Qi Ju Di Huang Wan

Lycium Fruit, Chrysanthemum and Rehmannia Pill · 杞菊地黄丸

Also known as: Lycii Chrysanthemum Rehmannia Pills, Qi Ju Di Huang Wan

A classical formula that nourishes the Liver and Kidneys to support eye health and clear vision. It is used for blurred vision, dry eyes, sensitivity to light, excessive tearing in wind, dizziness, and ringing in the ears caused by Liver and Kidney Yin deficiency. Built on the famous Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) with the addition of goji berry and chrysanthemum flower for their vision-supporting properties.

Origin Yi Ji Bao Jian (医级宝鉴) by Dong Xiyuan (董西园) — Qīng dynasty (清代)
Composition 8 herbs
Shu Di huang
King
Shu Di huang
Gou Qi Zi
Deputy
Gou Qi Zi
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Ju Hua
Assistant
Ju Hua
Ze Xie
Assistant
Ze Xie
Mu Dan Pi
Assistant
Mu Dan Pi
Fu Ling
Assistant
Fu Ling
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qi Ju Di Huang Wan is designed to correct these specific patterns.

Why Qi Ju Di Huang Wan addresses this pattern

This is the primary pattern for which Qi Ju Di Huang Wan was designed. When Kidney Yin is depleted, it fails to nourish the Liver (its 'child' organ in five-element theory). Since the Liver 'opens to the eyes' and Liver Blood and Yin are essential for visual clarity, this combined deficiency manifests prominently in the eyes: blurred vision, dry eyes, light sensitivity, and tearing in wind. The formula directly replenishes Kidney Yin with Shu Di Huang and Shan Zhu Yu, nourishes the Liver with Gou Qi Zi, and clears heat from the eyes with Ju Hua and Mu Dan Pi. The balanced 'three tonifying, three draining' architecture ensures replenishment without creating stagnation.

A practitioner would look for one or more of these signs

Blurry Vision

Gradual onset, worsening with fatigue or eye strain

Dry Eyes

Chronic dryness, gritty sensation

Photophobia

Sensitivity to light, difficulty in bright environments

Excessive Sweating

Tearing when exposed to wind (迎风流泪)

Dizziness

Chronic, mild dizziness or lightheadedness

Tinnitus

Ringing in the ears, often low-pitched

Lower Back Pain

Soreness and weakness in the lower back and knees

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qi Ju Di Huang Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, the eyes depend on nourishment from the Liver. The classical teaching 'the Liver opens to the eyes' (肝开窍于目) means that the health of the eyes reflects the condition of the Liver. When Liver Yin and Blood are sufficient, the eyes are moist, clear, and comfortable. When the Kidneys (the root source of Yin for the entire body) become depleted, they can no longer nourish the Liver, and the Liver in turn fails to moisten the eyes. This leads to chronic dryness, a gritty or sandy sensation, light sensitivity, and eye fatigue. The condition is often worsened by aging, excessive screen use, or chronic illness, all of which deplete Yin over time.

Why Qi Ju Di Huang Wan Helps

Qi Ju Di Huang Wan addresses dry eyes by replenishing the Yin at its deepest source. Shu Di Huang rebuilds Kidney Yin and Essence. Gou Qi Zi specifically nourishes the Liver and brightens the eyes. Shan Zhu Yu retains the Essence so it accumulates rather than leaking away. Ju Hua clears residual heat from the Liver channel that contributes to dryness. Modern research has shown that this formula can improve tear film stability and increase tear secretion markers, supporting its traditional use for eye dryness.

Also commonly used for

Blurry Vision

Gradual visual decline related to aging or overuse

Glaucoma

Chronic open-angle glaucoma as adjunctive support

Dizziness

Chronic dizziness from Liver-Kidney Yin deficiency

Tinnitus

Chronic tinnitus from Yin deficiency

Chronic Hepatitis

Chronic viral hepatitis with Liver-Kidney Yin deficiency pattern

Menopausal Symptoms

Perimenopausal symptoms with Yin deficiency features

Diabetes

As adjunctive support when Yin deficiency is the underlying pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qi Ju Di Huang Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qi Ju Di Huang Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qi Ju Di Huang Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qi Ju Di Huang Wan works at the root level.

