Pi Pa Qing Fei Yin

Loquat Decoction to Clear the Lungs · 枇杷清肺飲

Also known as: Eriobotrya Decoction to Clear the Lung, Eriobotrya Japonica Formula, Pi Pa Qing Fei Tang

A classical formula designed to clear excess Heat from the Lungs that manifests on the face as acne, red bumps, or rosacea. It works by cooling the Lungs, clearing Damp-Heat, and supporting the body's Qi to push toxins outward. It is most commonly used for facial skin conditions caused by Lung and Stomach Heat steaming upward to the face.

Origin Wài Kē Dà Chéng (外科大成), Volume 3, by Qí Kūn (祁坤) — Qīng dynasty, 1665 CE
Composition 6 herbs
Pi Pa Ye
King
Pi Pa Ye
Sang Bai Pi
Deputy
Sang Bai Pi
Huang Lian
Deputy
Huang Lian
Huang Qi
Deputy
Huang Qi
Ren Shen
Assistant
Ren Shen
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Pi Pa Qing Fei Yin is designed to correct these specific patterns.

Why Pi Pa Qing Fei Yin addresses this pattern

Lung Heat is the primary pattern this formula was designed to address. When excessive Heat accumulates in the Lungs, it disrupts the Lungs' role in governing the skin and regulating the surface of the body. The Lung channel passes through the face, so Lung Heat naturally rises and steams upward, manifesting as red, inflamed skin lesions, particularly on the forehead and around the nose. The original text calls this condition "Lung Wind rosacea" (肺风酒刺), indicating that Wind-Heat trapped in the Lung channel erupts outward through the skin.

Pi Pa Ye and Sang Bai Pi directly clear Heat from the Lung channel and restore the Lungs' descending function. Huang Lian and Huang Bai reinforce the Heat-clearing action and resolve any associated Damp-Heat or Fire toxins that are fueling the inflammation. The small dose of Ren Shen supports the body's Qi to help push the Heat and toxins outward for resolution.

A practitioner would look for one or more of these signs

Acne

Red, inflamed papules on the face, especially the forehead and around the nose

Rosacea

Facial redness and flushing, especially the nose area

Dry Mouth

Dryness of the mouth and nose from Heat consuming fluids

Constipation

Dry stools from Heat damaging intestinal fluids

Bad Breath

Mouth odor from internal Heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Pi Pa Qing Fei Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acne (known as fen ci, 粉刺, or "powder thorns") is understood primarily through the relationship between the Lungs, the Stomach, and the skin. The Lungs govern the skin and body hair, and the Lung channel traverses the face. When Heat accumulates in the Lungs, whether from external Wind-Heat invasion, internal dietary factors (rich and spicy foods generating Stomach Heat), or constitutional tendencies, it steams upward along the channel to the face and erupts through the skin.

Different acne patterns in TCM include Lung Heat (papular, slightly itchy lesions on the forehead and nose), Stomach Heat (oily skin with lesions around the mouth, chest, and back), Blood Heat (premenstrual flares with flushing), and Damp-Heat with Toxin (deep, painful nodular cysts). Pi Pa Qing Fei Yin specifically targets the Lung Heat pattern.

Why Pi Pa Qing Fei Yin Helps

Pi Pa Qing Fei Yin was originally formulated specifically for acne and rosacea-type facial eruptions caused by Lung Heat. Pi Pa Ye and Sang Bai Pi clear Heat directly from the Lung channel that governs the skin, while Huang Lian and Huang Bai resolve the Damp-Heat and Fire toxins that sustain the inflammatory process in the skin. The small dose of Ren Shen supports the body's Qi to expel toxins outward rather than allowing them to fester internally. Clinical research has shown that modified versions of this formula achieve significant improvement in acne lesion scores compared to standard treatments, with one study reporting a 94.29% total effectiveness rate over four weeks of treatment.

