Formula Pill (Wan)

Shu Gan Wan

Soothe the Liver Pill · 舒肝丸

Also known as: Shu Gan Wan, Shu Kan Wan, Comfort Liver Pill,

A classical formula that soothes the Liver and harmonizes the Stomach, used to relieve chest and rib-side fullness, stomach pain, acid reflux, belching, nausea, and general discomfort caused by Liver Qi stagnation affecting digestion. It is particularly suited when emotional stress leads to digestive disturbance with pain.

Origin Chinese Pharmacopoeia (中华人民共和国药典) — Traditional formula, codified in the modern Chinese Pharmacopoeia
Composition 13 herbs
Chuan Lian Zi
King
Chuan Lian Zi
Yan Hu Suo
Deputy
Yan Hu Suo
Bai Shao
Deputy
Bai Shao
Jiang Huang
Assistant
Jiang Huang
Mu Xiang
Assistant
Mu Xiang
Chen Xiang
Assistant
Chen Xiang
Sha Ren
Assistant
Sha Ren
Rou Dou Kou
Assistant
Rou Dou Kou
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shu Gan Wan is designed to correct these specific patterns.

Why Shu Gan Wan addresses this pattern

Shu Gan Wan directly targets Liver Qi stagnation with its large complement of Qi-moving herbs. Chuan Lian Zi drains constrained Liver Qi, while Mu Xiang, Chen Xiang, Zhi Ke, and Chen Pi ensure Qi flows freely through the chest, flanks, and abdomen. Bai Shao nourishes the Liver to address the root vulnerability (the Liver body needs nourishment to function smoothly). The combination of Qi-movers with Blood-movers (Yan Hu Suo, Pian Jiang Huang) reflects the classical understanding that prolonged Qi stagnation always leads to some degree of Blood stasis.

A practitioner would look for one or more of these signs

Hypochondriac Pain

Distending pain along the rib sides, worse with emotional upset

Chest Stiffness

Fullness and pressure in the chest

Irritability

Emotional tension, irritability, sighing

Belching

Frequent belching and acid reflux

Abdominal Distention

Bloating and abdominal distention

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shu Gan Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic gastritis often reflects a disharmony between the Liver and the Stomach. The Liver's role is to ensure smooth flow of Qi throughout the body. When emotional stress, frustration, or repressed feelings cause the Liver Qi to stagnate, it can 'overact' on the Stomach (following the controlling cycle where Wood overacts on Earth). This disrupts the Stomach's ability to 'ripen and decompose' food and to send food downward. The result is epigastric pain, bloating, nausea, belching, and acid regurgitation. A key diagnostic feature is that symptoms worsen with emotional upset and improve when the person feels relaxed. The tongue is often slightly dusky or has a thin white coating, and the pulse is wiry (a hallmark of Liver Qi constraint).

Why Shu Gan Wan Helps

Shu Gan Wan addresses both sides of the Liver-Stomach disharmony simultaneously. The King herb Chuan Lian Zi drains constrained Liver Qi and clears the Heat that develops from prolonged stagnation, directly targeting the root cause. The pairing of Yan Hu Suo with Chuan Lian Zi provides powerful pain relief. Meanwhile, the large group of Stomach-harmonizing herbs (Sha Ren, Dou Kou, Hou Po, Chen Pi, Chen Xiang) restores normal digestive function by transforming Dampness, moving Qi, and directing rebellious Stomach Qi downward. Fu Ling strengthens the Spleen to resist future Liver overacting. This dual approach makes Shu Gan Wan particularly effective for chronic gastritis where emotional stress is a clear trigger.

Also commonly used for

Peptic Ulcer

When associated with Liver Qi stagnation causing stomach pain

Cholecystitis

Chronic cholecystitis with rib-side pain and digestive upset

Choledocholithiasis

Gallstones with pain in the hypochondrium

Dyspepsia

Stress-related indigestion with bloating and epigastric discomfort

Irritable Bowel Syndrome

When associated with emotional stress and Liver-Spleen disharmony

Chronic Hepatitis

As adjunctive treatment for Liver Qi stagnation pattern

Intercostal Neuralgia

Rib-side pain following the Liver channel distribution

Amenorrhea

Menstrual pain associated with Liver Qi stagnation

Premenstrual Syndrome

Breast distension, mood changes, and digestive upset before menstruation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shu Gan Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shu Gan Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shu Gan Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shu Gan Wan works at the root level.

