Su He Xiang Wan

Storax Pill · 苏合香丸

Also known as: Chī Lì Jiā Wán (吃力伽丸, Storax Pill — original name from the Tang dynasty Guang Ji Fang), Bái Zhú Wán (白术丸, White Atractylodes Pill — early alternate name)

A classical emergency pill formula used to revive consciousness and relieve pain in situations where cold, turbidity, or phlegm have suddenly blocked the mind and caused collapse or fainting. It is intensely aromatic, warming, and penetrating, designed primarily for acute episodes of cold-type loss of consciousness, sudden chest or abdominal pain, and conditions where the body's Qi circulation has been severely obstructed by cold and turbid factors.

Origin Guang Ji Fang (《广济方》), recorded in Wai Tai Mi Yao (《外台秘要》); renamed in Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》) — Táng dynasty, ~752 CE (originally as Chī Lì Gā Wán); current name established in Sòng dynasty, ~1078–1151 CE
Composition 15 herbs
Su He Xiang
King
Su He Xiang
She Xiang
King
She Xiang
Bing Pian
King
Bing Pian
An Xi Xiang
King
An Xi Xiang
Xiang Fu
Deputy
Xiang Fu
Mu Xiang
Deputy
Mu Xiang
Tan Xiang
Deputy
Tan Xiang
Chen Xiang
Deputy
Chen Xiang
+7
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Su He Xiang Wan is designed to correct these specific patterns.

Why Su He Xiang Wan addresses this pattern

This is the primary pattern Su He Xiang Wan addresses. When cold phlegm and turbid pathogenic factors suddenly block the Heart orifice, the spirit (Shen) loses its residence and consciousness is lost. The patient collapses suddenly, the jaw clenches shut, and the face turns pale with cold limbs. The tongue coating is white and the pulse is slow (Chi). This is a critical emergency requiring immediate aromatic intervention to break through the blockage. Su He Xiang Wan achieves this through four powerfully aromatic King herbs (Su He Xiang, She Xiang, Bing Pian, An Xi Xiang) that penetrate the cold-phlegm obstruction, while the large group of warm Qi-moving Deputies (Ding Xiang, Chen Xiang, Tan Xiang, etc.) disperse cold and restore Qi circulation. The formula's overall warm nature makes it specifically suited for cold-type closed conditions, as opposed to heat-type closed conditions which require cooling formulas like An Gong Niu Huang Wan.

A practitioner would look for one or more of these signs

Loss Of Consciousness

Sudden collapse with loss of consciousness

Lockjaw

Clenched jaw (trismus)

Cold Extremities

Pale face with cold limbs, indicating cold obstruction

Slow Pulse

Slow or deep pulse (Chi Mai)

White Tongue Coating

White, greasy tongue coating indicating cold phlegm

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Su He Xiang Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Cold Blocking the Heart Orifice Phlegm Misting the Heart

TCM Interpretation

In TCM, stroke (Zhong Feng) is understood as a sudden disruption of the body's internal balance where wind, phlegm, fire, or cold invade and block the channels, collaterals, or organs. When stroke involves cold phlegm and turbidity blocking the Heart orifice, it presents as what is called a 'closed condition' (Bi Zheng): the patient suddenly loses consciousness, the jaw clenches shut, fists clench, and the limbs turn cold and pale. The tongue coating is white and the pulse slow. This is fundamentally different from the 'heat-type closed condition' where the face is flushed, the body hot, and the breath foul. The cold-type presentation indicates that cold turbidity has sealed off the Heart's connection to the spirit, preventing consciousness.

Why Su He Xiang Wan Helps

Su He Xiang Wan is the representative formula for cold-type closed stroke precisely because its composition is dominated by warm, intensely aromatic substances. The four King herbs (Su He Xiang, She Xiang, Bing Pian, An Xi Xiang) penetrate through the cold phlegm blockage to reopen the Heart orifice and restore consciousness. The warm Deputies (Ding Xiang, Chen Xiang, Tan Xiang, and others) disperse the cold and restore Qi circulation. Modern pharmacological research has confirmed that Su He Xiang Wan can improve blood circulation, protect blood vessel walls, and reduce the heart's oxygen demand. It is important to note that this formula is only appropriate for the cold-type presentation. If the stroke shows signs of heat (fever, red face, rapid pulse), An Gong Niu Huang Wan is used instead.

