Qi Li San

Seven-Thousandths of a Tael Powder · 七厘散

Also known as: Qi Li San (七厘散, Seven-Hundredths Powder)

A famous trauma medicine used to treat injuries from falls, blows, sprains, and fractures, as well as cuts and wounds. It works by resolving blood stasis, reducing swelling, stopping pain, and controlling bleeding. The formula can be taken internally in very small doses (about 2 grams) with rice wine or applied directly to the injured area as a powder.

Origin Liáng Fāng Jí Yè (良方集腋) by Xiè Yuánqìng — Qīng dynasty
Composition 8 herbs
Xue Jie
King
Xue Jie
Ru Xiang
Deputy
Ru Xiang
Mo Yao
Deputy
Mo Yao
Hong Hua
Deputy
Hong Hua
Er Cha
Assistant
Er Cha
Zhu Sha
Assistant
Zhu Sha
She Xiang
Envoy
She Xiang
Bing Pian
Envoy
Bing Pian
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qi Li San is designed to correct these specific patterns.

Why Qi Li San addresses this pattern

When the body suffers a traumatic blow, fall, or cut, the impact damages local blood vessels and disrupts the smooth flow of Qi and Blood through the channels. Blood escapes its vessels and pools in the surrounding tissues, creating stasis that manifests as bruising, swelling, sharp pain (worse with pressure), and restricted movement. If internal, it may cause chest or abdominal pain with a stabbing quality. Qi Li San directly targets this stasis with its core team of Blood-moving herbs (Xue Jie, Hong Hua, Ru Xiang, Mo Yao), while She Xiang and Bing Pian penetrate through blocked channels to ensure the medicine reaches the injured area. Er Cha and Xue Jie simultaneously address any active bleeding, making the formula uniquely suited for traumatic Blood stasis where both stagnation and hemorrhage may coexist.

A practitioner would look for one or more of these signs

Bruising

Purple or dark bruising at the injury site

Swelling

Local swelling and distension at the site of trauma

Pain Worsened By Pressure

Sharp, stabbing, fixed-location pain that worsens with pressure

Bleeding

Bleeding from lacerations or internal hemorrhage following trauma

Restricted Range Of Motion

Difficulty moving the affected limb or area

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qi Li San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, sprains and soft tissue injuries are understood as damage to the sinews (筋 jīn), which are governed by the Liver. When external force tears or overstretches the sinews, it disrupts the local flow of Qi and Blood through the channels, causing Blood to leak from damaged vessels and pool in the surrounding tissues. This creates a pattern of Qi and Blood stagnation characterized by swelling, bruising, sharp pain, and inability to move the affected area. The stagnation blocks nourishment from reaching the damaged sinews, slowing recovery.

Why Qi Li San Helps

Qi Li San's King herb Xue Jie (Dragon's Blood) directly breaks up the pooled stagnant Blood while promoting tissue healing. Ru Xiang and Mo Yao move both Qi and Blood to reduce swelling and restore circulation to the injured sinews, while Hong Hua ensures thorough dispersal of stasis. The Envoy herbs She Xiang and Bing Pian penetrate deep into the affected joint or tissue, driving the formula's action exactly where it is needed. Used externally as a paste mixed with rice wine, the formula can be applied directly to the swollen area for rapid relief.

Also commonly used for

Contusion

Contusions and bruising from trauma

Wound

Lacerations and external bleeding wounds

Skin Burns

Burns and scalds (external application)

Herpes Zoster Infection

Shingles (topical and oral use)

Amenorrhea

Painful menstruation from Blood stasis

Hemorrhoids

Hemorrhoids with stasis and swelling

Tendinitis

Tendon sheath cysts and tendinitis

Ulcer

Pressure sores / bedsores (topical)

Headaches

Migraine headaches from Blood stasis

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qi Li San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qi Li San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qi Li San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qi Li San works at the root level.

Qi Li San addresses the acute consequences of physical trauma on the body's Qi and Blood circulation. When a person suffers a blow, fall, cut, or fracture, the impact damages local tissues and blood vessels. In TCM terms, this disrupts the smooth flow of Qi and Blood through the channels and collaterals in the injured area. Blood that has escaped the vessels but cannot be reabsorbed congeals and stagnates, forming what is called Blood stasis (瘀血). This stagnant Blood blocks the channels, preventing fresh Qi and Blood from reaching the area, which produces the characteristic swelling, bruising, and fixed, stabbing pain of a traumatic injury.

