Yun Nan Bai Yao

Yunnan White Medicine · 云南白药

Also known as: Qu Huanzhang Bai Bao Dan (曲焕章百宝丹), Bai Bao Dan (百宝丹), Yunnan Paiyao,

A famous proprietary Chinese medicine used to stop bleeding, reduce swelling, relieve pain, and promote wound healing. It is widely used for traumatic injuries, surgical bleeding, and various internal bleeding conditions. Its exact formula is a nationally protected secret, but the primary active ingredient is believed to be San Qi (Notoginseng), a powerful herb known for its ability to both stop bleeding and invigorate blood circulation.

Origin Created by Qu Huanzhang (曲焕章) in 1902; no classical text source. Originally named "Qu Huanzhang Bai Bao Dan" (曲焕章百宝丹). The formula is a Chinese national-level protected secret (国家绝密). — Late Qīng dynasty, 1902 CE
Composition 9 herbs
San Qi
King
San Qi
Ca
Deputy
Cao Wu - Zhi (草乌/制, Processed Kusnezoff Monkshood Root)
Bing Pian
Assistant
Bing Pian
Sa
Assistant
San Yu Cao (散瘀草, Boea clarkeana)
Ba
Assistant
Bai Niu Dan (白牛胆, Inula cappa)
Ch
Assistant
Chuan Shan Long (穿山龙, Dioscorea nipponica)
Shan Yao
Assistant
Shan Yao
Ku
Assistant
Ku Liang Jiang (苦良姜, Alpinia officinarum / Lesser Galangal)
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yun Nan Bai Yao is designed to correct these specific patterns.

Why Yun Nan Bai Yao addresses this pattern

Traumatic injury causes direct damage to tissues and blood vessels, leading to extravasated Blood (bleeding) and localized Blood stasis (bruising, swelling). In TCM, this is a straightforward pattern of Blood stasis caused by external physical force rather than by internal organ dysfunction. The stagnant Blood blocks the channels and collaterals, causing pain (the principle that "where there is obstruction, there is pain"), swelling, and potentially ongoing bleeding if the stasis prevents proper vessel repair.

Yun Nan Bai Yao addresses this pattern through its core dual action: San Qi and San Yu Cao stop active bleeding while simultaneously invigorating Blood to resolve the stasis. Processed Cao Wu and Chuan Shan Long penetrate the channels to relieve pain and disperse deep swelling. Bing Pian clears local Heat from inflammation and helps the formula penetrate to the injury site. This comprehensive approach both arrests hemorrhage and promotes the resolution of stagnant Blood, allowing the body's natural healing process to proceed.

A practitioner would look for one or more of these signs

Bleeding

Active bleeding from cuts, wounds, or injuries

Bruising

Purple or dark bruising at site of injury

Swelling

Localized swelling and inflammation around the injury

Acute Pain

Sharp, fixed pain at the injury site that worsens with pressure

Soft Tissue Injury

Sprains, strains, and contusions

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yun Nan Bai Yao when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Stasis due to Trauma

TCM Interpretation

In TCM, traumatic injury is understood as external force disrupting the channels and collaterals, damaging blood vessels and causing Blood to leave its normal pathways. This creates two simultaneous problems: active bleeding (Blood escaping) and Blood stasis (extravasated Blood accumulating in the tissues). The stagnant Blood blocks the free flow of Qi and Blood through the injured area, resulting in the characteristic swelling, bruising, and pain. If the stasis is not properly resolved, it can delay healing and cause chronic pain.

The Spleen's role in holding Blood within the vessels may also be temporarily overwhelmed, and the local disruption can allow toxic pathogens to enter through broken skin. This is why trauma treatment in TCM always involves both stopping bleeding and resolving stasis, rather than focusing on one alone.

