Zhi Bao Dan

Greatest Treasure Special Pill · 至寶丹

Also known as: Ju Fang Zhi Bao Dan (局方至宝丹), Greatest Treasure Pellet

A powerful emergency formula used to revive consciousness in people who have become unresponsive due to high fever with heavy Phlegm blocking the mind. It belongs to the famous 'Three Treasures' of Chinese emergency medicine, and is especially suited when the person is silent and unresponsive, with labored breathing and thick Phlegm. It clears Heat, cuts through turbid Phlegm, and opens the sensory orifices to restore awareness.

Origin Ling Yuan Fang (《灵苑方》) by Shen Kuo; later recorded in Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》) — Sòng dynasty, ~1078 CE
Composition 11 herbs
Shui Niu Jiao
King
Shui Niu Jiao
She Xiang
King
She Xiang
Niu Huang
Deputy
Niu Huang
An Xi Xiang
Deputy
An Xi Xiang
Bing Pian
Deputy
Bing Pian
Da Zao
Deputy
Da Zao
Xiong Huang
Assistant
Xiong Huang
Zhu Sha
Assistant
Zhu Sha
+3
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Bao Dan is designed to correct these specific patterns.

Why Zhi Bao Dan addresses this pattern

This is the primary pattern Zhi Bao Dan addresses. When intense Heat consolidates body fluids into thick, turbid Phlegm, and this Phlegm blocks the Pericardium (the Heart's protective envelope through which the mind connects to the outside world), consciousness is lost. The person becomes unresponsive and silent, with labored breathing, audible Phlegm in the throat, a red tongue with greasy yellow coating, and a slippery, rapid pulse.

Zhi Bao Dan tackles this pattern with its powerful trio of aromatic herbs (She Xiang, Bing Pian, An Xi Xiang) that cut through the Phlegm obstruction, while Shui Niu Jiao and Niu Huang clear the underlying Heat that generated the Phlegm. The heavy mineral sedatives (Zhu Sha, Hu Po, Jin Bo, Yin Bo) then stabilize the spirit once the pathway is cleared. This formula is considered the most appropriate of the 'Three Treasures' when the dominant feature is Phlegm obstruction causing speechlessness and silence, rather than extreme high fever (where An Gong Niu Huang Wan would be preferred) or convulsions (where Zi Xue Dan would be chosen).

A practitioner would look for one or more of these signs

Loss Of Consciousness

Sudden loss of consciousness with no speech, the hallmark 'silent' presentation

Delirium

Incoherent mumbling or complete inability to speak

Fever

High fever with restlessness and agitation

Excessive Phlegm

Profuse Phlegm with coarse, labored breathing, possibly audible gurgling in the throat

Seizures

May accompany loss of consciousness in severe cases

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhi Bao Dan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM views acute stroke with sudden loss of consciousness as a condition where internal Wind stirs up, driving Phlegm and Heat upward to block the Heart's orifices. The Pericardium, which acts as the gatekeeper of the mind, becomes obstructed by thick, turbid Phlegm generated by intense Heat. This produces the 'closed' pattern (bi zheng): the person is unresponsive, the jaw may be clenched, fists closed, and breathing is coarse with audible Phlegm. The Liver and Heart are the primary organ systems involved, with Liver Wind rising and Heart orifices becoming blocked.

Why Zhi Bao Dan Helps

Zhi Bao Dan is used as emergency first aid during the acute 'closed' phase of stroke. She Xiang (musk) powerfully penetrates the Phlegm obstruction to reopen the blocked orifices and restore some degree of consciousness. Shui Niu Jiao (water buffalo horn) and Niu Huang (ox gallstone) clear the Heat and toxins that are driving the crisis. Dai Mao helps calm the internal Wind component. The heavy minerals Zhu Sha and Hu Po stabilize the spirit. This formula is specifically chosen over An Gong Niu Huang Wan when the stroke presentation features prominent Phlegm (coarse breathing, gurgling) with relatively less extreme fever, and the patient is notably silent and unresponsive rather than delirious.

