Kong Xian Dan

Control Mucus Special Pill · 控涎丹

Also known as: Zi Long Wan (子龙丸), Miao Ying Wan (妙应丸)

A powerful classical formula containing just three herbs, used to forcefully expel deeply lodged phlegm-fluid from the body. It is indicated for stubborn conditions caused by thick phlegm and fluid accumulation in the chest, under the diaphragm, or lodged in joints and tissues, causing wandering pain, heaviness, numbness, or lumps. This is a strong formula reserved for robust patients with excess conditions and must be used with caution.

Origin San Yin Ji Yi Bing Zheng Fang Lun (三因极一病证方论), Volume 13 — Southern Sòng dynasty, 1174 CE
Composition 3 herbs
Gan Sui
King
Gan Sui
Da Ji
King
Da Ji
Bai Jie Zi
Deputy
Bai Jie Zi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Kong Xian Dan is designed to correct these specific patterns.

Why Kong Xian Dan addresses this pattern

When phlegm-fluid (痰饮) accumulates and lodges in the chest and diaphragm area (胸膈), it blocks the normal flow of Qi and fluids, producing a wide range of seemingly unrelated symptoms. The phlegm may flow along the channels to cause wandering pain in the joints and limbs, settle in the tissue membranes to cause lumps and numbness, or obstruct the chest to cause fullness and cough with copious sticky sputum. Kong Xian Dan addresses this pattern by using Gan Sui and Da Ji to forcefully purge the deeply lodged fluid from the channels and organ cavities, while Bai Jie Zi disperses phlegm from the membrane spaces. The formula's strength lies in its ability to reach phlegm that has settled in locations inaccessible to gentler formulas.

A practitioner would look for one or more of these signs

Chest Pain

Sudden pain in chest and ribs with a sense of fullness

Moving Pain

Wandering pain in neck, back, limbs, and joints that shifts location

Skin Numbness

Cold numbness in hands and feet, heaviness in limbs

Excessive Salivation

Drooling during sleep, copious thick sticky sputum

Eye Fatigue

Mental dullness, drowsiness, excessive sleepiness

Loss Of Appetite

Poor appetite, food tastes bland

Headaches

Severe headache that feels too heavy to lift the head

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Kong Xian Dan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Phlegm

TCM Interpretation

In TCM, pleural effusion is understood as water-fluid (水饮) that has accumulated in the chest and rib region due to failure of the body's fluid metabolism. The Lung, Spleen, and Kidney all play roles in moving and transforming fluids. When these organs are overwhelmed or when pathogenic factors cause fluid to stagnate, water collects in the chest cavity, producing fullness, pain in the ribs, cough, and difficulty breathing. This is classified as a type of suspended fluid retention (悬饮). The condition is considered an excess pattern when the patient's overall constitution remains relatively strong despite the fluid accumulation.

Why Kong Xian Dan Helps

Kong Xian Dan directly addresses the accumulated fluid in the chest. Gan Sui is historically considered the strongest herb for penetrating deep channel pathways where fluid binds, while Da Ji drains fluid from the organ cavities. Together, they powerfully purge the retained fluid downward through the bowels. Modern clinical studies have shown this formula to be effective for tuberculous pleural effusion and post-surgical thoracic fluid, with one study reporting a total effective rate of 96.7% when added to standard therapy. Bai Jie Zi contributes by helping absorb residual fluid in the tissue membranes surrounding the lungs. The pill form allows for controlled, small-dose administration that is safer than a full decoction of these potent herbs.

Also commonly used for

Ascites

Abdominal fluid accumulation from various causes

Chronic Bronchitis

With copious phlegm and wheezing in robust patients

Edema

Generalized edema with excess constitution

Lipoma

Subcutaneous fatty lumps attributed to phlegm stagnation

Hyperlipidemia

Elevated blood lipids viewed as turbid phlegm in the blood

Asthma

Phlegm-excess type asthma in robust patients

Epilepsy

Phlegm misting the Heart orifices causing seizures

What This Formula Does

Every TCM formula has a specific set of actions — here's what Kong Xian Dan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Kong Xian Dan is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Kong Xian Dan works at the root level.

