Qing Hao Bie Jia Tang

Artemisia Annua and Soft-Shelled Turtle Shell Decoction · 青蒿鱉甲湯

Also known as: Sweet Wormwood and Soft-Shelled Turtle Shell Decoction, Artemisiae Annuae and Trionycis Decoction

A classical formula for lingering low-grade fevers that come on at night and ease by morning, especially after a prolonged illness. It works by nourishing the body's depleted fluids (Yin) while gently venting trapped heat outward, addressing the root cause of the fever rather than just suppressing symptoms.

Origin Wen Bing Tiao Bian (温病条辨), Volume 3, Lower Burner Chapter, by Wu Jutong (吴鞠通) — Qīng dynasty, 1798 CE
Composition 5 herbs
Bie Jia
King
Bie Jia
Qing Hao
King
Qing Hao
Shu Di Huang
Deputy
Shu Di Huang
Zhi Mu
Deputy
Zhi Mu
Mu Dan Pi
Assistant
Mu Dan Pi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Hao Bie Jia Tang is designed to correct these specific patterns.

Why Qing Hao Bie Jia Tang addresses this pattern

In the late stages of a warm (febrile) disease, prolonged Heat has consumed the body's Yin fluids. The depleted Yin can no longer keep Yang in check, producing a state of deficiency Heat. However, what makes this formula's pattern distinct from ordinary Yin deficiency Heat is that residual pathogenic Heat remains actively lodged in the Yin level, mixed among the Qi and Blood. This is not simply the body generating Heat due to Yin weakness; it is a combination of true pathogenic Heat hiding in depleted territory. Bie Jia penetrates the Yin level to nourish fluids and dislodge the pathogen, while Qing Hao vents it outward. Sheng Di Huang and Zhi Mu restore damaged Yin, and Mu Dan Pi clears Heat from the Blood. The formula addresses both the root (Yin depletion) and the branch (lurking pathogenic Heat) simultaneously.

A practitioner would look for one or more of these signs

High Fever

Fever that rises in the evening and resolves by early morning

Absence Of Sweating

No sweating as the fever subsides

Weight Loss

Progressive weight loss despite preserved appetite

Red Tongue

Red tongue with little or no coating

Rapid Pulse

Fine and rapid pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Hao Bie Jia Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Yin Deficiency Lurking Pathogen in the Yin Level

TCM Interpretation

Persistent low-grade fever, particularly one that follows a predictable daily rhythm of worsening in the evening and easing by morning, is understood in TCM as Heat arising from the Yin level. After a prolonged illness, the body's cooling, moistening Yin fluids become depleted. Without sufficient Yin to anchor and balance Yang, the body produces a kind of 'smouldering' Heat. In some cases, residual pathogenic factors from the original illness remain trapped deep in the body, further driving this cycle. The Kidney and Liver Yin are most commonly affected, and the Heat may involve the Blood level. The key diagnostic distinction is between pure Yin deficiency Heat (where there is no pathogen, just depletion) and Heat from a lurking pathogen in depleted Yin territory. This formula is designed specifically for the latter scenario, where both depletion and a residual pathogen are present.

Why Qing Hao Bie Jia Tang Helps

Qing Hao Bie Jia Tang addresses the two intertwined causes of this type of low-grade fever. Bie Jia enters the deep Yin level to nourish depleted fluids and search out the hidden pathogen, while Qing Hao's aromatic properties vent the dislodged Heat outward through the body's surface. Sheng Di Huang and Zhi Mu restore the damaged Yin, addressing the root deficiency that allows Heat to persist. Mu Dan Pi clears lurking fire from the Blood level, where chronic Heat tends to concentrate. By simultaneously replenishing fluids, dislodging the pathogen, and providing it an exit route, the formula breaks the self-perpetuating cycle of Yin depletion and Heat generation that sustains the fever.