Why Yun Nan Bai Yao Helps

Yun Nan Bai Yao is considered the premier trauma medicine in TCM precisely because it addresses both sides of the traumatic injury equation simultaneously. Its King herb San Qi stops active bleeding by promoting platelet aggregation and shortening clotting time, while simultaneously invigorating Blood circulation to prevent stagnant Blood from accumulating. Processed Cao Wu provides strong pain relief by warming and penetrating the channels. The supporting herbs like San Yu Cao and Chuan Shan Long reinforce both the hemostatic and stasis-resolving actions, while Bing Pian helps the formula reach the injury site rapidly. The formula can be used both internally (taken orally) and externally (applied as a powder or paste), making it extremely versatile for treating trauma of varying severity. Clinical studies have confirmed its effectiveness in reducing surgical blood loss by approximately 21%.

Also commonly used for

Bleeding

Perioperative and postoperative hemorrhage; shown to reduce blood loss in orthognathic surgery

Bleeding

Bleeding from internal or external hemorrhoids

Abnormal Uterine Bleeding

Menorrhagia and dysfunctional uterine bleeding

Soft Tissue Injury

Sprains, strains, and contusions with swelling and pain

Closed Fracture

Non-open bone fractures with surrounding tissue swelling and pain

Skin Infection

Abscesses, boils, and infected wounds

Ulcerative Colitis

Intestinal inflammation with bloody stool

Corneal Ulcers

Mouth ulcers and mucosal lesions

Diabetic Wounds

Chronic non-healing wounds in diabetic patients

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yun Nan Bai Yao does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yun Nan Bai Yao is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yun Nan Bai Yao works at the root level.

Yunnan Bai Yao addresses conditions where traumatic injury, surgical damage, or internal disease causes Blood to leave its normal pathways and accumulate as stasis. In TCM theory, when an external force strikes the body or internal pathology weakens the vessels, Blood can spill out (bleeding) or stagnate locally (bruising, swelling, pain). The key pathomechanism is a disruption of the normal circulation and containment of Blood. Escaped Blood that pools outside the vessels becomes "dead Blood" (stasis), which blocks fresh Blood from nourishing the tissues, generates swelling and pain, and prevents healing.

The brilliance of the formula lies in addressing both sides of this problem simultaneously. Ordinary hemostatic agents that simply clot Blood risk trapping stasis inside the body. A formula that only moves Blood might worsen bleeding. Yunnan Bai Yao resolves this paradox: it stops active bleeding by promoting platelet aggregation and shortening clotting time, while simultaneously dispersing the stagnant Blood that has already escaped the vessels. By clearing away stasis, it allows fresh Qi and Blood to reach the damaged area, reducing swelling, relieving pain, and enabling tissue repair. When toxic swelling is involved (as in infected wounds or abscesses), the formula's toxin-resolving action addresses the local accumulation of pathogenic Heat and inflammation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly bitter and slightly sweet with a mildly pungent, cooling sensation and subtle numbing quality from the processed aconitum component — bitter to clear stasis and toxins, sweet to support tissue repair, pungent to move Blood.

Ingredients

9 herbs

The herbs that make up Yun Nan Bai Yao, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
San Qi

San Qi

Tienchi ginseng

Dosage Proprietary (not disclosed)
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Stomach, Liver

Role in Yun Nan Bai Yao

San Qi is widely recognized as the primary active ingredient and the core of Yun Nan Bai Yao. It uniquely combines the seemingly contradictory abilities to stop bleeding (hemostasis) and invigorate Blood circulation to resolve stasis. This dual action allows it to arrest hemorrhage without trapping stagnant Blood in the body, making it the ideal King herb for treating trauma where both bleeding and Blood stasis coexist. It also has pain-relieving and swelling-reducing properties.
Deputy — Assists and enhances the King
Ca

Cao Wu - Zhi (草乌/制, Processed Kusnezoff Monkshood Root)

Dosage Proprietary (not disclosed)
Preparation Must be processed (制) to reduce toxicity

Role in Yun Nan Bai Yao

Processed Cao Wu strongly dispels Wind-Dampness, warms the channels, and provides powerful pain relief. It supports the King herb by addressing deep pain from traumatic injury and reducing swelling. Its processing (炮制) is critical to reduce the toxicity of its aconitine alkaloids to safe levels. The company has confirmed its presence in the formula and stated that their unique processing eliminates the toxic components.
Assistants — Supports or moderates other herbs
Bing Pian

