Dang Gui Liu Huang Tang

Tangkuei and Six Yellows Decoction · 當歸六黃湯

Also known as: Dang Gui Six Huang Decoction, Angelica and Six Yellows Decoction

A classical formula for night sweats caused by internal heat from Yin deficiency. It works by nourishing the body's cooling, moistening fluids (Yin) while clearing excess internal fire from all three body regions, and strengthening the body's surface defenses to stop the sweating. Li Dongyuan called it the "sage remedy for night sweats."

Origin Lan Shi Mi Cang (《兰室秘藏》Secrets from the Orchid Chamber) by Li Dongyuan — Jīn dynasty, c. 1249 CE (published posthumously 1276 CE)
Composition 7 herbs
Dang Gui
King
Dang Gui
Shu Di Huang
King
Shu Di Huang
Shu Di Huang
King
Shu Di Huang
Huang Lian
Deputy
Huang Lian
Huang Qin
Deputy
Huang Qin
Huang Qi
Deputy
Huang Qi
Huang Qi
Assistant
Huang Qi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui Liu Huang Tang is designed to correct these specific patterns.

Why Dang Gui Liu Huang Tang addresses this pattern

When Yin is depleted, the body loses its cooling, moistening capacity, and internal Fire rises unchecked. This Fire steams the remaining fluids outward, particularly during sleep when the body's defensive Qi retreats inward. The three King herbs (Dang Gui, Sheng Di Huang, Shu Di Huang) directly replenish the depleted Yin and Blood, rebuilding the body's cooling reservoir. The three fire-draining Deputies (Huang Lian, Huang Qin, Huang Bai) clear the pathological Heat across all three Burners, stopping the force that drives fluids outward. Huang Qi secures the exterior and prevents further fluid loss. This comprehensive approach addresses both the root cause (Yin deficiency) and the manifestation (Fire and sweating).

A practitioner would look for one or more of these signs

Night Sweats

Drenching sweats during sleep that stop upon waking

Low Grade Fever

Persistent low-grade fever or sensation of heat, especially in the afternoon and evening

Facial Flushing

Red face and flushed cheeks

Irritability

Restlessness and irritability with sensation of heat in the chest

Dry Mouth

Dry mouth and parched lips

Constipation

Dry, hard stools from fluid depletion

Dark Urine

Scanty, dark yellow urine

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Dang Gui Liu Huang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, night sweats are understood through the rhythm of Yin and Yang over the course of a day. During sleep, the body's defensive Qi (which patrols the surface during waking hours) retreats inward to circulate through the Yin organs. In a healthy person, this transition is smooth. But when Yin is depleted, the inward-moving defensive Qi encounters a body interior where Fire is unrestrained. This Fire overwhelms the weakened Yin, forcing fluids outward through the skin as sweat. Upon waking, the defensive Qi returns to the surface and provides enough containment to stop the sweating. The Kidney and Heart are the primary organs involved: the Kidney governs Yin fluids, and when Kidney Yin is insufficient, Heart Fire flares upward unchecked.

Why Dang Gui Liu Huang Tang Helps

Dang Gui Liu Huang Tang attacks night sweats from three directions simultaneously. First, the three King herbs (Dang Gui, Sheng Di Huang, Shu Di Huang) replenish the depleted Yin and Blood, restoring the body's cooling reservoir so that Water can once again restrain Fire. Second, the three bitter-cold Deputies (Huang Lian, Huang Qin, Huang Bai) directly drain the excess Fire from all three Burners, removing the driving force behind the sweating. Third, the doubled dose of Huang Qi strengthens the body's surface defenses, directly closing the pores and preventing fluid loss. Li Dongyuan called this formula the "sage remedy for night sweats" precisely because it addresses every link in the chain: Yin depletion, Fire flaring, and surface weakness.

Also commonly used for

Tuberculosis

Low-grade fever, night sweats, and wasting from chronic Yin-consuming disease

Diabetes

When presenting with thirst, dry mouth, and heat signs from Yin deficiency

Insomnia

Sleep disturbance from Yin deficiency with Fire disturbing the Heart spirit

Severe Heart Palpitations

Viral myocarditis or palpitations presenting with Yin deficiency and Fire pattern

Purpura

When associated with Yin deficiency and blood-Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Dang Gui Liu Huang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Dang Gui Liu Huang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Dang Gui Liu Huang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Dang Gui Liu Huang Tang works at the root level.