Also commonly used for

Fever Of Unknown Origin

Fever of unknown origin with Yin deficiency signs

Chronic Pyelonephritis

Chronic pyelonephritis with lingering low-grade fever

Fever

Post-surgical low-grade fever

Night Sweats

Night sweats associated with Yin deficiency Heat

Lupus

Systemic lupus erythematosus with Yin deficiency fever pattern

Cancer

Cancer-related fever after chemotherapy or radiotherapy

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Hao Bie Jia Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Hao Bie Jia Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Hao Bie Jia Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Hao Bie Jia Tang works at the root level.

This formula addresses a specific situation that arises in the late stages of a febrile (warm) disease: the body's cooling, moistening fluids (Yin) have already been damaged by prolonged Heat, and yet residual pathogenic Heat has not been fully cleared. Instead of remaining at the surface, this leftover Heat burrows deep into the Yin level of the body, hiding among the blood and body fluids.

The body's defensive Qi circulates on the outside during the day and retreats inward at night. When Heat is lurking deep in the Yin level, the inward movement of defensive Qi at night fans the hidden Heat, producing fever after dark. Come morning, the defensive Qi moves outward again, leaving the hidden Heat unstimulated, so the fever naturally subsides. But because the Yin fluids are depleted, the body lacks the moisture needed to produce sweat, so the fever resolves without sweating. The tongue is red with little coating (reflecting Yin depletion), and the pulse is thin and rapid (indicating both fluid loss and lingering Heat).

The clinical challenge is a double bind: the body needs Yin nourishment to recover, but purely enriching herbs tend to be heavy and cloying, which could trap the pathogen further. Conversely, cold bitter herbs that clear Heat could further dry out the already depleted Yin. The formula must simultaneously nourish Yin from the inside while venting the hidden Heat outward, a strategy Wu Tang called "entering first, then exiting" (先入后出).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and salty with sweet undertones. Bitter to clear Heat, salty to soften and enter the Yin level, sweet to nourish and moisten depleted fluids.

Target Organs

Channels Entered

Ingredients

5 herbs

The herbs that make up Qing Hao Bie Jia Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Bie Jia

Bie Jia

Chinese soft-shelled turtle shell

Dosage 15g
Temperature Cool
Taste Salty (咸 xián)
Organ Affinity Liver, Kidneys
Preparation Decoct first for 30 minutes (先煎)

Role in Qing Hao Bie Jia Tang

Enters deeply into the Yin level to nourish Yin and clear deficiency Heat from within. As a substance from a living creature, it has the unique ability to penetrate the collaterals and search out deeply lodged pathogenic Heat that ordinary Yin-tonifying herbs cannot reach.
Qing Hao

Qing Hao

Sweet wormwood

Dosage 6g
Temperature Cold
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Kidneys
Preparation Add in the last 5 minutes of decoction or steep in strained hot liquid (后下)

Role in Qing Hao Bie Jia Tang

Aromatic, bitter, and cold, it clears Heat and vents lurking pathogenic factors outward from the Yin level to the exterior. Works in tandem with Bie Jia in a complementary 'enter-then-exit' strategy: Bie Jia guides Qing Hao into the deep Yin level, while Qing Hao leads the pathogen outward through the Shaoyang.
Deputies — Assists and enhances the King
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Qing Hao Bie Jia Tang

Sweet and cold, it nourishes Yin and cools the Blood, reinforcing Bie Jia in clearing deficiency Heat from the collaterals and replenishing damaged fluids.
Zhi Mu

Zhi Mu

Anemarrhena rhizome

Dosage 6g
Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys

Role in Qing Hao Bie Jia Tang

Bitter and cold, it clears Heat and nourishes Yin. Assists the King herbs in clearing residual Heat and generating fluids, helping to break the cycle where Heat consumes Yin and Yin deficiency generates more Heat.
Assistant — Supports or moderates other herbs
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Qing Hao Bie Jia Tang

Cools the Blood and drains lurking fire from the Blood level. Assists Qing Hao in venting Heat outward, providing an 'internal clearing, external venting' effect that addresses Heat lodged in both the Qi and Blood aspects of the Yin level.