Also commonly used for

Myocardial Infarction

Acute chest pain with cold-type presentation

Encephalitis

Post-febrile stupor when fever has subsided but consciousness has not returned

Epilepsy

Loss of consciousness with cold phlegm obstruction

Abdominal Pain

Sudden severe cold-type abdominal pain

Loss Of Consciousness

Fainting or syncope from Qi reversal or cold blockage

Coma

When presentation fits cold-type closed pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Su He Xiang Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Su He Xiang Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Su He Xiang Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Su He Xiang Wan works at the root level.

Su He Xiang Wan addresses what TCM calls cold-type closed disorder (寒闭证, hán bì zhèng). In this condition, cold pathogenic factors combine with turbid Phlegm to obstruct the body's Qi circulation and block the sensory orifices, which are the gateways through which the Heart-mind (Shen) connects with the external world. When these orifices are sealed shut, consciousness is lost.

The mechanism works as follows: cold Phlegm or foul, turbid Qi (from epidemic pestilence, sudden emotional shock, or internal cold accumulation) congeals in the chest and obstructs the clear Yang Qi that normally rises to nourish the brain and maintain awareness. This produces the hallmark presentation: sudden collapse with loss of consciousness, clenched jaw, a pale face, cold limbs, white tongue coating, and a slow or tight pulse. When the same cold-turbid obstruction lodges in the chest or abdomen, it blocks Qi flow through the Heart and Stomach, causing sudden severe pain in the chest or belly. The key diagnostic distinction is that all signs point to Cold (pale face, cold extremities, white coating) rather than Heat. Because the orifices are "closed" rather than "collapsed," the patient's jaw is clenched tight and fists are gripped, unlike a collapsed (desertion) pattern where the body goes limp.

The formula works because its powerfully aromatic, warm herbs can penetrate through the Phlegm-cold obstruction, "steam open" the blocked orifices, and restore the smooth flow of Qi. Once Qi circulates freely again, the turbid Phlegm disperses, consciousness returns, and pain resolves.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid (pungent) and aromatic with mild bitter and sweet notes — the acrid taste opens, disperses, and moves Qi, while the aromatic quality penetrates through turbidity to restore consciousness.

Ingredients

15 herbs

The herbs that make up Su He Xiang Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Su He Xiang

Su He Xiang

Storax resin

Dosage 0.3 - 1g (in pill form; classical dose 15g in full batch)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Spleen
Preparation Gently warmed until liquid before incorporating into the honey pill mixture

Role in Su He Xiang Wan

Aromatically opens the orifices, revives consciousness, dispels cold, resolves turbidity, and regulates Qi. As the formula's namesake, it is the primary aromatic substance that penetrates through cold phlegm and turbidity blocking the Heart orifice.
She Xiang

She Xiang

Musk

Dosage 0.3 - 1g (in pill form; classical dose 30g in full batch)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Liver, Spleen
Preparation Ground separately into fine powder before mixing

Role in Su He Xiang Wan

Powerfully opens the orifices and revives consciousness, breaks through turbidity, and unblocks the channels and collaterals throughout the body. The most penetrating of all aromatic orifice-opening substances.
Bing Pian

Bing Pian

Borneol

Dosage 0.3 - 1g (in pill form; classical dose 15g in full batch)
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Spleen, Lungs
Preparation Ground separately into fine powder before mixing

Role in Su He Xiang Wan

Opens the orifices, clears the head, and breaks through turbidity. Works in concert with Su He Xiang and She Xiang to powerfully open closed conditions and restore consciousness.
An Xi Xiang