Kong Xian Dan addresses a condition where thick, stubborn Phlegm-fluid (痰饮) has accumulated deep within the body and become lodged in areas that ordinary Phlegm-resolving formulas cannot reach. In TCM theory, when the Spleen's function of transporting and transforming fluids is impaired, or when the Lungs and Kidneys fail to properly regulate water metabolism, fluid can accumulate and thicken over time into pathological Phlegm. This Phlegm is not the simple mucus one might cough up. It is an invisible, deeply embedded pathological substance that can lodge anywhere: between the membranes and tissues (皮里膜外), in the channels and collaterals, in the joints and bones, or around the organs.

Because this Phlegm-fluid follows Qi circulation, it can move and settle unpredictably throughout the body. When it lodges in the chest and flanks, it causes pain beneath the ribs. When it enters the channels and joints, it produces wandering pain that shifts location, with pulling sensations in the sinews and bones. When it obstructs the head, it causes severe headaches and mental fogginess with excessive drowsiness. When it blocks circulation to the limbs, it causes cold numbness. The tongue coating is typically sticky and greasy, and the pulse is wiry or slippery, both signs of deeply entrenched Phlegm obstruction. This is a condition of excess in a patient whose constitution is still relatively strong, but where gentler Phlegm-resolving methods have proven insufficient.

The formula works by forcefully driving this deeply lodged Phlegm-fluid out through the intestines and urinary tract. It is a drastic approach reserved for when the pathology is severe and deeply rooted, and the patient's overall strength can withstand the powerful purgation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and acrid (pungent). The bitter taste drives downward to purge accumulated fluid, while the acrid taste disperses and moves, helping dislodge Phlegm from deep tissue layers.

Channels Entered

Lung Spleen Kidney

Ingredients

3 herbs

The herbs that make up Kong Xian Dan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Kings — Main ingredient driving the formula
Gan Sui

Gan Sui

Kansui roots

Dosage Equal part (0.5 - 1.5g in pill form per dose)
Temperature Cold
Taste Bitter
Organ Affinity Spleen, Kidneys, Large Intestine, Lungs
Preparation Remove the heart (去心); vinegar-processed (醋制) to reduce toxicity

Role in Kong Xian Dan

Gan Sui is bitter and cold, entering the Lung, Kidney, and Large Intestine channels. It is the most penetrating of the three herbs, powerfully driving out water and fluid accumulation from the deep channels and passageways (经隧) of the body. It breaks through hard phlegm-fluid masses and accumulated stagnation, directing them downward and out through the bowels. As the classical teaching states, Gan Sui reaches into the hidden recesses where water and phlegm bind together.
Da Ji

Da Ji

Japanese thistle

Dosage Equal part (0.5 - 1.5g in pill form per dose)
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Heart, Liver
Preparation Remove the bark (去皮); use the purple variety (紫大戟) preferably

Role in Kong Xian Dan

Da Ji is bitter, acrid, and cold, entering the Lung, Spleen, Liver, and Kidney channels. It forcefully expels water and fluid from the organ systems (脏腑) and body cavities. Working alongside Gan Sui, Da Ji targets water retention at a broader level, draining fluid from the abdominal membranes and visceral spaces. Together, the two King herbs form a powerful pair that scours the body's deep recesses of pathological fluid while also entering the Blood level to help resolve masses and stasis.
Deputy — Assists and enhances the King
Bai Jie Zi

Bai Jie Zi

White mustard seeds

Dosage Equal part (0.5 - 1.5g in pill form per dose)
Temperature Warm
Taste Bitter
Organ Affinity Stomach, Lungs

Role in Kong Xian Dan

Bai Jie Zi is acrid and warm, entering the Lung channel. Its unique role in this formula is to reach phlegm lodged between the skin and membranes (皮里膜外), a location that other phlegm-resolving herbs cannot penetrate effectively. While the two King herbs drive out fluid from the deep channels and organ cavities, Bai Jie Zi disperses phlegm stuck in the superficial tissue layers, joints, and interstices of the body. Its warm, acrid nature also helps move Qi and open the network vessels, allowing the cold, bitter draining herbs to work more broadly.

Why This Combination Works

How the herbs in Kong Xian Dan complement each other

Overall strategy

This formula addresses a condition where thick, turbid phlegm-fluid (痰涎) has become deeply lodged throughout the body's channels, organs, joints, and tissue membranes. Because the pathological fluid is both widespread and deeply entrenched, gentle phlegm-transforming methods are insufficient. The formula employs three potent substances that together can reach every level of the body where fluid may hide, forcefully expelling it downward and outward.

