Bai He Di Huang Tang

Lily Bulb and Rehmannia Decoction · 百合地黃湯

Also known as: Lily Bulb and Rehmannia Decoction

A gentle, two-herb classical formula used to nourish the body's cooling, moistening reserves (Yin) in the Heart and Lungs, and to clear the low-grade internal Heat that arises when these reserves are depleted. It is best known for treating a pattern of vague mental fogginess, emotional withdrawal, sleep difficulty, fluctuating appetite, and inner restlessness — symptoms that in modern practice often overlap with depression, anxiety, insomnia, and menopausal complaints.

Origin Essentials from the Golden Cabinet (220 AD) — Hàn dynasty, ~200 CE
Composition 2 herbs
Bai He
King
Bai He
Shu Di Huang
Deputy
Shu Di Huang
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bai He Di Huang Tang is designed to correct these specific patterns.

Why Bai He Di Huang Tang addresses this pattern

This is the core pattern that Bai He Di Huang Tang was specifically designed to treat, known classically as Bai He Bing (百合病, "Lily Disease"). The underlying mechanism is Yin Deficiency of the Heart and Lungs generating internal Heat, which then spreads diffusely through the hundred vessels (百脉), disturbing the Spirit (Shen) and disrupting normal function throughout the body.

Bai He (Lily Bulb), the chief herb, enters the Lung and Heart channels. It nourishes Lung Yin, gently clears deficiency Heat from the Qi level, and calms the Spirit. As a classical commentary explains, Bai He "clears Heat from the Qi within the Lungs." Sheng Di Huang (raw Rehmannia juice), the deputy herb, enters the Heart and Kidney channels. It cools Heat in the Blood, nourishes the nutritive (Ying) level, and enriches Yin fluids. Together, the two herbs work on complementary levels: Bai He addresses the Qi-level Heat in the Lungs while Sheng Di Huang addresses Blood-level Heat rooted in Heart and Kidney Yin insufficiency. This two-pronged approach clears diffuse deficiency Heat without damaging Body Fluids, restoring harmony to the hundred vessels and settling the disturbed Spirit.

A practitioner would look for one or more of these signs

Mental Exhaustion

Mental disorientation and absent-mindedness, as if in a trance

Restlessness

Wanting to lie down but unable to rest, wanting to walk but unable to move

Loss Of Appetite

Fluctuating appetite: sometimes craving food, sometimes repulsed by it

Irritability

Vague sense of heat without true fever, vague sense of cold without true chills

Bitter Taste In The Mouth

Bitter taste in the mouth

Dark Urine

Dark or reddish urine

Taciturnity

Withdrawn silence, reluctance to speak

Insomnia

Difficulty sleeping due to restless Spirit

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bai He Di Huang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, depression often falls under the category of Yu Zheng (郁证, "depression pattern") or, when it presents with the characteristic trance-like quality described in the Jin Gui Yao Lue, Bai He Bing. The Heart houses the Spirit (Shen) and governs consciousness, while the Lungs govern the hundred vessels and the corporeal soul (Po). When Yin fluids of these two organs become depleted, whether from prolonged emotional turmoil, the aftermath of illness, or chronic overwork, the resulting deficiency Heat rises to disturb the Spirit. The person experiences a distinctive state where their mind feels foggy and detached, their motivation fluctuates unpredictably, and their behavior appears erratic to others. They may withdraw into silence, lose interest in food, or feel unable to rest despite exhaustion. This is distinct from Liver Qi Stagnation-type depression (which features more frustration and chest tightness) because the underlying mechanism is depletion rather than constraint.

Why Bai He Di Huang Tang Helps

Bai He Di Huang Tang targets the specific pathomechanism of depression rooted in Heart-Lung Yin Deficiency. Bai He (Lily Bulb) has a well-documented Spirit-calming effect. Classical texts describe it as being able to "calm the Heart, settle the gallbladder, and nourish the five organs." It gently clears deficiency Heat from the upper body while moistening and nourishing the depleted Lung and Heart Yin. Sheng Di Huang (raw Rehmannia juice) works at a deeper level, cooling Heat in the Blood, nourishing the Heart's nutritive aspect, and enriching Kidney Yin to replenish the root source of all Yin in the body. Modern pharmacological research has shown that this formula significantly increases serotonin (5-HT) and norepinephrine levels in the brain, which parallels the mechanism of conventional antidepressant medications. A meta-analysis of 83 clinical studies found that adding Bai He Di Huang Tang to conventional treatment improved depression scores while reducing adverse reactions compared to medication alone.

