Shi Zao Tang

Ten-Jujube Decoction · 十棗湯

Also known as: Ten Dates Decoction, Shi Zao Tang

A powerful classical formula used to forcefully expel accumulated water and fluid from the chest, flanks, and abdomen. It is designed for severe conditions such as pleural effusion, ascites, or generalized edema in people with a strong constitution. Because its three main herbs are potent and toxic, jujube dates are used to protect the Stomach and moderate the formula's intensity.

Origin Shang Han Lun (Treatise on Cold Damage) by Zhang Zhongjing — Eastern Hàn dynasty, c. 200 CE
Composition 4 herbs
Gan Sui
King
Gan Sui
Jing Da Ji
Deputy
Jing Da Ji
Yuan Hua
Deputy
Yuan Hua
Da Zao
Assistant
Da Zao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Zao Tang is designed to correct these specific patterns.

Why Shi Zao Tang addresses this pattern

This pattern, known classically as "suspended fluid" (xuan yin, 悬饮), involves pathological water and fluid that has accumulated in the chest and below the ribs. The fluid blocks the flow of Qi in the chest, causes pain in the flanks that worsens with coughing or breathing, and presses upward to disturb the Lungs and Stomach. Shi Zao Tang directly addresses this by using three potent water-expelling herbs: Yuan Hua targets chest and hypochondrium fluid specifically, while Gan Sui drives out fluid from the channels and Da Ji drains the organs. Da Zao protects the Stomach during the forceful purging. This formula is the primary classical treatment for suspended fluid when the patient's constitution is strong enough to tolerate drastic purgation.

A practitioner would look for one or more of these signs

Chest Pain

Pain in the chest and flanks, worsened by coughing, breathing, or turning

Shortness Of Breath

Shortness of breath from fluid compressing the lungs

Dry Heaving

Dry heaving or retching

Epigastric Coldness

Feeling of hardness and fullness below the heart

Headaches

Headache from fluid-turbidity rising upward

Dizziness

Dizziness and blurred vision

White Tongue Coating

White, slippery tongue coating

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Zao Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Fluid Retention in the chest and hypochondrium

TCM Interpretation

In TCM, pleural effusion corresponds most closely to "suspended fluid" (xuan yin), a condition where pathological water flows into the space beneath the ribs and around the lungs. This blocks the normal movement of Qi in the chest, impairs Lung function, and causes pain that worsens with breathing and coughing. The Spleen's failure to properly transform and transport fluids, combined with a breakdown in the Lung's ability to regulate the water passages, allows fluid to pool in these areas. The condition is classified as an interior excess pattern, meaning the pathogenic fluid is substantial and the body's constitution is still relatively strong.

Why Shi Zao Tang Helps

Shi Zao Tang is considered the classical first-choice formula for suspended fluid in patients with a strong constitution. Yuan Hua specifically targets fluid congestion in the chest and hypochondrium, while Gan Sui drives fluid from the channels and Da Ji drains the organs. Together, they powerfully expel the accumulated pleural fluid through the bowels. Da Zao protects the Stomach during this intense process. Clinical reports have documented significant absorption of pleural effusions after several doses of this formula, often with resolution within weeks.

Also commonly used for

Pleurisy

Exudative or serous pleurisy

Pericardial Effusion

Fluid accumulation around the heart

Chronic Nephritis

With significant edema and fluid retention

Pneumonia

With accompanying pleural fluid

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Zao Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Zao Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Zao Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Zao Tang works at the root level.

This formula addresses a condition where water and pathological fluids have accumulated massively within the body, particularly in the chest and hypochondrium (the area beneath the ribs), or have flooded the entire body as severe edema. In TCM, this is understood as an excess condition: the body's fluid metabolism has broken down, and water that should be moving and transforming has instead pooled and stagnated in places it does not belong.

When water accumulates in the chest and flanks, it is called 'suspended fluid retention' (悬饮 xuan yin). The trapped fluid obstructs the Qi mechanism in the chest, pressing upward on the Lungs and blocking normal breathing and descending. This produces coughing that pulls pain through the chest and ribs, shortness of breath, dry retching, and a feeling of hard fullness below the sternum. Because the fluid is a heavy Yin pathogen, it can also push upward to disturb the clear Yang of the head, causing headaches and dizziness. When water overflows into the limbs and abdomen, it creates generalized swelling, abdominal distention, and difficulty with urination and bowel movements, as the Triple Burner waterways are completely blocked.

