An Shen Bu Xin Wan

Calm the Spirit and Tonify the Heart Pill · 安神补心丸

Also known as: An Shen Bu Xin Pian (安神补心片, tablet form), Calm the Shen and Supplement the Heart Pills

A widely used Chinese patent medicine for calming the mind and supporting restful sleep. It is designed for people experiencing palpitations, insomnia, dizziness, and ringing in the ears caused by insufficient nourishment of the Heart and mild internal Heat from Yin deficiency. The formula works by nourishing Yin and Blood, calming the spirit, and gently clearing deficiency Heat.

Origin Zhong Yao Zhi Ji Shou Ce (中药制剂手册, Handbook of Chinese Medicine Preparations); later standardized in the Chinese Pharmacopoeia (中华人民共和国药典) — Modern formula (contemporary, 20th century)
Composition 10 herbs
Dan Shen
King
Dan Shen
Sh
Deputy
Shou Wu Teng (首乌藤, Ye Jiao Teng)
Zhen Zhu Mu
Deputy
Zhen Zhu Mu
Wu Wei Zi
Assistant
Wu Wei Zi
Nu Zhen Zi
Assistant
Nu Zhen Zi
Mo han lian
Assistant
Mo han lian
Shu Di huang
Assistant
Shu Di huang
Tu Si Zi
Assistant
Tu Si Zi
+2
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. An Shen Bu Xin Wan is designed to correct these specific patterns.

Why An Shen Bu Xin Wan addresses this pattern

When Heart Blood is insufficient, the spirit (Shen) loses its material foundation and becomes restless, leading to palpitations, insomnia, excessive dreaming, and poor memory. This formula addresses Heart Blood deficiency through multiple mechanisms: Dan Shen nourishes and moves Heart Blood, Shou Wu Teng directly nourishes the Heart and calms the spirit, while the Yin-tonifying herbs (Nu Zhen Zi, Mo Han Lian, Sheng Di Huang) replenish the deeper Yin and Blood reserves of the Liver and Kidney that supply the Heart. Zhen Zhu Mu anchors the unsettled spirit while the Blood is being rebuilt.

A practitioner would look for one or more of these signs

Palpitations

Palpitations that worsen with exertion or anxiety

Insomnia

Difficulty falling asleep or frequent waking

Dizziness

Dizziness or lightheadedness

Tinnitus

Ringing in the ears

Poor Memory

Forgetfulness and poor concentration

Anxiety

Mild anxiety and restlessness

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider An Shen Bu Xin Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, sleep depends on the smooth transition of Yang entering Yin at night. When the Heart has insufficient Blood or Yin to house the spirit (Shen), the spirit becomes 'homeless' and restless, unable to settle. Simultaneously, when Kidney Yin is depleted, it fails to send cooling Water upward to communicate with Heart Fire, allowing deficiency Heat to flare at night. This is why insomnia from Yin and Blood deficiency typically worsens at night, features vivid or disturbing dreams, and is accompanied by signs of Heat like night sweats and a warm sensation in the chest.

Why An Shen Bu Xin Wan Helps

An Shen Bu Xin Wan addresses insomnia through a three-pronged approach. First, it nourishes the Heart directly: Dan Shen cools and moves Heart Blood while Shou Wu Teng calms and nourishes the Heart spirit. Second, it treats the root Yin deficiency: Nu Zhen Zi, Mo Han Lian, Sheng Di Huang, and Tu Si Zi replenish the Liver and Kidney Yin that supports the Heart. Third, it anchors the restless spirit: Zhen Zhu Mu provides heavy, settling action while He Huan Pi eases emotional tension. Shi Chang Pu opens the Heart orifices to ensure these nourishing substances reach the spirit. Modern pharmacological research suggests the formula has sedative and sleep-promoting effects on the central nervous system.

Also commonly used for

Tinnitus

Tinnitus associated with Yin deficiency

Dizziness

Dizziness from Yin deficiency with Liver Yang rising

Neurasthenia

Neurasthenia with insomnia and mental fatigue

Menopausal Symptoms

Perimenopausal insomnia, hot flashes, and emotional changes

Arrhythmia

Mild cardiac arrhythmia with palpitations from Yin deficiency

Depression

Mild depressive states with insomnia and fatigue

What This Formula Does

Every TCM formula has a specific set of actions — here's what An Shen Bu Xin Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, An Shen Bu Xin Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that An Shen Bu Xin Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how An Shen Bu Xin Wan works at the root level.