Also commonly used for

Seizures

Seizure disorders with Phlegm-Heat pattern, including febrile seizures in children

Meningitis

Acute meningitis with fever, Phlegm, and altered consciousness

Hepatic Encephalopathy

Liver failure-related coma with Phlegm-Heat features

Epilepsy

Acute epileptic episodes with Phlegm-Heat pattern

Fever

Dangerously high fevers in infectious disease with impaired consciousness

Dysentery

Toxic dysentery with altered mental status

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhi Bao Dan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhi Bao Dan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhi Bao Dan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhi Bao Dan works at the root level.

Zhi Bao Dan addresses a critical condition in which intense pathogenic Heat has penetrated deep into the body and entered the Pericardium (the protective envelope around the Heart), while simultaneously causing body fluids to congeal into thick Phlegm. This combination of Phlegm and Heat blocks the orifices of the Heart, which in TCM is the organ that houses the spirit and governs consciousness. When the Heart's orifices become obstructed, the spirit has no clear passage through which to function, resulting in sudden loss of consciousness, inability to speak, delirium, and agitation.

The mechanism typically unfolds during severe febrile diseases (warm diseases or "Wen Bing"), stroke, heatstroke, or childhood convulsions. As intense Heat blazes within, it scorches and concentrates normal body fluids into thick, turbid Phlegm. This Phlegm, driven inward by the Heat, clogs the pathways to the Heart. The tongue turns red, the coating becomes yellow and greasy, and breathing becomes coarse with audible Phlegm. Among the "Three Treasures" of cooling orifice-opening formulas, Zhi Bao Dan is distinguished by its strength in aromatic orifice-opening and turbidity-transforming action, making it most suited when Phlegm turbidity is the dominant obstruction and the patient becomes mute and unresponsive rather than wildly delirious.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly aromatic and bitter with mineral heaviness — aromatic to penetrate orifices and dispel turbidity, bitter to clear Heat and resolve toxins, heavy mineral substances to anchor and settle the spirit.

Ingredients

11 herbs

The herbs that make up Zhi Bao Dan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 30g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Ground into fine powder

Role in Zhi Bao Dan

Clears Heat from the Heart and Nutritive level, cools the Blood, and resolves toxins. As a King herb, it directly addresses the core pathomechanism of intense Heat invading the Pericardium.
She Xiang

She Xiang

Musk

Dosage 3g (0.3g in modern preparations)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Liver, Spleen
Preparation Ground separately; do not heat

Role in Zhi Bao Dan

Powerfully aromatic, it penetrates through turbid Phlegm to open the blocked orifices and restore consciousness. As a co-King herb, it directly addresses the critical symptom of unconsciousness.
Deputies — Assists and enhances the King
Niu Huang

Niu Huang

Ox gallstone (cow bezoar)

Dosage 15g (1.5g in modern preparations)
Temperature Cool
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver
Preparation Ground separately into fine powder

Role in Zhi Bao Dan

Assists Shui Niu Jiao in clearing Heart Heat and resolving toxins, while also helping She Xiang open the orifices by clearing away Phlegm. Bridges both the heat-clearing and orifice-opening strategies.
An Xi Xiang

An Xi Xiang

Benzoin resin

Dosage 45g raw, processed to ~30g paste
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Preparation Dissolved in grain wine, filtered, then slowly simmered into a paste

Role in Zhi Bao Dan

Aromatic yet mild (not as harsh or drying as other aromatics), it dispels foul turbidity and opens the orifices. Combined with She Xiang and Bing Pian, the three aromatics powerfully cut through Phlegm obstruction.
Bing Pian

Bing Pian

Borneol

Dosage 3g (0.3g in modern preparations)
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Spleen, Lungs
Preparation Ground separately; do not heat

Role in Zhi Bao Dan

Highly aromatic, opens the sensory orifices and clears away turbid foulness. Works synergistically with She Xiang and An Xi Xiang to form a trio of orifice-opening aromatics.
Da Zao

Da Zao

Chinese date (Jujube fruit)

Dosage 30g
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Preparation Ground into fine powder