Crucially, this is not a deficiency-type edema. The patient's Zheng Qi (upright Qi) must still be relatively intact, strong enough to withstand aggressive treatment. The deep, wiry pulse confirms both the interior location and the binding quality of the accumulated fluid. Because the water has congealed into a formidable mass that gentle methods like bland percolation or mild diuresis cannot move, the treatment principle must be drastic purgation to force the water out through the bowels, following the Nei Jing principle of 'cleansing the organs and removing stale accumulation' (洁净府,去菀陈莝).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and acrid with underlying sweetness from the jujubes. The bitterness drains and purges downward, the acridity disperses accumulated fluids, and the sweetness of Da Zao protects the Stomach and moderates the harshness.

Target Organs

Channels Entered

Ingredients

4 herbs

The herbs that make up Shi Zao Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Gan Sui

Gan Sui

Kansui root

Dosage 0.5 - 1g (as powder)
Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Kidneys, Large Intestine
Preparation Ground into fine powder separately; not decocted. Often placed in capsules in modern use.

Role in Shi Zao Tang

The primary water-expelling herb. Gan Sui penetrates the channels and collaterals (jing sui) to drive out deeply lodged fluid accumulations. It is the most powerful of the three drastic purgatives and directly addresses the core pathomechanism of water retention throughout the body.
Deputies — Assists and enhances the King
Jing Da Ji

Jing Da Ji

Peking spurge root

Dosage 0.5 - 1g (as powder)
Temperature Cold
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Kidneys
Preparation Ground into fine powder separately; not decocted.

Role in Shi Zao Tang

Drains water and dampness from the organs (zang fu). Da Ji complements Gan Sui by targeting fluid accumulation within the viscera, particularly effective for abdominal fluid and water stagnation in the internal organs. It also helps reduce swellings and disperse nodules.
Yuan Hua

Yuan Hua

Genkwa flower bud

Dosage 0.5 - 1g (as powder)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen, Kidneys
Preparation Must be dry-fried (ao) until reddish before use to reduce toxicity. Ground into fine powder separately.

Role in Shi Zao Tang

Specializes in eliminating fluid and phlegm congestion from the chest and hypochondrium. Yuan Hua is acrid and warm, which helps it disperse and break up stubborn fluid accumulations in the upper body, particularly effective for suspended fluid (xuan yin) lodged beneath the ribs.
Assistant — Supports or moderates other herbs
Da Zao

Da Zao

Chinese date (Jujube fruit)

Dosage 10 pieces (large, plump dates)
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Preparation Broken open and decocted first in water to make a thick decoction. The herbal powder is then mixed into this date decoction for administration.

Role in Shi Zao Tang

Serves three critical purposes: moderates the harshness and toxicity of the three drastic purgatives; tonifies Qi and protects the Stomach to prevent the severe purging from damaging digestive function; and strengthens the Spleen (Earth) to help control Water, addressing both the pathogen and the body's resilience simultaneously.

Why This Combination Works

How the herbs in Shi Zao Tang complement each other

Overall strategy

When water and fluid accumulate severely in the chest, flanks, or abdomen, gentle methods of promoting urination or transforming dampness are insufficient. This formula employs three of the most powerful water-expelling substances in the materia medica, combined with jujube dates to protect the body's Qi, to forcefully purge pathological fluid through the stool.

King herb

Gan Sui (Kansui Root) serves as the King because of its unmatched ability to penetrate the channels and collaterals to expel deeply lodged fluid. Classical sources note that Gan Sui "reaches the fluid and water hidden in the deepest recesses" of the body. It is bitter and cold, directly driving accumulated water downward and out.

Deputy herbs

Jing Da Ji (Peking Spurge Root) and Yuan Hua (Genkwa Flower) each complement Gan Sui from a different angle. Da Ji specializes in draining water from the internal organs, while Yuan Hua is particularly effective at dispersing fluid and phlegm congestion from the chest and beneath the ribs. Together with Gan Sui, these three herbs cover every level of the body where pathological fluid can lodge: the channels, the organs, and the chest.