The core problem this formula addresses is a depletion of Yin in both the Liver and the Kidneys, with symptoms that particularly affect the eyes and head. In TCM, the Kidneys store Essence and are the root of Yin for the entire body. The Liver stores Blood and governs the free flow of Qi. These two organs share a close relationship: in Five Phase theory, the Kidneys (Water) nourish the Liver (Wood), and Kidney Essence and Liver Blood are mutually generating. When Kidney Yin becomes depleted, it can no longer nourish the Liver, leading to a dual deficiency of Liver and Kidney Yin.

Because the Liver "opens to the eyes" (肝开窍于目), the eyes depend on adequate Liver Blood and Yin for moisture, nourishment, and clear vision. When Liver Yin is insufficient, the eyes become dry, sensitive to light, and vision grows blurry. Furthermore, when Yin is weak, it fails to anchor Yang, allowing Liver Yang to rise unchecked. This rising Yang produces dizziness, headache, and tinnitus. In some cases, mild deficiency Heat also develops, as Yin can no longer keep the body's warming functions in check.

The formula addresses this entire cascade: it replenishes Kidney Yin at the root, nourishes the Liver to restore moisture and Blood supply to the eyes, gently clears any rising Heat or Yang, and stabilizes the relationship between the two organs so that the eyes and head are properly nourished again.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and slightly sour, with subtle bitter notes. Sweet to tonify and nourish, sour to astringe Essence, and mildly bitter to clear Heat from the Liver.

Channels Entered

Ingredients

8 herbs

The herbs that make up Qi Ju Di Huang Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 24g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Qi Ju Di Huang Wan

Strongly nourishes Kidney Yin, replenishes Essence (Jing), and tonifies the Blood. As the heaviest herb by dosage in the formula, it anchors the entire prescription by addressing the root cause: Kidney Yin deficiency. By filling the Kidney Essence, it provides the foundation for nourishing the Liver and eyes.
Deputies — Assists and enhances the King
Gou Qi Zi

Gou Qi Zi

Goji berries

Dosage 9 - 15g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Qi Ju Di Huang Wan

Nourishes and tonifies both the Liver and Kidneys, benefits the Essence, and brightens the eyes. It reinforces the King herb's Yin-nourishing action while adding a specific affinity for the Liver and eyes, making it one of the two key additions that distinguish this formula from Liu Wei Di Huang Wan.
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 12g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver
Preparation Prepared with wine (酒萸肉) to enhance its warming, Liver-nourishing action

Role in Qi Ju Di Huang Wan

Nourishes the Liver and Kidneys and restrains the leakage of Essence. Its astringent nature helps prevent Kidney Essence from draining away, enabling the tonic effect of Shu Di Huang to accumulate. It also supports the Liver, complementing Gou Qi Zi.
Shan Yao

Shan Yao

Yam

Dosage 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Qi Ju Di Huang Wan

Tonifies the Spleen and consolidates the Kidneys. The Spleen is the source of postnatal Essence, so strengthening it ensures a steady supply of nourishment to replenish Kidney Yin. It stabilizes the Essence and supports digestion so the rich tonic herbs are properly absorbed.
Assistants — Supports or moderates other herbs
Ju Hua

Ju Hua

Chrysanthemum flowers

Dosage 9 - 10g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Liver, Lungs

Role in Qi Ju Di Huang Wan

Clears the Liver, calms Liver Yang, disperses wind-heat, and brightens the eyes. It is the second key addition distinguishing this formula. While the other herbs nourish from below (tonifying Yin), Ju Hua works from above, gently clearing heat and excess from the head and eyes. Its cool, light nature balances the rich, heavy tonic herbs.
Ze Xie