At the same time, if the trauma is severe enough to tear open the skin or deeper vessels, Blood leaks outward as external bleeding. The body thus faces a paradox: Blood is both stuck where it shouldn't be (stasis causing swelling and pain) and escaping where it shouldn't (hemorrhage from the wound). Additionally, the sudden shock and pain of a serious injury can scatter the Heart spirit (Shen), causing fright, restlessness, or mental disturbance.

The formula's strategy directly mirrors this pathology: it must simultaneously break up the local Blood stasis to relieve pain and swelling, stop active bleeding to prevent further Blood loss, open the channels to restore normal circulation, and calm the spirit that has been disturbed by the shock of injury. Because the root problem is an acute, excess-type obstruction rather than an underlying deficiency, the approach is firmly one of moving and dispersing rather than tonifying.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid and bitter with aromatic qualities — acrid to move Qi and Blood through the channels, bitter to dispel stasis and reduce swelling, aromatic to penetrate obstructions and open the collaterals.

Target Organs

Ingredients

8 herbs

The herbs that make up Qi Li San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Xue Jie

Xue Jie

Dragon's blood resin

Dosage 30g (in total powder formula)
Temperature Neutral
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Heart, Liver

Role in Qi Li San

The principal herb, used in the largest dose. It powerfully invigorates Blood, dispels stasis, stops pain, and also has an astringent quality that stops bleeding and promotes tissue healing. It addresses the core pathomechanism of traumatic Blood stasis while simultaneously preventing excessive blood loss.
Deputies — Assists and enhances the King
Ru Xiang

Ru Xiang

Frankincense resin

Dosage 5g (in total powder formula)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Preparation Processed (制) - dry-fried to reduce gastric irritation

Role in Qi Li San

Invigorates Blood, promotes Qi movement, reduces swelling, and alleviates pain. Works alongside Mo Yao and Hong Hua to reinforce the King herb's stasis-resolving action, particularly for pain and swelling.
Mo Yao

Mo Yao

Myrrh resin

Dosage 5g (in total powder formula)
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Spleen
Preparation Processed (制) - dry-fried to reduce gastric irritation

Role in Qi Li San

Dispels Blood stasis, promotes Qi movement, reduces swelling, and stops pain. Pairs classically with Ru Xiang to enhance their combined effect on moving Qi and Blood and relieving pain.
Hong Hua

Hong Hua

Safflower flower

Dosage 5g (in total powder formula)
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver

Role in Qi Li San

A powerful Blood-invigorating herb that breaks up Blood stasis and promotes circulation. Supports the King herb's primary action of resolving traumatic stasis and pain.
Assistants — Supports or moderates other herbs
Er Cha

Er Cha

Catechu

Dosage 7.5g (in total powder formula)
Temperature Cool
Taste Bitter (苦 kǔ), Astringent (涩 sè)
Organ Affinity Heart, Lungs

Role in Qi Li San

Cool and astringent in nature, it clears Heat from the wound site, stops bleeding through astringency, and promotes tissue regeneration and wound healing. Balances the formula's strongly moving herbs with its stabilizing, wound-closing action.
Zhu Sha

Zhu Sha

Cinnabar

Dosage 4g (in total powder formula)
Temperature Cool
Taste Sweet (甘 gān)
Organ Affinity Heart
Preparation Prepared by water-levigation (水飞) to produce ultra-fine powder

Role in Qi Li San

Calms the spirit and settles fright. Traumatic injury often causes shock, panic, and mental agitation, and Zhu Sha addresses these secondary symptoms. It also has mild detoxifying and antiseptic properties.
Envoys — Directs the formula to its target
She Xiang

She Xiang

Musk

Dosage 0.4g (in total powder formula)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Liver, Spleen
Preparation Ground separately into fine powder, then blended in

Role in Qi Li San

Intensely aromatic and penetrating, it opens the channels and collaterals, allowing the other herbs to reach the site of injury. Its powerful ability to move through obstructions enhances the formula's overall stasis-resolving and pain-relieving actions.
Bing Pian

Bing Pian

Borneol

Dosage 0.4g (in total powder formula)
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Spleen, Lungs
Preparation Ground separately into fine powder, then blended in

Role in Qi Li San

Aromatic and penetrating like She Xiang, it clears Heat, relieves pain, and opens the channels to guide the formula's action to the injured area. Together with Musk, it ensures the formula's active substances reach deep into the affected tissues.

Why This Combination Works

How the herbs in Qi Li San complement each other

Overall strategy

Traumatic injury damages the body's vessels and channels, causing Blood to leave its normal pathways and stagnate locally, producing swelling, pain, and bruising. The formula simultaneously breaks up this stagnant Blood, stops active bleeding, opens blocked channels, and calms the spirit that is disturbed by the shock of injury.