Bing Pian

Borneol

Dosage Proprietary (not disclosed)
Temperature Cool
Taste Bitter
Organ Affinity Spleen, Heart, Lungs

Role in Yun Nan Bai Yao

Bing Pian opens the orifices, clears Heat, and relieves pain. In this formula it serves as a channel-guiding substance that helps direct the other herbs to the site of injury. Its cooling nature also helps moderate any excessive warmth from the processed Cao Wu, and its mild antiseptic quality supports the formula's ability to prevent wound infection.
Sa

San Yu Cao (散瘀草, Boea clarkeana)

Dosage Proprietary (not disclosed)

Role in Yun Nan Bai Yao

San Yu Cao, literally "stasis-dispersing herb," is a regional Yunnan medicinal plant that clears Heat, stops bleeding, resolves Blood stasis, and reduces swelling. It reinforces the hemostatic and stasis-resolving actions of the King herb San Qi from a different pharmacological angle.
Ba

Bai Niu Dan (白牛胆, Inula cappa)

Dosage Proprietary (not disclosed)

Role in Yun Nan Bai Yao

Bai Niu Dan has anti-inflammatory, analgesic, and anti-pathogenic properties. It assists by reducing swelling, alleviating pain, and helping to prevent infection at the wound site, complementing the formula's overall ability to address traumatic injuries comprehensively.
Ch

Chuan Shan Long (穿山龙, Dioscorea nipponica)

Dosage Proprietary (not disclosed)

Role in Yun Nan Bai Yao

Chuan Shan Long invigorates Blood circulation, unblocks the channels, and dispels Wind-Dampness. It supports pain relief and helps resolve deep tissue stasis and swelling from injuries, particularly in the muscles and joints.
Shan Yao

Shan Yao

Yam

Dosage Proprietary (not disclosed)
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Yun Nan Bai Yao

Shan Yao tonifies Spleen Qi and nourishes Yin. In this context, it serves as a stabilizing and supportive herb, helping to protect the Spleen and Stomach from the harsh nature of the other ingredients (particularly the processed Cao Wu), and supporting the body's overall recovery from injury and blood loss.
Ku

Ku Liang Jiang (苦良姜, Alpinia officinarum / Lesser Galangal)

Dosage Proprietary (not disclosed)

Role in Yun Nan Bai Yao

Ku Liang Jiang (a form of Gao Liang Jiang) warms the Middle Burner and alleviates pain. It helps warm the channels to move Blood, supporting the formula's ability to resolve stasis while also protecting the Stomach, which is particularly useful when the medicine is taken internally.
Envoy — Directs the formula to its target
La

Lao Guan Cao (老鹳草, Erodium stephanianum / Geranium wilfordii)

Dosage Proprietary (not disclosed)

Role in Yun Nan Bai Yao

Lao Guan Cao dispels Wind-Dampness, unblocks the channels and collaterals, and stops diarrhea. It helps direct the formula's effects throughout the channel network to reach injured areas in the extremities and soft tissues, and supports Blood circulation in the smaller collateral vessels.

Why This Combination Works

How the herbs in Yun Nan Bai Yao complement each other

Important note on formula composition

Yun Nan Bai Yao is a Chinese national-level secret formula (国家绝密). The exact composition, proportions, and manufacturing processes have never been officially disclosed. The ingredients listed here are based on partial disclosures to the US FDA and various published analyses, but the manufacturer has stated these may not fully represent the actual formula. The following rationale is therefore an informed interpretation based on available information, not a definitive classical formula analysis.

Overall strategy

The formula addresses the core problem of traumatic injury: bleeding, Blood stasis, swelling, pain, and risk of infection. Its genius lies in combining herbs that stop bleeding with herbs that simultaneously invigorate Blood, preventing the clinical problem where stopping bleeding traps stagnant Blood and causes secondary pain and swelling. This "stop bleeding without causing stasis" approach is the hallmark of the formula.