This formula addresses a pattern where the body's cooling, moistening Yin substance has become depleted, allowing internal Fire to blaze unchecked. In TCM theory, Yin and Yang exist in dynamic balance. When Kidney Yin becomes insufficient, it can no longer restrain Heart Fire. This uncontrolled Fire is sometimes called "deficiency Fire" (虚火), though the Heat symptoms it produces can be quite intense.

During sleep, the body's protective Qi (which circulates at the surface during the day) moves inward to circulate through the Yin organs. In a person with Yin deficiency, this inward movement of Yang Qi into an already Yin-depleted interior tips the balance further, causing Fire to flare. The Fire forces fluids outward through the skin as sweat, producing the characteristic night sweats (盗汗). Upon waking, the protective Qi returns to the surface and Yin settles, so the sweating stops. The same internal Fire causes a flushed face, dry mouth and lips, irritability, constipation, dark scanty urine, and a red tongue with a rapid pulse.

Because the sweating itself further damages both the Yin fluids and the protective Qi at the body's surface, a vicious cycle develops: Fire drives out fluids as sweat, fluid loss deepens the Yin deficiency, which worsens the Fire, which causes more sweating. The formula breaks this cycle by simultaneously replenishing the depleted Yin, draining the excess Fire from all three Burners (upper, middle, and lower body), and shoring up the weakened surface defense to prevent further fluid loss.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and sweet — the bitter taste from the three Huang herbs clears Heat and dries, while the sweet taste from Huang Qi, Dang Gui, and the two Rehmannias tonifies and nourishes.

Channels Entered

Heart Liver Kidney Lung

Ingredients

7 herbs

The herbs that make up Dang Gui Liu Huang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Dang Gui Liu Huang Tang

Nourishes and activates Blood, enriches the body's fluids. When Blood is abundant, it can restrain hyperactive Fire. Also moistens the intestines to address the dry stools that accompany this pattern.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Dang Gui Liu Huang Tang

Enters the Liver and Kidney channels to nourish Yin and clear deficiency-Heat. Its cool nature directly addresses the internal fire that drives the night sweats, while replenishing the depleted Yin fluids.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Dang Gui Liu Huang Tang

Enriches Kidney Yin and nourishes Blood and Essence. Together with Sheng Di Huang and Dang Gui, it restores the Yin-Blood foundation so that Water can control Fire.
Deputies — Assists and enhances the King
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Dang Gui Liu Huang Tang

Drains Fire from the Heart and Middle Burner. Its bitter, cold nature directly clears the heat that disturbs the spirit, causing restlessness and driving fluids outward as sweat.
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Dang Gui Liu Huang Tang

Clears Heat from the Upper Burner (Lung and chest). Works alongside Huang Lian and Huang Bai to drain fire comprehensively from all three Burners, eliminating the source of damage to Yin.
Huang Qi

Huang Qi

Astragalus root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Dang Gui Liu Huang Tang

Drains Fire from the Lower Burner and strengthens Kidney Yin by its action of clearing deficiency-fire. Completes the three-Burner fire-clearing strategy alongside Huang Qin and Huang Lian.
Assistant — Supports or moderates other herbs
Huang Qi

Huang Qi

Astragalus root

Dosage 12 - 18g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Dang Gui Liu Huang Tang

Used at double the dose of other herbs. Tonifies Qi and secures the body's exterior to stop sweating directly. Excessive sweating depletes not only Yin but also the body's defensive Qi, so Huang Qi shores up the weakened surface defenses. Combined with Dang Gui and Shu Di Huang, it also supports the generation of Qi and Blood.

Why This Combination Works

How the herbs in Dang Gui Liu Huang Tang complement each other

Overall strategy

This formula addresses a condition where depleted Yin allows internal Fire to flare unchecked, steaming fluids outward as night sweats. The strategy is threefold: replenish Yin and Blood at the root, directly drain the pathological Fire, and shore up the body's weakened surface defenses to stop the sweating.

King herbs

Dang Gui, Sheng Di Huang, and Shu Di Huang together nourish Blood and enrich Yin. Dang Gui replenishes Blood so that fluid loss from sweating is compensated. Sheng Di Huang, being cool in nature, both nourishes Yin and clears deficiency-Heat. Shu Di Huang, the prepared form, is warm and tonifying, deeply replenishing Kidney Yin and Essence. Together they restore the Water that has become insufficient to control Fire.