An Xi Xiang

Benzoin resin

Dosage 1 - 1.5g (in pill form; classical dose 30g in full batch)
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Preparation Traditionally decocted with ashless wine into a paste (用无灰酒熬膏)

Role in Su He Xiang Wan

Penetrates through turbidity surrounding the orifices, opens closed conditions, and restores consciousness. Also acts as a binder when processed into a paste with wine, helping to form the pill matrix.
Deputies — Assists and enhances the King
Xiang Fu

Xiang Fu

Nutgrass Galingale Rhizome

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)

Role in Su He Xiang Wan

Regulates Qi and resolves depression. As a leading Qi-regulating herb, it supports the aromatic King herbs by smoothing Qi flow throughout the body and addressing the underlying Qi stagnation.
Mu Xiang

Mu Xiang

Costus root

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, San Jiao (Triple Burner), Gallbladder

Role in Su He Xiang Wan

Moves Qi and alleviates pain, especially in the chest and abdomen. Complements the King herbs by addressing Qi stagnation pain in the middle and lower burners.
Tan Xiang

Tan Xiang

Sandalwood

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Heart, Lungs

Role in Su He Xiang Wan

Warm and aromatic, it moves Qi, harmonizes the Stomach, and relieves chest and abdominal pain. Particularly effective for chest impediment (Xiong Bi) with cold congealing in the Heart vessels.
Chen Xiang

Chen Xiang

Agarwood

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Kidneys

Role in Su He Xiang Wan

Descends Qi, warms the interior, and directs rebellious Qi downward. Adds a sinking, anchoring quality that balances the upward-dispersing nature of the other aromatic herbs.
Ding Xiang

Ding Xiang

Clove

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs, Kidneys

Role in Su He Xiang Wan

Warms the middle burner, descends rebellious Qi, and treats cold-type heart and abdominal pain. Reinforces the warming and Qi-moving actions of the other Deputy herbs.
Ru Xiang

Ru Xiang

Frankincense resin

Dosage 0.3 - 1g (in pill form; classical dose 15g in full batch; processed form)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Preparation Prepared/processed form (制乳香)

Role in Su He Xiang Wan

Regulates Qi, activates Blood, and relieves pain. Adds a Blood-moving component to the formula, addressing Blood stasis that accompanies Qi stagnation from cold obstruction.
Assistants — Supports or moderates other herbs
Bi Ba

Bi Ba

Long pepper fruit

Dosage 1 - 2g (in pill form; classical dose 30g in full batch)
Temperature Hot
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Stomach, Large Intestine

Role in Su He Xiang Wan

Acrid and hot, it powerfully warms the interior and disperses cold, enhancing the cold-dispersing and pain-relieving effects of the aromatic herbs. Specifically targets cold pain in the stomach and abdomen.
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 2 - 3g concentrate (in pill form; classical dose 60g in full batch)
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Used as concentrated powder (浓缩粉)

Role in Su He Xiang Wan

Clears Heart heat and resolves toxins. Though cold in nature, it serves as a restraining Assistant: it prevents the large group of warm-hot aromatic herbs from generating excessive heat, and protects the Heart from heat toxins that may arise during acute closed conditions.
Zhu Sha

Zhu Sha

Cinnabar

Dosage 1 - 2g (in pill form; classical dose 60g in full batch)
Temperature Cool
Taste Sweet (甘 gān)
Organ Affinity Heart
Preparation Processed by water-levigation (水飞) into ultrafine powder

Role in Su He Xiang Wan

Heavily sedates and calms the spirit, anchoring the Heart and settling fright. Like Water Buffalo Horn, its cold heavy nature serves as a restraining counterbalance to the warm, dispersing aromatics, while also calming agitation that may accompany the acute crisis.
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 1 - 2g (in pill form; classical dose 60g in full batch)
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Su He Xiang Wan