King herb

San Qi (Notoginseng) is the undisputed core of this formula. It is the premier herb in TCM for trauma because of its unique bidirectional effect on Blood: it promotes platelet aggregation and clotting to stop hemorrhage, while also invigorating Blood circulation to disperse existing stasis. The classical saying about San Qi is that it is "the foremost herb for stopping bleeding" and that it "stops bleeding without retaining stasis, invigorates Blood without causing uncontrolled bleeding." This paradoxical dual action is the pharmacological foundation of Yun Nan Bai Yao.

Deputy herb

Processed Cao Wu (Aconiti Kusnezoffii Radix Praeparata) provides powerful warming analgesia by penetrating deeply into the channels to dispel Cold, Wind, and Dampness. In severe traumatic injuries, intense pain is a major concern, and Cao Wu is one of the strongest pain-relieving herbs in the Chinese materia medica. Its processing is essential to convert the highly toxic aconitine into safer derivatives while preserving its therapeutic potency.

Assistant herbs

San Yu Cao (Boea clarkeana) reinforces the hemostatic and stasis-resolving actions of San Qi. Bai Niu Dan (Inula cappa) provides anti-inflammatory and antimicrobial support, helping prevent wound infection (a restraining assistant that addresses a secondary concern). Chuan Shan Long unblocks the channels and promotes circulation in injured tissues. Huai Shan Yao serves as a protective assistant, tonifying the Spleen and Stomach to buffer against the harsh properties of other ingredients and support recovery. Ku Liang Jiang warms the Middle Burner, helping to move Blood while protecting digestion.

Envoy herb

Lao Guan Cao guides the formula's effects through the channel network and collaterals, helping the active substances reach injured tissues in the extremities and soft tissues. Bing Pian also plays an envoy-like role, as its aromatic penetrating nature helps "open pathways" for the other herbs to reach affected areas rapidly.

Notable synergies

The most important synergy is between San Qi and the processed Cao Wu: San Qi stops bleeding and resolves stasis while Cao Wu provides deep pain relief, creating a comprehensive trauma treatment. The warming nature of Cao Wu and Ku Liang Jiang is balanced by the cooling properties of Bing Pian and San Yu Cao, preventing the formula from becoming excessively warming. The combination of Blood-moving herbs (San Qi, San Yu Cao, Chuan Shan Long) with the channel-guiding aromatics (Bing Pian, Lao Guan Cao) ensures the formula can address both internal and external injuries effectively.

How to Prepare

Traditional preparation instructions for Yun Nan Bai Yao

Important note: Yun Nan Bai Yao is a proprietary manufactured product, not a formula that individuals prepare at home. It is produced exclusively by the Yunnan Baiyao Group Co., Ltd. using a classified national-secret manufacturing process.

Administration of the powder (San Ji): For bleeding from knife wounds, gunshot wounds, or traumatic injuries of any severity, take 0.2–0.3g orally with warm water. For Blood stasis with swelling and pain (no active bleeding), take with rice wine. For gynecological conditions, take with rice wine, but for excessive menstrual bleeding or uterine hemorrhage, take with warm water instead. For toxic sores at the initial stage, take 0.25g internally and mix additional powder with rice wine to apply externally to the affected area. For suppurated sores, only internal administration is needed.

Capsule form: Take 1–2 capsules (0.25g each) orally, 4 times daily. Children aged 2–5 receive one quarter of the adult dose; children aged 6–12 receive half the adult dose. For severe traumatic injuries, take the red "insurance pill" (Bao Xian Zi) first, then continue with regular doses. Avoid broad beans, fish, and sour or cold foods for one day after taking the medicine. Contraindicated during pregnancy.

Common Modifications

How practitioners adapt Yun Nan Bai Yao for specific situations

Apply Yun Nan Bai Yao powder directly to the cleaned wound surface while simultaneously taking 0.2–0.3g internally with warm water. For severe trauma, take the red "insurance pill" (Bao Xian Zi) first. This combined internal and external approach provides the strongest hemostatic effect.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yun Nan Bai Yao should not be used or requires extra caution

Avoid

Pregnancy: The formula contains potent Blood-moving herbs that can stimulate uterine contractions and risk miscarriage. Strictly contraindicated in all trimesters.