Also commonly used for

Folliculitis

Facial folliculitis due to Lung and Stomach Heat

Perioral Dermatitis

Inflammatory lesions around the mouth and nose area

What This Formula Does

Every TCM formula has a specific set of actions — here's what Pi Pa Qing Fei Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Pi Pa Qing Fei Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Pi Pa Qing Fei Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Pi Pa Qing Fei Yin works at the root level.

The core disease mechanism addressed by Pi Pa Qing Fei Yin centers on Heat accumulating in the Lung system and forcing its way to the skin surface, particularly the face and nose.

In TCM theory, the Lungs govern the skin and body hair. When Heat builds up in the Lung channel, whether from external Wind-Heat invasion, excessive consumption of spicy and greasy foods, or constitutional Blood-Heat, it disrupts the Lungs' normal function of descending and distributing fluids. Instead of nourishing the skin evenly, this pathological Heat steams upward along the Lung channel and becomes trapped in the facial tissues. The face receives abundant Qi and Blood flow from multiple channels, making it especially vulnerable to Heat accumulation. The nose in particular is considered the external opening of the Lungs, so Lung Heat tends to manifest there prominently.

As Heat lodges in the skin, it congeals fluids and Blood into localized areas of stagnation, producing red, swollen, painful bumps that may discharge white or yellowish matter when broken. Over time, if the Heat is not cleared, it can injure Yin fluids and worsen into chronic conditions like persistent acne or rosacea. The formula works by clearing this Lung-level Heat at its source, draining Dampness-Heat from the body, and gently supporting the body's righteous Qi so it can expel the pathological Heat outward without becoming depleted.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter with a cool quality, reflecting its Heat-clearing and Dampness-draining therapeutic strategy, with mild sweet notes from Ren Shen and Gan Cao to protect the Stomach.

Channels Entered

Ingredients

6 herbs

The herbs that make up Pi Pa Qing Fei Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Pi Pa Ye

Pi Pa Ye

Loquat leaf

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach

Role in Pi Pa Qing Fei Yin

The lead herb and namesake of the formula. Pi Pa Ye clears Lung Heat, descends Lung Qi, and transforms Phlegm. As the main therapeutic agent, it directly addresses the core pathomechanism of Lung Heat steaming upward to the face, helping to cool the Lungs and restore their normal descending function.
Deputies — Assists and enhances the King
Sang Bai Pi

Sang Bai Pi

White mulberry root bark

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Spleen
Preparation Fresh bark preferred when available

Role in Pi Pa Qing Fei Yin

Reinforces the King herb by draining Heat specifically from the Lungs, promoting the downward movement of Lung Qi, and clearing retained fluid. The original text notes that fresh bark (鲜者更佳) is preferred for its stronger Heat-clearing action. It works alongside Pi Pa Ye to comprehensively clear Lung Heat.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Pi Pa Qing Fei Yin

A powerful cold, bitter herb that clears Heat and dries Dampness. In this formula, Huang Lian targets Stomach Heat and Fire toxins, addressing the Damp-Heat component that contributes to purulent, inflamed facial lesions. It works with Huang Bai to broadly clear Heat from multiple organ systems that contribute to facial eruptions.
Huang Qi

Huang Qi

Astragalus root

Dosage 3 - 6g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Pi Pa Qing Fei Yin

Clears Damp-Heat and drains Fire, especially from the Lower Burner. Paired with Huang Lian, the two bitter-cold herbs provide comprehensive Damp-Heat clearing action across multiple Burners. Huang Bai also resolves toxic Heat, helping to reduce inflamed, pus-filled skin lesions.
Assistant — Supports or moderates other herbs
Ren Shen

Ren Shen

Ginseng root

Dosage 1 - 3g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Pi Pa Qing Fei Yin

Used in a small dose to tonify Qi and support the body's righteous (zheng) Qi, helping to push toxins outward and prevent the strongly bitter-cold herbs from injuring the Spleen and Stomach. This follows the classical external medicine (waike) principle that adequate Qi is needed to expel toxins from the body (益气托毒外出).
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 1 - 3g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Pi Pa Qing Fei Yin

Harmonizes the actions of the other herbs in the formula, moderates the harshness of the bitter-cold herbs, and protects the Stomach. Its sweet flavor also helps generate fluids to counterbalance the drying nature of the Heat-clearing herbs.

