Formula Pill (Wan)

Si Sheng Wan

Four-Fresh Pill · 四生丸

Also known as: Sì Wèi Wán (四味丸, Four-Ingredient Pill)

A classical formula for stopping bleeding caused by Blood Heat. It uses four fresh (raw) herbs to cool the Blood and halt nosebleeds, vomiting of blood, or coughing up blood where the blood is bright red and accompanied by a dry mouth and throat.

Origin Fu Ren Da Quan Liang Fang (妇人大全良方, Complete Collection of Effective Formulas for Women) by Chen Ziming, with origins in Yang Shi Jia Cang Fang (杨氏家藏方) by Yang Tan — Southern Song dynasty (南宋), 1237 CE (Chen Ziming's text); precursor formula from 1178 CE (Yang Tan's text)
Composition 4 herbs
Ce Bai Ye
King
Ce Bai Ye
Di Huang
Deputy
Di Huang
He Ye
Assistant
He Ye
Ai Ye
Assistant
Ai Ye
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Si Sheng Wan is designed to correct these specific patterns.

Why Si Sheng Wan addresses this pattern

Blood-Heat recklessly moving (血热妄行) is the core pattern this formula addresses. When Heat enters the Blood level, it damages vessel walls and drives blood out of its normal pathways, causing bleeding that is bright red, sudden, and often from the upper body. The formula's entire composition targets this pattern: Ce Bai Ye and Sheng Di Huang powerfully cool the Blood and stop bleeding, He Ye clears Heat while dispersing stasis, and Ai Ye reinforces hemostasis while preventing the cold herbs from causing new stasis. The emphasis on fresh, unprocessed herbs maximizes cooling potency. This formula is specifically designed for acute, excess-type Blood-Heat bleeding rather than chronic deficiency bleeding.

A practitioner would look for one or more of these signs

Nosebleeds

Bright red blood, sudden onset

Vomiting Blood

Blood is fresh red, forcefully expelled

Coughing Up Blood

Bright red blood in sputum or pure blood

Dry Mouth

Dry mouth and throat from Heat consuming fluids

Red Tongue

Tongue red or deep red (绛), indicating Blood-level Heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Si Sheng Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Heat

TCM Interpretation

In TCM, recurrent or heavy nosebleeds are most commonly attributed to Heat affecting the Lung and Stomach channels, which pass through the nasal region. When the Liver stores excessive Heat (Liver Fire), it can "punish" the Lung (since Wood controls Metal in five-phase theory), driving hot blood upward to the nose. The blood is characteristically bright red, the flow can be profuse, and it is typically accompanied by signs of internal Heat such as a dry throat, irritability, and a red tongue.

Why Si Sheng Wan Helps

Si Sheng Wan directly targets the Blood-Heat mechanism underlying nosebleeds. Ce Bai Ye (Biota leaves) enters the Lung channel and is one of the most effective herbs for cooling the Blood in the nasal vessels. Sheng Di Huang cools Blood at a deeper level and replenishes the Yin fluids consumed by the Heat. He Ye clears ascending Heat in the Stomach channel (which passes alongside the nose), while Ai Ye strengthens the overall hemostatic effect. Clinical studies have shown effectiveness rates above 93% for nosebleeds treated with this formula as the base prescription.

Also commonly used for

Vomiting Blood

Hematemesis from gastric ulcers or other causes when due to Blood-Heat

Heavy Menstrual Bleeding

Especially menopausal dysfunctional uterine bleeding with Blood-Heat signs

Bleeding Gums

Gum bleeding with bright red blood and Heat signs

Purpura

Chronic idiopathic thrombocytopenic purpura with Blood-Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Si Sheng Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Si Sheng Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Si Sheng Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Si Sheng Wan works at the root level.

This formula addresses bleeding caused by Heat in the Blood level forcing blood out of the vessels, a condition known in TCM as "Blood-Heat recklessly moving" (血热妄行). When excessive Heat accumulates in the Blood, it damages the vessel walls and drives blood outward and upward, leading to bleeding from the upper body, particularly the nose, mouth, and lungs.

