Herb Fruit (果 guǒ / 果实 guǒ shí)

Bi Ba

Long pepper fruit · 荜茇

Piper longum L. · Fructus Piperis Longi

Also known as: Bi Bo (荜拨)

Bi Ba (Long pepper fruit) plant

Images shown are for educational purposes only

Long pepper is a warming spice used in Chinese medicine to relieve cold-related stomach and abdominal pain, nausea, vomiting, and diarrhea. It has a strong pungent, hot nature that makes it especially useful when digestive discomfort is triggered or worsened by cold food, cold weather, or a general tendency toward feeling cold in the belly. It is also used topically for toothache.

Category Interior-warming herbs (温里药)
Therapeutic focus Digestive Health Abdominal Pain Relief Nausea and Vomiting Relief Cardiovascular Health

TCM Properties

Temperature

Hot

Taste

Acrid / Pungent (辛 xīn)

Channels entered

Stomach, Large Intestine

Parts used

Fruit (果 guǒ / 果实 guǒ shí)

Educational content • Consult qualified TCM practitioners for diagnosis and treatment

What This Herb Does

Every herb has a specific set of actions — here's what Bi Ba does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bi Ba is primarily used to support these areas of health:

Digestive Health Abdominal Pain Relief Nausea and Vomiting Relief Cardiovascular Health

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bi Ba performs to restore balance in the body:

Warms the Interior and Dispels Cold Moves Qi and Alleviates Pain Stops vomiting and checks diarrhea

How these actions work

'Warms the middle and disperses Cold' means Bi Ba uses its hot, pungent nature to drive out cold that has accumulated in the Stomach and intestines. When cold lodges in the digestive tract, it constricts the flow of Qi and Blood, causing cramping abdominal pain, a cold sensation in the belly, and a preference for warmth and pressure. Bi Ba directly warms the Stomach and Large Intestine channels, breaking up this cold constriction. This is its primary and most clinically important action, used for conditions involving deep, persistent cold in the gut (what classical texts call 'long-standing cold in the intestines and Stomach').

'Descends Qi and stops pain' means Bi Ba helps Qi move downward in its normal direction through the digestive tract. When cold blocks this downward movement, Qi rebels upward, causing nausea, vomiting, or hiccups, or it stagnates in place, causing bloating and sharp pain. Bi Ba's pungent flavour is inherently dispersing and mobilizing, and combined with its hot temperature, it pushes through cold-type stagnation to restore normal Qi flow. Historically it has also been used externally for toothache (by packing the powdered herb into dental cavities) and for one-sided headaches (by insufflation into the nostril), reflecting its ability to move Qi and relieve pain through its penetrating, pungent quality.

'Stops vomiting and checks diarrhea' refers to Bi Ba's ability to warm the Spleen and Stomach to halt vomiting of clear fluids and watery diarrhea caused by cold. When the digestive organs are too cold, they cannot properly transform and transport food and fluids, leading to these symptoms. By restoring warmth to the middle, Bi Ba helps the digestive system function normally again.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Bi Ba is used to help correct these specific patterns.

Why Bi Ba addresses this pattern

Bi Ba is one of the most direct herbs for Stomach Cold. Its hot thermal nature and pungent taste target the Stomach channel specifically, warming the organ from within and dispersing accumulated cold. When cold congeals in the Stomach, it obstructs the smooth flow of Qi, leading to pain, poor appetite, and vomiting of clear fluids. Bi Ba's pungent quality mobilizes stagnant Qi while its hot temperature counteracts the cold pathogen. Classical texts describe it as a key herb for 'long-standing cold in the intestines and Stomach' (肠胃痼冷), indicating its suitability for chronic, deep-seated cold patterns rather than just acute episodes.

A practitioner would look for one or more of these signs

Abdominal Pain

Cold, cramping pain in the upper abdomen relieved by warmth

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting of clear or watery fluids

Diarrhea

Watery diarrhea with undigested food

Loss Of Appetite

Poor appetite with aversion to cold food

Commonly Used For

These are conditions where Bi Ba is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Stomach Cold Spleen and Stomach Qi Deficiency

TCM Interpretation

TCM understands chronic gastritis primarily as a disorder of the Stomach's ability to 'ripen and rot' food, often caused by long-standing cold accumulating in the middle. Cold constricts Qi flow in the Stomach, leading to pain, distension, acid regurgitation, and poor digestion. When the pattern is cold-predominant, patients typically report pain that is relieved by warmth and pressure, a preference for warm drinks, a pale tongue with white coating, and a slow or tight pulse. The Stomach's downward-directing function is impaired, so Qi rebels upward causing nausea and belching.