King herbs

Gan Sui and Da Ji serve as co-King herbs, forming the formula's drastic expelling power. Gan Sui specializes in penetrating the deep channel pathways (经隧) where water and phlegm bind in hidden recesses, breaking through hard accumulations and driving them out through the bowels. Da Ji focuses on draining water from the organ cavities (脏腑) and abdominal spaces. Together, they address fluid retention at both the channel-network level and the visceral-cavity level. Their combined bitter, cold, and downward-driving nature creates the formula's core purgative action.

Deputy herbs

Bai Jie Zi complements the two King herbs by targeting a location they cannot easily reach: the space between skin and membranes (皮里膜外). This is where phlegm often lodges to cause wandering joint pain, subcutaneous lumps, numbness, and tissue swelling. As Zhu Danxi stated, phlegm beneath the ribs and between membranes can only be reached by Bai Jie Zi. Its acrid warmth also helps move Qi and open the network vessels, counterbalancing the purely cold, purgative nature of the King herbs and enabling the formula to address phlegm in the superficial body layers as well as the deep interior.

Notable synergies

The classical commentator Wang Jinsan explained the three herbs' complementary targeting: Bai Jie Zi (white, entering the Lung) reaches the upper burner, Gan Sui (yellow, entering the Spleen) works in the middle burner, and Da Ji (dark, entering the Kidney) descends to the lower burner. Together, they draw water from all three burners and expel it via the waterways. The pairing of Gan Sui with Da Ji is especially potent: Gan Sui's strength in clearing channel-pathway fluid is amplified by Da Ji's power over organ-cavity fluid, and vice versa. Adding Bai Jie Zi extends their reach to the superficial tissue planes, making this three-herb combination more versatile than either the two cold purgatives alone or Bai Jie Zi by itself.

How to Prepare

Traditional preparation instructions for Kong Xian Dan

Grind all three herbs in equal parts into a fine powder. Mix with flour paste (面糊) to form small pills about the size of a wutong seed (approximately 3-4mm in diameter). Dry the pills in the sun.

Take 5 to 10 pills (approximately 1.5 to 4.5g total) at bedtime or in the early morning on an empty stomach, swallowed with warm, mild ginger decoction (淡姜汤) or plain warm water. For patients with strong constitutions and vigorous phlegm, the pill count may be gradually increased. After the formula takes effect and produces watery stools, the patient should eat a small bowl of thin rice porridge to protect the Stomach and Spleen. Dosage may be given daily or every other day depending on the patient's response. Start with a small dose and increase gradually.

Important caution: Gan Sui and Da Ji are toxic and must not be combined with Gan Cao (licorice) in any concurrent prescription, as these are classically incompatible (十八反). This formula is strictly contraindicated in pregnancy, in those with constitutional weakness, and in patients with loose stools.

Common Modifications

How practitioners adapt Kong Xian Dan for specific situations

Added
Zhu Sha

0.3 - 0.5g, settles the spirit and clears phlegm from the Heart orifices

When phlegm mists the Heart orifices causing confusion, mania, or epileptic episodes, adding Zhu Sha (cinnabar) directs the formula's phlegm-clearing action toward the Heart while calming the spirit.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Kong Xian Dan should not be used or requires extra caution

Avoid

Pregnancy. Gan Sui and Da Ji are classified as toxic and have strong cathartic actions that can stimulate uterine contractions and potentially cause miscarriage. Classical texts explicitly note Da Ji can 'bring down the fetus' (堕胎).

Avoid

Patients with constitutional weakness, Qi deficiency, or depleted body fluids. This is a powerful purgative formula designed only for conditions of excess (实证). Using it in deficient patients can cause dangerous fluid and electrolyte depletion.

Avoid

Patients currently taking medications containing Gan Cao (Licorice). Gan Sui and Da Ji are classically listed as incompatible with Gan Cao (十八反, the Eighteen Incompatibles). Concurrent use may cause toxic reactions.

Caution

Elderly or frail patients. The formula's drastic purgative nature may cause severe diarrhea, dehydration, and electrolyte imbalance in those without robust constitution.

Caution

Patients with chronic kidney disease or compromised renal function. The strong cathartic and diuretic effects may worsen kidney burden and electrolyte disturbances.