This formula addresses a condition rooted in emotional frustration or stress that disrupts the Liver's natural function of ensuring the smooth flow of Qi throughout the body. In TCM, the Liver is described as preferring free and unobstructed movement (条达). When emotions like anger, resentment, or chronic frustration go unresolved, the Liver's Qi becomes knotted and stagnant, a pattern called Liver Qi constraint (肝气郁滞).

Because the Liver channel runs along the sides of the torso, stagnant Liver Qi produces distending pain in the ribs and flanks. The blocked Qi also creates a sensation of chest oppression and a frequent urge to sigh deeply (as sighing temporarily relieves the pressure). Emotionally, the person may swing between feeling depressed and irritable. When Qi stagnation persists, it inevitably affects Blood circulation, causing mild Blood stasis that intensifies the pain. If the constrained Liver Qi "crosses over" to invade the Stomach and Spleen (a pattern called Wood overacting on Earth), digestive symptoms like bloating, belching, and epigastric fullness appear.

The formula works by restoring the Liver's free-flowing nature, moving the stagnant Qi outward and downward while gently activating Blood circulation to address the secondary stasis. It follows the classical principle from the Huang Di Nei Jing: "When Wood is constrained, free it" (木郁达之).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter with a mild sour-sweet undertone. The acrid quality disperses stagnation and moves Qi, the bitter quality directs Qi downward, and the sour-sweet combination softens and nourishes the Liver.

Ingredients

13 herbs

The herbs that make up Shu Gan Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Chuan Lian Zi

Chuan Lian Zi

Sichuan chinaberries

Dosage 6 - 9g
Temperature Cold
Taste Bitter
Organ Affinity Spleen, Liver, Small Intestine

Role in Shu Gan Wan

Drains Liver Qi, clears depressed Heat from the Liver channel, and relieves pain. As the chief herb, it directly addresses the core pathomechanism of Liver Qi stagnation generating constraint Heat, and guides the formula to the Liver and Stomach.
Deputies — Assists and enhances the King
Yan Hu Suo

Yan Hu Suo

Corydalis tubers

Dosage 6 - 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Heart, Liver, Lungs
Preparation Vinegar-processed (醋制) to enhance pain-relieving and Blood-moving properties

Role in Shu Gan Wan

Powerfully invigorates Blood and moves Qi to stop pain. Paired with Chuan Lian Zi, this creates the famous analgesic combination Jin Ling Zi San, which is the core pain-relieving mechanism of the formula.
Bai Shao

Bai Shao

White peony roots

Dosage 6 - 12g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen
Preparation Wine-fried (酒炒) to enhance its ability to enter the Liver channel

Role in Shu Gan Wan

Nourishes Liver Blood, softens the Liver, and alleviates pain. Balances the many moving and dispersing herbs in the formula by preserving Liver Yin, preventing the Qi-moving herbs from consuming Liver Blood.
Assistants — Supports or moderates other herbs
Jiang Huang

Jiang Huang

Turmeric

Dosage 3 - 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Liver, Spleen

Role in Shu Gan Wan

Moves Blood, breaks up stagnation, and alleviates pain. Reinforces the Blood-moving action of Yan Hu Suo and helps resolve Blood stasis that accompanies prolonged Qi stagnation.
Mu Xiang

Mu Xiang

Costus roots

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Gallbladder, Large Intestine, Liver, Lungs, Spleen, Stomach

Role in Shu Gan Wan

Promotes the movement of Qi in the Spleen and Stomach, alleviates pain and distention in the abdomen. Addresses the secondary pattern of Stomach and Spleen Qi stagnation caused by Liver overacting.
Chen Xiang

Chen Xiang

Agarwood

Dosage 1 - 3g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Stomach, Kidneys, Lungs