King herb

Xue Jie (Dragon's Blood) is the undisputed King, used in the highest dose. It enters the Blood level directly, powerfully dispersing stasis and stopping pain, while its astringent quality also stops bleeding and promotes wound healing. This dual action of both moving stagnant Blood and stopping fresh bleeding is the core therapeutic principle of the entire formula.

Deputy herbs

Ru Xiang (Frankincense) and Mo Yao (Myrrh) form a classic pair that reinforces the King's stasis-resolving action from a complementary angle: they promote the movement of both Qi and Blood, reduce swelling, and generate new tissue. Hong Hua (Safflower) adds further Blood-invigorating power, ensuring that stasis is thoroughly dispersed so that fresh Blood can nourish the injured tissues.

Assistant herbs

Er Cha (Catechu) is a restraining assistant: its cool, astringent nature counterbalances the warm, dispersing character of the other herbs, helping stop bleeding and close wounds without opposing the formula's stasis-resolving direction. Zhu Sha (Cinnabar) is a counteracting assistant: it addresses the secondary symptom of mental agitation and fright that commonly accompanies traumatic injury, calming the spirit through its heavy, settling nature.

Envoy herbs

She Xiang (Musk) and Bing Pian (Borneol) are the Envoys. Both are intensely aromatic substances that penetrate through blocked channels and collaterals, guiding the formula's therapeutic action deep into the injured site. They dramatically enhance the formula's ability to reach stagnation wherever it lodges in the body.

Notable synergies

The pairing of Ru Xiang and Mo Yao is one of the most celebrated in Chinese medicine for trauma: together they move Qi and Blood synergistically, producing stronger pain relief and tissue regeneration than either achieves alone. The combination of She Xiang and Bing Pian creates a powerful channel-opening effect that drives the entire formula into the affected tissues. The balance between strongly dispersing herbs (Xue Jie, Hong Hua, She Xiang) and astringent or settling herbs (Er Cha, Zhu Sha) allows the formula to resolve stasis without causing uncontrolled bleeding.

How to Prepare

Traditional preparation instructions for Qi Li San

All eight herbs are ground separately into very fine powder. Zhu Sha (Cinnabar) is prepared by water-levigation (水飞 shuǐ fēi) to produce an ultra-fine, purified powder. She Xiang (Musk) and Bing Pian (Borneol) are ground separately due to their volatile, aromatic nature. The remaining five herbs (Xue Jie, Ru Xiang, Mo Yao, Hong Hua, Er Cha) are ground together into fine powder. All powders are then carefully blended, sifted, and mixed thoroughly.

Internal use: Take 1 to 1.5 grams per dose, 1 to 3 times daily, mixed with warm yellow rice wine (黄酒 huáng jiǔ) or warm water. The classical single dose is "seven li" (七厘), approximately 2.1 grams. Do not exceed the recommended dose, as the formula contains potent aromatic and Blood-moving substances that can deplete the body's Qi if overused.

External use: Mix an appropriate amount of powder with yellow rice wine or liquor to form a paste, and apply directly to the injured area. Can also be sprinkled as dry powder on bleeding wounds.

Common Modifications

How practitioners adapt Qi Li San for specific situations

Added
San Qi

San Qi (三七), 3-6g powder - powerfully stops bleeding and resolves stasis without leaving residual stasis

Gu Sui Bu

Gu Sui Bu (骨碎补), 9-15g - promotes bone healing and mends sinews

San Qi reinforces the formula's dual action of stopping bleeding while resolving stasis, and Gu Sui Bu specifically targets bone repair, making this combination particularly suited for fracture recovery.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qi Li San should not be used or requires extra caution

Avoid

Pregnancy: this formula is absolutely contraindicated during pregnancy. The formula's strongly moving, aromatic, and Blood-activating herbs (especially She Xiang/musk and Hong Hua/safflower) can stimulate uterine contractions and cause miscarriage. Classical sources explicitly state it 'depletes Qi and causes abortion' (耗气堕胎).

Caution

Active menstruation: the formula's powerful Blood-moving properties may increase menstrual bleeding. Women during their menstrual period should use with caution.

Avoid

Liver or kidney impairment: the formula contains Zhu Sha (cinnabar), which contains mercury sulfide. Patients with existing liver or kidney dysfunction are prohibited from internal use, as mercury accumulates in these organs and may worsen damage.