Tonifies Qi, strengthens the Spleen, dries Dampness, and transforms turbidity. This reinforcing Assistant supports the body's righteous Qi, preventing the intensely dispersing aromatics from depleting the body's vital force. The original formula name 'Chi Li Ga Wan' refers to this herb, signaling the importance of protecting Qi even in an emergency orifice-opening formula.
He Zi

He Zi

Chebulic myrobalan fruit

Dosage 1 - 2g (in pill form; classical dose 60g in full batch)
Temperature Neutral
Taste Bitter (苦 kǔ), Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Lungs, Large Intestine
Preparation Use the flesh only (诃子肉), remove the pit

Role in Su He Xiang Wan

Astringes and restrains leaking Qi while transforming phlegm. Its binding, consolidating nature prevents the strongly dispersing aromatic herbs from over-dissipating the body's normal Qi. Paired with Bai Zhu, it creates a complementary 'tonify and contain' safety mechanism.

Why This Combination Works

How the herbs in Su He Xiang Wan complement each other

Overall strategy

Su He Xiang Wan treats cold-type closed conditions (Han Bi) where cold phlegm and turbid Qi have suddenly blocked the Heart orifice and obstructed Qi circulation, causing loss of consciousness or severe pain. The prescription strategy is to break through the blockage with intensely aromatic, warm, orifice-opening substances while simultaneously moving stagnant Qi, dispersing cold, and preventing the vigorous dispersal from depleting the body's righteous Qi.

King herbs

Su He Xiang (Styrax), She Xiang (Musk), Bing Pian (Borneol), and An Xi Xiang (Benzoin) form an unusually powerful group of four King herbs. Each is intensely aromatic with the ability to penetrate through phlegm and turbidity to open the orifices and restore consciousness. Together they produce a synergistic effect far greater than any single aromatic could achieve alone. Su He Xiang is specifically warm in nature and excels at clearing cold turbidity, while She Xiang is the most penetrating substance in the entire pharmacopoeia for unblocking channels and orifices.

Deputy herbs

Six aromatic Qi-moving herbs serve as Deputies: Xiang Fu, Mu Xiang, Tan Xiang, Chen Xiang, Ding Xiang, and Ru Xiang. These reinforce the King herbs by moving Qi throughout the chest, abdomen, and channels, resolving the underlying Qi stagnation that accompanies the closed condition. Each has a slightly different target: Tan Xiang and Chen Xiang focus on the chest, Mu Xiang and Ding Xiang on the middle burner, Xiang Fu on the Liver Qi system, and Ru Xiang adds Blood-moving action to address concurrent Blood stasis.

Assistant herbs

Bi Ba (Long Pepper) is a reinforcing Assistant whose acrid-hot nature powerfully warms the interior and enhances cold-dispersing pain relief. Shui Niu Jiao (Water Buffalo Horn) and Zhu Sha (Cinnabar) are restraining Assistants: their cool-to-cold and heavy natures counterbalance the intense warmth of the other herbs, preventing excessive heat generation while calming the spirit and clearing toxins from the Heart. Bai Zhu (Atractylodes) and He Zi (Terminalia) are a protective pair: Bai Zhu tonifies the Spleen Qi and dries Dampness, while He Zi astringes and restrains the leakage of Qi. Together they prevent the many acrid, dispersing aromatics from over-consuming the body's vital Qi.

Notable synergies

The pairing of Bai Zhu and He Zi is the formula's most distinctive structural feature: one tonifies Qi while the other contains it, creating a safety net that allows the powerful aromatic herbs to work aggressively without exhausting the patient. The contrast between the mostly warm aromatic herbs and the cool Shui Niu Jiao plus Zhu Sha ensures the formula opens cold-type blockages without tipping into excess heat. The six Deputy aromatic herbs create an overlapping web of Qi-moving effects across multiple organ systems and body regions, ensuring comprehensive relief of stagnation.