Role in Shu Gan Wan

Promotes the movement of Qi and directs rebellious Qi downward. Its descending nature helps counter nausea, belching, and acid reflux by restoring the normal downward direction of Stomach Qi.
Sha Ren

Sha Ren

Amomum fruits

Dosage 3 - 6g
Temperature Warm
Taste Pungent
Organ Affinity Kidneys, Spleen, Stomach

Role in Shu Gan Wan

Transforms Dampness, moves Qi, and strengthens the Stomach. Addresses the Dampness and food stagnation that often accompany Liver-Spleen disharmony.
Rou Dou Kou

Rou Dou Kou

Nutmeg

Dosage 3 - 6g
Temperature Warm
Taste Pungent
Organ Affinity Large Intestine, Spleen, Stomach

Role in Shu Gan Wan

Transforms Dampness, moves Qi, and warms the middle. Works with Sha Ren to restore Stomach function and relieve bloating and nausea.
Hou Pu

Hou Pu

Houpu Magnolia bark

Dosage 3 - 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen, Stomach
Preparation Ginger-processed (姜制) to enhance its warming and Stomach-harmonizing action

Role in Shu Gan Wan

Moves Qi, transforms Dampness, and relieves distention and fullness. Addresses the abdominal bloating and fullness that results from Liver Qi overacting on the Spleen.
Chen Pi

Chen Pi

Tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen

Role in Shu Gan Wan

Regulates Qi, dries Dampness, and harmonizes the Stomach. Supports the middle burner and helps prevent the many moving herbs from causing excessive dispersal.
Zhi Ke

Zhi Ke

Bitter oranges

Dosage 3 - 9g
Temperature Warm
Taste Bitter, Pungent, Sour
Organ Affinity Spleen, Stomach
Preparation Stir-fried (炒) to moderate its harsh Qi-breaking action

Role in Shu Gan Wan

Moves Qi and reduces distention, particularly in the chest and abdomen. Helps relieve the sense of chest and rib-side fullness that is the hallmark complaint of this pattern.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 6 - 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Shu Gan Wan

Strengthens the Spleen and drains Dampness. Supports the Spleen so it can properly transform and transport, which is critical when the Liver is overacting on it. Also calms the spirit.
Envoy — Directs the formula to its target
Zhu Sha

Zhu Sha

Cinnabar

Dosage 0.3 - 1g
Temperature Cool
Taste Sweet
Organ Affinity Heart
Preparation Do NOT decoct. Dissolve in the finished decoction or take separately in pill/powder form. Contains mercury and must not be heated.

Role in Shu Gan Wan

Calms the Heart and settles the spirit, addressing the anxiety and restlessness that often accompany Liver Qi stagnation. Also serves to anchor the many dispersing herbs and prevent them from being overly stimulating.

Why This Combination Works

How the herbs in Shu Gan Wan complement each other

Overall strategy

This formula addresses Liver Qi stagnation that has begun to affect the Stomach and Spleen, causing both pain and digestive disturbance. The strategy combines soothing the Liver and moving Qi with harmonizing the Stomach, transforming Dampness, and invigorating Blood to stop pain.

King herbs

Chuan Lian Zi (Melia fruit) serves as the King herb because it directly enters the Liver channel to drain constrained Qi and clear the depressed Heat that often develops when Liver Qi stagnates for a prolonged period. Its bitter, cold nature addresses the root cause while also directing the formula's action to the Liver.

Deputy herbs

Yan Hu Suo (Corydalis rhizome) powerfully moves both Blood and Qi to stop pain. Together with Chuan Lian Zi, it forms the classical pairing known as Jin Ling Zi San, one of the most effective analgesic combinations in TCM. Bai Shao (White Peony root) nourishes Liver Blood and softens the Liver, providing a crucial counterbalance to the many acrid, dispersing herbs in the formula. Without it, the formula would be overly drying and moving.

Assistant herbs

The assistant herbs form three functional groups. First, Pian Jiang Huang (Turmeric) reinforces the Blood-moving, pain-relieving action of the Deputies. Second, a large group of aromatic Qi-movers addresses the Stomach and Spleen: Mu Xiang and Chen Xiang move Qi and direct it downward to stop nausea and belching; Sha Ren and Dou Kou Ren transform Dampness and warm the middle; Hou Po, Chen Pi, and Zhi Ke relieve distention and fullness. Third, Fu Ling strengthens the Spleen and drains Dampness, supporting the digestive system that the Liver has been overacting upon.

