Hua Ban Tang

Transform Maculae Decoction · 化斑湯

Also known as: Transform Blotches Decoction, Resolve Maculae Decoction

A classical formula for treating high fever accompanied by red skin blotches (maculae), intense thirst, and restlessness during severe febrile illnesses. It works by simultaneously clearing intense Heat from both the Qi level and the Blood level, cooling the Blood, and resolving toxins. In modern practice, rhinoceros horn has been replaced by water buffalo horn (Shui Niu Jiao).

Origin Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Pathogen Diseases) by Wu Jutong (吴鞠通) — Qīng dynasty, 1798 CE
Composition 6 herbs
Shi Gao
King
Shi Gao
Shui Niu Jiao
Deputy
Shui Niu Jiao
Xuan Shen
Deputy
Xuan Shen
Zhi Mu
Assistant
Zhi Mu
Gan Cao
Envoy
Gan Cao
Jing Mi
Envoy
Jing Mi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Hua Ban Tang is designed to correct these specific patterns.

Why Hua Ban Tang addresses this pattern

Hua Ban Tang directly addresses the condition where pathogenic Heat has blazed through both the Qi level (manifesting as high fever, intense thirst, and a yellow tongue coating) and the Blood level (manifesting as red maculae on the skin, a deep crimson tongue body, and rapid pulse). Wu Jutong specifically created this formula for situations in warm-febrile disease where Heat is not confined to a single level. Shi Gao and Zhi Mu clear the fierce Qi-level Heat, while Shui Niu Jiao (replacing Xi Jiao) and Xuan Shen cool the Blood and resolve toxins. This dual-level approach is what distinguishes Hua Ban Tang from formulas that address only one level.

A practitioner would look for one or more of these signs

High Fever

Intense, burning fever that may worsen at night

Skin Rashes

Red maculae (flat, non-raised blotches) appearing across the body

Excessive Thirst

Intense thirst with desire for cold drinks

Restlessness

Irritability and agitation due to Heat disturbing the Heart

Red Tongue

Deep crimson (绛) tongue body with yellow coating

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Hua Ban Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Heat in the Blood Qi and Blood level Heat

TCM Interpretation

In TCM, purpura (subcutaneous bleeding that produces purple or red spots) is understood as a condition where intense Heat in the Blood forces it to extravasate out of its normal vessels and pathways, spilling under the skin. This is classified as 'muscle-level bleeding' (肌衄). The Heart governs Blood and the Lung governs the skin, so when Fire-Heat invades these organs, the vessels lose their integrity and Blood escapes. If there is also Qi-level Heat (manifesting as fever and thirst), the condition involves both levels simultaneously.

Why Hua Ban Tang Helps

Hua Ban Tang addresses both the Qi-level and Blood-level Heat that drive purpura. Shi Gao and Zhi Mu clear the systemic Heat that inflames the vessels, while Shui Niu Jiao (replacing Xi Jiao) directly enters the Blood to cool it and resolve toxins, helping to stop the extravasation. Xuan Shen nourishes the Yin reserves that have been depleted by the sustained Heat, supporting the body's ability to contain Blood within its vessels. Clinical reports have documented the use of this formula for allergic purpura with favorable outcomes.

Also commonly used for

Meningitis

Epidemic cerebrospinal meningitis with fever and purpura

Sepsis

Severe infections with high fever and disseminated intravascular coagulation

Measles

Measles with intense Heat and macular rash

Scarlet Fever

Scarlet fever with Blood-Heat pattern

Hemorrhagic Fevers

Epidemic hemorrhagic fever

What This Formula Does

Every TCM formula has a specific set of actions — here's what Hua Ban Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Hua Ban Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Hua Ban Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Hua Ban Tang works at the root level.

Hua Ban Tang addresses a specific and dangerous stage of Warm Disease (温病, Wen Bing) in which intense pathogenic Heat, having entered through the upper body, blazes through the Yangming (Stomach) system and penetrates into the Blood level. In TCM theory, the Yangming system governs the muscles and flesh. When extreme Heat accumulates in Yangming without a route of escape, it "steams" from the interior outward, scorching the Blood vessels and forcing Blood out of its normal pathways. This produces the characteristic maculae: flat, red or dark red blotches that spread across the skin and do not fade under pressure.