An Shen Bu Xin Wan addresses a pattern where the Heart lacks sufficient Blood and Yin to anchor the Shen (spirit), while at the same time deficiency Heat ("empty Fire") rises up to agitate it. In TCM, the Heart houses the Shen, meaning it governs consciousness, sleep, and emotional stability. When Heart Blood is depleted, often from prolonged overthinking, emotional strain, chronic illness, or aging, the Shen has no "home" to rest in, leading to restlessness, insomnia, palpitations, and anxiety.

This Blood deficiency typically has a deeper root in Liver and Kidney Yin insufficiency. The Kidneys store Yin (the body's cooling, moistening, and nourishing reserves), while the Liver stores Blood and helps regulate its distribution. When Kidney Yin becomes depleted, it can no longer restrain the body's Yang, allowing deficiency Heat to flare upward. This rising empty Fire disturbs the Heart, producing symptoms like palpitations, irritability, insomnia with vivid dreams, tinnitus, and dizziness. The tinnitus and dizziness arise because the head and ears, being the highest points of the body, are easily affected when Yin fails to anchor Yang and empty Heat rises.

The formula works by replenishing Heart Blood, nourishing Liver and Kidney Yin to address the root deficiency, subduing rising Yang, and clearing deficiency Heat, thereby restoring the Shen to its rightful dwelling place in a well-nourished Heart.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly astringent and slightly sour with bitter undertones. The astringent quality (from Wu Wei Zi and Zhen Zhu Mu) helps consolidate and astringe the Shen, the sour taste nourishes Yin and contains leakage, and the bitter notes (from Dan Shen) cool Heat and direct the formula's action downward.

Channels Entered

Ingredients

10 herbs

The herbs that make up An Shen Bu Xin Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Dan Shen

Dan Shen

Red sage roots

Dosage 300g (in manufactured pill proportion)
Temperature Cool
Taste Bitter
Organ Affinity Heart, Liver

Role in An Shen Bu Xin Wan

As the principal herb, Dan Shen enters the Heart and Liver channels to activate Blood circulation, cool the Blood, clear Heart Heat, and calm restlessness. It directly addresses the dual pathomechanism of Blood deficiency and deficiency Heat disturbing the Heart spirit. Its ability to both nourish and move Blood prevents stasis while settling the mind.
Deputies — Assists and enhances the King
Sh

Shou Wu Teng (首乌藤, Ye Jiao Teng)

Dosage 5 parts (in An Shen Gao proportion)

Role in An Shen Bu Xin Wan

Nourishes the Heart, calms the spirit, and promotes the harmonious interplay of Yin and Yang needed for restful sleep. As the highest-proportion herb in the An Shen Gao paste, it directly supports the King herb's spirit-calming action while addressing insomnia through its gentle sedative effect.
Zhen Zhu Mu

Zhen Zhu Mu

Mother of pearl

Dosage 20 parts (in An Shen Gao proportion)
Temperature Cold
Taste Salty, Sweet
Organ Affinity Heart, Liver
Preparation Traditionally calcined (煅) before use

Role in An Shen Bu Xin Wan

Settles and anchors the spirit through its heavy, mineral nature. It subdues Liver Yang rising and calms Heart restlessness, directly targeting the palpitations and dizziness that arise when deficiency Heat and unanchored Yang disturb the upper body. As the heaviest-proportion ingredient in the paste (20 parts), it provides the formula's 'grounding' quality.
Assistants — Supports or moderates other herbs
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 150g (in manufactured pill proportion)
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs
Preparation Steamed (蒸) before use

Role in An Shen Bu Xin Wan

Astringes Kidney essence, calms the Heart spirit, and generates fluids. Its sour, astringent nature prevents the leakage of Yin fluids and helps contain the restless spirit. It also supports the Heart-Kidney axis by tonifying the Kidney while settling the Heart.
Nu Zhen Zi

Nu Zhen Zi

Glossy privet fruits

Dosage 4 parts (in An Shen Gao proportion)
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Kidneys, Liver
Preparation Steamed (蒸) before use

Role in An Shen Bu Xin Wan

Nourishes Liver and Kidney Yin, supporting the root cause of Heart Blood deficiency. By replenishing the Yin of the lower body, it helps anchor Yang and reduce the deficiency Heat that rises to disturb the Heart spirit.
Mo han lian

Mo han lian

Eclipta herbs

Dosage 3 parts (in An Shen Gao proportion)
Temperature Cold
Taste Sour, Sweet
Organ Affinity Kidneys, Liver