Caution

Should not be used for prolonged periods. Even in robust patients, this formula is intended for short-term use to break through stubborn pathology, then discontinued or replaced with gentler formulas.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Absolutely contraindicated in pregnancy. Gan Sui (Kansui Root) and Da Ji (Euphorbia/Knoxia Root) are both classified as toxic cathartics. Classical texts specifically note that Da Ji can 'bring down the fetus' (下痞堕胎). Both herbs stimulate strong intestinal peristalsis and can provoke uterine contractions, posing serious risk of miscarriage. Bai Jie Zi (White Mustard Seed) is also warming and dispersing, further making this formula entirely unsafe during pregnancy. This formula must never be used in pregnant women under any circumstances.

Breastfeeding

Contraindicated during breastfeeding. Gan Sui and Da Ji are classified as toxic herbs with potent cathartic properties. Their active compounds (including euphorbia diterpenes and other irritant substances) may transfer into breast milk and cause gastrointestinal distress or toxicity in the nursing infant. Bai Jie Zi also contains mustard oil glycosides that are potentially irritating. The strong purgative action of the formula can also cause fluid depletion in the mother, potentially reducing milk supply. Nursing mothers should avoid this formula entirely.

Children

Kong Xian Dan is generally not suitable for children. The formula contains Gan Sui and Da Ji, both classified as toxic herbs with drastic purgative effects. Children's organ systems, particularly the Spleen and Stomach, are considered physiologically immature in TCM and are highly vulnerable to damage from harsh cathartics. The risk of severe diarrhea, dehydration, and electrolyte imbalance is significantly greater in pediatric patients. If a practitioner in exceptional circumstances considers its use in an older child or adolescent with robust constitution, the dosage must be drastically reduced (typically to one-quarter to one-third of the adult dose) and administered under close medical supervision with careful monitoring. This decision should only be made by a highly experienced practitioner.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Kong Xian Dan

Diuretics (loop diuretics, thiazides, potassium-sparing): Kong Xian Dan has potent cathartic and fluid-expelling effects. Concurrent use with pharmaceutical diuretics may cause dangerous fluid loss, dehydration, and electrolyte imbalances (particularly hypokalemia and hyponatremia). This combination should be avoided.

Cardiac glycosides (e.g. digoxin): The severe diarrhea and fluid loss caused by Gan Sui and Da Ji can deplete potassium. Hypokalemia significantly increases the risk of digoxin toxicity, which can cause life-threatening cardiac arrhythmias.

Licorice-containing medications or supplements: Both Gan Sui and Da Ji are listed among the classical Eighteen Incompatibles (十八反) as being antagonistic to Gan Cao (Glycyrrhiza/Licorice). Concurrent use with any licorice-containing products, including pharmaceutical preparations, cough syrups, or supplements, may produce toxic reactions.

Anticoagulants and antiplatelet drugs: Da Ji has been noted in classical texts to have some blood-moving properties (入血分, 消瘀化瘀). While this is not its primary action, caution is warranted if combined with warfarin, heparin, or similar drugs, as there is a theoretical risk of additive effects.

Electrolyte-sensitive medications (lithium, certain antiarrhythmics): The dramatic fluid shifts caused by this formula can alter serum concentrations of drugs with narrow therapeutic windows, particularly lithium. Lithium levels may rise dangerously as the body becomes dehydrated.

Usage Guidance

Practical advice for getting the most out of Kong Xian Dan

Best time to take

Traditionally taken at bedtime (临卧) with warm ginger decoction or warm water. Some modern practitioners prefer early morning on an empty stomach.

Typical duration

Short-term use only: typically 1-3 doses, reassessed after each administration. Rarely exceeds 1-2 weeks of intermittent dosing (every other day). Discontinue once symptoms improve.

Dietary advice

While taking Kong Xian Dan, avoid cold and raw foods, greasy or fried foods, and dairy products, as these can generate more Phlegm and Dampness, directly opposing the formula's purpose. Avoid alcohol, which generates Damp-Heat and stresses the liver. Light, easily digestible foods such as congee (rice porridge), steamed vegetables, and clear soups are recommended to support the Spleen and Stomach during the strong purgative action. Because this formula causes significant fluid loss through catharsis, it is important to maintain adequate hydration with warm fluids (warm water, ginger tea) but avoid excessive fluid intake that could counteract the treatment. After taking the formula, once adequate purgation has occurred, a period of gentle dietary nourishment is advisable to restore the body's fluids and Qi.