Why Bi Ba Helps

Bi Ba directly addresses the cold pathogen lodged in the Stomach through its hot thermal nature and pungent taste. It enters the Stomach channel and warms the organ from within, restoring normal Qi movement downward. Its pungent quality breaks through cold-induced stagnation, relieving pain and distension. Modern pharmacological research has shown that its active compound piperine has gastroprotective effects and can inhibit gastric acid secretion and protect against experimental gastric ulcers. However, because Bi Ba is purely warming and dispersing (not tonifying), it works best for chronic gastritis when combined with Qi-tonifying herbs.

Also commonly used for

Abdominal Pain

Cold-type epigastric and abdominal pain

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting due to Stomach cold

Diarrhea

Cold-type diarrhea with undigested food

Nausea

Nausea and acid regurgitation from cold

Headaches

Migraine and one-sided headache

Toothache

Dental caries pain (topical use)

Irritable Bowel Syndrome

Cold-predominant IBS with diarrhea

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Hot

Taste

Acrid / Pungent (辛 xīn)

Channels Entered

Stomach Large Intestine

Parts Used

Fruit (果 guǒ / 果实 guǒ shí)

Dosage & Preparation

These are general dosage guidelines for Bi Ba — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

1.5–3g

Maximum dosage

Up to 5g in acute cold-pattern conditions, under practitioner supervision. Do not exceed standard doses for routine use, as overuse can dissipate true Qi and stir internal Fire.

Dosage notes

The standard decoction dose is 1.5–3g. For warming the Stomach and stopping pain in cold abdominal conditions, 1.5–3g in decoction is typical. When used in pills or powders, smaller amounts (0.5–1g as powder per dose) are common. For external use in toothache, a small amount of powder is placed directly into the cavity of a decayed tooth, or a wax pill containing Bi Ba and Hu Jiao powder is inserted. For headache, a pinch of powder may be insufflated (blown into the nostril). Do not use large doses or take for prolonged periods, as this can exhaust Qi and damage the Spleen and Lung.

Preparation

Bi Ba is typically crushed before adding to a decoction. When used in pills or powders (its most common traditional form), it is ground to a fine powder. For external use in toothache, it is ground to powder and packed into the dental cavity, sometimes mixed with melted wax to form a tiny pellet. The Lei Gong Pao Zhi Lun describes an older processing method: remove the stem, soak in vinegar overnight, dry-roast, then scrape clean. This was said to reduce its tendency to injure the Lung.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Bi Ba does

Processing method

Soaked in vinegar overnight, then dried and the outer husk scraped off. Based on the method described in Lei Gong Pao Zhi Lun.

How it changes properties

Vinegar processing moderates the herb's extremely hot and dispersing nature, makes it somewhat more astringing and directing toward the Liver channel, and reduces potential side effects on the Lungs. The classical text notes this processing is intended to 'prevent harm to the Lungs and prevent Qi from surging upward.'

When to use this form

When Bi Ba's raw form is too dispersing for the patient, or when targeting pain conditions with a Liver channel component. Also preferred for patients with any tendency toward Lung heat or Qi counterflow.

Common Herb Pairs

These ingredients are traditionally combined with Bi Ba for enhanced therapeutic effect

Gao Liang Jiang
Gao Liang Jiang 1:1.5 (Bi Ba : Gao Liang Jiang)

Both herbs are hot and pungent and enter the Stomach, but they warm slightly different aspects. Gao Liang Jiang (Galangal) is particularly strong at warming the Stomach and stopping vomiting, while Bi Ba excels at descending Qi and stopping pain in the intestines. Together they provide comprehensive warming coverage for the entire digestive tract, addressing both upper (nausea, vomiting) and lower (diarrhea, abdominal cramps) cold symptoms simultaneously.

When to use: Severe cold accumulation in the Stomach and intestines with both vomiting and diarrhea, cramping abdominal pain, and cold limbs. This is the classical combination seen in Da Yi Han Wan.