Why This Combination Works

How the herbs in Qing Hao Bie Jia Tang complement each other

Overall strategy

The formula addresses a situation where residual pathogenic Heat has burrowed deep into the body's Yin (fluid and nutritive) level after a prolonged warm disease, while the Yin fluids themselves are depleted. The prescription must simultaneously nourish Yin without trapping the pathogen and vent Heat without further damaging fluids. It achieves this through a unique 'enter and exit' (先入后出) strategy that is the hallmark of this formula.

King herbs

Bie Jia and Qing Hao serve as co-Kings with complementary roles. Bie Jia, salty and cold, penetrates directly into the deepest Yin level to nourish Yin and search out lurking pathogens within the collaterals. Qing Hao, aromatic and cold, clears Heat and leads the pathogen outward to the exterior. Wu Jutong described their synergy: Qing Hao cannot reach the deep Yin level on its own, but Bie Jia guides it in; Bie Jia cannot push the pathogen outward on its own, but Qing Hao leads it out.

Deputy herbs

Sheng Di Huang and Zhi Mu reinforce the Yin-nourishing and Heat-clearing actions of the King herbs. Sheng Di Huang is cool and sweet, replenishing damaged Yin fluids and cooling the Blood. Zhi Mu is bitter and moistening, clearing residual Heat while generating fluids, preventing the formula from being too drying.

Assistant herbs

Mu Dan Pi serves as a reinforcing Assistant. It cools the Blood and drains lurking fire (伏火) from the Blood level, complementing Qing Hao's action of venting Heat outward. Together, Mu Dan Pi and Qing Hao create an 'internal clearing, external venting' (内清外透) dynamic.

Notable synergies

The Bie Jia and Qing Hao pairing is the formula's most celebrated synergy, embodying the 'enter then exit' principle. Mu Dan Pi paired with Qing Hao creates another key dynamic: Mu Dan Pi clears lurking fire within the Blood while Qing Hao vents it outward, working two fronts simultaneously. The overall design combines three therapeutic strategies in one prescription: nourishing Yin, clearing Heat, and venting the pathogen, achieving what neither pure tonification nor pure clearing could accomplish alone.

How to Prepare

Traditional preparation instructions for Qing Hao Bie Jia Tang

Use approximately 1000 mL of water. Add Bie Jia (Soft-Shelled Turtle Shell) first and decoct for 30 minutes before adding the remaining herbs. Add Qing Hao (Artemisia Annua) during the last 5 minutes of boiling, or steep it in the strained hot liquid, as its aromatic volatile compounds are destroyed by prolonged heat. Reduce the liquid to approximately 400 mL. Divide into two doses and take warm, twice daily.

Common Modifications

How practitioners adapt Qing Hao Bie Jia Tang for specific situations

Added
Tian Hua Fen

9-12g, clears Heat and generates fluids to relieve thirst

Removed
Shu Di Huang

Removed because its rich, cloying nature is less suited when fluids need to be actively generated rather than simply nourished

When thirst is prominent, it indicates that fluid depletion is more severe in the Stomach and Lung. Tian Hua Fen (Trichosanthes Root) replaces Sheng Di Huang because it more effectively generates fluids and clears Heat from the Stomach, directly addressing the thirst mechanism.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Hao Bie Jia Tang should not be used or requires extra caution

Avoid

External pathogen invasion with fever (excess-type Heat). This formula is designed for deficiency-Heat from Yin depletion, not for acute febrile conditions with a strong pathogen still at the exterior or Qi level.

Avoid

Yang deficiency or Spleen-Stomach cold. The formula's cold-natured, Yin-nourishing herbs can further injure Yang and impair digestion in patients with underlying Yang deficiency or cold in the middle burner.

Avoid

Yin deficiency with impending convulsions or internal wind stirring. Classical sources note that patients with Yin depletion showing signs of imminent spasms or convulsions should not use this formula.