Ze Xie

Water plantain

Dosage 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Qi Ju Di Huang Wan

Drains Kidney turbidity and leaches dampness. It prevents the rich, cloying nature of Shu Di Huang from causing stagnation in the Kidneys, which could generate more deficiency heat. Paired with Shu Di Huang, it ensures that tonification does not lead to congestion.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Qi Ju Di Huang Wan

Clears deficiency heat from the Liver and cools the Blood. It moderates the warming, astringent nature of Shan Zhu Yu, preventing that herb from generating excess heat. It also directly addresses any Liver fire that may be contributing to eye symptoms.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Qi Ju Di Huang Wan

Strengthens the Spleen and drains dampness. It supports Shan Yao in fortifying the Spleen while preventing fluid accumulation from the heavy tonic herbs. Together with Ze Xie and Mu Dan Pi, it forms the 'three draining' component that keeps the formula balanced and prevents stagnation.

Why This Combination Works

How the herbs in Qi Ju Di Huang Wan complement each other

Overall strategy

This formula addresses Liver and Kidney Yin deficiency at its root while simultaneously clearing the eyes and head. It builds on the time-tested 'three tonifying, three draining' (三补三泻) architecture of Liu Wei Di Huang Wan, adding Gou Qi Zi and Ju Hua to specifically target the Liver-eye axis.

King herb

Shu Di Huang (Prepared Rehmannia) serves as the sole King herb, used in the largest dose. It powerfully enriches Kidney Yin and replenishes Essence, addressing the root deficiency that underlies all the symptoms. Since the Kidneys are the 'mother' of the Liver in five-element theory, restoring Kidney Yin automatically provides the foundation for nourishing Liver Yin and, by extension, the eyes.

Deputy herbs

Gou Qi Zi (Goji Berry) nourishes both the Liver and Kidneys, benefits the Essence, and has a long-established reputation for brightening the eyes. It directly reinforces the King herb while targeting the Liver, bridging the gap between Kidney nourishment and eye support. Shan Zhu Yu (Cornus) nourishes the Liver and Kidneys and, crucially, uses its astringent quality to prevent Essence from leaking away, allowing the tonic effect to build up. Shan Yao (Chinese Yam) stabilizes the system from the Spleen side, ensuring the postnatal source of nourishment functions well enough to sustain the formula's replenishing work.

Assistant herbs

Ju Hua (Chrysanthemum) is a reinforcing assistant that clears Liver heat and calms rising Liver Yang, directly relieving eye symptoms like light sensitivity, blurred vision, and tearing. Its cool, light, ascending nature complements the heavy, descending tonic herbs. Ze Xie (Alisma) is a restraining assistant that drains Kidney turbidity and dampness, counteracting the heavy, cloying nature of Shu Di Huang to prevent fluid stagnation. Mu Dan Pi (Tree Peony Bark) is also a restraining assistant that clears deficiency fire from the Liver and cools the Blood, tempering the warming tendency of Shan Zhu Yu. Fu Ling (Poria) reinforces the Spleen alongside Shan Yao while draining dampness, ensuring the rich tonic herbs do not bog down digestion.

Notable synergies

The Gou Qi Zi and Ju Hua pairing is the signature of this formula. Gou Qi Zi nourishes from the Yin side (enriching Liver and Kidney substance), while Ju Hua clears from the Yang side (dispersing Liver heat and calming the eyes). Together they achieve what neither does alone: simultaneously replenishing and clearing the eyes. The 'three tonifying' herbs (Shu Di Huang, Shan Zhu Yu, Shan Yao) and 'three draining' herbs (Ze Xie, Mu Dan Pi, Fu Ling) are an elegant balanced pair inherited from Liu Wei Di Huang Wan, ensuring that tonification does not create stagnation and that draining does not weaken further.