Why This Combination Works

How the herbs in Pi Pa Qing Fei Yin complement each other

Overall strategy

This formula addresses Lung Heat and Damp-Heat steaming upward to the face, causing acne and rosacea-type lesions. The prescription strategy combines strong Lung Heat clearing with broad Damp-Heat resolution, while including a small amount of Qi-tonifying support to help the body expel toxins outward through the skin.

King herbs

Pi Pa Ye (Loquat Leaf) serves as the sole King herb. It is cool and bitter, entering the Lung and Stomach channels, making it ideally suited to clear Heat from the Lungs and restore the Lungs' natural descending function. When Lung Heat is excessive, the Lungs lose their ability to properly distribute fluids and Qi downward; instead, Heat and turbid substances steam upward to the face. Pi Pa Ye directly corrects this by cooling the Lungs and redirecting Qi downward.

Deputy herbs

Three herbs serve as Deputies. Sang Bai Pi (Mulberry Root Bark) specifically drains Lung Heat and promotes urination, reinforcing the King herb's action from a slightly different angle by helping to clear Heat through the water passages. Huang Lian (Coptis) and Huang Bai (Phellodendron) form a classic bitter-cold pairing that clears Damp-Heat and Fire toxins broadly. Huang Lian focuses on the middle and upper body (Stomach and Heart Fire), while Huang Bai drains Damp-Heat from the lower body, ensuring that pathogenic Heat is addressed at all levels.

Assistant herbs

Ren Shen (Ginseng) acts as a restraining Assistant in a small dose. In the tradition of external medicine (waike), a formula that only clears and purges without supporting the body's Qi risks driving toxins inward rather than expelling them. The small dose of Ren Shen supports Qi to "push toxins outward" (托毒外出), a key principle in treating skin eruptions. It also prevents the four bitter-cold herbs from damaging the Spleen and Stomach.

Envoy herbs

Gan Cao (Licorice) harmonizes all the ingredients, smoothing out the strongly bitter-cold nature of the formula. Its sweet flavor also protects the Stomach and generates fluids, preventing the drying side effects of the Heat-clearing herbs.

Notable synergies

The Pi Pa Ye and Sang Bai Pi pairing is a well-known combination for clearing Lung Heat: Pi Pa Ye descends Lung Qi while Sang Bai Pi drains Lung Heat downward through the water passages. Together they provide a thorough clearing of the Lung system. The Huang Lian and Huang Bai pairing covers Damp-Heat across all three Burners, ensuring that the source Heat driving the facial eruptions is addressed comprehensively rather than just symptomatically at the Lung level.

How to Prepare

Traditional preparation instructions for Pi Pa Qing Fei Yin

Use one and a half zhōng (approximately 300 mL) of water. Bring herbs to a boil, then simmer until about 200 mL (seven-tenths) of liquid remains. Strain and take on an empty stomach or between meals (shí yuǎn fú, 食远服), once daily.

In modern clinical practice, use the standard decoction method: soak herbs in approximately 400-500 mL of cold water for 20-30 minutes, bring to a boil, then simmer on low heat for 20-25 minutes. Strain, add a second decoction of water, and combine the two extractions. Divide into two doses, taken morning and evening on an empty stomach.