Envoy herbs

Zhu Sha (Cinnabar) calms the Heart and settles the spirit. Liver Qi stagnation frequently causes irritability, anxiety, and restlessness. Zhu Sha anchors the spirit and prevents the many moving, aromatic herbs from being overly stimulating. It also directs the formula's calming action to the Heart.

Notable synergies

The Chuan Lian Zi and Yan Hu Suo pairing (Jin Ling Zi San) is the formula's analgesic core, addressing both Qi stagnation and Blood stasis pain. The Sha Ren and Dou Kou Ren pairing powerfully aromatically transforms Dampness in the middle burner. Bai Shao working alongside the many Qi-moving herbs creates a sophisticated balance: the formula moves without depleting, disperses without damaging Yin.

How to Prepare

Traditional preparation instructions for Shu Gan Wan

In its traditional pill form (Shu Gan Wan), the herbs are ground into fine powder and formed into pills with honey or water. The standard modern dosage is typically one pill (approximately 9g) taken twice daily with warm water. When adapted as a decoction, decoct all herbs in approximately 600ml of water, simmering to about 300ml. Divide into two doses taken warm, one in the morning and one in the evening, ideally on an empty stomach. Note: Zhu Sha (Cinnabar) should NOT be decocted but dissolved separately in the strained decoction, as heating can release toxic mercury vapor.

Common Modifications

How practitioners adapt Shu Gan Wan for specific situations

Added
Dan Shen

15g, to invigorate Blood in the Liver

Tao Ren

9g, to break up Blood stasis

When pain is fixed, stabbing, or worse at night, Blood stasis is prominent. Dan Shen and Tao Ren strengthen the Blood-moving action of Yan Hu Suo and Pian Jiang Huang to resolve deeper stasis.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shu Gan Wan should not be used or requires extra caution

Caution

Not suitable for Liver Yin deficiency or Blood deficiency patterns. The formula is acrid and drying in nature and may further deplete Yin and Blood if used for the wrong pattern. Signs to watch for include a dry red tongue with little coating, night sweats, and a thin rapid pulse.

Caution

Avoid in Liver Yang rising or Liver Fire blazing patterns (e.g. severe headache, red face, bitter taste, irritability with constipation). The acrid, dispersing herbs may aggravate upward-flaring conditions.

Caution

Not appropriate for prolonged use. Because many ingredients are aromatic, acrid, and drying, extended use can consume Qi and injure Yin.

Caution

Use with caution during pregnancy. Chuan Xiong (Ligusticum) and Xiang Fu (Cyperus) are both Qi-moving and Blood-invigorating herbs that may stimulate uterine activity.

Caution

Not suitable for patterns involving Dampness-Heat accumulation in the Liver and Gallbladder with strong Heat signs. The warm, acrid nature of the formula may worsen Heat.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. The formula contains Chuan Xiong (Ligusticum chuanxiong), which invigorates Blood and has documented uterine-stimulating effects, and Xiang Fu (Cyperus rotundus), which strongly moves Qi. Together these herbs could theoretically promote uterine contractions. While the formula is not absolutely contraindicated, it should only be used during pregnancy under the guidance of a qualified practitioner, and only if the clinical need clearly outweighs the risk. Dosage reduction of Chuan Xiong and Xiang Fu may be advisable.

Breastfeeding

No specific contraindication during breastfeeding has been established for this formula. The herbs are generally mild in toxicity. However, the acrid and Qi-moving nature of Chuan Xiong, Xiang Fu, and Chen Pi means that active compounds may transfer into breast milk in small amounts. There is insufficient data to confirm safety. Practitioners should use clinical judgment and monitor both mother and infant. If the breastfeeding mother shows signs of Yin or Blood deficiency, this formula's drying nature may reduce milk production, which depends on adequate Blood and fluids.