Also commonly used for

Anxiety

Generalized anxiety disorder, especially with somatic symptoms and Yin Deficiency Heat signs

Neuroses

Neuroses and neurasthenia with mental confusion, fatigue, and emotional lability

Hysteria

Hysteria (conversion disorder) with erratic behavior and emotional outbursts

Autonomic Dysfunction

Autonomic nervous system dysfunction with fluctuating symptoms that defy clear diagnosis

Itchy Skin

Senile pruritus (elderly skin itching) due to Blood Dryness from Yin Deficiency

Hyperthyroidism

Thyroid hyperfunction with palpitations, weight loss, sweating, and insomnia when presenting with Yin Deficiency Heat

Sleepwalking

Somnambulism (sleepwalking) from Heart Spirit not being properly anchored at night

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bai He Di Huang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bai He Di Huang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bai He Di Huang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bai He Di Huang Tang works at the root level.

This formula addresses a condition the Jin Gui Yao Lue calls "Bai He Bing" (百合病, lily disease), described as a state where "all the hundred vessels share one origin, and all contribute to the disease" (百脉一宗,悉致其病也). The underlying problem is a depletion of Yin in the Heart and Lungs, with low-grade internal Heat smoldering through the blood vessels and disturbing the mind.

The Heart houses the spirit (Shen), and the Lungs govern the hundred vessels. When Yin fluid in these two organs becomes depleted — often after a prolonged febrile illness, chronic emotional strain, or overwork — Heat from deficiency begins to spread diffusely through the vascular system. Because the Heat is not strong or localised but rather scattered across the entire body, it produces a strange collection of vague, contradictory symptoms: feeling hot yet not truly feverish, wanting to eat yet unable to stomach food, wanting to sleep yet lying awake, wanting to move yet lacking the will to do so. The spirit, deprived of the cooling nourishment that Heart and Lung Yin normally provide, becomes unanchored, producing mental fogginess, emotional withdrawal, and a dreamlike sense of disconnection.

Importantly, the Heat also enters the nutritive (Ying) and Blood levels, drying and consuming fluids further. This creates a vicious cycle: Yin depletion generates deficiency Heat, which in turn consumes more Yin. The bitter taste, dark urine, red tongue with little coating, and fine rapid pulse all confirm that Heat has penetrated deeply into the Yin layers rather than sitting at the surface.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and bitter with a cooling quality — sweet to nourish Yin and moisten dryness, bitter to gently clear deficiency Heat.

Channels Entered

Heart Lung Kidney

Ingredients

2 herbs

The herbs that make up Bai He Di Huang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Bai He

Bai He

Lily bulb

Dosage 15 - 30g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs
Preparation Soak overnight in water; discard the soaking water when white foam appears, then rinse before decocting

Role in Bai He Di Huang Tang

The principal herb of the formula and its namesake. Bai He is sweet, slightly cold, and enters the Heart and Lung channels. It nourishes Lung and Heart Yin, gently clears deficiency Heat from the Qi level, calms the spirit (Shen), and settles the ethereal soul (Po). In this formula it directly addresses the core presentation of Lily Disease (Bai He Bing): the mental restlessness, emotional instability, and erratic behaviour caused by Yin deficiency with internal Heat spreading through the hundred vessels.
Deputy — Assists and enhances the King
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 15 - 30g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Preparation Originally used as fresh Rehmannia juice (生地黄汁); when using dried Sheng Di Huang instead of juice, decoct normally

Role in Bai He Di Huang Tang

Sheng Di Huang is sweet, bitter, and cold, entering the Heart, Liver, and Kidney channels. It enriches Yin and generates fluids, cools the Blood, and clears Heat from the nutritive (Ying) and Blood levels. In this formula it supports Bai He by addressing the deeper layer of the pathology: nourishing Kidney Yin to control Heart Fire, cooling the Blood to calm the spirit, and draining residual Heat downward through the bowels. The original formula calls for its fresh juice (Sheng Di Huang Zhi), emphasizing its cold, fluid-rich nature for maximum Yin-nourishing and Heat-clearing effect.