The classical trigger described by Wu Jutong is the misuse of sweating methods in warm disease. Since warm pathogens enter through the mouth and nose (not through the exterior surface as cold pathogens do), forcing sweat is futile and instead drives the Heat deeper. The Heat, already fierce in the Qi level, then invades the nutritive (Ying) and Blood levels. At this stage, the intense Heat disturbs the Heart spirit, causing delirium and confused speech, produces raging thirst from severe fluid damage, and generates the red maculae from Blood being forced out of vessels. The tongue turns deep crimson with dry yellow coating, and the pulse becomes rapid and surging. These signs all point to a condition where both the Qi and Blood levels are simultaneously engulfed in Heat.

The pathomechanism thus involves a dual crisis: blazing Yangming Qi-level Heat consuming fluids, and toxic Heat invading the Blood level causing hemorrhagic skin eruptions and disturbing the spirit. If the Kidney Yin (the body's deepest reserve of cooling Water) is not protected, the "source" may be catastrophically depleted, a situation Wu Jutong described as the "spring being suddenly cut off" (泉源暴绝). The formula must therefore clear Qi-level Heat, cool and detoxify the Blood, and protect the body's Yin reserves simultaneously.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly sweet-cold and salty-cold, with the sweetness of Shi Gao and Gan Cao to clear Heat and protect fluids, the saltiness of Shui Niu Jiao to enter the Blood level and direct action downward, and the bitterness of Zhi Mu to drain Fire and preserve Yin.

Channels Entered

Stomach Lung Heart Kidney

Ingredients

6 herbs

The herbs that make up Hua Ban Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shi Gao

Shi Gao

Gypsum

Dosage 30g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Preparation Crush and decoct first for 15-20 minutes

Role in Hua Ban Tang

Clears blazing Heat from the Qi level, particularly from the Lung and Stomach. As the principal herb, it addresses the core pathomechanism of intense Yangming-level Heat that has spread to the muscle layer and skin, causing maculae. Its acrid-sweet and very cold nature powerfully drains Fire and generates fluids.
Deputies — Assists and enhances the King
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 30 - 60g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Shaved into thin slices (镑片), decocted first for 3 hours or more. Original Xi Jiao dosage was 6g.

Role in Hua Ban Tang

Enters the Blood level to cool the Blood, clear Heart Fire, resolve toxins, and push maculae outward. The original formula used rhinoceros horn (Xi Jiao), now replaced by water buffalo horn due to wildlife protection laws. Its salty-cold nature directly enters the Blood to address the Blood-level Heat component of the pathomechanism.
Xuan Shen

Xuan Shen

Ningpo figwort root

Dosage 9 - 12g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys

Role in Hua Ban Tang

Cools the Blood, resolves toxic Heat, and nourishes Yin. It draws upon Kidney Yin to ascend and connect with Lung fluids, preventing the source of Yin from being suddenly exhausted by the intense Heat. This creates a circuit of Water and Metal working together to counterbalance Fire.
Assistant — Supports or moderates other herbs
Zhi Mu

Zhi Mu

Anemarrhena rhizome

Dosage 12g
Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys

Role in Hua Ban Tang

Clears Heat from the Lung and Stomach, nourishes Yin and moistens Dryness. Supports Shi Gao in draining Qi-level Heat while protecting the Lung (Metal) from being overwhelmed by the excessive Yangming (Stomach) Heat.
Envoys — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 9 - 10g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Use raw (sheng) form, not honey-prepared

Role in Hua Ban Tang

Clears Heat and resolves toxins, supplements the Middle Burner, and harmonizes all the other herbs in the formula. Protects the Stomach from being damaged by the strongly cold properties of the other ingredients.
Jing Mi

Jing Mi

Non-glutinous rice

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Lungs

Role in Hua Ban Tang

Protects the Stomach and preserves its fluids. The strongly cold herbs in the formula could damage the Middle Burner, and rice cushions this effect while also helping to generate body fluids. Rice is considered the 'grain of Yangming,' making it the natural protective agent for the Stomach.

Why This Combination Works

How the herbs in Hua Ban Tang complement each other

Overall strategy

This formula addresses a situation where intense Heat has blazed through both the Qi level and the Blood level simultaneously. The prescription logic follows the principle stated in the original text: "when Heat rages internally, treat with salty-cold substances, assisted by bitter-sweet ones." The strategy combines the powerful Qi-level Heat-clearing framework of Bai Hu Tang (White Tiger Decoction) with Blood-cooling and toxin-resolving agents.