Assistant herbs

Da Zao (Jujube Date, 10 pieces) is a restraining and reinforcing assistant. It fulfills three roles: (1) it buffers the toxicity of the three drastic purgatives; (2) it tonifies the Spleen and Stomach, protecting digestive function from the violent purging action; and (3) it strengthens Earth to control Water, embodying the classical principle of "bolstering the Spleen to overcome Water" (yi tu sheng shui). The name of the formula itself, "Ten-Jujube Decoction," highlights the central importance of this protective strategy.

Notable synergies

The combination of Gan Sui, Da Ji, and Yuan Hua is the classical trio for drastic water expulsion. Each targets a different compartment of the body (channels, organs, and chest respectively), ensuring comprehensive drainage. The use of Da Zao decoction as the vehicle rather than plain water is not incidental: it simultaneously delivers the medicine and shields the digestive system, allowing the body to withstand the formula's intensity.

How to Prepare

Traditional preparation instructions for Shi Zao Tang

Grind Yuan Hua (dry-fried until reddish), Gan Sui, and Jing Da Ji separately into fine powder in equal parts, then combine. Decoct 10 large, plump jujube dates (Da Zao) in approximately 300 ml of water until reduced to about half (roughly 150 ml). Strain out the dates, then stir the herbal powder into the warm date decoction.

For a person of strong constitution, take 0.5 to 1 gram of the combined powder per dose. For someone weaker or of smaller build, take only 0.5 gram. Take on an empty stomach in the early morning. If purging is insufficient and the condition persists, the dose may be increased by 0.5 gram the following day. Once vigorous watery bowel movements are achieved, stop the formula immediately and nourish the body with thin rice porridge (mi zhou) to restore Stomach Qi. Modern practice often places the powder into capsules and takes them with the date decoction to reduce direct irritation to the stomach lining.

Common Modifications

How practitioners adapt Shi Zao Tang for specific situations

Added
Da Fu Pi

9-15g, moves Qi and reduces abdominal distension

Qian Niu Zi

6-9g, promotes urination and reinforces water expulsion

Hou Pu

6-9g, moves Qi and reduces fullness

When ascites is accompanied by significant Qi stagnation, adding herbs that move Qi and promote urination helps direct water downward through multiple routes, reducing the burden of purging through the bowels alone.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Zao Tang should not be used or requires extra caution

Avoid

Pregnancy. All three active herbs (Gan Sui, Da Ji, Yuan Hua) are toxic and strongly purgative, posing serious risk to the fetus.

Avoid

Patients with significant Qi deficiency or weak constitution (体虚). Zhang Zhongjing specifically distinguished dosing for 'strong persons' versus 'weak persons,' and the formula should not be given to those with severely depleted Zheng Qi.

Avoid

Concurrent use with Gan Cao (Licorice) in any form. Gan Sui, Da Ji, and Yuan Hua are all listed in the classical 'Eighteen Incompatibilities' (十八反) as antagonistic to Gan Cao. Co-administration may increase toxicity to the heart, liver, and kidneys.

Avoid

Unresolved exterior (surface-level) pattern. The Shang Han Lun explicitly states 'only when the exterior is resolved may one attack' (表解者乃可攻之). If exterior Wind-Cold symptoms remain, the exterior must be resolved first.

Avoid

Fluid retention due to deficiency (Spleen Yang deficiency or Kidney Yang deficiency edema without excess). This formula is only for robust excess-type water accumulation where the body's Zheng Qi can still tolerate aggressive purgation.

Avoid

Patients with active gastrointestinal bleeding, ulcers, or severe gastric inflammation. The three toxic herbs are highly irritating to the gastrointestinal mucosa.

Caution

Patients who are elderly, frail, or convalescing. If the condition truly requires purgation in a weakened patient, practitioners may alternate with Spleen-tonifying formulas (先补后攻 or 攻补交替).