Avoid

Prolonged or excessive internal use: due to the mercury content in Zhu Sha (cinnabar), this formula must not be taken internally at doses exceeding the recommended amount (about 1 to 1.5 grams per dose) or for extended periods. Regular monitoring of blood and urine mercury levels is advisable if internal use continues beyond a few days.

Avoid

Allergy to any component: individuals with known sensitivity to any ingredient, particularly resinous substances like Ru Xiang (frankincense) or Mo Yao (myrrh), should avoid this formula.

Caution

Bleeding from Qi or Blood deficiency: this formula addresses bleeding caused by traumatic Blood stasis. If bleeding stems from deficiency rather than stasis (for example, Spleen-Qi failing to hold the Blood), this formula's strongly moving nature could worsen the condition.

Caution

Open infected wounds (internal use): when applied externally, the formula should not be used on wounds that are already infected with pus, as the powder may trap infection.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Absolutely contraindicated during pregnancy. Multiple herbs in this formula pose serious risks: - She Xiang (Musk/Moschus): one of the strongest channel-opening and Blood-moving substances in TCM, with a well-documented ability to stimulate uterine contractions and induce miscarriage. This alone makes the formula unsafe. - Hong Hua (Safflower): a powerful Blood-invigorating herb that promotes menstrual flow and is classically contraindicated in pregnancy. - Ru Xiang (Frankincense) and Mo Yao (Myrrh): both strongly move Blood and Qi, with potential to destabilize pregnancy. - Bing Pian (Borneol): an aromatic, penetrating substance that enhances the movement of other herbs through the body. Classical texts explicitly warn that this formula "depletes Qi and causes abortion" (耗气堕胎). The combination of these aromatic, Blood-moving agents creates a synergistic risk far greater than any single herb alone. Even topical application should be approached with caution during pregnancy, as She Xiang and Bing Pian can be absorbed through the skin.

Breastfeeding

Contraindicated during breastfeeding. The primary concern is Zhu Sha (cinnabar), which contains mercury sulfide (HgS). Mercury can be transferred through breast milk to the nursing infant. Even small amounts of mercury exposure pose risks to an infant's developing nervous system, kidneys, and liver. The aromatic, strongly moving herbs (She Xiang/musk and Bing Pian/borneol) may also transfer through breast milk and are not considered safe for infants. External-only use on areas away from the breast may be considered with practitioner guidance if the breastfeeding mother requires treatment for a traumatic injury, but internal use should be strictly avoided.

Children

The standard Qi Li San formula containing Zhu Sha (cinnabar) is generally considered unsuitable for children when taken internally. The Chinese Pharmacopoeia and expert consensus documents for related products (such as Die Da Qi Li Pian) explicitly list children as a prohibited group for internal use. The mercury content of Zhu Sha poses particular risks for developing nervous systems, with animal studies showing dose-dependent memory impairment in juvenile subjects exposed to cinnabar. If topical application is needed for a child's traumatic injury, it should be used sparingly, on intact skin only, and under direct practitioner supervision. Note that "Er Ke Qi Li San" (儿科七厘散, Pediatric Qi Li San) is an entirely different formula designed for childhood febrile convulsions and should not be confused with this trauma formula.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qi Li San

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel, rivaroxaban): Qi Li San strongly invigorates Blood and dispels stasis. Concurrent use with pharmaceutical blood thinners or antiplatelet agents may potentiate anticoagulant effects and significantly increase the risk of bleeding. Hong Hua (safflower), Xue Jie (dragon's blood), Ru Xiang (frankincense), and Mo Yao (myrrh) all have demonstrated effects on platelet aggregation and blood flow.

Mercury-containing medications and hepato/nephrotoxic drugs: The formula contains Zhu Sha (cinnabar/HgS). Co-administration with other drugs that stress the liver or kidneys (e.g. acetaminophen at high doses, aminoglycoside antibiotics, NSAIDs with renal effects, methotrexate) may compound organ toxicity. Combining cinnabar-containing formulas with potassium bromide or potassium iodide is specifically warned against in Chinese pharmacology, as mercury ions can react with bromide or iodide ions in the gut to form highly toxic mercuric bromide or mercuric iodide.

Sedatives and CNS depressants: Zhu Sha (cinnabar) has a sedating, spirit-calming action. Concurrent use with pharmaceutical sedatives, anxiolytics, or sleep medications may produce additive central nervous system depression.

Usage Guidance

Practical advice for getting the most out of Qi Li San

Best time to take

Best taken on an empty stomach, mixed with warm rice wine (huang jiu) or warm water, 1 to 3 times daily depending on severity of injury.

