-12g, clears Lung Heat

Zhi Zi

6-9g, drains Heat through urination

When the pathogenic factor transforms from Cold to Heat (indicated by yellow nasal discharge, possible fever), Huang Qin and Zhi Zi are added to clear the emerging Heat from the Lungs while the base formula continues to open the nasal passages.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xin Yi San should not be used or requires extra caution

Avoid

Yin deficiency with Empty Fire (symptoms such as chronic dry mouth, night sweats, hot flashes). The formula's many warm, acrid, dispersing herbs will further deplete Yin fluids and worsen Heat signs.

Avoid

Nasal conditions due to Heat patterns presenting with thick yellow nasal discharge, red tongue with yellow coating, and rapid pulse. This formula is designed for Wind-Cold, not Wind-Heat or Damp-Heat.

Avoid

Pregnancy. Xin Yi (Magnolia flower) may stimulate uterine contractions, and the formula contains multiple acrid dispersing herbs that are not appropriate during pregnancy.

Caution

Patients with profuse sweating or significant Qi deficiency. The strong dispersing and ascending nature of the formula may further deplete Qi and body fluids.

Caution

Prolonged use beyond the acute symptomatic phase. Classical texts caution that extended use of Wind-dispersing formulas will deplete vital essence and Yin fluids. As a classical teaching states: 'all Wind-dispelling medicines inevitably dry out essential fluids.'

Caution

Concurrent use with theophylline or other narrow-therapeutic-index drugs metabolized by CYP1A2. Research has shown Xin Yi San contains potent CYP1A2 inhibitors (particularly imperatorin from Bai Zhi) that can increase adverse effects when combined with theophylline.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Xin Yi (Magnolia flower bud) has been traditionally recognized as capable of stimulating uterine contractions. The formula also contains Xi Xin (Asarum) and multiple strongly acrid, dispersing herbs (Chuan Xiong, Qiang Huo, Fang Feng) that move Qi and Blood vigorously, which could pose risks to the developing fetus. Classical sources specify that Xin Yi's uterine-stimulating properties are only appropriate during active labor. Women who are pregnant or planning to become pregnant should not use this formula.

Breastfeeding

No specific classical prohibitions exist for breastfeeding mothers. However, the formula contains Xi Xin (Asarum), which has potent volatile compounds, and Mu Tong (Akebia), which may transfer bioactive substances through breast milk. The strongly acrid and dispersing nature of the formula could theoretically affect milk quality or quantity in some individuals. If breastfeeding mothers need to use this formula, it should be under professional guidance and for the shortest duration necessary. Monitor the infant for any signs of restlessness, loose stools, or feeding changes.

Children

Classical sources include pediatric adaptations of Xin Yi San with reduced dosage. The Ming Dynasty text Qi Xiao Liang Fang specifies "one qian per serving" for children (half the adult dose). The classical principle states that children's organs are 'delicate and immature' and cannot tolerate heavy medication. Modern pediatric use should follow similar reductions: generally one-third to one-half the adult dose depending on the child's age and weight. Xin Yi (Magnolia flower) has fine hairs that can irritate the throat, so it must be wrapped in cloth when decocting (bao jian). Xi Xin (Asarum) should be used cautiously in children at minimal doses. Not recommended for infants under age 3 due to the potency of the volatile aromatic herbs. For children over 3, use under professional supervision with close monitoring. Stop use if the child develops dizziness, dry mouth, or irritability.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xin Yi San

Theophylline and aminophylline: This is the most well-documented interaction. Bai Zhi (Angelica dahurica) in this formula contains furanocoumarins, particularly imperatorin, which are potent inhibitors of CYP1A2, the primary enzyme responsible for theophylline metabolism. Research has shown that concurrent use of Xin Yi San can decrease theophylline clearance by 27-33%, prolong its half-life, and increase adverse effects including headaches and tachycardia. Patients taking theophylline should avoid this formula or have their theophylline dose adjusted under medical supervision.

Other CYP1A2 substrates: Given the demonstrated CYP1A2 inhibitory activity, caution is warranted with other medications primarily metabolized by this enzyme, including caffeine, clozapine, olanzapine, duloxetine, melatonin, and fluvoxamine. Plasma levels of these drugs could potentially be elevated.

Gan Cao (Glycyrrhiza/Licorice): The formula contains processed licorice, which with prolonged use may cause pseudoaldosteronism (fluid retention, potassium loss, blood pressure elevation). This is relevant for patients on antihypertensives, diuretics, digoxin, or corticosteroids, where electrolyte imbalances could be clinically significant.

Usage Guidance

Practical advice for getting the most out of Xin Yi San

Best time to take

After meals (食后), traditionally mixed with clear green tea, taken 2-3 times daily.

Typical duration

Acute use: 3-7 days for common cold with nasal congestion. For chronic rhinitis or sinusitis, may be used for 2-4 weeks with periodic reassessment, but should not be taken long-term without modification due to the drying nature of the acrid herbs.

Dietary advice

While taking this formula, avoid cold and raw foods (such as iced drinks, raw salads, ice cream, and chilled fruit) as these can worsen the Cold obstruction in the nasal passages and counteract the warming, dispersing effect of the herbs. Avoid greasy, oily, or heavy foods that generate Dampness and Phlegm, which can worsen nasal congestion. Favor warm, lightly cooked foods and warm beverages. Ginger tea, congee with scallions, and light soups are supportive. Avoid excessive dairy products, which are considered Phlegm-producing in TCM and may worsen nasal discharge. The original formula is traditionally taken with clear green tea (茶清), so pairing with a light green tea is appropriate and historically consistent.