Caution

Prolonged or repeated use. This is a short-course emergency formula, not for extended therapy. The classical instruction is to stop once effective purging is achieved and then nourish with rice porridge (糜粥自养).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Absolutely contraindicated in pregnancy. All three active herbs (Gan Sui, Da Ji, and Yuan Hua) are classified as toxic (有毒) and are powerful cathartics that cause intense purgation and fluid loss. Yuan Hua in particular has historically been noted for its ability to stimulate uterine activity. The violent purging action of the formula poses a direct risk of miscarriage, fetal distress, and serious harm to both the mother and fetus. Classical sources explicitly state 孕妇忌用 (contraindicated in pregnant women). There is no safe modification of this formula for use during pregnancy.

Breastfeeding

Contraindicated during breastfeeding. Gan Sui, Da Ji, and Yuan Hua are all classified as toxic herbs containing diterpene esters and other irritant compounds. These substances have the potential to pass into breast milk and could cause severe gastrointestinal irritation, diarrhea, or toxicity in a nursing infant. Additionally, the intense purgation and fluid loss caused by this formula would likely disrupt milk production. No studies exist to establish a safe threshold. Breastfeeding mothers should not take this formula.

Children

Shi Zao Tang is generally not appropriate for children due to the extreme toxicity and potency of its three active herbs. Children have immature digestive systems and lower body weight, making them highly vulnerable to the severe purgative effects, dehydration, and electrolyte imbalance that this formula can cause. Classical sources only differentiate dosing between 'strong adults' (1 qian bi) and 'weak adults' (half qian bi) and make no provision for pediatric use. If a pediatric case with severe excess-type fluid retention were to arise, treatment should be under the close supervision of an experienced practitioner in a clinical setting, with extremely small doses and careful monitoring. In most cases, milder water-regulating formulas would be preferred for children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Zao Tang

Diuretics (furosemide, hydrochlorothiazide, spironolactone): Shi Zao Tang causes massive fluid and electrolyte loss through intense purgation. Concurrent use with pharmaceutical diuretics significantly increases the risk of dangerous dehydration, hypokalemia, hyponatremia, and circulatory collapse.

Cardiac glycosides (digoxin): The electrolyte depletion caused by this formula, particularly potassium loss, can potentiate digoxin toxicity and increase the risk of fatal cardiac arrhythmias.

Anticoagulants and antiplatelet agents (warfarin, aspirin): Da Ji (Euphorbia pekinensis) has blood-moving properties. Concurrent use may theoretically increase bleeding risk, though clinical data are limited.

Antihypertensives: The rapid fluid loss from this formula can cause abrupt drops in blood pressure, which may be compounded by antihypertensive medications, leading to hypotension or syncope.

Any formula or medication containing Gan Cao (Licorice/Glycyrrhiza): All three active herbs are listed in the classical 'Eighteen Incompatibilities' as antagonistic to Gan Cao. Modern research suggests co-administration increases toxicity to the liver, kidneys, and heart. This includes pharmaceutical products containing licorice extract.

Corticosteroids: Both corticosteroids and drastic purgation can cause potassium depletion, compounding the electrolyte disturbance risk.

Usage Guidance

Practical advice for getting the most out of Shi Zao Tang

Best time to take

Early morning on an empty stomach (平旦服, ping dan fu), as specifically instructed in the Shang Han Lun. This allows the full purgative effect to occur during daytime hours when the patient can be monitored.

Typical duration

Acute, short-term use only: typically 1 to 3 doses on consecutive or alternate days, stopped immediately once effective purging is achieved.

Dietary advice

During treatment, eat only bland, easily digestible foods. After effective purging (得快下利后), immediately switch to thin rice porridge (糜粥) to nourish the Stomach and restore Qi, as Zhang Zhongjing specifically instructed. Avoid cold, raw, greasy, or heavy foods that burden the Spleen and promote further fluid accumulation. Avoid alcohol entirely. Do not consume any foods or supplements containing licorice (Gan Cao). Stay well-hydrated with warm fluids between doses to prevent excessive dehydration, but do not drink large quantities at once. Rest and avoid physical exertion during the treatment course.