Avoid

Known allergy or previous adverse reaction to Yunnan Bai Yao or any of its components. Allergic reactions including anaphylactic shock have been documented.

Avoid

History of severe cardiac arrhythmia. The formula contains processed Cao Wu (Aconiti Kusnezoffii Radix), which even in processed form retains trace amounts of aconitum alkaloids that may affect cardiac rhythm.

Avoid

Do not exceed the recommended dosage (maximum 0.5g per dose, 4g per day). Overdose can cause nausea, vomiting, pallor, cold limbs, and in severe cases acute renal failure.

Caution

Concurrent use with anticoagulant or antiplatelet medications (warfarin, aspirin, clopidogrel, heparin) without medical supervision. The formula's hemostatic and Blood-invigorating actions may unpredictably alter coagulation.

Caution

Patients with liver disease should use with caution, as the formula may increase liver enzymes.

Caution

Do not apply externally to wounds that have already formed pus or abscesses. External application is only appropriate for early-stage injuries and clean wounds.

Caution

Patients with a history of penicillin allergy should exercise extra caution, as a higher-than-expected proportion of adverse reactions have been observed in this population.

Caution

Avoid prolonged use. Long-term continuous use has been associated with potential cardiovascular and renal damage.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Yunnan Bai Yao is a potent Blood-moving formula. Its strong Blood-invigorating (Huo Xue Hua Yu) actions pose a significant risk of stimulating uterine contractions, potentially causing miscarriage or premature labor. The formula is known to contain processed Cao Wu (Aconiti Kusnezoffii Radix), a substance in the aconitum family whose alkaloids carry additional risk of developmental toxicity. Animal studies established a developmental no-observed-adverse-effect-level (NOAEL) of only 0.5 g/kg, suggesting a narrow safety margin. Additionally, its main ingredient, San Qi (Panax notoginseng), contains ginsenosides that may exert estrogenic effects, adding another layer of hormonal concern. Pregnant women should not use Yunnan Bai Yao in any form (oral, topical, or otherwise) without explicit direction from a qualified healthcare provider.

Breastfeeding

Safety during breastfeeding has not been formally studied. The formula contains processed Cao Wu (Aconiti Kusnezoffii Radix), which even after processing retains trace levels of aconitum alkaloids. Whether these compounds transfer into breast milk at clinically significant levels is unknown. San Qi (Panax notoginseng) ginsenosides have demonstrated estrogenic activity in laboratory studies, which could theoretically affect lactation or the nursing infant's hormonal environment. Given these unknowns, breastfeeding mothers should avoid Yunnan Bai Yao or use it only under direct supervision of a qualified healthcare practitioner. If short-term external application to a wound is needed, the risk is likely lower than oral use, but caution is still advised.

Children

Yunnan Bai Yao has historically been used in pediatric settings in China for conditions such as bleeding and soft tissue injuries. Dosage must be reduced according to age and body weight. A common guideline: children under 2 years should generally not take it orally unless under strict medical supervision. For children aged 2-5, a typical oral dose is approximately one-quarter to one-third of the adult dose (roughly 0.06-0.08g per dose). Children aged 5-12 may take about half the adult dose. The "Insurance Pill" (保险子) included in each package is generally not given to young children. Because the formula contains processed Cao Wu (Aconiti Kusnezoffii Radix), which retains trace aconitum alkaloids, extra caution is warranted in children, whose lower body weight makes them more vulnerable to dose-related toxicity. Parents should always consult a qualified practitioner before giving Yunnan Bai Yao to a child.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yun Nan Bai Yao

Anticoagulants and antiplatelet agents (warfarin, rivaroxaban, aspirin, clopidogrel, heparin, enoxaparin): Yunnan Bai Yao has complex effects on coagulation. Its primary ingredient, San Qi (Panax notoginseng), promotes platelet aggregation and hemostasis, but notoginseng saponins have also demonstrated antiplatelet and fibrinolytic activity in laboratory studies. Combined use may unpredictably enhance or oppose the effects of these drugs, risking either excessive bleeding or unwanted clotting. Close medical monitoring is essential.