How to Prepare

Traditional preparation instructions for Su He Xiang Wan

Grind all fifteen ingredients into an extremely fine powder. Set aside the Styrax (Su He Xiang), Musk (She Xiang), Borneol (Bing Pian), and Water Buffalo Horn concentrate (Shui Niu Jiao). Process Cinnabar (Zhu Sha) by water-levigation into ultrafine powder. Crush the remaining ten herbs (An Xi Xiang, Tan Xiang, Chen Xiang, Ding Xiang, Xiang Fu, Mu Xiang, Ru Xiang, Bi Ba, Bai Zhu, He Zi) into fine powder. Separately grind the Musk, Borneol, and Water Buffalo Horn concentrate finely, then combine with the other powders, sieve, and mix evenly.

Gently warm the Styrax until liquid, add an appropriate amount of refined honey, and blend with the mixed powder to form honey pills. Dry at low temperature. Each pill weighs approximately 3g (large honey pill) or 2.4g (water-honey pill). Take 1 pill orally, 1 to 2 times daily, with warm water. For children, reduce the dose accordingly. For patients in coma who cannot swallow, administer via nasogastric tube.

Common Modifications

How practitioners adapt Su He Xiang Wan for specific situations

Added
Lai Fu Zi

Prepared Aconite, 3-6g, to powerfully warm Yang and disperse internal cold

Gan Jiang

Dried Ginger, 3-6g, to warm the middle burner and assist Yang recovery

When the cold obstruction is particularly severe with signs of Yang collapse (extremely cold limbs, barely perceptible pulse), adding Fu Zi and Gan Jiang strengthens the formula's ability to rescue Yang and drive out deep cold.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Su He Xiang Wan should not be used or requires extra caution

Avoid

Hot closed disorders (re bi, 热闭): fever, flushed face, red eyes, restlessness, delirium, red tongue with yellow coating, rapid pulse. These indicate Heat trapping in the Pericardium, requiring cool-opening formulas like An Gong Niu Huang Wan instead.

Avoid

Pregnancy: the formula contains She Xiang (Musk) which is a classical pregnancy-prohibited substance due to its strong penetrating action and potential to stimulate uterine contractions, and Ru Xiang (Frankincense) which moves Blood. Multiple other aromatic herbs in the formula strongly move Qi and Blood.

Avoid

Collapsed or desertion patterns (tuo zheng, 脱证): if the patient shows signs of Yang collapse such as profuse cold sweating, open mouth, relaxed hands, urinary incontinence, and a faint, scattered pulse, this formula is inappropriate. Opening formulas are for closed (bi) conditions, not open/collapsed ones.

Caution

Prolonged or preventive use: the formula is designed for acute emergency use only. As the Qing dynasty physician Wu Yiluo warned, the many aromatic herbs in this formula scatter the body's Qi. Extended use can deplete the body's vital Qi, worsening fatigue, shortness of breath, and dry mouth.

Caution

Yin deficiency with internal Heat: patients with a constitutional pattern of Yin deficiency (dry mouth, night sweats, heat in the palms and soles) should use this formula with great caution, as its warm, aromatic, and dispersing nature can further consume Yin fluids.

Caution

Contains Zhu Sha (Cinnabar, mercury sulfide): not suitable for patients with impaired kidney or liver function due to potential mercury accumulation with repeated dosing. Must not be taken long-term.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. She Xiang (Musk) is one of the most strongly prohibited herbs in pregnancy in classical TCM, recognized for its powerful penetrating and orifice-opening properties that can stimulate uterine contractions and potentially cause miscarriage. Ru Xiang (Frankincense) invigorates Blood circulation. The formula as a whole is intensely aromatic and Qi-moving, which poses additional risk during pregnancy. It should not be used by pregnant women under any circumstances.

Breastfeeding

Not recommended during breastfeeding. The formula contains She Xiang (Musk) and multiple potent aromatic substances whose transfer into breast milk has not been studied but is pharmacologically plausible given their highly volatile and penetrating nature. Zhu Sha (Cinnabar) contains mercury sulfide, and even small amounts of mercury passing into breast milk could pose a risk to infants. Bing Pian (Borneol) is lipophilic and may also transfer into breast milk. Given that this formula is intended for acute emergency situations rather than ongoing use, it should be avoided in nursing mothers unless the clinical situation is life-threatening and no alternatives exist.