Shi Zao Tang originates from Shang Han Lun (Treatise on Cold Damage) by Zhang Zhongjing Eastern Hàn dynasty, c. 200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Zao Tang and its clinical use

Shang Han Lun (伤寒论), Clause 152

Original: 太阳中风,下利,呕逆,表解者,乃可攻之。其人漐漐汗出,发作有时,头痛,心下痞硬满,引胁下痛,干呕,短气,汗出不恶寒者,此表解里未和也,十枣汤主之。

Translation: In Tai Yang Wind-Strike with diarrhea and retching, only when the exterior is resolved may one attack [the interior]. If the person has intermittent slight sweating occurring at intervals, headache, hard fullness and distention below the heart pulling pain into the hypochondrium, dry retching, shortness of breath, and sweating without aversion to cold, this indicates the exterior is resolved but the interior is not harmonized. Shi Zao Tang governs this.

Jin Gui Yao Lue (金匮要略), Phlegm-Fluids and Cough chapter

Original: 脉沉而弦者,悬饮内痛。病悬饮者,十枣汤主之。

Translation: When the pulse is deep and wiry, this indicates suspended fluid retention with internal pain. For the condition of suspended fluid retention, Shi Zao Tang governs.

Jin Gui Yao Lue (金匮要略), Phlegm-Fluids and Cough chapter

Original: 夫有支饮家,咳烦,胸中痛者,不卒死,至一百日,或一岁,宜十枣汤。

Translation: For a person with longstanding propping fluid retention who has cough with vexation and pain in the chest, and who has not died suddenly but has suffered for a hundred days or even a year, Shi Zao Tang is appropriate.

Zhu Jie Shang Han Lun (注解伤寒论) by Cheng Wu-Ji

Original: 辛以散之,芫花之辛,以散饮;苦以泄之,甘遂、大戟之苦,以泄水。水者,肾所主也;甘者,脾之味也。大枣之甘者,益土而胜水。

Translation: The acrid disperses: the acridity of Yuan Hua disperses the fluid retention. The bitter drains: the bitterness of Gan Sui and Da Ji drains the water. Water is governed by the Kidneys; sweetness is the flavor of the Spleen. The sweetness of Da Zao strengthens Earth to overcome Water.

Historical Context

How Shi Zao Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shi Zao Tang originates from Zhang Zhongjing's Shang Han Lun (Discussion of Cold Damage, c. 200 CE), where it appears in the Tai Yang disease chapter. It is also referenced in the Jin Gui Yao Lue in the chapter on Phlegm-Fluids and Cough. The formula's name, 'Ten Jujubes Decoction,' highlights the ten large dates rather than the three toxic active herbs, a deliberate naming choice that underscores Zhang Zhongjing's emphasis on protecting the Stomach and Spleen even while deploying the most violent purgation available.

The Tang dynasty text Wai Tai Mi Yao (外台秘要) records an alternate name, 'Zhu Que Tang' (朱雀汤, Vermilion Bird Decoction), attributed to the monk-physician 'Shen Shi' (深师). The Song dynasty physician Chen Yan (陈言) adapted the formula in his San Yin Fang (三因方) by blending the three powdered herbs with jujube paste to form pills, making the formula easier to dose and less harsh on the stomach. Li Shizhen praised this adaptation in the Ben Cao Gang Mu. The Qing dynasty commentator Ke Qin noted that this was Zhang Zhongjing's most drastic water-expelling formula and emphasized that because Gan Cao is incompatible with all three active herbs, the choice of Da Zao as the moderating agent was not arbitrary but the only viable option. Guo Yong of the Song dynasty famously warned that if misused, this formula could kill faster than the Cheng Qi purgatives.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Shi Zao Tang

1

Feasibility of vinegar processing of toxic herbs in Shi-Zao-Tang: toxicity reduction, efficacy preservation in malignant ascites rats and underlying pharmacodynamic mechanisms (Preclinical study, 2025)

Xi LJ, Shi YM, An LY, Yang JX, Qi YX, Yang T, et al. Chinese Medicine, 2025.

This study compared standard Shi Zao Tang with a version using vinegar-processed Gan Sui and Da Ji in rats with malignant ascites. The vinegar-processed version showed reduced intestinal toxicity while preserving water-expelling efficacy. Mechanistic findings suggested the formula promoted water excretion via the cAMP-PKA-CREB-AQP3 pathway and reduced vascular permeability via VEGFA-VEGFR2 signaling through gut microbiota modulation.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.