The Liver stores Blood and belongs to Wood. When Liver Fire flares, it can "punish" the Lung (Metal), since Wood controls Metal in the five-phase cycle. This causes coughing or spitting of blood. Liver Fire can also rebel against the Stomach, forcing blood upward as vomiting of blood. The Heat also consumes Yin fluids, producing dryness of the mouth and throat, a red or deep red tongue, and a wiry, rapid pulse. The bleeding is characteristically bright red because the Heat is vigorous and the blood is being forcefully expelled.

Because the root cause is Heat in the Blood driving blood recklessly out of its proper channels, the treatment principle is to cool the Blood and stop the bleeding. However, an important concern is that overly cold and astringent approaches can congeal blood and create stasis. This formula addresses that risk through its careful composition.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and sweet — bitter to clear Heat and cool Blood, sweet to nourish Yin and generate fluids, with mild astringency to help contain bleeding.

Ingredients

4 herbs

The herbs that make up Si Sheng Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Ce Bai Ye

Ce Bai Ye

Arborvitae Leaf

Dosage 12g
Temperature Cold
Taste Bitter (苦 kǔ), Astringent (涩 sè)
Organ Affinity Lungs, Liver, Spleen
Preparation Must be used fresh (生) and unprocessed; do not char or dry

Role in Si Sheng Wan

Cools the Blood and stops bleeding. As the primary hemostatic herb in the formula, it directly targets bleeding from Blood-Heat, particularly in the upper body (nosebleeds, coughing blood). Used fresh to maximize its cooling properties.
Deputy — Assists and enhances the King
Di Huang

Di Huang

Rehmannia root

Dosage 15g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Kidneys
Preparation Must be used raw (生地黄), not the prepared form (熟地黄)

Role in Si Sheng Wan

Clears Heat and cools the Blood at a deep level while nourishing Yin and generating fluids. Addresses both the bleeding and the dryness symptoms (dry mouth and throat) caused by Heat consuming Yin fluids. Supports the King herb's cooling action.
Assistants — Supports or moderates other herbs
He Ye

He Ye

Lotus leaf

Dosage 9g
Temperature Neutral
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Spleen, Stomach
Preparation Must be used fresh (生)

Role in Si Sheng Wan

Cools Blood and clears Heat, with a mild ability to disperse stasis. Helps stop bleeding while preventing the formula from creating Blood stasis. Particularly effective for bleeding related to the Stomach (vomiting of blood).
Ai Ye

Ai Ye

Mugwort leaf

Dosage 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Spleen, Kidneys
Preparation Must be used fresh (生); fresh Ai Ye is less warm than dried, making it appropriate for a Blood-Heat formula

Role in Si Sheng Wan

Warms channels and stops bleeding. Though warm in nature, its strong hemostatic action reinforces the formula's ability to stop bleeding. Its warmth moderates the cold nature of the other three herbs, preventing excessive coldness from congealing blood into stasis.

Why This Combination Works

How the herbs in Si Sheng Wan complement each other

Overall strategy

Since the pathomechanism is Heat in the Blood forcing blood out of the vessels in the upper body, the formula combines cooling, hemostatic herbs with a mild blood-moving quality to stop bleeding without causing Blood stasis. The use of all four herbs in their fresh (raw, unprocessed) form is deliberate: raw herbs are cooler in nature than their dried or prepared counterparts, maximizing the formula's Blood-cooling effect.

King herbs

Ce Bai Ye (fresh Biota leaves) is the King. It is cold in nature, enters the Lung and Liver channels, and is one of the most potent cooling hemostatic herbs available. It directly addresses bleeding from Blood-Heat, particularly nosebleeds and coughing of blood, by cooling the Blood and constricting damaged vessels.

Deputy herbs

Sheng Di Huang (raw Rehmannia root) serves as Deputy. It is sweet and cold, enters the Heart, Liver, and Kidney channels, and powerfully clears Heat from the Blood level while nourishing Yin and generating fluids. This addresses both the bleeding and the Yin damage caused by the Heat (dry mouth and throat), and supports the King herb's cooling action from a deeper level.