Children

This formula can be used in children with appropriate dosage reduction, but it is not commonly prescribed for very young children (under age 5) because Liver Qi stagnation patterns from emotional causes are less common in this age group. For children aged 6–12, dosages are typically reduced to one-third to one-half of the adult dose. For adolescents (13+), two-thirds of the adult dose is common. Practitioners should be cautious with the acrid, drying herbs (Chuan Xiong, Xiang Fu) in children, as pediatric constitutions tend more toward Yin insufficiency. The formula is most relevant in older children and adolescents presenting with stress-related digestive complaints or mood disturbance with a wiry pulse.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shu Gan Wan

Gan Cao (Glycyrrhiza/Licorice): Glycyrrhizin in licorice can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure). This may interact with antihypertensives, diuretics, cardiac glycosides (e.g. digoxin), and corticosteroids. Although the dose in this formula is small (1.5g), caution is still warranted in patients on these medications.

Chuan Xiong (Ligusticum chuanxiong): Has documented antiplatelet and anticoagulant activity. Patients taking blood thinners (warfarin, heparin, aspirin, clopidogrel) or NSAIDs should use this formula with caution due to increased bleeding risk. Chuan Xiong may also potentiate the effects of antihypertensive medications.

Chai Hu (Bupleurum): Bupleurum saponins have been shown to affect hepatic cytochrome P450 enzyme activity, which could alter the metabolism of many pharmaceuticals. Patients on medications with narrow therapeutic windows (e.g. cyclosporine, certain anticonvulsants) should be monitored. Bupleurum may also interact with interferon therapy used in hepatitis treatment.

General note: As with all Qi-moving formulas, concurrent use with sedatives or anxiolytics should be monitored, as the formula's mood-regulating effects may have additive interactions.

Usage Guidance

Practical advice for getting the most out of Shu Gan Wan

Best time to take

On an empty stomach, 30 minutes before meals, typically twice daily (morning and late afternoon). The classical instruction specifies taking it before meals (食前服) to optimize absorption and Qi-moving effects.

Typical duration

Acute flare-ups: 1–2 weeks. Chronic Liver Qi stagnation patterns: 4–8 weeks with periodic reassessment, adjusting the formula as symptoms change.

Dietary advice

Avoid greasy, fried, and heavy foods that burden the Liver and impair Qi flow. Limit alcohol, as it generates Dampness-Heat and worsens Liver constraint. Reduce spicy, hot foods if there are signs of Heat (irritability, red tongue). Favor lightly cooked vegetables, especially leafy greens, which support the Liver's spreading function. Foods like celery, chrysanthemum tea, mint tea, and green citrus peel can complement the formula's Qi-moving action. Eat regular, moderate meals and avoid eating while angry or stressed, as emotional eating directly stagnates Liver Qi.

Shu Gan Wan originates from Chinese Pharmacopoeia (中华人民共和国药典) Traditional formula, codified in the modern Chinese Pharmacopoeia

Classical Texts

Key passages from the classical Chinese medical texts that first described Shu Gan Wan and its clinical use

《医学统旨》(Yi Xue Tong Zhi):
"治怒火伤肝,左胁作痛,血菀于上。"
"Treats anger-Fire injuring the Liver, pain in the left hypochondrium, and Blood congesting upward."

《景岳全书》(Jing Yue Quan Shu):
"柴胡、芍药以和肝解郁为主;香附、枳壳、陈皮以理气滞;川芎以活其血;甘草以和中缓痛。"
"Chai Hu and Shao Yao are the principals for harmonizing the Liver and resolving constraint; Xiang Fu, Zhi Ke, and Chen Pi regulate Qi stagnation; Chuan Xiong invigorates the Blood; Gan Cao harmonizes the center and eases pain."

《谦斋医学讲稿》(Qian Zhai Yi Xue Jiang Gao) by Qin Bowei:
"本方即四逆散加川芎、香附和血理气,治疗胁痛,寒热往来,专以疏肝为目的。用柴胡、枳壳、香附理气为主,白芍、川芎和血为佐,再用甘草以缓之。系疏肝的正法,可谓善于运用古方。"
"This formula is Si Ni San with the addition of Chuan Xiong and Xiang Fu to harmonize Blood and regulate Qi, treating rib pain and alternating chills and fever, with the sole purpose of spreading the Liver. Chai Hu, Zhi Ke, and Xiang Fu regulate Qi as the main strategy; Bai Shao and Chuan Xiong harmonize Blood as assistants; Gan Cao moderates them all. This is the orthodox method for spreading the Liver, and represents a masterful adaptation of a classical formula."