Hu Jiao
Hu Jiao 1:1

Bi Ba and Hu Jiao (Black Pepper) are botanical relatives from the Piperaceae family, both hot and pungent. Black Pepper has a stronger downward-directing action to expel cold and disperse phlegm, while Bi Ba has stronger analgesic properties. Together they powerfully warm the Stomach and intestines and stop cold-type pain. This pair is classically used in powder form for toothache, packed directly into dental cavities.

When to use: Toothache from dental caries (topical application), or severe cold-type abdominal pain and diarrhea requiring strong warming intervention.

Gan Jiang
Gan Jiang 1:1

Gan Jiang (Dried Ginger) warms the Spleen and restores Yang, while Bi Ba focuses on the Stomach and Large Intestine to disperse cold and stop pain. Together they address both the Spleen and Stomach simultaneously: Gan Jiang supports the Spleen's transforming function from the root, and Bi Ba directly tackles the cold causing pain in the Stomach and gut.

When to use: Spleen-Stomach Deficiency Cold with chronic diarrhea, abdominal pain, and poor digestion of food. This combination appears in formulas like Da Yi Han Wan and Bi Ba San.

Rou Gui
Rou Gui 1:1

Rou Gui (Cinnamon Bark) warms the Kidney Yang and the Gate of Vitality (ming men), providing deep warming from below, while Bi Ba warms the middle directly. Together they address cold originating from Kidney Yang deficiency that manifests as digestive cold symptoms. Rou Gui also strengthens the body's foundational warmth, making the warming effect more sustained.

When to use: Chronic cold in the digestive tract with underlying Kidney Yang deficiency, seen in patients with cold limbs, sore lower back, and chronic watery diarrhea alongside stomach pain. This combination is found in Da Yi Han Wan.

Key Formulas

These well-known formulas feature Bi Ba in a prominent role

Su He Xiang Wan 苏合香丸 Assistant

Su He Xiang Wan is one of the most famous emergency formulas for cold-type sudden collapse and loss of consciousness. Bi Ba serves as an assistant herb, enhancing the formula's warming and pain-relieving effects alongside a large group of aromatic substances. This showcases Bi Ba's ability to warm the interior and assist in opening blocked Qi flow during cold obstruction, and its role in chest pain conditions linked to cold constriction of the Heart vessels.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Gao Liang Jiang
Bi Ba vs Gao Liang Jiang

Both are hot, pungent herbs that warm the Stomach and stop pain, and they belong to the same Interior-warming category. However, Gao Liang Jiang (Galangal) enters only the Spleen and Stomach and is especially strong at stopping vomiting, making it the preferred choice when nausea and vomiting dominate the picture. Bi Ba also enters the Large Intestine and has a stronger analgesic and Qi-descending action, making it more suitable when intestinal cold pain and diarrhea are prominent, or when pain (including headache and toothache) is the main complaint.

Hu Jiao
Bi Ba vs Hu Jiao

Bi Ba and Hu Jiao (Black Pepper) are closely related plants with very similar taste and thermal nature. Both warm the middle and disperse cold. However, Hu Jiao has a stronger action in descending Qi and resolving phlegm, and is more commonly used as a food spice for daily prevention of cold accumulation. Bi Ba has a more sustained warming and analgesic effect and is primarily used as medicine rather than condiment. Bi Ba can also be used externally for toothache and nasally for headache, applications less commonly associated with Hu Jiao.

Gan Jiang
Bi Ba vs Gan Jiang

Both warm the interior, but they differ in scope and depth. Gan Jiang (Dried Ginger) enters the Spleen, Stomach, Heart, and Lung channels, has a much broader range of actions (restoring collapsed Yang, warming the Lungs to resolve thin phlegm), and is a far more versatile herb used as the primary interior-warming agent in many formulas. Bi Ba has a narrower focus on the Stomach and Large Intestine with particular strength in stopping cold-type pain. When the primary need is analgesic warming of the gut, Bi Ba may be preferred. When broader systemic warming or Yang rescue is needed, Gan Jiang is the better choice.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Bi Ba