Caution

Patients with poor appetite and significant Spleen deficiency with loose stools. The cold and enriching nature of several herbs (Sheng Di Huang, Zhi Mu, Bie Jia) may further burden a weak digestive system. Use with caution and consider adding Spleen-supporting herbs if necessary.

Caution

Pregnancy. Mu Dan Pi (Moutan bark) promotes Blood circulation, which may pose a risk during pregnancy. Use only under close practitioner supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Mu Dan Pi (Moutan bark) has Blood-invigorating properties that may theoretically stimulate uterine circulation. While the dose used in this formula is moderate, pregnant women should only take this formula under the supervision of a qualified practitioner who can assess whether the clinical benefit outweighs the risk. There is no specific evidence of teratogenicity, but the overall cold and Blood-cooling nature of the formula warrants careful consideration during pregnancy.

Breastfeeding

No specific contraindication during breastfeeding has been established for this formula. The herbs used are generally mild at their standard doses. However, the cold nature of the formula could theoretically affect milk quality or volume in mothers with underlying Spleen deficiency. Sheng Di Huang and Zhi Mu are cooling and could contribute to loose stools in the nursing infant if significant amounts transfer through breast milk. Breastfeeding mothers should use this formula under practitioner guidance, with attention to any changes in the infant's digestion.

Children

This formula has been used in pediatric practice for conditions such as post-pneumonia low-grade fever in children and pediatric summer Heat syndrome. Dosages should be reduced proportionally based on age and body weight, typically to one-third to one-half of the adult dose for children over 6 years old. Bie Jia (turtle shell) should still be decocted first (先煎) and Qing Hao added near the end of cooking. The cold and Yin-enriching herbs may be harder on children's immature digestive systems, so practitioners often add gentle Spleen-supporting herbs (such as Tai Zi Shen or Mai Ya) when using this formula in children. Not generally recommended for infants under 1 year without specialist guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Hao Bie Jia Tang

Anticoagulants and antiplatelet drugs: Mu Dan Pi (Moutan bark) has Blood-invigorating and mild anticoagulant properties. Concurrent use with warfarin, heparin, or antiplatelet medications (aspirin, clopidogrel) may theoretically increase bleeding risk.

Antihypertensive medications: Zhi Mu (Anemarrhena) has been shown in pharmacological studies to have mild blood-pressure-lowering effects. Combined use with antihypertensive drugs could potentially enhance hypotensive effects.

Hypoglycemic agents: Zhi Mu and Sheng Di Huang have both been reported to have mild blood-sugar-lowering activity. Patients on insulin or oral hypoglycemics should monitor blood sugar more closely.

Immunosuppressive drugs: Artemisinin-related compounds in Qing Hao have documented immune-modulating effects. Patients on immunosuppressive therapy should use this formula with caution, as it may interfere with the intended immunosuppressive action.

Usage Guidance

Practical advice for getting the most out of Qing Hao Bie Jia Tang

Best time to take

Twice daily, taken warm, ideally in the late morning and late afternoon/early evening (before the typical onset of nighttime fever).

Typical duration

Typically prescribed for 1 to 3 weeks, reassessed by a practitioner as symptoms evolve. Longer courses may be needed for chronic low-grade fevers.

Dietary advice

While taking this formula, avoid spicy, greasy, and fried foods, which can generate internal Heat and counteract the formula's cooling effects. Alcohol should also be avoided as it produces Heat and consumes Yin. Light, easily digestible foods are preferable. Foods that gently nourish Yin are supportive, such as pear, lotus root, lily bulb, mung bean, tofu, and clear soups. Cold and raw foods should be eaten in moderation to avoid burdening the Spleen, especially in patients who already have weak digestion.