Historical Context

How Shu Gan Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shu Gan Tang (疏肝汤), more commonly known as Chai Hu Shu Gan San (柴胡疏肝散, Bupleurum Powder to Spread the Liver), is one of the most widely used formulas in the Qi-regulating category of Chinese medicine. Its earliest recorded source is the Yi Xue Tong Zhi (《医学统旨》, Comprehensive Guide to Medicine), and it was later collected in the Ming Dynasty masterwork Jing Yue Quan Shu (《景岳全书》, Complete Works of Jing Yue), compiled by Zhang Jiebin (张介宾, 1563–1640) around 1624. It also appears in the Zheng Zhi Zhun Sheng (《证治准绳》, Standards of Diagnosis and Treatment) citing the Yi Xue Tong Zhi.

The formula is a deliberate evolution of the much older Si Ni San (四逆散, Frigid Extremities Powder) from Zhang Zhongjing's Shang Han Lun. The modification replaced Zhi Shi (Fructus Aurantii Immaturus) with the gentler Zhi Ke (Fructus Aurantii), and added Chen Pi, Chuan Xiong, and Xiang Fu to strengthen the Qi-moving and Blood-activating effects. While Si Ni San balanced Liver and Spleen equally, this formula shifted the emphasis decisively toward spreading and unblocking the Liver.

Over the centuries, this formula became a foundational prescription that practitioners routinely modify. The Qing Dynasty text Yi Lüe Liu Shu (《医略六书》) expanded the formula with Shan Zhi Zi and Bo He for cases involving depressive Heat and bleeding. In modern clinical practice, it remains one of the most commonly prescribed base formulas for stress-related disorders, and has become a major subject of pharmacological research, particularly for depression and functional gastrointestinal disorders.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Shu Gan Wan

1

Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials (Systematic Review & Meta-Analysis, 2018)

Sun Y, Xu X, Zhang J, Chen Y. BMC Complementary and Alternative Medicine. 2018; 18(1): 66.

This review pooled data from 42 RCTs and found that Chai Hu Shu Gan San, used alone or combined with conventional antidepressants, significantly improved depression scores compared to antidepressants alone. The formula appeared particularly promising for post-stroke and postpartum depression.

DOI
2

Effectiveness and safety of Chaihu-Shugan-San for treating depression: An updated systematic review and meta-analysis (Systematic Review & Meta-Analysis, 2024)

Zhang X, Zhao Q, Wang Y, Mao Y, Sun Y, Bian X. Medicine (Baltimore). 2024; 103(26): e38668.

An updated meta-analysis of 15 clinical studies (1034 patients) found that combining this formula with antidepressants significantly improved depressive symptoms and response rates compared to antidepressants alone, with no increase in adverse effects.

DOI
3

Chaihu-Shugan-San, an oriental herbal preparation, for the treatment of chronic gastritis: a meta-analysis of randomized controlled trials (Meta-Analysis, 2013)

Qin F, Liu JY, Yuan JH. Journal of Ethnopharmacology. 2013; 146(2): 433–439.

This meta-analysis evaluated the formula's effectiveness for chronic gastritis. The pooled results indicated it was more effective than conventional Western medicine for improving gastritis symptoms, though the authors noted that included studies had methodological limitations.

PubMed
4

Chaihu-Shugan-San for patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis (Systematic Review & Meta-Analysis, 2025)

Qu X, Sun J, Shen Y, Dong J, Li X, Ma Y, Sun J. Medicine (Baltimore). 2025; 104(18): e42303.

This review assessed the formula's effect on nonalcoholic fatty liver disease across multiple RCTs, finding significant improvements in liver enzyme levels (ALT, AST) and blood lipid profiles compared to conventional treatments.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.