Bi Ba (Piper longum) is sometimes confused with or substituted by Piper retrofractum (Java long pepper, 假荜拨), a closely related Southeast Asian species with similar but not identical properties. The Ben Cao Gang Mu records that Duan Chengshi warned that seeds of Qing Zhou Fang Feng (Saposhnikovia divaricata) could be used to adulterate Bi Ba, though Li Shizhen dismissed this as unlikely given the very different appearance (Fang Feng seeds are round like coriander seeds, quite unlike the elongated fruit spike of Bi Ba). Hu Jiao (black pepper, Piper nigrum) shares similar piperine content and pungent flavor but has a completely different fruit shape (round vs. elongated spike). Authentic Bi Ba should be verified by its characteristic elongated spike form, dark color, and distinctive sharp aroma.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Bi Ba

Non-toxic

Bi Ba is not classified as toxic in the Chinese Pharmacopoeia. However, its strongly acrid and hot nature means overuse can cause harm. Classical sources specifically warn that excessive consumption dissipates true Qi and weakens the intestines (Ben Cao Yan Yi), and can stir Spleen and Lung Fire, causing blurred vision (Ben Cao Gang Mu). The main active compound piperine can cause gastrointestinal irritation at high doses. At standard doses (1.5–3g), the herb is considered safe. The Lei Gong Pao Zhi Lun recommended vinegar-processing to reduce its tendency to injure the Lung and cause upward Qi counterflow.

Contraindications

Situations where Bi Ba should not be used or requires extra caution

Avoid

Excess Heat or Fire patterns (shi re yu huo): Bi Ba is acrid and hot in nature. It should not be used when there is genuine internal Heat, such as burning stomach pain, thirst for cold drinks, bitter taste in the mouth, or foul-smelling diarrhea with a burning sensation at the anus.

Avoid

Yin deficiency with Fire signs (yin xu huo wang): People with constitutional Yin deficiency showing symptoms like hot palms and soles, facial flushing, night sweats, or dry mouth should avoid this herb, as its hot nature will further consume Yin fluids and aggravate Heat.

Caution

Overuse or prolonged administration: Classical sources warn that excessive use dissipates the body's true Qi, weakening the intestines and causing a bearing-down sensation. The Ben Cao Gang Mu cautions that overuse can stir Fire of the Spleen and Lung and cause blurred vision.

Caution

Lung conditions with Heat: The Lei Gong Pao Zhi Lun warns that improper use can injure the Lung and cause rebellious Qi (upper Qi counterflow). Caution is advised in patients with Lung Heat or Lung Yin deficiency.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Bi Ba is strongly acrid and hot, and its Qi-moving, downward-directing properties could potentially disturb the fetus. Some contemporary Chinese materia medica references list pregnant women under the "use with caution" category. While it is not classified as outright contraindicated (禁用) in pregnancy in the Chinese Pharmacopoeia, there are no safety studies confirming its safety for pregnant women. It should generally be avoided unless specifically prescribed by an experienced practitioner who has determined the benefits outweigh the risks.

Breastfeeding

No specific classical or modern safety data exists for Bi Ba use during breastfeeding. Given its strongly acrid and hot nature, its volatile and pungent compounds (particularly piperine) may transfer into breast milk and could theoretically cause gastrointestinal irritation or Heat-related symptoms in the nursing infant. Use with caution and only under practitioner guidance. If used, low doses and short duration are advisable.

Children

Contemporary Chinese materia medica references advise caution when using Bi Ba in children. Its strongly hot and acrid nature makes it potentially harsh for the developing digestive systems of young children. If used, dosage should be significantly reduced in proportion to the child's age and weight, and treatment duration should be kept short. It is generally not recommended for infants or very young children. An experienced pediatric TCM practitioner should supervise any use.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bi Ba

Cytochrome P450 enzyme modulation: Piperine, the main active compound in Bi Ba, is a well-documented modulator of drug-metabolizing enzymes, particularly CYP3A4, CYP2D6, CYP1A2, and CYP2C9, as well as UDP-glucuronosyltransferase enzymes. It also inhibits P-glycoprotein (a drug efflux transporter). This means piperine can significantly increase the blood levels and bioavailability of many pharmaceutical drugs, potentially causing toxicity. Drugs with a narrow therapeutic index are of particular concern.