Kong Xian Dan originates from San Yin Ji Yi Bing Zheng Fang Lun (三因极一病证方论), Volume 13 Southern Sòng dynasty, 1174 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Kong Xian Dan and its clinical use

Chen Wuze (陈无择), San Yin Ji Yi Bing Zheng Fang Lun (三因极一病证方论):
Original text describes the presentation: 「痰涎伏在胸膈上下,忽然胸背、颈项、腰胯隐痛不可忍,筋骨牵引钓痛,走易不定,或手足冷痹,或头痛不可忍,或神志昏倦多睡,或饮食无味,痰唾稠粘,夜间喉中痰鸣,多流涎唾。」
Translation: "When Phlegm-fluid hides above and below the diaphragm, there is sudden unbearable hidden pain in the chest, back, neck, and hips, with pulling and dragging pain in the sinews and bones that shifts location; or cold numbness of the hands and feet; or unbearable headache; or mental dullness with excessive drowsiness; or loss of appetite; with thick sticky sputum, nighttime gurgling in the throat, and copious drooling."

Li Shizhen (李时珍), quoted in Yi Fang Ji Jie (医方集解):
「痰涎为物,随气升降,无处不到。入心则迷癫痫,入肺则塞窍为喘咳背冷,入肝则膈痛干呕、寒热往来;入经络则麻痹疼痛,入筋骨则牵引钓痛,入皮肉则瘰疬痈肿。陈无择三因方并以控涎丹主之,殊有奇效。此乃治痰之本。」
Translation: "Phlegm-fluid as a substance follows Qi ascending and descending, reaching everywhere. Entering the Heart it causes confusion and epilepsy; entering the Lungs it blocks the orifices causing wheezing, cough, and cold back; entering the Liver it causes diaphragmatic pain, dry retching, and alternating chills and fever; entering the channels it causes numbness and pain; entering the sinews and bones it causes pulling and dragging pain; entering the skin and flesh it causes scrofula and swellings. Chen Wuze in his San Yin Fang treats all these with Kong Xian Dan, with remarkably extraordinary results. This is treating Phlegm at its root."

Wang Jinsan (王晋三) on the formula name:
「控,引也。涎读作羡,湎涎也,水流貌。引三焦之水,湎涎出于水道也。芥子色白入肺而达上焦,甘遂色黄入脾而行中焦,大戟色黑入肾而走下焦。」
Translation: "'Kong' means to draw out. 'Xian' [read as羡] means flowing water. It draws out water from the Three Burners, causing it to flow out through the waterways. Bai Jie Zi (white mustard seed), white in color, enters the Lungs and reaches the Upper Burner; Gan Sui, yellow in color, enters the Spleen and moves through the Middle Burner; Da Ji, black in color, enters the Kidneys and goes to the Lower Burner."

Historical Context

How Kong Xian Dan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Kong Xian Dan was created by the Southern Song dynasty physician Chen Yan (陈言), courtesy name Wuze (无择), and recorded in his landmark work San Yin Ji Yi Bing Zheng Fang Lun (三因极一病证方论, "Treatise on Formulas According to the Three Categories of Pathogenic Causes"), published in 1174 CE. Chen Wuze is famous for systematizing TCM pathology into three categories of causation: external causes (六淫, the Six Excesses), internal causes (七情, the Seven Emotions), and causes that are neither internal nor external. Kong Xian Dan appears in the Phlegm-fluid section of this text.

The formula is recognized as a derivative of Zhang Zhongjing's earlier Shi Zao Tang (Ten Jujube Decoction) from the Han dynasty, which also uses Gan Sui and Da Ji but adds Yuan Hua (Daphne flower) and uses jujube to buffer the toxicity. Kong Xian Dan replaces Yuan Hua with Bai Jie Zi (white mustard seed), which specifically targets Phlegm in the membranes and subcutaneous tissues, giving the formula a broader reach. It also shifts from decoction to pill form, making it easier to dose precisely and somewhat gentler in its action. The formula is also known as Zi Long Wan (子龙丸), a name found in the Wai Ke Quan Sheng Ji (外科全生集).

Throughout subsequent dynasties, many famous physicians championed this formula. Li Shizhen in the Ming dynasty praised it extensively, and Qing dynasty physicians including Zhang Lu (张璐, author of Yi Tong) and Li Zhongzi (李中梓) recorded successful case studies. Wang Jinsan provided an influential analysis of the formula's name and herb-color-organ correspondences. In modern times, the renowned physician Zhu Liangchun widely applied Kong Xian Dan for conditions including lymphadenitis, tuberculous pleurisy, chronic joint inflammation, and ascites.