Deputy herbs

Huang Lian, Huang Qin, and Huang Bai form the "three yellows" that drain Fire comprehensively across all three Burners. Huang Qin clears Heat from the Upper Burner (chest and Lungs), Huang Lian drains Fire from the Heart and Middle Burner, and Huang Bai clears Fire from the Lower Burner (Kidneys). By eliminating Fire at every level, they remove the force that was steaming Yin fluids outward as sweat and causing restlessness, flushing, and irritability.

Assistant herbs

Huang Qi is used at double the dose of every other herb in the formula. This is a reinforcing assistant with a specific additional role: because prolonged sweating damages not only Yin but also the body's defensive Qi, the surface becomes loose and porous. Huang Qi tonifies Qi and firms up the exterior, directly stopping the sweating. It also protects the Spleen and Stomach from the cold, bitter nature of the three fire-draining deputies, and when combined with Dang Gui and Shu Di Huang, supports the generation of new Qi and Blood.

Notable synergies

The pairing of Dang Gui with Huang Qi echoes the famous Dang Gui Bu Xue Tang, simultaneously tonifying Qi and nourishing Blood. The combination of Sheng Di Huang (cool, Yin-nourishing) with Shu Di Huang (warm, Essence-enriching) creates a balanced approach to Yin replenishment that neither over-cools nor stagnates. The three bitter-cold fire-draining herbs balanced against the sweet-warm Huang Qi exemplifies the principle of combining clearing and supplementing in a single formula.

How to Prepare

Traditional preparation instructions for Dang Gui Liu Huang Tang

The original text instructs to grind the herbs into a coarse powder (粗末). Take 15g of the powder per dose, add two cups of water (approximately 400 mL), and decoct down to one cup (approximately 200 mL). Strain and take before meals. For children, halve the dose.

In modern practice, the whole herbs are typically decocted together directly: combine all herbs with approximately 600 mL of water, bring to a boil over high heat, then simmer on low heat for 20 to 30 minutes. Strain and divide into two doses per day, taken warm before meals.

Common Modifications

How practitioners adapt Dang Gui Liu Huang Tang for specific situations

Added
Fu Xiao Mai

15 - 30g, astringes sweating

Shan Zhu Yu

9 - 12g, astringes Yin and restrains fluid loss

Fu Xiao Mai and Shan Zhu Yu are both astringent substances that directly restrain sweating. They reinforce Huang Qi's surface-securing action when sweating is profuse and the base formula alone is insufficient.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Dang Gui Liu Huang Tang should not be used or requires extra caution

Avoid

Spleen and Stomach deficiency with poor appetite and loose stools. The formula contains multiple bitter-cold herbs (Huang Lian, Huang Qin, Huang Bai) and heavy Yin-nourishing herbs (Sheng Di Huang, Shu Di Huang) that can further impair a weak digestive system.

Avoid

Night sweats due to Yang deficiency or Qi deficiency without signs of Heat. This formula is designed for Fire-excess sweating with clear Heat signs (red face, dry mouth, rapid pulse). Using it for cold-type sweating would worsen the condition.

Caution

Exterior pathogen invasion (common cold or flu) with active sweating. The formula's tonifying and Yin-nourishing nature could trap the pathogen inside the body.

Caution

Patients with significant Dampness or Phlegm accumulation. The cloying nature of Dang Gui, Sheng Di Huang, and Shu Di Huang may worsen Dampness.

Caution

Patients taking anticoagulant or antiplatelet medications, due to Dang Gui's blood-activating properties.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Dang Gui (Angelica sinensis) has mild blood-activating properties that could theoretically stimulate uterine contractions. Huang Bai (Phellodendron bark) and Huang Lian (Coptis) are strongly bitter and cold, which may be harsh during pregnancy. While none of the herbs are classified as strictly forbidden in pregnancy, the overall cold nature of the formula and the presence of blood-moving Dang Gui warrant caution. Should only be used during pregnancy under the direct supervision of a qualified practitioner when the clinical benefit clearly outweighs the risk.

Breastfeeding

Use with caution during breastfeeding. The formula's bitter-cold herbs (Huang Lian, Huang Qin, Huang Bai) may transfer through breast milk, and some infants may be sensitive to these compounds, potentially causing digestive upset or loose stools. Dang Gui and Huang Qi components are generally considered compatible with breastfeeding and are even commonly used postpartum. However, the strongly cold overall nature of this formula could theoretically reduce milk supply in some women by impairing Spleen and Stomach function. Should only be used during breastfeeding under practitioner supervision, and the infant should be monitored for any changes in feeding, digestion, or behavior.