Why This Combination Works

How the herbs in Bai He Di Huang Tang complement each other

Overall strategy

Bai He Di Huang Tang addresses the core pathology of Lily Disease (Bai He Bing): Yin deficiency of the Heart and Lung with internal Heat spreading diffusely through the hundred vessels (百脉), disturbing the spirit and causing erratic mental and physical behaviour. The prescription strategy is elegantly simple: nourish Yin at two levels (the Qi level through the Lung, and the Blood level through the Kidney-Heart axis), gently clear deficiency Heat, and allow the spirit to settle naturally once its material foundation is restored.

King herb

Bai He (Lily Bulb) serves as the King. Its sweet, slightly cold nature enters the Lung and Heart. As noted in the Qian Jin Fang Yan Yi, Bai He acts as the sovereign that "calms the Heart, supplements the spirit, and removes Heat from the Middle." It nourishes Lung Yin and clears Heat from the Qi level, directly addressing the upper source of the disease. Bai He also has a recognized calming effect on the spirit: classical sources describe it as able to "calm the Heart, settle the gallbladder, nourish the five organs." For a condition marked by mental confusion, restlessness, and erratic desires, Bai He both replenishes the depleted Yin and quiets the disturbed Shen.

Deputy herb

Sheng Di Huang (used as fresh juice in the original) is the Deputy. While Bai He works primarily at the Qi level and in the upper body (Lung and Heart), Sheng Di Huang works at the deeper Blood and nutritive (Ying) levels, entering the Heart and Kidney. As described in the Jin Gui Yao Lue Xin Dian: "Bai He, white in colour, enters the Lung and clears Heat from the Qi; Di Huang, dark in colour, enters the Kidney and removes Heat from the Blood." Together they treat both the Qi and Blood simultaneously, so that all the hundred vessels are cleared of pathological Heat. The fresh juice form maximizes its cooling and fluid-generating properties.

Notable synergies

The pairing of Bai He and Sheng Di Huang is the formula's defining synergy. Bai He works from above (Lung) and Sheng Di Huang from below (Kidney), creating a top-to-bottom clearing and nourishing action. One addresses Heat in the Qi, the other Heat in the Blood. Neither herb alone could accomplish what they achieve together: a comprehensive restoration of Yin fluids across all the body's vessels, which is precisely what the diffuse, hard-to-localize symptoms of Lily Disease require. The formula's power lies not in complexity but in the precision of this single pairing, which is why the classical text cautions against adding unnecessary herbs.

How to Prepare

Traditional preparation instructions for Bai He Di Huang Tang

Classical method (from the Jin Gui Yao Lue): Wash the Lily Bulb (Bai He) in water and soak it overnight. When white foam appears on the surface, discard the soaking water. Add fresh spring water (approximately 400 mL) and decoct until reduced to approximately 200 mL. Strain out the dregs. Separately, prepare one cup (approximately 200 mL) of fresh Rehmannia juice (Sheng Di Huang Zhi). Add the Rehmannia juice to the Bai He decoction and continue simmering until the total volume reduces to approximately 300 mL. Divide into two warm doses and take on the same day.

Modern simplified method: Soak the dried Bai He pieces in water for 30 minutes before decocting. Combine both herbs with approximately 600 mL of water and decoct over medium heat for 30 to 40 minutes until reduced to about 250 to 300 mL. Strain and divide into two doses, taken warm in the morning and evening.

Important notes: Once the formula takes effect, do not continue taking additional doses unnecessarily, as the cold and moistening nature of Rehmannia may cause loose stools with prolonged use. After taking the formula, stools may turn dark black (resembling lacquer) due to the natural colour of Rehmannia. This is a normal sign that the formula is working and will resolve once the formula is discontinued.

Common Modifications

How practitioners adapt Bai He Di Huang Tang for specific situations

Added
Suan Zao Ren

Suan Zao Ren (dry-fried), 15-30g, to nourish Heart Blood and calm the spirit

Ye Jiao Teng

Ye Jiao Teng, 15-30g, to nourish the Heart and promote sleep

When deficiency Heat specifically disturbs sleep, adding Suan Zao Ren and Ye Jiao Teng strengthens the formula's ability to nourish Heart Blood and settle the spirit for the night.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bai He Di Huang Tang should not be used or requires extra caution

Avoid

Excess Fire patterns in the Lungs and Heart. This formula is designed for Yin deficiency with empty Heat, not for excess, full-Heat conditions. Using it for excess Fire would fail to clear the pathogen and the cold, moistening nature of the herbs could trap the Heat.