Common Modifications

How practitioners adapt Pi Pa Qing Fei Yin for specific situations

Added
Shu Di Huang

12-15g, cools Blood and nourishes Yin

Mu Dan Pi

9g, cools Blood and clears Heat from the Blood level

Chi Shao

9g, clears Heat and invigorates Blood to reduce redness

When Heat has entered the Blood level, causing visible facial vascular dilation and flushing, adding Blood-cooling herbs addresses the deeper layer of Heat that the base formula's Qi-level herbs cannot fully reach.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Pi Pa Qing Fei Yin should not be used or requires extra caution

Caution

Acne or skin conditions caused by Spleen deficiency with Dampness (characterized by pale complexion, loose stools, fatigue, and a pale tongue with white coating). This formula is predominantly cold and bitter, which can further damage a weak digestive system.

Caution

Acne driven by Blood Stasis or Phlegm-Dampness without significant Heat signs. The formula is designed for Heat patterns and will not address the root cause in these cases.

Caution

Cold-type constitutions or patients with Yang deficiency showing signs such as cold limbs, preference for warm drinks, pale tongue, and slow pulse. The cold nature of Huang Lian and Huang Bai can aggravate Yang deficiency.

Caution

Prolonged unsupervised use. The bitter-cold herbs (Huang Lian, Huang Bai) can injure Stomach Qi and Spleen Yang over time. Treatment courses should be limited and reassessed regularly.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. While none of the six herbs in this formula are classified as strongly prohibited during pregnancy, Huang Lian (Coptis) and Huang Bai (Phellodendron) are intensely bitter and cold, which may adversely affect the digestive system and potentially disturb fetal development if used in large doses or over extended periods. Ren Shen (Ginseng) is generally safe but can interact with other medications commonly used in pregnancy. Pregnant individuals should only use this formula under the direct guidance of a qualified practitioner, and only when the Lung-Heat pattern is clearly established and the benefits outweigh the risks.

Breastfeeding

Generally considered acceptable for short-term use during breastfeeding, but caution is warranted. Huang Lian (Coptis) contains berberine, which has been shown to transfer into breast milk in small amounts and could potentially cause gastrointestinal upset in the infant, including loose stools or decreased feeding. The bitter-cold nature of the formula may also theoretically reduce milk production by impairing Spleen and Stomach function, which TCM considers essential for generating breast milk. If used during breastfeeding, the formula should be prescribed at reduced doses, for the shortest effective duration, and the infant should be monitored for any digestive changes.

Children

Pi Pa Qing Fei Yin is primarily used for acne-type conditions that typically arise around puberty, so it is most relevant for adolescents rather than young children. For adolescents (approximately 12 years and older), dosages should be reduced to roughly 50-75% of the adult dose depending on body weight and constitution. The formula is generally not appropriate for children under 12 years of age, as their digestive systems are still developing and the bitter-cold properties of Huang Lian and Huang Bai can easily damage Spleen and Stomach Qi in younger patients, potentially causing loss of appetite, nausea, or diarrhea. If used in adolescents, treatment duration should be kept short (typically 2-4 weeks) with careful monitoring of digestive function.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Pi Pa Qing Fei Yin

Berberine-containing herbs (Huang Lian, Huang Bai): These herbs contain berberine, which has known interactions with several pharmaceutical drug classes. Berberine may enhance the effects of hypoglycemic drugs (such as metformin and sulfonylureas), increasing the risk of hypoglycemia. It may also interact with anticoagulants and antiplatelet medications by affecting platelet aggregation. Berberine inhibits certain cytochrome P450 enzymes (particularly CYP3A4 and CYP2D6), potentially increasing blood levels of drugs metabolized through these pathways, including cyclosporine, certain statins, and some antidepressants.

Ren Shen (Ginseng): Ginseng may interact with blood thinners such as warfarin, potentially reducing their effectiveness. It may also interact with monoamine oxidase inhibitors (MAOIs) and stimulant medications. Ginseng can affect blood sugar levels, so patients taking diabetes medications should monitor glucose levels closely.

Gan Cao (Licorice root): Even in small doses, Gan Cao may interact with corticosteroids (potentiating their effects), antihypertensives (by promoting sodium retention and potassium loss), digoxin and cardiac glycosides (hypokalemia increases toxicity risk), and diuretics (compounding potassium loss).