Specific interactions of note:

  • Phenytoin, carbamazepine, and other anticonvulsants: Piperine may increase serum levels by inhibiting hepatic metabolism.
  • Theophylline: Piperine has been shown to increase theophylline bioavailability.
  • Rifampin and other antibiotics: Piperine may alter absorption and metabolism.
  • Curcumin (turmeric) and other supplements: Piperine markedly enhances curcumin absorption (up to 20-fold), which is used therapeutically but represents a significant pharmacokinetic interaction.
  • Propranolol and other beta-blockers: Piperine may increase blood levels.

Patients taking any prescription medication should consult their physician before using Bi Ba, especially at doses above culinary amounts.

Dietary Advice

Foods and dietary considerations when taking Bi Ba

When taking Bi Ba for cold-pattern conditions, avoid cold and raw foods, iced drinks, and excessive quantities of cold-natured fruits (such as watermelon or pear), as these counteract the warming therapeutic intent. Bi Ba has traditionally been combined with warm foods such as cooked grains and milk (as in the famous Emperor Taizong formula). Avoid eating too much spicy or greasy food concurrently, as Bi Ba is itself very pungent and adding further Heat can lead to excessive dryness or Fire symptoms.

Botanical Description

Physical characteristics and morphology of the Bi Ba source plant

Piper longum L. (family Piperaceae) is a perennial, herbaceous climbing vine that can grow several meters long. The lower stems creep along the ground while the upper portions climb using supports. The stems have prominent ridges and grooves and are covered with fine powdery hairs when young, which soon fall off. Leaves are papery, alternate, and variable in shape: lower leaves are ovate to somewhat kidney-shaped with cordate (heart-shaped) bases, while upper leaves are more ovate-oblong. Leaf blades are typically 6–8 cm long and 4 cm wide, with prominent veins on the underside.

The plant is dioecious (male and female flowers on separate plants). Male flower spikes are slender and erect, up to 5–7 cm long, while female spikes are shorter, about 1.5–2.5 cm. The small spherical berries (about 2 mm across) are embedded along the spike, forming a dense, cylindrical fruit cluster resembling a catkin. Fruits are green when immature, turning to black when ripe. The plant thrives in tropical forests, preferring shaded, moist environments at elevations around 580 meters, growing among bamboo groves, banana plantations, and along riverbanks.

Sourcing & Harvesting

Where Bi Ba is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

September to October, when the fruit spikes change from green (or yellow) to black-brown.

Primary growing regions

In China, Bi Ba is primarily produced in Yunnan (southeastern to southwestern regions) and Guangdong provinces, with Yunnan considered the main domestic production area. Guangxi and Fujian also cultivate it. Internationally, major production comes from Indonesia, the Philippines, Vietnam, India, Nepal, Sri Lanka, and Bangladesh. The plant originates from tropical South and Southeast Asia, and the best quality herb traditionally comes from the warm, humid lowland forests of Yunnan.

Quality indicators

Good quality Bi Ba fruit spikes are plump, large, firm, and solid, with a dark black-brown color and a strong, distinctive aromatic smell and intensely pungent, spicy taste. The spike should be intact and cylindrical, about 1.5–3.5 cm long and 0.3–0.5 cm in diameter, with neatly arranged small protuberances on the surface. The cross-section should appear granular and slightly reddish, with white endosperm visible in the tiny individual fruits. Avoid spikes that are thin, broken, light in color, or lacking in aroma and pungency, as these indicate inferior quality or improper storage.

Classical Texts

Key passages from the classical Chinese medical texts that describe Bi Ba and its therapeutic uses

《本草纲目》(Ben Cao Gang Mu) — Li Shizhen

「荜茇，为头痛、鼻渊、牙痛要药，取其辛热能入阳明经散浮热也。」

"Bi Ba is a key herb for headache, nasal congestion with turbid discharge, and toothache. Its acrid-hot nature allows it to enter the Yangming channel and disperse superficial Heat."

《本草拾遗》(Ben Cao Shi Yi) — Chen Cangqi

「温中下气，补腰脚，消食，除胃冷，阴疝，痃癖。」

"Warms the Middle, descends Qi, strengthens the lower back and legs, promotes digestion, eliminates Stomach Cold, and treats yin-type hernial disorders and abdominal masses."

《海药本草》(Hai Yao Ben Cao)

「主老冷心痛，水泻，虚痢，呕逆醋心，产后泄利。」

"Governs chronic cold heart pain, watery diarrhea, deficiency dysentery, nausea with acid reflux, and postpartum diarrhea."