Avoid

Spleen and Stomach deficiency with cold, manifesting as loose stools, poor appetite, or abdominal distension. Sheng Di Huang (raw Rehmannia) is cold and heavy, and can easily damage a weak Spleen, causing diarrhea. The original text itself warns that Sheng Di Huang 'is cold and moistening; excessive use may cause diarrhea.'

Avoid

Conditions caused by external pathogens (Wind-Cold or Wind-Heat invasion). This nourishing, inward-directed formula would retain the external pathogen rather than expel it.

Caution

Phlegm-Dampness or turbid Phlegm obstructing the Heart orifices. The moistening, Yin-nourishing nature of both herbs can worsen Dampness and Phlegm accumulation.

Caution

Concurrent use of tonifying Qi herbs such as Huang Qi and Ren Shen, warming herbs like Fu Zi and Rou Gui, or rich cloying substances like E Jiao and Gui Ban. Classical guidelines specifically warn against combining this formula with such herbs, as they counteract its light, clearing therapeutic strategy.

Caution

Once the formula takes effect, it should be discontinued promptly. The classical instruction states 'zhong bing, wu geng fu' (中病,勿更服) — once the condition improves, do not continue taking it, as overuse of cold, moistening Sheng Di Huang may cause diarrhea.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe, but use with caution and under professional guidance. Neither Bai He (lily bulb) nor Sheng Di Huang (raw Rehmannia root) is classified as a prohibited herb during pregnancy. However, Sheng Di Huang is cold in nature and can be heavy on digestion. In large doses, its cold, moistening properties could theoretically affect Spleen function, which is especially important during pregnancy for supporting the fetus. The original formula uses a very large dose of fresh Rehmannia juice, which may cause loose stools. If prescribed during pregnancy, a practitioner would typically reduce the dosage of Sheng Di Huang and monitor digestive function closely. No specific risks of uterine stimulation or teratogenicity have been associated with either herb.

Breastfeeding

No specific contraindications during breastfeeding have been documented for this formula. Bai He (lily bulb) is a common food item in Chinese cuisine with a long safety record. Sheng Di Huang (raw Rehmannia) is cold in nature, and in TCM theory, excessively cold herbs taken by a nursing mother could potentially affect the infant through breast milk, possibly contributing to loose stools in a sensitive infant. However, Rehmannia is not known to contain toxic compounds that transfer through breast milk. If the nursing mother has signs of Spleen deficiency or if the infant is prone to digestive weakness, the formula should be used cautiously with reduced dosage or discontinued if the infant develops loose stools. Consult a qualified practitioner.

Children

This formula can be used in children, but with appropriate dosage reduction based on age and body weight. General pediatric dosage guidelines: children under 5 years should receive approximately one-quarter to one-third of the adult dose; children aged 5-10 may take one-third to one-half; and children over 10 may take one-half to two-thirds of the adult dose. Since Sheng Di Huang is cold and can be hard on a child's relatively delicate digestive system, practitioners should start with conservative doses and monitor for loose stools or reduced appetite. The formula may be relevant for children showing signs of Yin deficiency with restlessness, such as difficulty sleeping, night sweats, or anxiety after a febrile illness. However, a qualified practitioner should always assess the child's overall pattern before prescribing, as children tend toward Spleen deficiency more readily than adults.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bai He Di Huang Tang

No major drug interactions have been specifically documented for this simple two-herb formula. However, the following theoretical considerations apply based on the known pharmacological properties of its ingredients:

  • Anticoagulant and antiplatelet medications (e.g. warfarin, aspirin): Sheng Di Huang (raw Rehmannia) has blood-cooling properties and may have mild effects on blood viscosity. Although no strong clinical evidence exists for a significant interaction, caution is advisable when used alongside blood-thinning medications.
  • Antidiabetic medications: Rehmannia contains catalpol and other iridoid glycosides that have been shown in preclinical studies to have hypoglycemic effects. Concurrent use with insulin or oral hypoglycemics could theoretically potentiate blood sugar lowering. Blood glucose should be monitored.
  • Sedatives and CNS depressants (e.g. benzodiazepines, sleeping pills): Given the demonstrated sedative and anxiolytic effects of BDT in preclinical research, additive sedation is theoretically possible when combined with pharmaceutical sedatives or anxiolytics.
  • Antidepressant medications (SSRIs, SNRIs, MAOIs): Research suggests BDT may increase brain serotonin and norepinephrine levels and inhibit monoamine oxidase activity. Concurrent use with antidepressants, particularly MAOIs, could theoretically increase the risk of serotonergic side effects. Professional supervision is recommended.