Role in Zhi Bao Dan

Clears Heat, resolves toxins, calms the Liver, and settles Wind tremors and convulsions. Reinforces Shui Niu Jiao's heat-clearing action while adding a sedative, spirit-calming effect.
Assistants — Supports or moderates other herbs
Xiong Huang

Xiong Huang

Realgar

Dosage 30g (3g in modern preparations)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Stomach, Large Intestine
Preparation Water-flown (水飞) into ultrafine powder to reduce toxicity

Role in Zhi Bao Dan

Cuts through stubborn Phlegm and resolves toxins. Adds a secondary Phlegm-dissolving action that supports the aromatic orifice-openers from a different angle.
Zhu Sha

Zhu Sha

Cinnabar

Dosage 30g (3g in modern preparations)
Temperature Cool
Taste Sweet (甘 gān)
Organ Affinity Heart
Preparation Water-flown (水飞) into ultrafine powder to reduce toxicity

Role in Zhi Bao Dan

Heavy mineral that enters the Heart to weigh down and calm the restless spirit. Provides sedation and helps stabilize consciousness once the orifices are reopened.
Hu Po

Hu Po

Amber

Dosage 30g (3g in modern preparations)
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Liver, Urinary Bladder

Role in Zhi Bao Dan

Calms the Heart and settles the spirit, with a secondary ability to invigorate Blood and disperse stasis. Complements Zhu Sha's sedative action.
Envoys — Directs the formula to its target
Jin Bo

Jin Bo

Gold foil

Dosage 50 sheets (half incorporated into formula, half as coating)
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver

Role in Zhi Bao Dan

Enters the Heart channel. Its heavy nature anchors and calms the spirit, directing the formula's action toward the Heart to settle restlessness after orifices are opened.
Jin Bo

Jin Bo

Gold foil

Dosage 50 sheets
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver

Role in Zhi Bao Dan

Complements Jin Bo in calming the Heart and settling the spirit. Together, the precious metal leaves direct and harmonize the formula's action on the Heart and mind.

Why This Combination Works

How the herbs in Zhi Bao Dan complement each other

Overall strategy

Zhi Bao Dan addresses a critical emergency: intense Heat has generated thick, turbid Phlegm that blocks the Pericardium (the Heart's protective envelope), causing loss of consciousness. The formula's strategy prioritizes aromatic orifice-opening to cut through the Phlegm blockage and restore awareness, while simultaneously clearing the underlying Heat and calming the spirit with heavy minerals.

King herbs

Shui Niu Jiao (water buffalo horn, substituting for the now-banned rhinoceros horn) is cool and salty, entering the Heart channel to clear intense Heat from the Nutritive level and resolve toxins. She Xiang (musk) is the most penetrating aromatic substance in TCM, able to cut through even the thickest Phlegm obstruction to reopen the sensory orifices. Together, these two Kings tackle both sides of the problem simultaneously: the Heat that generates Phlegm, and the blocked orifices that cause unconsciousness.

Deputy herbs

Niu Huang (ox gallstone) occupies a pivotal bridging role: it reinforces Shui Niu Jiao's ability to clear Heart Heat and resolve toxins, while also clearing Phlegm from the orifices alongside She Xiang. Dai Mao (hawksbill turtle shell) further assists in clearing Heat and calming internal Wind that may cause tremors or convulsions. An Xi Xiang (benzoin) and Bing Pian (borneol) are two additional aromatics that, together with the King herb She Xiang, form a triple aromatic combination of exceptional orifice-opening power. An Xi Xiang is notable for being fragrant yet relatively mild, avoiding the harsh drying tendency of some aromatics.

Assistant herbs

Xiong Huang (realgar) serves as a reinforcing assistant, attacking stubborn Phlegm and toxins from a mineral angle that the aromatic herbs cannot fully address. Zhu Sha (cinnabar) and Hu Po (amber) are restraining assistants: once the orifices are forced open and consciousness begins to return, these heavy sedative minerals stabilize the spirit and prevent agitation or delirium from rebounding.

Envoy herbs

Jin Bo (gold leaf) and Yin Bo (silver leaf) enter the Heart channel and use their heavy, settling quality to direct the entire formula toward the Heart and Pericardium. They anchor the spirit in its proper place after the aromatic herbs have cleared the pathway, harmonizing the formula's dual actions of opening and calming.