Children

Classical sources explicitly note that children may take Su He Xiang Wan, with the original Guang Ji Fang text stating that elderly persons and children should take one pill (approximately 2g for modern honey pills) rather than the standard adult dose. As an emergency formula for acute loss of consciousness, it may be used in children when the pattern clearly matches cold-type closure. For children who cannot swallow, the pill can be dissolved in warm water and administered via nasogastric tube. However, the formula contains Zhu Sha (Cinnabar, containing mercury sulfide), which poses particular concern in pediatric use due to children's lower body weight and developing organ systems. It should only be used for genuine emergencies, never as a preventive or tonic, and the duration should be as brief as possible. Not suitable for neonates or very young infants without specialist guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Su He Xiang Wan

Cinnabar (Zhu Sha) and reducing agents: The formula contains Zhu Sha (朱砂), which consists of mercury sulfide (HgS). It must not be taken concurrently with potassium iodide, sodium bromide, potassium iodide, sodium iodide, ferrous sulfate, or nitrite salts, as these reducing agents can react with mercury in the gastrointestinal tract to form toxic mercury bromide or mercury iodide precipitates, potentially causing severe drug-induced enteritis.

Classical herb pairing caution (Ding Xiang and Yu Jin): The formula contains Ding Xiang (Clove), which according to the traditional "Nineteen Incompatibilities" (十九畏) is incompatible with Yu Jin (Curcuma tuber). Patients concurrently taking herbal formulas or supplements containing Yu Jin should avoid combining them with Su He Xiang Wan.

Anticoagulant and antiplatelet drugs: Several ingredients (Ru Xiang/Frankincense, She Xiang/Musk, Bing Pian/Borneol) have Blood-invigorating or circulation-promoting properties. Concurrent use with warfarin, heparin, aspirin, or clopidogrel may theoretically increase bleeding risk and should be closely monitored.

Cardiac glycosides (Digoxin): Borneol (Bing Pian) has been shown in pharmacological studies to influence drug absorption and may alter the bioavailability of co-administered drugs. Patients taking digoxin or other narrow-therapeutic-index cardiac drugs should exercise caution.

Usage Guidance

Practical advice for getting the most out of Su He Xiang Wan

Best time to take

At the onset of acute symptoms (emergency use). Classical texts specify taking on an empty stomach (空心); for unconscious patients, administer via nasogastric tube at any time.

Typical duration

Acute emergency use only: 1–3 doses. Not intended for prolonged or preventive use.

Dietary advice

While taking this formula, avoid cold, raw, and greasy foods, as these can generate further Phlegm and Cold, directly opposing the formula's warming and Phlegm-transforming action. The classical instructions specify taking it on an empty stomach (空心服之) with well water or warm water. If the patient has regained consciousness and can eat, light, warm, easily digestible foods such as plain congee or clear broth are most appropriate. Avoid alcohol unless specifically directed, though the classical texts note that warm wine may also be used to dissolve the pill.

Su He Xiang Wan originates from Guang Ji Fang (《广济方》), recorded in Wai Tai Mi Yao (《外台秘要》); renamed in Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》) Táng dynasty, ~752 CE (originally as Chī Lì Gā Wán); current name established in Sòng dynasty, ~1078–1151 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Su He Xiang Wan and its clinical use

《外台秘要》卷十三 引《广济方》(Wài Tái Mì Yào, citing Guǎng Jì Fāng):
「广济疗传尸骨蒸,殗殜肺痿,疰忤鬼气,卒心痛,霍乱吐痢,时气鬼魅,瘴疟,赤白暴痢,瘀血月闭,痃癖疔肿,惊痫,鬼忤中人,吐乳狐魅,吃力伽丸。」
Translation: "Guǎng Jì [Fāng] treats transmission-corpse bone-steaming, wasting cough, ghost-inflicted Qi disturbance, sudden heart pain, cholera with vomiting and diarrhea, seasonal pestilence and malignant spirits, miasmic malaria, acute red and white dysentery, Blood stasis and menstrual blockage, abdominal masses and boils, fright epilepsy, ghost-strike affecting people, and infantile vomiting of milk — [using] Chī Lì Jiā Wán (Atractylodes Pill)."