Usage Guidance

Practical advice for getting the most out of Bai He Di Huang Tang

Best time to take

Divided into two doses per day, taken warm on an empty stomach or 30 minutes before meals, in the morning and late afternoon.

Typical duration

Often taken for 1 to 4 weeks, with reassessment after improvement. The classical text instructs to stop once the condition responds ('zhong bing, wu geng fu').

Dietary advice

While taking this formula, favor light, easily digestible foods that support Yin and fluids. Good choices include congee (rice porridge), pears, white fungus (tremella) soup, lotus seeds, mung beans, and mild-flavored vegetables. Avoid spicy, greasy, or heavily warming foods such as chili, garlic, ginger, lamb, deep-fried food, and strong alcohol, as these generate internal Heat and counteract the formula's cooling, nourishing action. The classical sources specifically warn against using tonifying herbs like Huang Qi or warming substances like cinnamon alongside this formula, and the same principle applies to strongly warming or rich foods. Also avoid raw, ice-cold foods and excessive dairy, which can impair Spleen function and worsen the digestive burden from Sheng Di Huang.

Bai He Di Huang Tang originates from Essentials from the Golden Cabinet (220 AD) Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bai He Di Huang Tang and its clinical use

Jin Gui Yao Lue (金匮要略) — Zhang Zhongjing

Original indication passage:
「百合病,不经吐、下、发汗,病形如初者,百合地黄汤主之。」
"For Bai He disease that has not undergone vomiting, purging, or sweating, and the disease manifestation remains as at the beginning, Bai He Di Huang Tang governs it."

Description of Bai He disease:
「百合病者,百脉一宗,悉致其病也。意欲食复不能食,常默默,欲卧不能卧,欲行不能行,饮食或有美时,或有不用闻食臭时,如寒无寒,如热无热,口苦,小便赤,诸药不能治,得药则剧吐利,如有神灵者,身形如和,脉微数。」
"In Bai He disease, the hundred vessels converge at a single source, and all contribute to the illness. The person wants to eat but cannot eat, is often silent, wants to lie down but cannot, wants to walk but cannot. Sometimes food seems appealing, sometimes even the smell is intolerable. There seems to be chills but no true chills, seems to be fever but no true fever. The mouth is bitter, the urine is dark. No medicine seems to work, and taking medicine only causes violent vomiting or diarrhea, as if possessed by spirits. The body appears outwardly normal, and the pulse is faint and slightly rapid."

Jin Gui Yao Lue Xin Dian (金匮要略心典) — You Yi

「百合色白入肺,而清气中之热;地黄色黑入肾,而除血中之热。气血即治,百脉俱清,虽有邪气,亦必自下。服后大便如漆,则热除之验也。」
"Bai He is white and enters the Lung, clearing Heat from the Qi level. Di Huang is dark and enters the Kidney, eliminating Heat from the Blood level. When both Qi and Blood are treated, all the hundred vessels become clear, and even if pathogenic factors remain, they will naturally descend and be eliminated. After taking the formula, the stool becomes black like lacquer — this is the sign that Heat has been cleared."

Qian Jin Fang Yan Yi (千金方衍义)

「百合病若不经发汗、吐、下,而血热自汗,用百合为君,安心补神,能去中热,利大小便,导涤痰积;但佐生地黄汁以凉血,血凉则热毒解而蕴结自行,故大便当去恶沫也。」
"If Bai He disease has not undergone sweating, vomiting, or purging, yet there is Blood-Heat with spontaneous sweating, use Bai He as the chief herb to calm the Heart and nourish the Spirit. It can clear internal Heat, promote urination and bowel movement, and guide out accumulated Phlegm. Sheng Di Huang juice is added as assistant to cool the Blood. When the Blood cools, Heat-toxin resolves and accumulations disperse naturally, so the stool should expel foul matter."

Historical Context

How Bai He Di Huang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Bai He Di Huang Tang first appears in Zhang Zhongjing's Jin Gui Yao Lue (Synopsis of the Golden Chamber), written in the early 3rd century during the Eastern Han dynasty. It is the principal formula in the chapter on "Bai He, Fox Creeper, and Yin-Yang Toxin Diseases" (百合狐惑阴阳毒病脉证治), which describes a group of conditions affecting the mind and body after illness.