Notable synergies

The triple aromatic combination of She Xiang, Bing Pian, and An Xi Xiang produces an orifice-opening effect far greater than any single aromatic alone, as each penetrates turbidity through a different mechanism (animal, mineral, and plant-resin). The pairing of Shui Niu Jiao with Niu Huang combines two animal-origin substances that together clear Heat at both the Qi and Blood levels while resolving Phlegm. The heavy minerals (Zhu Sha, Hu Po, Jin Bo, Yin Bo) collectively counterbalance the formula's intensely ascending and dispersing aromatics, ensuring the spirit is settled rather than scattered after the orifices reopen.

How to Prepare

Traditional preparation instructions for Zhi Bao Dan

Grind Shui Niu Jiao (water buffalo horn) and Dai Mao (hawksbill turtle shell) into fine powder. Separately water-fly Zhu Sha (cinnabar) and Xiong Huang (realgar) into ultrafine powder. Dissolve An Xi Xiang (benzoin) in grain-based wine (without sediment), stir and allow to settle, filter to remove impurities, then slowly simmer the clear liquid over low heat until it forms a thick paste (original 45g reduces to approximately 30g of paste).

Combine all remaining powdered ingredients (Niu Huang, She Xiang, Bing Pian) thoroughly. Warm the An Xi Xiang paste in a double-boiler (water bath) until pliable, then incorporate all powdered ingredients and knead into a uniform mass. Form into pills the size of a Chinese parasol tree seed (approximately 3g each). Store in a tightly sealed, non-porous container.

Dosage: dissolve 3 to 5 pills (approximately 3g total) in a warm Ren Shen (ginseng) decoction and take by mouth. For children around two years old, administer 2 pills dissolved in ginseng decoction. Alternatively, pills may be dissolved in a small cup of warm children's urine mixed with 3 to 5 drops of fresh ginger juice for acute emergency use.

Common Modifications

How practitioners adapt Zhi Bao Dan for specific situations

Added
Gou Teng

12g, to extinguish internal Wind and stop tremors

Quan Xie

3g, a powerful Wind-extinguishing agent for severe convulsions

When Phlegm-Heat generates internal Wind causing convulsions, adding Wind-extinguishing herbs addresses this secondary symptom that the base formula's aromatics alone cannot fully control.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhi Bao Dan should not be used or requires extra caution

Avoid

Yin Deficiency with spirit disturbance (阴虚神昏): The formula contains many aromatic, drying substances that consume Yin and Body Fluids. It must not be used when unconsciousness is caused by Yin Deficiency rather than Phlegm-Heat obstruction.

Avoid

Pregnancy: The formula contains Musk (She Xiang), which strongly moves Qi and Blood and can stimulate uterine contractions, posing a risk of miscarriage. Cinnabar (Zhu Sha) and Realgar (Xiong Huang) also carry heavy-metal concerns for fetal development.

Avoid

Cold-type closure patterns (寒闭证): When unconsciousness is caused by Cold obstruction rather than Heat, this cooling formula is inappropriate. A warming orifice-opening formula such as Su He Xiang Wan should be considered instead.

Avoid

Collapsed patterns (脱证): When unconsciousness is accompanied by signs of collapse such as profuse sweating, open mouth, urinary incontinence, and fading pulse, the priority is to rescue Yang and consolidate the exterior, not to open the orifices.

Caution

Prolonged or unsupervised use: The formula contains Cinnabar (mercury sulfide) and Realgar (arsenic disulfide), which carry risks of cumulative heavy-metal toxicity with extended use. It should only be used short-term for acute emergencies.

Caution

Kidney or liver impairment: Patients with pre-existing kidney or liver disease may be more vulnerable to the toxic effects of the mineral ingredients (Cinnabar, Realgar). Use with extreme caution and close monitoring if no alternative exists.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. Musk (She Xiang) is one of the strongest Qi- and Blood-moving substances in the materia medica and has a well-documented ability to stimulate uterine contractions, carrying a significant risk of miscarriage. The classical source text itself lists this formula for treating difficult labor and retained dead fetus, confirming its powerful action on the uterus. Additionally, Cinnabar (Zhu Sha, containing mercury sulfide) and Realgar (Xiong Huang, containing arsenic disulfide) pose potential risks of heavy-metal exposure to the developing fetus. There are no circumstances under which this formula should be used during pregnancy.