Assistant herbs

Sheng He Ye (fresh Lotus leaf) is a reinforcing Assistant. It is cool in nature, enters the Liver and Stomach channels, and clears Heat while having a mild ability to scatter stasis. This prevents stopped blood from congealing into problematic clots and specifically helps with vomiting of blood by addressing Stomach-level Heat.

Sheng Ai Ye (fresh Mugwort leaf) is a restraining Assistant. Uniquely among the four herbs, Ai Ye is warm in nature and is renowned for its hemostatic properties. Its inclusion serves two purposes: it powerfully reinforces the bleeding-stopping effect of the formula, and its warmth moderates the cold nature of the other three herbs, preventing the formula from being so cold that it congeals blood into stasis. Fresh Ai Ye is less warm than dried Ai Ye, making it appropriate here.

Notable synergies

The combination of three cold herbs with one warm herb (a "three cold, one warm" structure) is the hallmark of this formula's design. This prevents excessive coldness from causing Blood stasis while still maintaining a strongly cooling overall effect. Additionally, all herbs entering the Liver channel creates a focused action on the organ responsible for storing Blood and most commonly implicated in Blood-Heat bleeding.

How to Prepare

Traditional preparation instructions for Si Sheng Wan

The classical method calls for taking equal portions of all four herbs in their fresh (raw) form, pounding them together into a paste, and forming pills the size of a chicken egg (approximately 30g each). One pill is taken per dose, dissolved in boiling water. This is typically taken without regard to meals.

In modern clinical practice, fresh herbs are often difficult to obtain, so the formula is commonly adapted as a decoction. When made as a decoction, standard modern dosages are used (Ce Bai Ye 12g, Sheng Di Huang 15g, He Ye 9g, Ai Ye 9g), decocted in water and taken warm. Alternatively, fresh herbs may be pounded to extract the juice, which is taken cool or slightly warmed.

Common Modifications

How practitioners adapt Si Sheng Wan for specific situations

Added
Xiao Ji

15g, strengthens cooling and hemostasis

Bai Mao Gen

15 - 30g, cools Blood and stops bleeding

Ou Jie

9 - 15g, stops bleeding and disperses stasis

Xian He Cao

15 - 30g, astringes and stops bleeding

When bleeding is copious and urgent, additional hemostatic herbs are needed to reinforce the formula's Blood-cooling and bleeding-stopping power.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Si Sheng Wan should not be used or requires extra caution

Avoid

Bleeding caused by Spleen Qi deficiency failing to control Blood (Spleen not holding Blood pattern). This formula cools Blood and is designed for Heat in the Blood, not for deficiency-type bleeding where the blood is pale and accompanied by fatigue and weak digestion.

Avoid

Bleeding due to Blood stasis without Heat signs. Si Sheng Wan is a cooling formula and may worsen stasis if the underlying cause is cold congealing the Blood rather than Heat forcing Blood out of the vessels.

Avoid

Prolonged or excessive use beyond the acute bleeding episode. Classical commentary warns that this formula should only be used temporarily to arrest active hot bleeding. Prolonged use of its cold nature can congeal Blood into stasis and impair the generation of new Blood.

Caution

Patients with cold constitutions or Yang deficiency. The predominantly cold nature of this formula can further damage Yang Qi and worsen cold-type symptoms such as cold limbs, pale complexion, and loose stools.

Caution

Patients with pre-existing Spleen and Stomach deficiency with poor digestion. Sheng Di Huang (raw Rehmannia) is rich and cloying, which may impair Spleen function and cause digestive discomfort in those with weak digestion.

Caution

Use caution when taking concurrently with anticoagulant or antiplatelet medications, as the hemostatic and Blood-cooling effects of the formula may theoretically interact with these drugs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Sheng Di Huang (raw Rehmannia) is very cold in nature and in large doses could potentially affect the fetus through excessive cooling. Sheng Ai Ye (raw mugwort leaf) in its fresh/raw form is milder than the processed version but mugwort is traditionally associated with uterine effects. While none of the four herbs are classic abortifacients, the overall cold nature of the formula and its Blood-moving (anti-stasis) properties in the lotus leaf and mugwort leaf warrant caution. Pregnant women should only use this formula under direct supervision of a qualified practitioner and only when the clinical need (active hemorrhage due to Blood Heat) clearly outweighs potential risks.

