Formula

Xi Jiao Di Huang Tang

犀角地黄汤

Also known as:

Qing Re Di Huang Tang (清热地黄汤, Clear Heat and Rehmannia Decoction)

Properties

Heat-clearing formulas · Cold

Key Ingredients

Shui Niu Jiao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A classical emergency formula used when severe internal Heat has entered the Blood, causing abnormal bleeding (nosebleeds, vomiting blood, blood in stool or urine), dark purple skin discolouration, high fever, and mental confusion or agitation. It works by powerfully cooling the Blood, clearing Heat toxins, nourishing depleted body fluids, and dispersing blood clots that form when Heat scorches the Blood. Originally using rhinoceros horn, modern versions substitute water buffalo horn.

Formula Category*

Main Actions*

  • Clears Heat and Resolves Toxicity
  • Cools the Blood
  • Invigorates Blood and Dispels Stasis
  • Nourishes Yin

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xi Jiao Di Huang Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Xi Jiao Di Huang Tang addresses this pattern

This is the primary pattern addressed by this formula. When pathogenic Heat penetrates deep into the Blood level, it produces three categories of disturbance: it agitates the Heart spirit (causing delirium and mania-like behaviour), it forces Blood out of the vessels recklessly (causing various types of bleeding and skin eruptions), and it scorches Yin fluids, thickening the Blood and leading to stasis. Shui Niu Jiao directly enters the Blood level to clear Heat and calm the spirit. Sheng Di Huang cools the Blood while replenishing the Yin that Heat has consumed. Chi Shao and Mu Dan Pi clear residual Heat from the Blood while actively dispersing the stasis that invariably accompanies Blood-level Heat. The formula thus addresses all three consequences of Heat in the Blood simultaneously.

A practitioner would look for one or more of these signs

Hematemesis

Vomiting blood due to Heat forcing Blood upward out of the vessels

Nosebleeds

Nosebleeds from Heat damaging the upper Blood vessels

Dark Blood In Stool

Dark or black stool indicating Heat-driven bleeding in the lower body

Blood In Urine

Blood in the urine from Heat damaging the lower Blood vessels

Skin Rashes

Dark purple-black macules (Ban) on the skin from Blood extravasating into the tissues

Delirium

Delirious speech or mania-like agitation from Heat disturbing the Heart spirit

Fever

High fever with a deep crimson tongue that has raised prickles

How It Addresses the Root Cause*

Xi Jiao Di Huang Tang addresses a critical stage in the progression of febrile (Heat) disease: the deepest penetration of pathogenic Heat into the Blood level (血分, xue fen). In the Warm Disease (Wen Bing) framework, Heat can progress inward through four stages — Defensive (Wei), Qi, Nutritive (Ying), and Blood (Xue). This formula targets the most severe stage, where Heat has fully invaded the Blood.

When intense Heat enters the Blood level, it produces three overlapping types of damage. First, because the Heart governs Blood and houses the spirit (shen), Heat in the Blood disturbs the mind, causing restlessness, delirium, and in severe cases manic behavior. Second, Heat forces Blood out of its normal channels — it "drives the Blood recklessly" (迫血妄行). Blood that overflows upward causes vomiting of blood and nosebleeds; blood that spills downward causes bloody stool and urine; blood that leaks into the skin produces dark purplish rashes (斑, ban). Third, extreme Heat scorches the fluids within the Blood, thickening it and causing stagnation. This stagnant Blood (瘀血) combines with Heat to form a vicious cycle: the tongue becomes deep crimson and dry, stools turn black, and the person may swish water in the mouth but not want to swallow it (because the Heat sits deep in the Yin level, steaming fluids upward to the mouth).

The key therapeutic challenge is threefold: Heat must be cleared or the Blood will never calm; stagnant Blood must be dispersed or it will accumulate and cause further harm; and Yin must be replenished or the Fire will never be extinguished. As the Qing dynasty physician Ye Tianshi famously stated: "Once Heat enters the Blood, one must directly cool the Blood and disperse the Blood." This formula answers all three needs simultaneously.

Formula Properties*

Temperature

Cold

Taste Profile

Predominantly bitter and sweet with a salty undertone — bitter to clear Heat, sweet to nourish Yin and Blood, salty to enter the Blood level and soften hardness.