Breastfeeding

Strongly discouraged during breastfeeding. The formula contains Cinnabar (Zhu Sha), which contains mercury sulfide, and Realgar (Xiong Huang), which contains arsenic disulfide. These heavy metals may transfer into breast milk and pose toxicity risks to the nursing infant, whose immature liver and kidneys are especially vulnerable. Musk (She Xiang) is also a potent substance whose effects on lactation and transfer through breast milk are not well studied. If an acute emergency necessitates use of this formula in a breastfeeding mother, breastfeeding should be suspended for the duration of treatment and a safe period afterward, under professional medical guidance.

Children

Zhi Bao Dan has been traditionally used for pediatric emergencies such as childhood convulsions (小儿惊厥) caused by Phlegm-Heat. However, several important cautions apply: 1. Dosage must be strictly reduced according to the child's age and body weight. Traditionally, children receive one-quarter to one-half of the adult pill dose, dissolved in warm water or administered via nasogastric tube if the child cannot swallow. 2. The formula contains Cinnabar (mercury sulfide) and Realgar (arsenic disulfide), which are of particular concern in children due to their lower body weight and immature detoxification capacity. Use should be limited to the shortest possible duration under close medical supervision. 3. This is an emergency formula, not a routine pediatric medicine. Once consciousness is restored and the acute crisis has resolved, the formula should be discontinued immediately. 4. Not suitable for infants under 1 year of age without specialist supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhi Bao Dan

Cinnabar (Zhu Sha) and Realgar (Xiong Huang) — Heavy-metal interactions: Cinnabar contains mercury sulfide (HgS) and Realgar contains arsenic disulfide (As₂S₂). These may interact with drugs that are nephrotoxic or hepatotoxic (such as aminoglycoside antibiotics, NSAIDs, or acetaminophen), potentially compounding organ toxicity. Concurrent use with other sources of mercury or arsenic exposure should be strictly avoided.

Anticoagulant and antiplatelet medications: Musk (She Xiang) strongly moves Qi and Blood, and Water Buffalo Horn (Shui Niu Jiao) has blood-cooling properties. These may theoretically potentiate the effects of warfarin, heparin, aspirin, or other anticoagulants, increasing bleeding risk.

Sedatives and CNS depressants: Cinnabar and Amber (Hu Po) have spirit-sedating properties. They may enhance the effects of benzodiazepines, barbiturates, or other central nervous system depressants, leading to excessive sedation.

Bromides and iodides: Classical TCM pharmacology advises that Cinnabar is incompatible with certain mineral salts. Concurrent use with bromide or iodide-containing medications should be avoided.

Usage Guidance

Practical advice for getting the most out of Zhi Bao Dan

Best time to take

Administered immediately upon onset of acute symptoms, regardless of meals. Traditionally taken with warm water, or dissolved in a Ren Shen (Ginseng) decoction for patients with weak constitution, or in a mixture of fresh ginger juice and children's urine (classical method) for robust patients with strong pulse.

Typical duration

Emergency/acute use only: typically 1–3 days maximum, discontinued as soon as consciousness is restored.

Dietary advice

During treatment with Zhi Bao Dan, avoid greasy, heavy, or phlegm-producing foods such as fried foods, dairy, fatty meats, and excessively sweet foods, as these generate more Phlegm and counteract the formula's turbidity-transforming action. Cold and raw foods should also be avoided as they may impair digestion of these potent mineral and animal substances. Light, easily digestible foods such as rice porridge (congee) and clear soups are most appropriate, especially since this formula is typically used during acute illness when digestive function is already compromised. Alcohol should be strictly avoided due to its Heat-generating nature and potential interaction with the mineral ingredients.