The name "Bai He disease" (百合病) is itself a point of scholarly debate. The classical text explains it as "bai mai yi zong" (百脉一宗) — "the hundred vessels converging at one source" — suggesting a systemic disturbance affecting all the body's channels. Some later scholars have proposed the disease was named after the herb that treats it, much as "Gui Zhi syndrome" is named after Gui Zhi Tang. The formula is remarkably simple: just two ingredients, lily bulb and fresh Rehmannia juice. This minimalist design reflects Zhang Zhongjing's principle that for conditions of deficiency and internal disharmony, gentle nourishing is more effective than complex intervention.

The formula was later recorded in Sun Simiao's Bei Ji Qian Jin Yao Fang (Prescriptions Worth a Thousand Gold, 7th century Tang dynasty), and appears in numerous subsequent works including Li Zhongzi's Shang Han Kuo Yao (Ming dynasty) and Wang Tailin's Tui Si Ji Lei Fang Ge Zhu (Qing dynasty). In 2018, China's National Administration of Traditional Chinese Medicine included Bai He Di Huang Tang in its first official catalogue of 100 Classic Famous Formulas (古代经典名方目录第一批), recognizing its enduring clinical importance and marking it for modern pharmaceutical development. Notably, research into the exact historical dosage of "seven lily bulbs" and "one sheng of Rehmannia juice" has been a focus of recent scholarship, with studies determining this corresponds to approximately 240g of fresh lily bulb and 200mL of juice from about 400g of fresh Rehmannia root.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Bai He Di Huang Tang

1

Meta-analysis of clinical efficacy of Baihe Dihuang Decoction for depression, menopausal syndrome, and insomnia (2022)

Peng L, Zhang XF, Guo DY, Zhai BT, Liang YJ, Chen ZZ, Zou JB, Shi YJ. Evidence-Based Complementary and Alternative Medicine, 2022, vol. 2022, article 8559176.

A meta-analysis reviewing 83 clinical studies found that Baihe Dihuang Decoction was used primarily for insomnia (24 studies), depression (17 studies), and menopausal syndrome (14 studies). The analysis concluded that combining Baihe Dihuang Decoction with conventional treatment produced better therapeutic outcomes and fewer adverse reactions than conventional treatment alone across these three conditions.

2

Antidepressant-like effects of Baihe Dihuang Tang via cerebral monoamine neurotransmitters in a mouse model (2012)

Chen ML, Gao J, He XR, Chen Q. Evidence-Based Complementary and Alternative Medicine, 2012, vol. 2012, article 419257.

This preclinical study investigated the antidepressant effect of BDT using the forced swim test and tail suspension test in mice. BDT at 9 and 18 g/kg doses significantly reduced immobility time in both tests. The mechanism involved increased levels of serotonin (5-HT) and noradrenaline (NA) in the brain, suggesting that BDT exerts antidepressant effects by modulating monoamine neurotransmitter levels.

PubMed
3

Metabolomic analysis of the anxiolytic effect of Baihe Dihuang Decoction in a chronic restraint stress rat model (2024)

Tang L, Liu J, Yang H, Zhao HQ, Hu C, Ma SJ, Qing YH, Yang L, Zhou RR, Zhang SH. Drug Design, Development and Therapy, 2024, vol. 18, pp. 2227-2248.

This preclinical study used a chronic restraint stress rat model to investigate the anxiolytic mechanisms of Baihe Dihuang Decoction through multi-dimensional omics approaches including 16S rRNA gut microbiome sequencing, non-targeted fecal metabolomics, and targeted hippocampal neurotransmitter analysis. The results showed that BDD improved anxiety-like behaviors and modulated gut microbiota composition, fecal metabolites, and hippocampal neurotransmitter levels.

4

Mechanism of Baihe Dihuang Tang improving psychological suboptimal health via plasma metabolic profiles and network analysis (2019)

Tian JS, Meng Y, Wu YF, Zhao L, Xiang H, Jia JP, Qin XM. Journal of Pharmaceutical and Biomedical Analysis, 2019, vol. 169, pp. 99-110.

A clinical metabolomics study that screened human subjects with psychological suboptimal health state and analyzed their plasma metabolic profiles before and after BDT treatment. The study identified 22 differential metabolites and 15 plasma biomarkers regulated by BDT, indicating that the formula primarily works through regulating pyruvate metabolism and phenylalanine metabolism, with functional targets including MAOA and MAOB related to monoamine neurotransmitter regulation.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.