Role in An Shen Bu Xin Wan

Partners with Nu Zhen Zi as the classical Er Zhi Wan pair to nourish Liver and Kidney Yin. It also cools the Blood and stops bleeding, reinforcing the Yin-nourishing foundation that prevents deficiency Fire from flaring upward.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 2 parts (in An Shen Gao proportion)
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in An Shen Bu Xin Wan

Clears Heat, cools the Blood, and nourishes Yin. As raw Rehmannia (not the prepared form), it specifically targets the deficiency Heat component, cooling the Blood level while supplementing Yin fluids to address the root deficiency.
Tu Si Zi

Tu Si Zi

Cuscuta seeds

Dosage 3 parts (in An Shen Gao proportion)
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver, Spleen

Role in An Shen Bu Xin Wan

Tonifies the Kidney, strengthens Yin and Yang in a balanced manner, and secures essence. It supports the formula's root-level treatment by reinforcing the Kidney foundation upon which Heart spirit stability depends.
He Huan Pi

He Huan Pi

Silktree albizia barks

Dosage 3 parts (in An Shen Gao proportion)
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Liver

Role in An Shen Bu Xin Wan

Relieves emotional constraint, calms the spirit, and promotes a sense of ease. It specifically addresses the emotional dimension of insomnia, helping to dissolve worry, anxiety, and depressive feelings that prevent restful sleep.
Envoy — Directs the formula to its target
Shi Chang Pu

Shi Chang Pu

Sweetflag rhizomes

Dosage 100g (in manufactured pill proportion)
Temperature Warm
Taste Bitter
Organ Affinity Stomach, Heart, Liver

Role in An Shen Bu Xin Wan

Opens the orifices of the Heart, transforms turbidity, and calms the spirit. Its aromatic, penetrating nature ensures the formula's nourishing substances can reach the Heart, while its ability to clear the sensory orifices addresses the tinnitus and dizziness symptoms. It harmonizes the formula by balancing the heavy, Yin-nourishing herbs with light, aromatic movement.

Why This Combination Works

How the herbs in An Shen Bu Xin Wan complement each other

Overall strategy

The formula addresses a pattern where insufficient Heart Blood and Yin fails to anchor the spirit, while deficiency Heat from depleted Kidney Yin rises to further agitate the Heart. The prescription simultaneously nourishes Yin and Blood at the root level, anchors and calms the spirit directly, and gently clears deficiency Heat to restore peaceful sleep and emotional stability.

King herbs

Dan Shen serves as the King herb, entering the Heart and Liver channels. It activates Blood to prevent stagnation while cooling the Blood and clearing Heart Fire. This dual action addresses both the Blood deficiency (which leaves the spirit unsettled) and the deficiency Heat (which agitates the mind), making it ideal for the formula's core pathomechanism of Heart Blood insufficiency with internal deficiency Fire.

Deputy herbs

Shou Wu Teng (Ye Jiao Teng) directly nourishes the Heart and promotes the harmonious interplay of Yin and Yang necessary for sleep. Zhen Zhu Mu provides heavy, mineral-based anchoring that subdues rising Liver Yang and settles the restless spirit. Together, one nourishes softly while the other anchors firmly, complementing the King herb's Blood-level actions from two different angles.

Assistant herbs

The Yin-nourishing group of Nu Zhen Zi, Mo Han Lian, Sheng Di Huang, and Tu Si Zi addresses the root deficiency. Nu Zhen Zi and Mo Han Lian form the classical Er Zhi Wan pairing to replenish Liver and Kidney Yin. Sheng Di Huang (raw Rehmannia, which is cool-natured and Heat-clearing, not the warm prepared form) cools the Blood while nourishing Yin. Tu Si Zi supports the Kidney foundation in a balanced, gentle way. Wu Wei Zi serves as a restraining assistant, its sour astringent nature preventing further loss of Yin fluids and containing the restless spirit. He Huan Pi acts as a reinforcing assistant by relieving emotional tension and worry that compound the sleep disturbance.

Envoy herbs

Shi Chang Pu uses its aromatic, penetrating quality to open the Heart orifices and ensure the formula's heavier nourishing substances reach their target. It balances the overall composition by adding upward, dispersing movement to what is otherwise a predominantly descending, anchoring formula. It also directly addresses tinnitus and mental fogginess.

Notable synergies

Dan Shen and Shou Wu Teng together address the Heart from complementary angles: Dan Shen clears Heat and moves Blood while Shou Wu Teng gently nourishes and calms, creating a balanced approach to Heart spirit disturbance. Nu Zhen Zi and Mo Han Lian (the Er Zhi Wan pair) synergistically replenish Liver and Kidney Yin far more effectively together than either alone. Zhen Zhu Mu and Shi Chang Pu balance each other: the heavy mineral anchors and descends while the aromatic herb lifts and opens, preventing the formula from becoming overly cloying or heavy.