CYP450 enzyme substrates: Research suggests that notoginseng saponins may affect cytochrome P450 enzymes, particularly CYP3A, CYP1A2, and CYP2E1. This could alter the metabolism and blood levels of many pharmaceutical drugs processed through these pathways, potentially increasing side effects of CYP3A substrates or decreasing effectiveness of CYP1A2/2E1 substrates.

NSAIDs (ibuprofen, naproxen, etc.): Both Yunnan Bai Yao and NSAIDs affect platelet function and inflammatory pathways. Concurrent use may increase gastrointestinal bleeding risk or produce unpredictable effects on coagulation.

Hormone-sensitive conditions: Ginsenoside Rg1 from notoginseng has demonstrated estrogen-like activity in laboratory studies. Patients taking hormonal therapies or with hormone-sensitive cancers should exercise caution.

Usage Guidance

Practical advice for getting the most out of Yun Nan Bai Yao

Best time to take

Four times daily at evenly spaced intervals, taken with warm water (for bleeding) or warm rice wine (for injuries with pain and swelling but no active bleeding).

Typical duration

Acute trauma or surgical use: 3-7 days. Should not be used continuously for extended periods without medical supervision.

Dietary advice

While taking Yunnan Bai Yao, avoid sour and cold/raw foods, fava beans (broad beans), and fish, as these are traditionally listed as dietary prohibitions (食忌) in the product instructions. Spicy, greasy, and heavily stimulating foods should also be limited. When taking the formula for injuries without active bleeding, it is traditionally recommended to swallow the powder with warm rice wine (黄酒) to enhance its Blood-moving effect. When treating active bleeding (such as vomiting blood or heavy menstrual bleeding), take the powder with warm water only, not with alcohol. Resume a normal diet after discontinuing the formula.

Yun Nan Bai Yao originates from Created by Qu Huanzhang (曲焕章) in 1902; no classical text source. Originally named "Qu Huanzhang Bai Bao Dan" (曲焕章百宝丹). The formula is a Chinese national-level protected secret (国家绝密). Late Qīng dynasty, 1902 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yun Nan Bai Yao and its clinical use

Because Yunnan Bai Yao is a modern proprietary formula created in 1902 by Qu Huanzhang (曲焕章), it does not appear in the classical medical texts of TCM. Its formula has been classified as a national-level state secret in China since 1955, and no classical textual quotations exist for it.

However, the core therapeutic principle underlying the formula draws on a long tradition in Chinese medicine. The Ben Cao Gang Mu Shi Yi (《本草纲目拾遗》) describes San Qi (三七), the principal known ingredient, in these terms: 「人参补气第一,三七补血第一,味同而功亦等」"Ren Shen (Ginseng) is first among Qi tonics; San Qi is first among Blood tonics — their flavors are alike and their powers are equal." This passage speaks to the extraordinary regard in which San Qi was held, explaining why it became the foundation of a hemostatic formula of such renown.

Historical Context

How Yun Nan Bai Yao evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yunnan Bai Yao was created in 1902 by Qu Huanzhang (曲焕章, 1880–1938), a folk physician from Jiangchuan County in Yunnan Province. Originally named "Qu Huanzhang Bai Bao Dan" (曲焕章百宝丹, literally "Qu Huanzhang's Panacea"), it was the product of over a decade of travel through the mountains of southern Yunnan, where Qu learned from local ethnic minority healers (including the Yi and Bai peoples) and studied the region's extraordinary botanical diversity.