How to Prepare

Traditional preparation instructions for Qi Ju Di Huang Wan

The traditional preparation is as a honey pill (蜜丸). The eight herbs are ground into a fine powder and sifted. For water-honey pills, mix every 100g of powder with 35–50g of refined honey and an appropriate amount of water, form into small pills, and dry. For large honey pills, mix with 80–110g of refined honey per 100g of powder, and form into pills weighing 9g each.

Standard adult dosage for large honey pills is one pill (9g), taken twice daily on an empty stomach with warm water. For water-honey pills, the standard dose is approximately 6g (about 60 small pills), twice daily. The formula is also available in modern concentrated pill, capsule, tablet, and oral liquid forms.

When used as a decoction (汤剂), the standard proportions are: Shu Di Huang 24g, Shan Zhu Yu 12g, Shan Yao 12g, Ze Xie 9g, Mu Dan Pi 9g, Fu Ling 9g, Gou Qi Zi 9–15g, Ju Hua 9–10g. Decoct with water and take in two divided doses daily.

Common Modifications

How practitioners adapt Qi Ju Di Huang Wan for specific situations

Added
Niu Xi

6–12g, strengthens the lower back and knees, guides the formula downward to the Kidneys

Du Zhong

9–12g, tonifies the Liver and Kidneys, strengthens sinews and bones

When lower back and knee weakness is a dominant complaint, adding these two herbs reinforces the Kidney-tonifying action and specifically strengthens the lumbar region and lower limbs.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qi Ju Di Huang Wan should not be used or requires extra caution

Caution

Spleen and Stomach Yang deficiency with loose stools or diarrhea. The formula's rich, Yin-nourishing herbs (especially Shu Di Huang) are cloying and can further impair an already weak digestive system.

Avoid

Active exterior pattern (common cold, flu, fever). Tonifying and enriching herbs can trap the pathogen inside the body and worsen or prolong the illness. The formula should be suspended until the exterior condition resolves.

Avoid

Kidney Yang deficiency presenting with cold limbs, pallor, profuse clear urination, and cold low back. This formula is designed for Yin deficiency patterns and would further deplete Yang if used inappropriately.

Caution

Dampness or Phlegm accumulation with heavy limbs, a greasy tongue coat, and poor appetite. The rich, moistening nature of Shu Di Huang may worsen Dampness.

Avoid

Known allergy or hypersensitivity to any ingredient in the formula.

Caution

Patients with severe chronic conditions (hypertension, heart disease, liver disease, diabetes, kidney disease) should only use this formula under professional medical supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe in standard doses, but should only be used during pregnancy under professional guidance. The formula contains no strongly moving, Blood-breaking, or uterine-stimulating herbs. However, the cloying nature of Shu Di Huang (prepared Rehmannia) may aggravate nausea or digestive sluggishness common in pregnancy. Mu Dan Pi (tree peony bark) has mild Blood-cooling and Blood-moving properties, which warrants caution in pregnancy, though at the dosages used in this formula the risk is low. Official Chinese OTC labeling states that pregnant women should use this product under physician guidance.

Breastfeeding

Generally considered compatible with breastfeeding at standard doses, but official labeling recommends use under physician guidance for nursing mothers. The formula's ingredients are gentle, nourishing herbs with a long history of safe use. No specific concerns about transfer of harmful substances through breast milk have been documented. The rich, Yin-nourishing quality of the formula may even theoretically support postpartum recovery. However, the cloying nature of Shu Di Huang could potentially reduce appetite or cause digestive discomfort in sensitive individuals, which might indirectly affect milk production if nutrition intake is impaired.