Qing Hao Bie Jia Tang originates from Wen Bing Tiao Bian (温病条辨), Volume 3, Lower Burner Chapter, by Wu Jutong (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Hao Bie Jia Tang and its clinical use

Wu Tang (吴瑭), Wen Bing Tiao Bian (《温病条辨》), Lower Burner Chapter:

「夜热早凉,热退无汗,热自阴来者,青蒿鳖甲汤主之。」

"When there is nighttime fever and morning coolness, the fever recedes without sweating, and the Heat comes from the Yin level, Qing Hao Bie Jia Tang governs it."

Wu Tang's own commentary on the formula's design:

「此方有先入后出之妙,青蒿不能直入阴分,有鳖甲领之入也;鳖甲不能独出阳分,有青蒿领之出也。」

"This formula has the elegance of 'first entering, then exiting.' Qing Hao cannot directly enter the Yin level; it needs Bie Jia to lead it in. Bie Jia cannot exit the Yang level on its own; it needs Qing Hao to lead it out."

Wu Tang's detailed explanation of the formula's pathomechanism (Wen Bing Tiao Bian):

「邪气深伏阴分,混处于气血之中,不能纯用养阴,又非壮火,更不得任用苦燥。故以鳖甲蠕动之物,入肝经至阴之分,既能养阴,又能入络搜邪;以青蒿芳香透络,从少阳领邪外出。」

"The pathogenic Qi lurks deeply in the Yin level, intermingled with Qi and Blood. One cannot use purely Yin-nourishing [herbs], nor is this a blazing fire condition, nor should one resort to bitter drying [methods]. Therefore, Bie Jia, a creature of creeping movement, enters the deepest Yin aspect of the Liver channel, being able both to nourish Yin and to search the collaterals for pathogens; Qing Hao, with its aromatic quality, penetrates the collaterals and leads the pathogen out through the Shaoyang."

Historical Context

How Qing Hao Bie Jia Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Hao Bie Jia Tang was created by the Qing dynasty physician Wu Tang (吴瑭, courtesy name Jutong 鞠通, 1758-1836) and recorded in his landmark work Wen Bing Tiao Bian (Systematic Differentiation of Warm Diseases), first published in 1813. The formula appears in the Lower Burner (下焦) chapter, addressing the final stages of warm disease when the pathogen has penetrated to the deepest level of the body.

Wu Tang explicitly described this formula as an adaptation of the Xiao Chai Hu Tang (Minor Bupleurum Decoction) method from Zhang Zhongjing's Shang Han Lun, re-engineered for warm disease. He explained that since Xiao Chai Hu Tang was designed for cold-damage conditions that injure Yang, its Yang-protecting herbs (Ren Shen, Gan Cao, Sheng Jiang) were replaced with Yin-nourishing ones, because warm disease injures Yin rather than Yang. He credited the theoretical approach to Ye Tianshi (叶天士), the great Qing dynasty physician whose case records Wu Tang systematized throughout the Wen Bing Tiao Bian. Wu Tang's famous line about the formula captures its genius: Qing Hao cannot enter the Yin level alone but Bie Jia guides it in, while Bie Jia cannot exit the Yang level alone but Qing Hao leads it out.

Modern clinicians have expanded its use well beyond the original warm-disease context. It has become a widely used formula for unexplained low-grade fevers, post-infectious recovery fevers, tuberculosis-related fevers, postoperative fevers, and cancer-related fevers, wherever the underlying pattern matches Yin deficiency with lurking Heat.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Qing Hao Bie Jia Tang

1

Literature review and case report on Qing-Hao-Bie-Jia Decoction for lung cancer-related fever (2026)

Chu XG, Zhang WH, Luo B, Yang F, Lv WM, Zhou SY, Han ZX. Frontiers in Medicine. 2026;13:1717877.

This study combined a systematic review of published case reports with a clinical case to examine the use of modified Qing Hao Bie Jia Tang for managing fever in lung cancer patients. The review traced the formula's classical origins and found consistent reports of successful defervescence in cancer patients with Yin-deficiency Heat patterns. The evidence level remains low (case reports only) and the authors call for prospective controlled trials.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.