How to Prepare

Traditional preparation instructions for An Shen Bu Xin Wan

The formula is manufactured as a concentrated water pill (浓缩水丸). The preparation involves two distinct stages:

An Shen Gao (安神膏, Spirit-Calming Paste): He Huan Pi, Tu Si Zi, and Mo Han Lian (3 parts each), Nu Zhen Zi steamed (4 parts), Shou Wu Teng (5 parts), Sheng Di Huang (2 parts), and Zhen Zhu Mu (20 parts) are combined and decocted in water twice: the first decoction for 3 hours, the second for 1 hour. The decoctions are combined, filtered, and concentrated to a relative density of 1.21 at 80-85°C.

Final pill formation: Dan Shen (300g), Wu Wei Zi steamed (150g), and Shi Chang Pu (100g) are ground into fine powder, then mixed with 560g of An Shen Gao. The mixture is formed into pills, dried, and polished or coated with sugar. Standard dosage is 15 pills three times daily, taken orally with warm water.

Common Modifications

How practitioners adapt An Shen Bu Xin Wan for specific situations

Added
Suan Zao Ren

9-15g, nourishes Heart Yin and calms spirit

Bai Zi Ren

9-12g, nourishes Heart Blood and calms the mind

Suan Zao Ren and Bai Zi Ren are the most important Heart-nourishing sedative herbs in TCM. Adding them strengthens the formula's direct spirit-calming action for cases where insomnia is the dominant complaint.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where An Shen Bu Xin Wan should not be used or requires extra caution

Avoid

External pathogenic invasion with fever (colds, flu, acute infections). The nourishing, inward-directing nature of this formula can trap pathogens inside the body.

Avoid

Excess-type insomnia caused by Phlegm-Fire, Liver Fire, or Food Stagnation. This formula is designed for deficiency patterns and will not address the root cause of excess conditions.

Caution

Pregnancy. Dan Shen (Salvia root) activates Blood circulation, which poses a theoretical risk during pregnancy.

Caution

Spleen and Stomach deficiency with poor digestion, loose stools, or poor appetite. The formula contains several Yin-nourishing and cloying herbs (Di Huang, Nu Zhen Zi) that may burden a weak digestive system.

Caution

Patients taking anticoagulant or antiplatelet medications (e.g. warfarin, aspirin, clopidogrel). Dan Shen has documented anticoagulant and antiplatelet properties that may potentiate bleeding risk.

Avoid

Known allergy or hypersensitivity to any of the formula's ingredients.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Dan Shen (Salvia miltiorrhiza root) is the chief herb and has known Blood-activating properties, which raises a theoretical risk of stimulating uterine contractions or promoting bleeding. The official Chinese Pharmacopoeia label advises that pregnant women should take this formula only under the guidance of a physician. It is not classified as absolutely contraindicated, but most sources recommend caution or avoidance during pregnancy unless the benefit clearly outweighs the risk.

Breastfeeding

The official Chinese Pharmacopoeia label advises that breastfeeding women should use this formula under the guidance of a physician. Dan Shen (Salvia miltiorrhiza) and He Shou Wu-derived Shou Wu Teng (Polygonum multiflorum vine) are the primary herbs of concern. While no specific adverse effects on nursing infants have been documented, the potential for active compounds to pass into breast milk has not been formally studied. He Shou Wu-related herbs have been associated with rare hepatotoxicity in adults, so caution is warranted. Breastfeeding mothers should consult a qualified practitioner before use.

Children

The official label states that children must use this formula under the guidance of a physician and with adult supervision. No specific pediatric dosage is established in the Chinese Pharmacopoeia for this patent medicine. It is generally not recommended for young children (under 6 years) without professional assessment. For older children and adolescents, practitioners may reduce the standard adult dose by approximately one-third to one-half, but this should be determined on a case-by-case basis. If symptoms do not improve within 7 days of use, medical consultation is recommended.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with An Shen Bu Xin Wan

Anticoagulant and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Dan Shen (Salvia miltiorrhiza) is the chief herb in this formula and has well-documented anticoagulant, antiplatelet, and fibrinolytic properties. Its active compounds (tanshinones, salvianolic acids) can potentiate the effects of blood-thinning medications, increasing the risk of bleeding. Concurrent use requires close monitoring of coagulation parameters (INR).