Target Organs
Heart Liver Stomach
Channels Entered
Heart Liver Stomach

Formula Origin

Bei Ji Qian Jin Yao Fang (備急千金要方)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Miscellaneous Info

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Ingredients in Xi Jiao Di Huang Tang

Detailed information about each herb in Xi Jiao Di Huang Tang and their roles

Kings
Deputies
Assistants
Shui Niu Jiao
Shui Niu Jiao

Water buffalo horn

Dosage: 30 - 60g

Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Parts Used Animal — part (动物部分 dòng wù bù fèn)
Role in Xi Jiao Di Huang Tang

The chief herb of the formula. Salty and cold, it enters directly into the Blood level to clear the Heart, cool the Blood, and resolve Heat toxins. It calms the Blood so that bleeding stops and the mind clears. Originally rhinoceros horn (Xi Jiao) was used, but water buffalo horn (Shui Niu Jiao) is now the standard substitute.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 15 - 30g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Xi Jiao Di Huang Tang

Assists the King herb in clearing Heat and cooling the Blood. It also nourishes Yin and generates fluids, which is critical because intense Blood-level Heat severely depletes the body's Yin fluids. This dual action of clearing Heat while replenishing what Heat has consumed makes it an essential complement to Shui Niu Jiao.

Chi Shao
Chi Shao

Red peony root

Dosage: 9 - 15g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver
Parts Used Root (根 gēn)
Role in Xi Jiao Di Huang Tang

Cools the Blood and disperses Blood stasis. When intense Heat enters the Blood, the Blood thickens and tends to clot. Chi Shao prevents this stagnation from forming while reinforcing the Blood-cooling action of the King and Deputy herbs. The original text uses the name Shao Yao (芍药), which in this Blood-Heat context is understood as Chi Shao (red peony root).

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 6 - 12g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Xi Jiao Di Huang Tang

Cools the Blood and disperses stasis that has already formed. Mu Dan Pi is uniquely suited here because it can break up extravasated Blood (Blood that has leaked out of the vessels) without accelerating Blood flow or worsening bleeding. Together with Chi Shao, it ensures that while Heat is cleared and Blood is cooled, old stasis does not linger.

Modern Research (1 study)

  • Systematic Review Protocol: Efficacy and Safety of Xijiao Dihuang Decoction in Treating Henoch-Schönlein Purpura (2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Divided into 2–3 doses daily, taken warm on an empty stomach or between meals for optimal absorption. In acute emergencies, doses may be given more frequently as directed by the prescribing practitioner.

Typical Duration

Acute use: typically 3–7 days, reassessed frequently. This is an emergency-grade formula for active Blood-level Heat and should be discontinued or modified once the acute condition stabilizes.

Dietary Advice

While taking this formula, avoid hot, spicy, greasy, and fried foods, which can generate internal Heat and counteract the cooling action of the herbs. Alcohol should be strictly avoided as it heats the Blood. Favor cooling, easily digestible foods such as mung bean soup, pear, watermelon, cucumber, lotus root, and fresh leafy greens. Because the formula is strongly cold, those with fragile digestion should also limit raw, cold, and icy foods to prevent further burdening the Spleen and Stomach. Congee (rice porridge) is a good staple while taking this formula, as it supports digestion and fluid replenishment.

Special Populations

Pregnancy

Use with caution during pregnancy. Mu Dan Pi (Moutan Cortex) and Chi Shao (Red Peony Root) both activate Blood circulation and disperse stasis, which may stimulate uterine contractions and increase the risk of miscarriage or premature labor. The formula should only be considered during pregnancy in life-threatening situations where Blood-level Heat poses a greater immediate danger than the risks of treatment, and only under close medical supervision.

Breastfeeding

Use with caution during breastfeeding. The formula's strongly cold nature may potentially affect the nursing infant through breast milk, possibly causing digestive upset (loose stools or reduced appetite) in the baby. Mu Dan Pi and Chi Shao have Blood-activating properties whose transfer through breast milk has not been formally studied. If required for a serious Blood-Heat condition in the mother, short-term use under practitioner supervision is reasonable, but the infant should be monitored for signs of digestive disturbance or unusual fussiness.

Pediatric Use

Xi Jiao Di Huang Tang has documented pediatric use, particularly for conditions like Henoch-Schönlein purpura (allergic purpura) in children. Dosages should be reduced proportionally based on age and body weight, typically to one-third to one-half the adult dose for children aged 6–12, and one-quarter for younger children. Because of the formula's strongly cold nature, pediatric use requires careful attention to the child's digestive function. If stomach discomfort, poor appetite, or loose stools develop, the formula should be modified with Spleen-protective additions (such as Sha Ren or Ji Nei Jin) or the dosage reduced. This formula should only be used in children when clear signs of Blood-level Heat are present and should be discontinued promptly once the acute condition resolves.

Cautions & Warnings

Xi Jiao Di Huang Wan is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Xi Jiao Di Huang Wan.