Breastfeeding

No specific classical prohibitions exist for use during breastfeeding. However, the formula's cold nature may theoretically affect breast milk quality or the nursing infant's digestion if taken in large doses or for prolonged periods. Sheng Di Huang (raw Rehmannia) is particularly cold and cloying, which could contribute to digestive upset in a sensitive infant through breast milk transfer. Since this formula is only intended for short-term acute use to stop active bleeding, brief therapeutic courses under practitioner guidance are unlikely to pose significant risk. If breastfeeding mothers require this formula, they should be monitored for any changes in milk supply or signs of digestive cold in the infant.

Children

Si Sheng Wan may be used in children with appropriate dose reduction under practitioner supervision. Since the original formula is made from fresh herbs pounded into large pills (about 30g each for adults), pediatric doses should be scaled proportionally by body weight, typically one-third to one-half the adult dose for school-age children and less for younger children. The formula's cold nature requires particular caution in children, whose Spleen and Stomach are considered constitutionally immature in TCM. Prolonged use should be strictly avoided in pediatric patients. If the child shows signs of poor appetite, loose stools, or abdominal discomfort, the formula should be discontinued promptly. This formula is not suitable for infants without specific practitioner guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Si Sheng Wan

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Si Sheng Wan is a hemostatic (Blood-stopping) formula, so its effects may theoretically counteract or complicate anticoagulant therapy. Conversely, Sheng Di Huang (raw Rehmannia) has been reported in pharmacological studies to have mild effects on blood viscosity. Concurrent use could produce unpredictable effects on coagulation and should be avoided without medical supervision.

Antihypertensive medications: Sheng Di Huang has been shown in some studies to have mild blood pressure-lowering effects. Combined use with antihypertensive drugs could theoretically enhance hypotensive effects, though this is unlikely to be clinically significant at standard formula doses.

Iron supplements: The tannins present in Ce Bai Ye (Platycladus orientalis leaf) and He Ye (lotus leaf) may reduce iron absorption if taken concurrently. It is advisable to separate dosing by at least two hours.

Usage Guidance

Practical advice for getting the most out of Si Sheng Wan

Best time to take

Not restricted by time of day (classical instruction: 不拘时, "regardless of time"). Take as needed when bleeding is active.

Typical duration

Acute use only: 1–3 days, discontinued as soon as bleeding stops (classical principle: 中病即止, stop when the condition responds).

Dietary advice

While taking Si Sheng Wan, avoid hot, spicy, and pungent foods (such as chili peppers, garlic, ginger, fried foods, and alcohol) as these generate Heat and may counteract the formula's cooling hemostatic action. Also avoid greasy, rich foods that can impair Spleen function and hinder the formula's absorption, since Sheng Di Huang is already cloying by nature. Favor cooling, bland, and easily digestible foods such as congee, fresh vegetables, pear, watermelon, mung bean soup, and lotus root. Lotus root is particularly well-suited as it has its own mild hemostatic properties in the Chinese dietary tradition.

Si Sheng Wan originates from Fu Ren Da Quan Liang Fang (妇人大全良方, Complete Collection of Effective Formulas for Women) by Chen Ziming, with origins in Yang Shi Jia Cang Fang (杨氏家藏方) by Yang Tan Southern Song dynasty (南宋), 1237 CE (Chen Ziming's text); precursor formula from 1178 CE (Yang Tan's text)

Classical Texts

Key passages from the classical Chinese medical texts that first described Si Sheng Wan and its clinical use

Ke Qin (柯琴), quoted in Shan Bu Ming Yi Fang Lun (删补名医方论, part of Yi Zong Jin Jian):