《本经逢原》(Běn Jīng Féng Yuán):
「苏合香,聚诸香之气而成,能透诸窍脏,辟一切不正之气,凡痰积气厥,必先以此开导,治痰以理气为本也。」
Translation: "Styrax gathers the Qi of many fragrances into one. It can penetrate through all the orifices and organs and ward off every kind of pathogenic Qi. Whenever there is Phlegm accumulation or Qi reversal with loss of consciousness, one must first use this [substance] to open and guide [the pathways]. Treating Phlegm takes regulating Qi as its foundation."

《本草从新》吴仪洛 (Běn Cǎo Cóng Xīn, by Wú Yíluò, Qing dynasty):
「今人滥用苏合丸,不知诸香走散真气,每见服之,轻病致重,重病即死,惟气体壮实者,庶可暂服一、二丸,否则当深戒也。」
Translation: "People nowadays use Su He [Xiang] Wan indiscriminately, not realizing that the many aromatics scatter the body's true Qi. I have often seen that taking it turns mild illness severe and severe illness fatal. Only those with a strong, robust constitution may temporarily take one or two pills; otherwise, one must exercise the utmost caution."

Historical Context

How Su He Xiang Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Su He Xiang Wan has a remarkably long history that stretches back well over a thousand years. Recent scholarship based on Dunhuang and Turfan manuscripts has traced a closely related formula (a "ghost-inflicted heart pain formula") to manuscripts from the Gaochang Kingdom period (approximately 460–640 CE), predating the Tang dynasty sources previously thought to be the earliest. The formula first appeared in conventional medical literature under the name Chī Lì Jiā Wán (吃力伽丸, "Atractylodes Pill") in the Tang dynasty text Guǎng Jì Fāng (《广济方》, compiled during the Kaiyuan era, 713–741 CE), and was subsequently recorded in Sun Simiao's Qiān Jīn Yì Fāng and Wang Tao's Wài Tái Mì Yào. The name "Chī Lì Jiā" is believed to be a transliteration from a Central Asian or Sanskrit word for Atractylodes (Bai Zhu), reflecting the formula's origins along the Silk Road trade routes, where aromatic resins like styrax and benzoin were imported from the Western Regions.

During the Song dynasty, the Imperial Medical Bureau compiled the Tài Píng Huì Mín Hé Jì Jú Fāng (《太平惠民和剂局方》), renaming the formula Su He Xiang Wan after its principal aromatic ingredient. A famous anecdote from Shen Kuo's Mèng Xī Bǐ Tán (《梦溪笔谈》) records that Song Emperor Zhenzong personally bestowed a bottle of medicinal wine made by dissolving Su He Xiang Wan in alcohol upon the ailing Grand Marshal Wang Wenzheng, after which it spread from exclusive court use to wider application among the populace.

In the modern era, Su He Xiang Wan has given rise to several important derivative formulas. Guan Xin Su He Wan (冠心苏合丸), a streamlined five-ingredient version, and She Xiang Bao Xin Wan (麝香保心丸) were both developed from Su He Xiang Wan's framework for treating coronary heart disease. The original formula's Qing Mu Xiang (青木香) has been replaced by Mu Xiang (木香) in modern versions due to the discovery that the original herb contains nephrotoxic aristolochic acid; rhinoceros horn has been substituted with concentrated water buffalo horn; and natural musk has been replaced with synthetic musk. The formula was included in China's COVID-19 treatment guidelines (7th edition, 2020) for critically ill patients presenting with cold-closure patterns.