《本草便读》(Ben Cao Bian Du)

「荜拨，大辛大热，味类胡椒，入胃与大肠，阳明药也。温中散寒，破滞气，开郁结，下气除痰。」

"Bi Ba is greatly acrid and greatly hot, similar in taste to pepper. It enters the Stomach and Large Intestine, and is a Yangming channel herb. It warms the Middle, scatters Cold, breaks through stagnant Qi, opens bound constraint, descends Qi, and eliminates Phlegm."

《本草正义》(Ben Cao Zheng Yi)

「荜茇，脾肾虚寒之主药。」

"Bi Ba is a primary herb for deficiency-Cold of the Spleen and Kidney."

Historical Context

The history and evolution of Bi Ba's use in Chinese medicine over the centuries

Bi Ba (荜茇/荜拨) is not native to China but was introduced from South and Central Asia along the Silk Road. Its Chinese name is a transliteration of the Sanskrit word Pippali. As Li Shizhen noted in the Ben Cao Gang Mu, the various Chinese transcriptions (毕勃, 逼拨, 毕茇) all derive from this foreign word. The herb first appeared in Chinese records in the Nan Fang Cao Mu Zhuang (Account of Plants and Trees of the Southern Regions), and was formally documented as a medicinal substance in the Kai Bao Ben Cao (Song Dynasty, 973 CE), though earlier texts such as the Tang Ben Cao already described it as coming from Persia.

A famous historical anecdote records that Emperor Taizong of the Tang Dynasty suffered from a condition called "Qi dysentery" (气痢), causing uncontrollable flatulence and diarrhea. After many failed treatments, a commoner offered a simple remedy of Bi Ba simmered in cow's milk. The emperor recovered promptly. This story was recorded by Liu Yuxi and later cited in the Ben Cao Gang Mu, which explained the rationale: the cool nature of milk and the hot nature of Bi Ba together harmonize Yin and Yang. The herb is also widely used in Tibetan and Mongolian medicine, reflecting its pan-Asian medicinal heritage.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Bi Ba

1

Systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research (2020)

Yadav V, Krishnan A, Vohora D. Journal of Ethnopharmacology, 2020, 247:112255.

A comprehensive systematic review following PRISMA guidelines that surveyed research from 1967 to 2019 on Piper longum. The review identified piperine and piperlongumine as major alkaloid constituents and catalogued a wide range of demonstrated pharmacological activities including anti-inflammatory, analgesic, antioxidant, antimicrobial, anticancer, immunomodulatory, anti-diabetic, and hepatoprotective effects. The authors concluded that while preclinical evidence is extensive, more controlled clinical trials are needed.

DOI
2

Therapeutic spectrum of piperine for clinical practice: a scoping review (2022)

Yadav SS, Singh MK, Hussain S, Dwivedi P, Khattri S, Singh K. Critical Reviews in Food Science and Nutrition, 2023, 63(22):5813-5840.

A scoping review examining the clinical applications of piperine (the primary bioactive alkaloid in Bi Ba). The review highlighted piperine's bioenhancing effect on other drugs by modulating gastrointestinal absorption, altering p-glycoprotein transporter activity, and modifying cytochrome P450 enzyme expression. Clinical interest has focused on arthritis, metabolic syndrome, diabetes, skin infections, and gastrointestinal and liver disorders. Multiple clinical trials exploring piperine's application in cancer, neurological, and respiratory diseases were identified.

DOI
3

Relaxant Effects of Piperine and Piperlongumine from Piper longum Fruits on Porcine Coronary Artery (Preclinical, 2024)

Noguchi K, Teramura M, Kitagawa A, Ejima M, Ueda C, Kanae H. Biological and Pharmaceutical Bulletin, 2024, 47(1):130-137.

This laboratory study investigated the cardiovascular effects of piperine and piperlongumine (both found in Piper longum fruit) on isolated porcine coronary arteries. Both compounds relaxed blood vessels by inhibiting calcium-channel-mediated contractions, with piperlongumine showing additional ability to inhibit intracellular calcium release. The findings provide a pharmacological basis for the traditional use of Bi Ba in treating chest pain from coronary heart disease.

DOI

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.