Usage Guidance

Practical advice for getting the most out of Pi Pa Qing Fei Yin

Best time to take

30 minutes to 1 hour after meals (食远服), twice daily, to reduce the potential for the bitter-cold herbs to irritate an empty stomach.

Typical duration

Typically prescribed for 2-4 weeks, then reassessed. May be extended for chronic acne or rosacea, but bitter-cold formulas should not be used indefinitely without monitoring digestive function.

Dietary advice

While taking this formula, avoid spicy, greasy, fried, and heavily seasoned foods, as these generate internal Heat and Dampness that directly counteract the formula's cooling action. Alcohol should also be avoided, as it is warming in nature and promotes Damp-Heat. Limit rich dairy products and excessively sweet foods, which can generate Phlegm-Dampness and worsen skin congestion. Favor light, cooling foods such as mung beans, cucumber, winter melon, pear, celery, lettuce, and barley (Job's tears). Green tea in moderate amounts is also supportive. Ensuring adequate water intake helps the body clear Heat through normal fluid metabolism.

Pi Pa Qing Fei Yin originates from Wài Kē Dà Chéng (外科大成), Volume 3, by Qí Kūn (祁坤) Qīng dynasty, 1665 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Pi Pa Qing Fei Yin and its clinical use

《医宗金鉴·外科心法要诀》(Yī Zōng Jīn Jiàn, Imperial Medical Compendium):

「此证由肺经血热而成。每发于面鼻,起碎疙瘩,形如黍屑,色赤肿痛,破出白粉汁,日久皆成白屑,形如黍米白屑。宜内服枇杷清肺饮。」

Translation: "This condition arises from Blood-Heat in the Lung channel. It frequently occurs on the face and nose, forming small bumps resembling millet grains, red and swollen with pain. When broken, they discharge a white powdery fluid. Over time they all become white flakes, resembling millet-like white scales. It is appropriate to take Pi Pa Qing Fei Yin internally."


《彤园妇人科》(Tóng Yuán Fù Rén Kē):

「鼻起碎疙瘩,形如黍屑,色赤肿痛,破出粉汁,日久成白屑,或成黍粒,皆由肺经血热而成。内服枇杷清肺饮。」

Translation: "Small bumps arise on the nose, shaped like millet grains, red, swollen, and painful. When broken they discharge a powdery fluid. Over time they become white flakes or millet-like granules. All of these arise from Blood-Heat in the Lung channel. Take Pi Pa Qing Fei Yin internally."

Historical Context

How Pi Pa Qing Fei Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Pi Pa Qing Fei Yin first appeared in the Wai Ke Da Cheng (外科大成, Great Compendium of External Medicine), written by the Qing Dynasty imperial physician Qi Kun (祁坤, courtesy name Guang Sheng 广生) in 1665 (the fourth year of the Kangxi reign). Qi Kun served as an imperial medical officer in the Qing court and was renowned for his expertise in external medicine (surgery and dermatology). He compiled the text to systematize treatments for surgical and dermatological conditions, organizing them by body region.

The formula gained even wider recognition when Qi Kun's grandson, Qi Hongyuan (祁宏源), was commissioned to participate in compiling the Yi Zong Jin Jian (医宗金鉴, Imperial Medical Compendium) in 1742 under the editorship of Wu Qian. Qi Hongyuan used the Wai Ke Da Cheng as the foundation for the Wai Ke Xin Fa Yao Jue (外科心法要诀) section of this imperially sponsored encyclopedia. Through this channel, Pi Pa Qing Fei Yin became one of the standard formulas in official medical education throughout the Qing Dynasty. In 2020, the Chinese National Medical Products Administration listed Pi Pa Qing Fei Yin (formula #94) in its first batch of Classical Famous Formulas (古代经典名方), recognizing its enduring clinical importance.