Children

This formula was originally derived from Liu Wei Di Huang Wan, which was itself created by the Song Dynasty pediatrician Qian Yi specifically for children. Qi Ju Di Huang Wan can be used in children, but official labeling states that children should take it under physician guidance and adult supervision. Dosage should be reduced according to the child's age and body weight: roughly one-quarter to one-third of the adult dose for children aged 3-6, and one-half for children aged 7-14. The honey pill form may need to be broken into smaller pieces for younger children. The formula is not typically used in infants or very young children (under age 3) without specific professional recommendation. Young patients presenting with eye strain from excessive screen use may benefit from this formula if a Yin deficiency pattern is confirmed.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qi Ju Di Huang Wan

Official Chinese pharmacopeia labeling states that drug interactions for Qi Ju Di Huang Wan are "not yet clearly established" (尚不明确). However, based on the pharmacological properties of its individual herbs, the following theoretical interactions merit awareness:

  • Antihypertensive medications: The formula has demonstrated blood-pressure-lowering effects in clinical studies. When combined with antihypertensive drugs (ACE inhibitors, calcium channel blockers, beta-blockers), an additive hypotensive effect is possible. Blood pressure should be monitored if used concurrently.
  • Hypoglycemic agents: Several ingredients (particularly Shan Yao and Gou Qi Zi) may have mild blood-sugar-lowering effects. Diabetic patients on insulin or oral hypoglycemics should monitor blood glucose levels.
  • Anticoagulant and antiplatelet drugs: Mu Dan Pi (tree peony bark) has mild Blood-activating properties. While the effect at standard formula doses is minor, caution is advisable when combined with warfarin, heparin, or antiplatelet agents.
  • Diuretics: Ze Xie and Fu Ling both promote urination. Concurrent use with pharmaceutical diuretics could theoretically enhance fluid loss.

Patients taking any prescription medications should consult their healthcare provider before adding this formula.

Usage Guidance

Practical advice for getting the most out of Qi Ju Di Huang Wan

Best time to take

Twice daily, ideally 30-60 minutes after meals to reduce any digestive heaviness from the rich, Yin-nourishing herbs. Some classical sources recommend taking it in the evening, as Yin-nourishing formulas align with the body's natural evening Yin cycle.

Typical duration

Often taken for 4-8 weeks as an initial course, then reassessed. As a gentle tonic formula, it may be used long-term (months) for chronic Yin deficiency conditions under practitioner guidance. If symptoms do not improve after 4 weeks, seek professional evaluation.

Dietary advice

Avoid foods that are hard to digest, greasy, or overly rich, as these can impair absorption and worsen the formula's tendency toward cloying dampness. Cold and raw foods (ice cream, cold salads, raw fish) should be minimized, as they can weaken the Spleen's digestive function and counteract the formula's nourishing effects. Spicy, hot foods (chili peppers, strong alcohol, deep-fried foods) should also be limited, as they generate Heat and can aggravate the underlying Yin deficiency. Foods that support the formula's action include dark leafy greens, goji berries, black sesame seeds, walnuts, mulberries, chrysanthemum tea, and dark-colored fruits like blueberries and blackberries. These foods nourish Liver Blood and Kidney Essence. Adequate hydration is important for supporting Yin.

Qi Ju Di Huang Wan originates from Yi Ji Bao Jian (医级宝鉴) by Dong Xiyuan (董西园) Qīng dynasty (清代)

Classical Texts

Key passages from the classical Chinese medical texts that first described Qi Ju Di Huang Wan and its clinical use

《医级宝鉴·卷八》(Yī Jí Bǎo Jiàn, Volume 8) by Dong Xiyuan (董西园), Qing Dynasty:

This is the original source text for Qi Ju Di Huang Wan. The formula was recorded for the treatment of Liver and Kidney insufficiency with unclear vision (肝肾不足,视物不清). The text prescribed the base of Liu Wei Di Huang Wan with the addition of Gou Qi Zi (wolfberry) and Ju Hua (chrysanthemum) to strengthen the formula's ability to nourish the Liver, brighten the eyes, and clear Liver Heat.

Related classical principle:

「肝开窍于目,肝受血而能视」
"The Liver opens to the eyes; when the Liver receives Blood, it enables vision."

This classical teaching, reflected across multiple foundational texts, explains why eye disorders in TCM are so often treated through the Liver and Kidney systems. It forms the theoretical foundation for Qi Ju Di Huang Wan's clinical application.