King herb

Shi Gao (Gypsum) is the King because the root of the problem lies in overwhelming Yangming Heat. Since the Yangming (Stomach) channel governs the muscles and flesh, and maculae manifest across the entire body surface, the intense Qi-level Heat must be cleared first. Shi Gao's acrid-sweet, intensely cold nature drains this Fire from the Lung and Stomach, serving as the formula's anchor.

Deputy herbs

Shui Niu Jiao (Water Buffalo Horn, replacing Xi Jiao) and Xuan Shen serve as Deputies. As Wu Jutong explains, once the disease has progressed to producing maculae, the pathology is no longer confined to the Qi level alone. Shui Niu Jiao enters the Blood level directly with its salty-cold nature, cooling the Blood, resolving toxins, and helping push the maculae outward. Xuan Shen draws upon Kidney Yin to rise and connect with the Lung, establishing a Water-Metal circuit that prevents the body's deepest fluid reserves from being abruptly exhausted by the raging Heat.

Assistant herb

Zhi Mu (Anemarrhena) is a reinforcing Assistant that supports Shi Gao in clearing Qi-level Heat while also nourishing Yin and moistening Dryness. It specifically protects the Lung (Metal) from being overwhelmed by the Yangming's excessive Heat, maintaining the Lung's downward-directing and fluid-distributing function.

Envoy herbs

Sheng Gan Cao (raw Licorice) and Bai Jing Mi (white rice) both serve as Envoys. Gan Cao clears Heat, resolves toxins, and harmonizes the formula's intensely cold herbs so they do not injure the Spleen and Stomach. Jing Mi specifically protects the Stomach and preserves its fluids, acting as a buffer against the formula's cold properties.

Notable synergies

The Shi Gao and Zhi Mu pairing (from Bai Hu Tang) powerfully clears Qi-level Heat while generating fluids. The Shui Niu Jiao and Xuan Shen pairing simultaneously cools Blood and nourishes Yin, addressing the Blood-level component. Together, these two pairs create a dual-action strategy that clears Heat from both the Qi and Blood levels, which neither pair could achieve alone. This is the formula's distinctive contribution compared to pure Qi-level formulas like Bai Hu Tang or pure Blood-level formulas like Xi Jiao Di Huang Tang.

How to Prepare

Traditional preparation instructions for Hua Ban Tang

Use 8 cups of water. Add the crushed Shi Gao (and Shui Niu Jiao shavings, which require extended decoction of at least 3 hours) first. Then add the remaining herbs and Bai Jing Mi (white rice). Bring to a boil and reduce heat, cooking until approximately 3 cups remain. Strain and take one cup per dose, three times during the day. Re-cook the dregs to yield one more cup, taken once at night.

Note: The original formula specified Xi Jiao (rhinoceros horn), which is now prohibited. Modern practice substitutes Shui Niu Jiao (water buffalo horn) at a significantly increased dosage (30-60g vs. the original 6g of Xi Jiao), shaved into thin slices and decocted first for a prolonged period.

Common Modifications

How practitioners adapt Hua Ban Tang for specific situations

Added
Niu Huang

Add An Gong Niu Huang Wan (one pill) or Zi Xue Dan to open the orifices and clear Heat from the Heart

When Heat penetrates the Pericardium causing loss of consciousness and delirium, the aromatic orifice-opening action of An Gong Niu Huang Wan or Zi Xue Dan is needed alongside Hua Ban Tang's Heat-clearing to restore clarity.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Hua Ban Tang should not be used or requires extra caution

Avoid

Spleen and Stomach Yang Deficiency or Cold patterns. This is a strongly cold formula that will further damage Yang in patients with underlying deficiency-cold constitutions.

Avoid

Skin eruptions caused by external Wind-Cold or due to Qi and Blood Deficiency. The formula is designed for Heat-toxin in the Qi and Blood levels, not for eruptions from Cold or deficiency origins.

Avoid

Use of Wind-dispersing or upward-lifting herbs simultaneously. Wu Jutong explicitly prohibits combining this formula with Sheng Ma (Cimicifuga), Chai Hu (Bupleurum), Dang Gui, Fang Feng, Qiang Huo, Bai Zhi, Ge Gen, and San Chun Liu, as these warm, drying, or upward-moving herbs can damage Yin fluids and worsen the condition.

Caution

Cases where the rash or maculae have not fully emerged and the pathogen is still primarily at the Wei (defensive) level. The formula addresses Heat that has already penetrated the Qi and Blood levels.

Caution

Patients with pre-existing severe diarrhea or loose stools, as the cold nature of the formula may further weaken digestive function.