Xin Yi San originates from Yan Shi Ji Sheng Fang (严氏济生方, Yan's Formulas to Aid the Living) by Yan Yonghe Sòng dynasty, 1253 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xin Yi San and its clinical use

Original source text from the Yan Shi Ji Sheng Fang (《严氏济生方》):

「治肺虚,风寒湿热之气加之,鼻内壅塞,涕出不已,或气息不通,或不闻香臭。」

"Treats Lung deficiency upon which Wind, Cold, Dampness, and Heat have been imposed, causing nasal congestion with continuous discharge, inability to breathe through the nose, or loss of smell."

Commentary from the Yi Fang Ji Jie (《医方集解》):

「肺经湿热上蒸于脑,入鼻而生息肉,犹湿地得热而生芝菌也。辛夷、升麻、白芷能引胃中清阳上行头脑,防风、藁本能入巅顶燥湿祛风,细辛散热通窍,川芎散郁疏肝,木通、茶清泻火下行,甘草甘平,缓其辛散也。」

"Dampness and Heat in the Lung channel steam upward to the brain and enter the nose to produce polyps, just as mushrooms grow on damp ground exposed to warmth. Xin Yi, Sheng Ma, and Bai Zhi guide the Stomach's clear Yang upward to the head and brain. Fang Feng and Gao Ben enter the crown of the head to dry Dampness and expel Wind. Xi Xin disperses Heat and opens the orifices. Chuan Xiong disperses stagnation and assists the Liver. Mu Tong and clear tea drain Fire downward. Gan Cao, sweet and neutral, moderates the acrid dispersing action."

From the Ling Shu, Mai Du chapter (《灵枢·脉度》):

「肺气通于鼻,肺和则鼻能知香臭矣。」

"The Qi of the Lung opens to the nose. When the Lung is in harmony, the nose can distinguish fragrant from foul."

Historical Context

How Xin Yi San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xin Yi San originates from the Yan Shi Ji Sheng Fang (《严氏济生方》, Formulas for Aid in Living from the Yan Family), compiled by the Song Dynasty physician Yan Yonghe (严用和) around 1253 CE. Yan Yonghe was known for his practical clinical approach, and this formula reflects his focus on treating common, everyday conditions with elegantly balanced prescriptions.

The formula was recognized by the Chinese National Administration of Traditional Chinese Medicine in 2018 when it was included in the first official Directory of Classical and Famous Prescriptions (《古代经典名方目录》), confirming its enduring clinical value. Throughout history, later physicians preserved the core formula while making various modifications. Common historical changes included adding Cang Er Zi (Xanthium fruit) at half dose to strengthen the nasal-opening effect, or adding Bo He (Mint) for additional Wind-dispersing action. Some Qing Dynasty versions adjusted the ratios, increasing the dose of the ascending and descending herbs while reducing Xi Xin and Xin Yi, reflecting evolving clinical preferences. The Qi Xiao Liang Fang (《奇效良方》) notably included a pediatric version with reduced dosage, prescribing "one qian per serving" instead of the standard two.

A distinctive feature of the original formula is its administration method: the powdered herbs are taken mixed with clear green tea (茶清调服). The bitter, cool nature of green tea counterbalances the warm, acrid character of the formula, prevents the Wind-dispersing herbs from being excessively drying, and helps direct turbid pathogenic factors downward.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Xin Yi San

1

Randomized double-blind clinical trial of Xin-yi-san for perennial allergic rhinitis (2010)

Yang SH, Yu CL, Chen YL, Chiao SL, Chen ML. International Immunopharmacology, 2010, 10(8):951-958.

In a randomized, double-blind, placebo-controlled trial, 108 patients with perennial allergic rhinitis received Xin Yi San or placebo for 3 months. The study found that Xin Yi San significantly reduced nasal symptoms, decreased nasal airflow resistance, lowered serum IgE levels against house dust mite allergens, and modulated immune markers including increased IL-10, sICAM-1, and IL-8 production. The authors concluded Xin Yi San alone is effective for perennial allergic rhinitis through diverse immunomodulatory effects.

PubMed
2

CYP1A2 inhibition by Xin-yi-san and interaction with theophylline: human and in vitro study (2024)

Kao LT, Chen AC, Wang HJ, Wen YL, Lu CK, Liaw CC, Tsai KC, Ueng YF. Phytomedicine, 2024, 130:155760.

This study investigated the pharmacokinetic interaction between Xin Yi San and theophylline. Xin Yi San was found to contain potent CYP1A2 inhibitors, primarily the furanocoumarin imperatorin from Bai Zhi (Angelica dahurica). In a retrospective analysis of over 200,000 theophylline users, concurrent Xin Yi San use was associated with approximately double the risk of headaches and significantly increased tachycardia. The finding is clinically relevant for patients taking both theophylline and this herbal formula.

3

Identification of imperatorin as the perpetrator in Xin-yi-san-theophylline interaction: pharmacokinetic study in rats (2023)

Kao LT, Chen AC, Wang HJ, Wen YL, Lu CK, Liaw CC, Tsai KC, Ueng YF. Journal of Pharmacy and Pharmacology, 2023.

This preclinical study in rats confirmed that Xin Yi San extract and its component imperatorin non-competitively inhibit theophylline oxidation by CYP1A2. Xin Yi San decreased theophylline clearance by 27-33% and prolonged its elimination half-life by 29% in a dose-dependent manner. The study identified imperatorin as the primary compound responsible for this herb-drug interaction.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.