Children

The original classical text explicitly states that children should take half the adult dose (小儿减半服之). In modern practice, dosage should be adjusted according to the child's age and weight. For children under 6, doses are typically reduced to one-quarter to one-third of the adult amount. For children 6 to 12, one-third to one-half doses are common. The bitter taste of the three Huang herbs (Huang Lian, Huang Qin, Huang Bai) may be difficult for children to tolerate, and honey or jujube may be added to improve palatability. The formula's cold nature requires careful monitoring in children, whose digestive systems are more delicate. Discontinue or reduce dose if loose stools or poor appetite develop. This formula should only be used in children with clear signs of Yin deficiency with Heat, and under professional guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Dang Gui Liu Huang Tang

Anticoagulant and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel): Dang Gui (Angelica sinensis) contains compounds that may inhibit platelet aggregation and enhance the effects of blood-thinning medications, increasing bleeding risk.

Antidiabetic medications (metformin, insulin, sulfonylureas): Several herbs in this formula, including Huang Qi (Astragalus) and Sheng Di Huang (Rehmannia), have been shown to have hypoglycemic effects. Concurrent use may potentiate blood sugar lowering, requiring closer monitoring of glucose levels.

Antihypertensive medications: Huang Qi may affect blood pressure regulation. Patients on antihypertensive drugs should be monitored for changes in blood pressure when taking this formula.

Immunosuppressant drugs (cyclosporine, methotrexate): The formula has demonstrated immunomodulatory effects, including suppression of T lymphocyte proliferation and dendritic cell function. Concurrent use with immunosuppressants may have unpredictable additive effects and should be closely monitored.

Iron supplements: The tannins in Huang Qin and Huang Lian may bind with iron and reduce its absorption. If iron supplementation is needed, it should be taken at least two hours apart from this formula.

Usage Guidance

Practical advice for getting the most out of Dang Gui Liu Huang Tang

Best time to take

On an empty stomach (空腹), traditionally before meals, as specified in the original text. Commonly taken twice daily, morning and evening.

Typical duration

Typically prescribed for 1 to 4 weeks, reassessed by a practitioner as sweating resolves and Heat signs diminish.

Dietary advice

Avoid spicy, fried, greasy, and heavily seasoned foods, which can generate Heat and counteract the formula's cooling effects. Alcohol should also be avoided as it generates Damp-Heat and damages Yin. Favor cooling, Yin-nourishing foods such as pears, lotus root, lily bulb, mung beans, cucumber, and white fungus (tremella). Light, easily digestible meals are recommended to protect the Spleen and Stomach from the formula's bitter-cold herbs. Avoid excessive consumption of cold or raw foods if there are any signs of digestive weakness, as the formula already contains substantial cold-natured herbs.

Dang Gui Liu Huang Tang originates from Lan Shi Mi Cang (《兰室秘藏》Secrets from the Orchid Chamber) by Li Dongyuan Jīn dynasty, c. 1249 CE (published posthumously 1276 CE)

Classical Texts

Key passages from the classical Chinese medical texts that first described Dang Gui Liu Huang Tang and its clinical use

Li Dongyuan (李东垣), Lan Shi Mi Cang (《兰室秘藏·自汗门》):

「当归六黄汤,治盗汗之圣药也。」
"Dang Gui Liu Huang Tang is the sage formula for treating night sweats."

Wu Qian (吴谦), Yi Zong Jin Jian · Shan Bu Ming Yi Fang Lun (《医宗金鉴·删补名医方论》):

「用当归以养液,二地以滋阴,令阴液得其养也。用黄芩泻上焦火,黄连泻中焦火,黄柏泻下焦火,令三火得其平也。又于诸寒药中加黄芪……盖阳争于阴,汗出营虚,则卫亦随之而虚。故倍加黄芪者,一以完已虚之表,一以固未定之阴。」
"Dang Gui is used to nourish the fluids, the two Rehmannias to enrich the Yin, so that the Yin fluids receive proper nourishment. Huang Qin drains Fire from the Upper Burner, Huang Lian drains Fire from the Middle Burner, Huang Bai drains Fire from the Lower Burner, so that the three Fires are brought to equilibrium. Furthermore, Huang Qi is added among all these cold herbs... When Yang contends with Yin and sweating causes the nutritive aspect to become deficient, the defensive aspect also weakens. Therefore Huang Qi is doubled: partly to restore the already weakened Exterior, and partly to consolidate the still-unsettled Yin."