Historical Context

How Qi Ju Di Huang Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qi Ju Di Huang Wan has its roots in one of the most celebrated formula lineages in Chinese medicine. The story begins with Zhang Zhongjing's Shen Qi Wan (Kidney Qi Pill) from the Jin Gui Yao Lue (Han Dynasty), which used eight herbs including warming agents Fu Zi (aconite) and Rou Gui (cinnamon bark) to treat Kidney Yang deficiency. Centuries later, the Song Dynasty pediatrician Qian Yi (钱乙) modified this formula for children by removing the two warming herbs, reasoning that children have abundant Yang and do not need additional warming. This created Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill), recorded by his student Yan Xiaozhong in the Xiao Er Yao Zheng Zhi Jue (Key to Therapeutics of Children's Diseases).

The addition of Gou Qi Zi and Ju Hua to Liu Wei Di Huang Wan has a complex textual history. An early precursor appeared in the Ming Dynasty text Shen Shi Yao Han (審視瑶函), which described a "modified Liu Wei Di Huang Wan" with four additional herbs including Gou Qi Zi and Ju Hua plus Wu Wei Zi and Ji Li. The Qing Dynasty text Ma Zhen Quan Shu (麻疹全书) later streamlined this to just Gou Qi Zi and Ju Hua, calling it "Qi Ju Liu Wei Wan." The formula as it is known today, under the name Qi Ju Di Huang Wan (or Qi Ju Di Huang Tang as a decoction), was formally established in the Qing Dynasty physician Dong Xiyuan's (董西园) Yi Ji (医级, also known as Yi Ji Bao Jian 医级宝鉴), where it was prescribed for Liver-Kidney insufficiency with blurred vision.

The renowned 20th-century physician Pu Fuzhou (蒲辅周), honored as a "National Medical Sage," documented a notable case of a 38-year-old woman with debilitating dizziness and fatigue diagnosed as Liver-Kidney Yin deficiency with Yang hyperactivity. He prescribed Qi Ju Di Huang Wan taken nightly alongside Sang Shen Gao (mulberry paste) in the morning. After six months of continuous use, the patient fully recovered, demonstrating the formula's value as a long-term tonic.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Qi Ju Di Huang Wan

1

Systematic Review: Chinese Herbal Medicine Qi Ju Di Huang Wan for Essential Hypertension (2013)

Wang J, Xiong X, Yang G, Zhang Y, Liu Y, Zhang Y, et al. Evidence-Based Complementary and Alternative Medicine, 2013, Volume 2013, Article ID 262685.

This systematic review included 10 randomized controlled trials with 1,024 patients total. The meta-analysis found that Qi Ju Di Huang Wan combined with standard antihypertensive drugs was more effective in lowering blood pressure and improving TCM symptom scores compared to antihypertensive drugs alone. However, the authors noted that the overall methodological quality of the included trials was low, with issues including lack of blinding and allocation concealment.

PubMed
2

RCT: Clinical Evaluation of Chi-Ju-Di-Huang-Wan for Dry Eye (2005)

Chang YH, Lin HJ, Li WC. Phytotherapy Research, 2005, 19(4): 349-354.

This randomized controlled trial included 80 dry eye patients divided into treatment (formula plus eye drops) and control (placebo plus eye drops) groups. Results showed a significant improvement in Rose Bengal test scores at week 2 and tear break-up time at week 4 in the treatment group. The study concluded that the formula is an effective stabilizer of tear film and reduces corneal epithelium abnormalities.

3

Systems Pharmacology Study: Mechanism of Qiju Dihuang Pill in Ophthalmic Diseases (2022)

Medicine (Baltimore), 2022, 101(31).

This computational study used systems pharmacology approaches (ADME screening, drug targeting, molecular docking, and GO/KEGG enrichment analysis) to investigate the active ingredients and molecular mechanisms of the formula in treating ophthalmic diseases including glaucoma and cataracts. The analysis identified multiple potential active compounds and biological targets, suggesting the formula works through multiple anti-inflammatory and neuroprotective pathways.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.