Zhi Bao Dan originates from Ling Yuan Fang (《灵苑方》) by Shen Kuo; later recorded in Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》) Sòng dynasty, ~1078 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhi Bao Dan and its clinical use

《温病条辨》(Wen Bing Tiao Bian) by Wu Jutong, Volume 1:
"此方会萃各种灵异,皆能补心体,通心用,除邪秽,解热结,共成拨乱反正之功。大抵安宫牛黄丸最凉,紫雪次之,至宝又次之。主治略同,而各有所长,临用对证斟酌可也。"
"This formula gathers together various potent and extraordinary substances, all capable of supplementing the Heart substance, unblocking the Heart's function, expelling foul pathogenic influences, and resolving Heat binding, together accomplishing the work of restoring order from chaos. In general, An Gong Niu Huang Wan is the most cooling, Zi Xue is next, and Zhi Bao Dan comes after. Their main indications are broadly similar, yet each has its own strengths; the practitioner should weigh the specific presentation and choose accordingly."

《绛雪园古方选注》(Jiang Xue Yuan Gu Fang Xuan Zhu):
"至宝丹,治心脏神昏,从表透里之方也。犀角、牛黄、玳瑁、琥珀,以有灵之品内通心窍;朱砂、雄黄、金银箔,以重坠之药安镇心神;佐以龙脑、麝香、安息香,搜剔幽隐诸窍。"
"Zhi Bao Dan treats spirit-clouding of the Heart, a formula that penetrates from the exterior to the interior. Rhinoceros horn, Ox Gallstone, Hawksbill Shell, and Amber are spiritually potent substances that internally open the Heart's portals. Cinnabar, Realgar, Gold Foil, and Silver Foil are heavy, settling substances that anchor and calm the Heart spirit. Borneol, Musk, and Benzoin serve as assistants, seeking out and clearing even the most hidden orifices."

《太平惠民和剂局方》(Tai Ping Hui Min He Ji Ju Fang), "Treating Various Wind" chapter:
"疗卒中急风不语,中恶气绝,中诸物毒暗风,中热疫毒,阴阳二毒,山岚瘴气毒,蛊毒水毒。产后血晕,口鼻出血,恶血攻心。烦躁气喘吐逆。难产闷乱,死胎不下。"
"Treats sudden Wind-Strike with loss of speech, collapse from foul Qi, poisoning by various toxins, Heat epidemics, dual Yin-Yang toxins, mountain miasma and pestilential Qi, as well as postpartum blood-fainting, nosebleeds and oral bleeding, pathogenic blood attacking the Heart, agitation, panting and vomiting, difficult labor with confusion, and retained dead fetus."

Historical Context

How Zhi Bao Dan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhi Bao Dan was originally devised by a physician named Zheng Gan (郑感) and first recorded in Shen Kuo's Ling Yuan Fang (《灵苑方》), an early medical work by the famed Northern Song polymath (1031–1095). Shen Kuo, better known for his scientific masterwork Meng Xi Bi Tan (Dream Pool Essays), was also a dedicated collector of proven medical formulas. The formula was later recorded in the Su Shen Liang Fang (《苏沈良方》), a compilation interweaving Shen Kuo's prescriptions with those of the great literary figure Su Shi (Su Dongpo).

Due to its outstanding clinical effectiveness, Zhi Bao Dan was subsequently incorporated into the Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》), the Song Dynasty's official government pharmaceutical formulary, where it was placed as the very first formula in the "Treating Various Wind" chapter. From this point on, it became known as "Ju Fang Zhi Bao Dan" (局方至宝丹). It joined An Gong Niu Huang Wan and Zi Xue Dan to form the celebrated "Three Treasures of Cool Opening" (凉开三宝), three emergency formulas for Heat-related loss of consciousness. A popular clinical aphorism captures their distinct characters: "muddled and confused, use An Gong Wan; banging and crashing, use Zi Xue; silent and still, use Zhi Bao Dan" (糊里糊涂安宫丸,乒乒乓乓是紫雪,不声不响至宝丹). The formula's name, meaning "Supreme Treasure Elixir," reflects its composition of rare and precious animal, mineral, and resin ingredients.