Original: 「阴虚而阳无所附,则火炎上焦,阳盛则阳络伤,故血上溢于口鼻也。凡草木之性,生者凉而熟之则温,熟者补而生者泻。四味皆清寒之品,尽取其生者,而捣烂为丸,所以全其水气,不经火煮,更远于火令矣。生地多膏清心肾而通血脉之源,柏叶西指清肺金而调荣卫之气,艾叶芳香入脾胃而擅去瘀生新之权,荷叶法震入肝家而和藏血摄血之用。五志之火既清,五藏之阴安堵,则阴平阳秘,而血归经矣。」

Translation: "When Yin is deficient and Yang has nothing to anchor to, Fire flares in the upper burner. When Yang is excessive, the Yang collateral vessels are damaged, and Blood overflows upward through the mouth and nose. Among plants, those used raw are cooling while those processed by heat become warming; processed herbs supplement while raw ones drain. All four ingredients are cool and cold in nature, and all are used raw, pounded into pills to preserve their watery nature. They are not boiled by fire, keeping them far from the influence of Fire. Raw Rehmannia, rich in moisture, clears the Heart and Kidneys and opens the source of the blood vessels. Cypress leaf, pointing west, clears the Lung-Metal and regulates the Nutritive and Defensive Qi. Mugwort leaf, fragrant, enters the Spleen and Stomach and excels at dispelling stasis to generate the new. Lotus leaf, embodying the rising energy of the east, enters the Liver and harmonizes the storing and restraining of Blood. When the Fire of the five emotions is cleared and the Yin of the five Zang organs is settled, then Yin is calm and Yang is secure, and Blood returns to its channels."

Ke Qin (柯琴), continued:

Original: 「是方也,可暂用以遏妄行之热血,如多用则反伤荣。盖血得寒则瘀血不散,而新血不生也。设但知清火凉血,而不用归脾养荣等剂以善其后,鲜有不绵连岁月而毙者。非立法之不善,妄用者之过耳。」

Translation: "This formula may be used temporarily to arrest recklessly moving hot Blood, but if overused it will instead damage the Nutritive level. For when Blood encounters cold, stagnant Blood does not disperse and new Blood cannot be generated. If one only knows how to clear Fire and cool Blood without following up with formulas like Gui Pi Tang to nourish the Spleen and nurture the Nutritive Qi, few patients will avoid lingering illness and eventual death. This is not a flaw in the formula's design, but a fault of those who misuse it."

Historical Context

How Si Sheng Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Si Sheng Wan has an interesting evolution across the Song dynasty. The formula first appeared under the name "Si Wei Wan" (四味丸, "Four-Ingredient Pill") in Yang Tan's (杨倓) Yang Shi Jia Cang Fang (杨氏家藏方), published in 1178 CE during the Southern Song dynasty. In that version, the formula was listed as "lotus leaf, mugwort leaf, cypress leaf, and raw Rehmannia" for treating vomiting of blood, but the three leaves were not specified as needing to be used fresh or raw.

The famous Song dynasty gynecology specialist Chen Ziming (陈自明, c. 1190–1270) then made a critical modification: he changed all three leaves to be used in their raw, fresh state (生用), included the formula in his landmark gynecological text Fu Ren Da Quan Liang Fang (妇人大全良方, "Complete Collection of Effective Formulas for Women"), and renamed it Si Sheng Wan (四生丸, "Four Fresh Pill"). The word "Sheng" (生, "raw/fresh") in the name emphasizes what makes this formula distinctive: all four herbs must be used fresh and unprocessed. This is because raw herbs are cooling and draining in nature, while processed herbs tend to be warming and supplementing. By insisting on raw forms, Chen Ziming maximized the formula's Blood-cooling and Heat-clearing power.

The formula was later included in the Qing dynasty imperial medical compendium Yi Zong Jin Jian (医宗金鉴, 1742) within the Shan Bu Ming Yi Fang Lun (删补名医方论) section, where the commentator Ke Qin (柯琴) provided an influential analysis of its mechanism. Ke Qin emphasized that the formula should only be used as an emergency measure for acute hot bleeding and must be followed by tonifying formulas such as Gui Pi Tang to nourish the Spleen and Blood, warning that prolonged use would congeal Blood and prevent regeneration.