In 1916, the formula was officially registered and approved for public sale by the Yunnan provincial government. By 1923, Qu had refined it into a system of "one medicine, three elixirs, and one rescue pill" (一药化三丹一子), comprising ordinary, medium, and premium grades of the powder plus a special "Insurance Pill" (保险子) for severe trauma. During the 1938 Battle of Taierzhuang, one of China's first major victories against Japan, Qu donated over 30,000 bottles to the Yunnan troops. Soldiers carried the powder into combat, and its dramatic battlefield effectiveness made it nationally famous. In the 1940s, army commander Wu Xuexian avoided amputation of his severely injured leg thanks to treatment by Qu Huanzhang, further cementing the formula's legendary reputation.

After Qu's death in 1938, his wife Miao Lanying (缪兰瑛) safeguarded the secret formula and eventually donated it to the People's Republic of China government in 1955. It was subsequently classified as a national-level state secret. Today, Yunnan Bai Yao is one of only four medicines to receive China's highest "Grade One Protected Chinese Medicine" status (alongside Ejiao, Pian Zai Huang, and Long Mu Zhuang Gu Chong Ji). The formula remains a protected state secret, though regulatory requirements in the United States and Hong Kong have led to partial disclosure of some ingredients.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Yun Nan Bai Yao

1

Systematic review and meta-analysis of RCTs on hemostasis and antiulcer efficacy (2014)

Yang B, Xu ZQ, Zhang H, Xu FY, Shi XY, Zou Z, et al. Int J Clin Exp Med. 2014;7(3):461-482.

This meta-analysis pooled data from 55 RCTs involving 5,150 patients. It found that Yunnan Bai Yao used alone was more effective than standard hemostatic drugs for treating hemorrhage (RR 1.16), and showed benefits for uterine hemorrhage, ulcerative colitis, and skin ulcers in subgroup analysis. However, the authors noted significant heterogeneity and possible publication bias across trials.

PubMed
2

Systematic review and meta-analysis: Adjuvant treatment for hemoptysis (2022)

Wang et al. Evidence-Based Complementary and Alternative Medicine. 2022;2022:4931284.

This meta-analysis of 13 RCTs (1,379 patients) evaluated Yunnan Bai Yao plus conventional treatment versus conventional treatment alone for hemoptysis. The combination showed a higher effective rate (RR 1.18), lower hemoptysis volume, shorter bleeding duration, and shorter hospitalization. No significant heterogeneity was found for the primary outcome.

3

RCT: Preoperative Yunnan Bai Yao reduces blood loss in orthognathic surgery (2009)

Tang ZL, Wang X, Yi B, Li ZL, Liang C, Wang XX. Int J Oral Maxillofac Surg. 2009;38(3):261-266.

A prospective, randomized, double-blind, placebo-controlled trial with 87 patients undergoing bimaxillary orthognathic surgery. Three days of preoperative Yunnan Bai Yao capsules reduced mean intraoperative blood loss by approximately 21% (330.5 mL vs. 420.3 mL in the control group). No allergic reactions, thromboembolic events, or other side effects were observed.

4

Multi-center intensive monitoring study of adverse drug reactions (2019)

Li B, Feng S, Wu ZH, Kwong JSW, Hu J, Wu N, et al. Ann Transl Med. 2019;7(6):118.

This large-scale post-marketing surveillance study monitored 31,556 patients across 163 hospitals in China who used Yunnan Bai Yao capsules. Adverse events occurred in 2.35% of patients, but most were deemed unrelated to the drug. Adverse drug reactions attributed to Yunnan Bai Yao were infrequent and mostly mild (gastrointestinal symptoms, allergic reactions), with no new serious ADRs identified.

5

Comprehensive review: Pharmacological mechanisms, therapeutic applications, and clinical evidence (2025)

Qian H, Zhang W, Zhang M, Ma S, Zhen M, He H, Ren X. Front Pharmacol. 2025;16:1589035.

A systematic review analyzing 87 studies from 2000 to 2025 across five databases. The review confirmed Yunnan Bai Yao's effects in hemostasis (via platelet GPIIb/IIIa activation and coagulation factor promotion), wound healing (VEGF and TGF-β1 upregulation), anti-inflammation (arachidonic acid metabolism regulation), and antibacterial activity. The authors noted quality control challenges due to the formula's secret status.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.