Zhang Jingyue (张景岳), Jing Yue Quan Shu (《景岳全书》):

「阳证自汗或盗汗者,但察其脉证有火,或夜热烦渴,或便热喜冷之类,皆阳盛阴虚也,宜当归六黄汤为第一。」
"For spontaneous sweating or night sweats of the Yang-excess type, whenever the pulse and signs show Fire, such as night fevers, irritable thirst, or hot bowels with preference for cold, all indicating excess Yang with Yin deficiency, Dang Gui Liu Huang Tang should be the first choice."

Historical Context

How Dang Gui Liu Huang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Dang Gui Liu Huang Tang was created by Li Dongyuan (李东垣, also known as Li Gao 李杲), one of the four great masters of the Jin-Yuan period of Chinese medicine. It appears in his work Lan Shi Mi Cang (《兰室秘藏》, Secrets from the Orchid Chamber), in the chapter on spontaneous sweating (自汗门), where he declared it "the sage formula for treating night sweats" (治盗汗之圣药也). The formula is notable for being a development of Li's earlier and even more famous formula Dang Gui Bu Xue Tang (当归补血汤), which contains only Dang Gui and Huang Qi. To this base, he added Sheng Di Huang and Shu Di Huang for Yin nourishment, plus the "three Yellows" (Huang Qin, Huang Lian, Huang Bai) to drain Fire from all three Burners.

The formula's name, "Dang Gui and Six Yellows Decoction," is a mnemonic: besides Dang Gui, all six remaining herbs contain the character 黄 (huang, meaning "yellow") in their names. This made the formula easy to remember and teach across generations. Later commentators, notably Wu Kun in the Yi Fang Kao and Wu Qian in the Yi Zong Jin Jian, provided influential analyses of the formula's logic, particularly praising the seemingly paradoxical inclusion of warm, Qi-tonifying Huang Qi among so many cold herbs. The Ming dynasty physician Zhang Jingyue endorsed it as "the first choice" for sweating disorders with clear Heat signs. In modern clinical practice, the formula has been extended well beyond night sweats to conditions sharing the same Yin-deficiency-Fire-excess mechanism, including menopausal hot flashes, hyperthyroidism, and certain autoimmune conditions.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Dang Gui Liu Huang Tang

1

Preclinical study: DGLHT ameliorates imiquimod-induced psoriasis-like skin inflammation in mice (2018)

Nguyen LTH, Ahn SH, Nguyen UT, Yang IJ. Phytomedicine, 2018, Volume 47, Pages 48-57.

This preclinical study investigated the anti-inflammatory and immunomodulatory effects of Dang Gui Liu Huang Tang in a mouse model of psoriasis. The formula had previously been shown to inhibit T lymphocyte proliferation and suppress dendritic cell function. In this study, topical application of the formula's ethanolic extract significantly reduced psoriasis-like skin inflammation in mice. The mechanism involved inhibition of IL-22 production and suppression of ERK1/2, JNK, and STAT3 signaling pathways in stimulated skin cells.

2

Systematic review protocol: DLH decoction for managing menopausal symptoms (2018)

Lee HW, Jun JH, Lim HS, Zhang F, Yang F, Lee MS. Medicine, 2018, Volume 97, Issue 6, e9760.

This protocol and subsequent systematic review evaluated randomized controlled trials of Dang Gui Liu Huang Tang (and modified versions) for menopausal symptoms. Five RCTs met inclusion criteria. Using the Kupperman index, the formula showed ameliorative effects on menopausal symptoms potentially equivalent to conventional drug therapies, though the certainty of evidence was rated as very low due to unclear risk of bias in most domains of the included studies.

PubMed
3

Clinical pilot study: Modified DGLHT eases sleep sweats in elderly terminal cancer patients (2016)

Huang YC, Chang HH, Chiu SC, Lai YL, Chen YJ. International Journal of Gerontology, 2016, Volume 10, Issue 2, Pages 96-99.

A clinical study of 41 elderly patients with terminal cancer suffering from sleep sweats used a modified Dang Gui Liu Huang Tang (with added Fu Xiao Mai and Mu Li). Sleep sweating was completely relieved in approximately 70% of patients, with the average time for 50% reduction being 5.3 days. Additionally, 78% of patients experienced improved appetite as a beneficial side effect.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.