CYP450-metabolised drugs: Research has shown that Dan Shen's active components (particularly tanshinone IIA and cryptotanshinone) can inhibit or induce several cytochrome P450 enzymes, including CYP1A2, CYP3A4, and CYP2C9. This may alter the plasma levels of drugs metabolised through these pathways, such as certain statins, calcium channel blockers, and benzodiazepines.

Sedative and hypnotic medications: Wu Wei Zi (Schisandra) and several other herbs in this formula have documented central nervous system depressant effects. Concurrent use with benzodiazepines, Z-drugs (e.g. zolpidem), barbiturates, or other sedatives may produce additive sedation.

Digoxin: Dan Shen has been reported to increase serum digoxin levels in some cases. Patients on cardiac glycosides should exercise caution and have their drug levels monitored.

Usage Guidance

Practical advice for getting the most out of An Shen Bu Xin Wan

Best time to take

Three times daily with warm water, ideally 30 minutes after meals. The evening dose may be taken 1-2 hours before bedtime for best sleep-promoting effect.

Typical duration

Commonly taken for 2-4 weeks initially. If no improvement within 7 days, medical re-evaluation is recommended. May be used for 1-3 months under practitioner guidance for chronic insomnia.

Dietary advice

Avoid alcohol, tobacco, and spicy, greasy, or heavily seasoned foods while taking this formula, as these can generate internal Heat and counteract its Yin-nourishing, spirit-calming effects. Favour calming, Yin-nourishing foods such as lotus seeds, lily bulb (bai he), Chinese dates (da zao), mulberries, black sesame, walnuts, millet porridge, and congee. Avoid strong tea, coffee, and other stimulants, especially in the evening, as they agitate the Shen and work against the formula's sedative action. Eat light, easily digestible meals at dinner time. Heavy meals before bed can generate Phlegm-Heat and disturb sleep.

An Shen Bu Xin Wan originates from Zhong Yao Zhi Ji Shou Ce (中药制剂手册, Handbook of Chinese Medicine Preparations); later standardized in the Chinese Pharmacopoeia (中华人民共和国药典) Modern formula (contemporary, 20th century)

Classical Texts

Key passages from the classical Chinese medical texts that first described An Shen Bu Xin Wan and its clinical use

An Shen Bu Xin Wan is a modern Chinese patent medicine (中成药) rather than a classical formula from the ancient texts. It is recorded in the Chinese Pharmacopoeia (中国药典) and the earlier Zhong Yao Zhi Ji Shou Ce (中药制剂手册, Handbook of Chinese Medicine Preparations). There are no classical quotes from historical texts directly associated with this formula.

However, the therapeutic strategy it embodies draws on classical principles. The concept that Heart Blood insufficiency and deficiency Fire disturbing the spirit leads to insomnia and palpitations is discussed throughout foundational texts. The Su Wen states: 「血气者,人之神」 ("Blood and Qi are the foundation of a person's spirit"), reflecting the classical understanding that an adequate supply of Blood to the Heart is essential for peaceful sleep and a calm mind.

Historical Context

How An Shen Bu Xin Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

An Shen Bu Xin Wan is a modern Chinese patent medicine (中成药) rather than an ancient classical formula. It first appeared in the Zhong Yao Zhi Ji Shou Ce (中药制剂手册, Handbook of Chinese Medicine Preparations), a mid-20th century reference work that standardised many traditional herbal preparations for modern pharmaceutical production. It was subsequently included in the Chinese Pharmacopoeia (中华人民共和国药典), where its standardised composition and quality control specifications are officially recorded.

The formula represents a synthesis of classical principles rather than a single classical source. Its strategy of nourishing Heart Blood and Yin while calming the Shen draws on the same therapeutic lineage as famous classical formulas like Tian Wang Bu Xin Dan (Heavenly Emperor's Heart-Tonifying Elixir). However, An Shen Bu Xin Wan uses a distinct composition with a unique manufacturing method: several of its herbs (He Huan Pi, Tu Si Zi, Mo Han Lian, Shou Wu Teng, Di Huang, Zhen Zhu Mu, and Nu Zhen Zi) are first concentrated into a thick paste called An Shen Gao (安神膏, Spirit-Calming Paste), which is then combined with powdered Dan Shen, Wu Wei Zi, and Shi Chang Pu to form the pills. This two-stage processing reflects modern Chinese pharmaceutical innovation applied to traditional herbal principles.

The formula became one of the most widely used over-the-counter (OTC) Chinese patent medicines for insomnia and anxiety in China, classified as an OTC Category A medicine under the national drug regulatory system.