Typical duration

Acute use only: typically 3 to 7 days for traumatic injuries, not exceeding 7 days for internal use due to cinnabar content. External application may continue slightly longer under practitioner guidance.

Dietary advice

While taking Qi Li San internally, avoid cold and raw foods, which can constrict blood vessels and impede the formula's Blood-moving action. Avoid excessively spicy or heating foods and alcohol beyond the small amount of rice wine (huang jiu) used to administer the formula, as these may aggravate bleeding or heat in the injured area. Light, easily digestible, nourishing foods that support Blood production (such as cooked dark leafy greens, bone broth, and moderate amounts of lean protein) are beneficial during recovery from traumatic injury. The classical instruction to take the formula with warm rice wine serves to enhance its Blood-moving and channel-opening effects.

Qi Li San originates from Liáng Fāng Jí Yè (良方集腋) by Xiè Yuánqìng Qīng dynasty

Classical Texts

Key passages from the classical Chinese medical texts that first described Qi Li San and its clinical use

Formula verse (方歌):
「七厘散治跌打伤,血竭红花冰麝香,乳没儿茶朱砂末,外敷内服均见长。」
"Qi Li San treats traumatic injuries: Dragon's Blood and Safflower, Borneol and Musk; Frankincense, Myrrh, Catechu, and Cinnabar powder — excellent whether applied externally or taken internally."

From the Zhong Yi Fang Ji Xue Jiang Yi (中医方剂学讲义, Textbook of TCM Formulas):
「本方是伤科名方。方中血竭、红花祛瘀活血;乳香、没药行气祛瘀,消肿止痛;儿茶清热止血;朱砂镇心安神;麝香、冰片辛散走窜,善于行气血,止疼痛。合用以奏活血散瘀,定痛止血之效。惟方中香窜走泄,行气祛瘀之药,皆能耗气堕胎,故孕妇忌服。」
"This formula is a famous prescription in trauma medicine. Dragon's Blood and Safflower dispel stasis and invigorate Blood. Frankincense and Myrrh move Qi, dispel stasis, reduce swelling, and stop pain. Catechu clears Heat and stops bleeding. Cinnabar calms the Heart and settles the spirit. Musk and Borneol are acrid and penetrating, excelling at moving Qi and Blood to stop pain. Together they achieve the effects of invigorating Blood, dispersing stasis, stopping pain, and halting bleeding. However, the aromatic, penetrating, and stasis-dispelling herbs in this formula all deplete Qi and can cause miscarriage, so it is prohibited during pregnancy."

Preparation note from the Tong Shou Lu (同寿录):
「上为极细末,瓷瓶收贮,黄蜡封口,贮久更妙。」
"Grind all into an extremely fine powder, store in a porcelain bottle, and seal with beeswax. The longer it is stored, the better it becomes."

Historical Context

How Qi Li San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qi Li San originates from the Tong Shou Lu (《同寿录》, "Records of Shared Longevity"), a text from the Qing Dynasty. Some sources also attribute variants to the Liang Fang Ji Yi (《良方集腋》, "Collection of Fine Formulas"), compiled around 1762. The formula became one of the most celebrated prescriptions in Chinese trauma medicine (伤科), comparable in fame to Yun Nan Bai Yao for treating injuries.

The name "Qi Li San" (七厘散) literally means "Seven-Li Powder," where "seven li" (七厘) refers to the tiny dose of approximately 0.21 grams (seven li being a traditional unit of weight). This unusually small dosage reflects the formula's potency: its strongly aromatic, penetrating herbs (especially musk and borneol) are so powerful that only a tiny amount is needed. The classical instructions specify taking just seven li of the powder washed down with rice wine (烧酒), while simultaneously applying more powder mixed with wine to the injury site. For severe lacerations, the dry powder was sprinkled directly into the wound.

The original instructions also note that the powder should be ground extremely fine, sealed in porcelain bottles with beeswax, and that "the longer it is stored, the better" (贮久更妙). This reflects an understanding that the aromatic compounds in the formula mature and integrate over time. In modern practice, the original She Xiang (natural musk) has largely been replaced by artificial musk (人工麝香) due to wildlife conservation concerns, and the formula is widely available as a manufactured patent medicine produced by companies such as Tong Ren Tang. Modern clinical applications have expanded beyond classical trauma to include conditions like ganglion cysts, herpes zoster, deep vein thrombosis (used as a topical acupoint paste), and acute lumbar sprains.