Caution

Prolonged use beyond the acute phase. Once the high fever subsides and maculae resolve, the formula should be discontinued to avoid injuring Stomach Qi and Yin with excessive cold.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Shui Niu Jiao (Water Buffalo Horn, the modern substitute for Xi Jiao) and Shi Gao are both strongly cold substances that could potentially affect the fetus through excessive cooling. Xuan Shen is cold and descending in nature. While none of these herbs are classically categorized as abortifacient, the overall intensely cold nature of this formula warrants careful assessment by a qualified practitioner. This formula is intended for acute, life-threatening febrile conditions, so if a pregnant patient genuinely presents with this pattern, the benefit of treating the acute crisis may outweigh the risk. However, the formula should not be used casually or for mild conditions during pregnancy.

Breastfeeding

Caution is advised during breastfeeding. The formula's strongly cold nature (dominated by Shi Gao and Shui Niu Jiao) may transfer cooling properties through breast milk, potentially causing digestive upset or loose stools in the nursing infant. Xuan Shen and Zhi Mu, while not known to be toxic, contribute to the overall cold character. This formula is designed for acute, severe febrile conditions and should only be used during breastfeeding when the clinical situation demands it. Short-term use for genuine high-fever emergencies, under practitioner guidance, is likely acceptable, but the infant should be monitored for signs of digestive disturbance. Discontinue as soon as the acute condition resolves.

Children

Hua Ban Tang can be used in children for acute febrile conditions with maculae, but dosages must be substantially reduced according to age and body weight. A common approach is to reduce all herb doses to one-third to one-half of the adult amount for children over age 6, and one-quarter for younger children. The cold nature of the formula requires particular caution in infants and toddlers whose digestive systems are immature and easily damaged by cold herbs. Monitor closely for loose stools or reduced appetite, and discontinue promptly once the fever breaks and maculae fade. This formula is for short-term acute use only in pediatric patients. A qualified practitioner should always supervise pediatric administration.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Hua Ban Tang

Gan Cao (Licorice): Glycyrrhizic acid in Gan Cao can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure) when combined with corticosteroids, diuretics (especially thiazides and loop diuretics), or cardiac glycosides like digoxin. Patients on antihypertensive medications should be monitored, as Gan Cao may counteract their effects.

Shi Gao (Gypsum) and mineral calcium: The calcium sulfate in Shi Gao may theoretically interfere with the absorption of tetracycline antibiotics, fluoroquinolones, and bisphosphonates if taken concurrently. A gap of at least two hours between doses is advisable.

Shui Niu Jiao (Water Buffalo Horn): Animal-derived substances with potential anticoagulant or anti-platelet properties may potentiate the effects of warfarin, heparin, aspirin, or other blood-thinning medications, increasing bleeding risk. Patients on anticoagulant therapy should be closely monitored.

Xuan Shen (Scrophularia): Xuan Shen has documented mild cardiac effects and should be used cautiously alongside cardiac glycosides (digoxin) due to potential additive effects on heart rate.

Usage Guidance

Practical advice for getting the most out of Hua Ban Tang

Best time to take

Three times during the day and once at night, as specified in the original text (日三服,夜一服). Ideally taken between meals for faster absorption during acute febrile illness.

Typical duration

Acute use only: typically 1–5 days, reassessed daily based on fever, maculae, and mental clarity. Discontinue once acute symptoms resolve.

Dietary advice

Avoid spicy, greasy, fried, and warming foods (lamb, ginger, chili, garlic, alcohol) that may aggravate internal Heat and counteract the formula's cooling effects. Also avoid raw and cold foods that could impair an already stressed digestive system. Favor light, easily digestible, cooling foods such as mung bean soup, pear, watermelon, winter melon, lotus root, cucumber, and plain rice congee. Adequate hydration is essential, as this pattern involves significant fluid loss from high fever. Small, frequent meals of bland food are preferable to heavy meals.

Hua Ban Tang originates from Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Pathogen Diseases) by Wu Jutong (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Hua Ban Tang and its clinical use

Wu Jutong (吴鞠通), Wen Bing Tiao Bian (《温病条辨》), Upper Burner Chapter, Article 16:

「太阴温病,不可发汗,发汗而汗不出者,必发斑疹……发斑者,化斑汤主之。」

"In Taiyin warm disease, sweating methods must not be used. If sweating is attempted but no sweat comes out, maculae and papules will inevitably appear... For maculae, Hua Ban Tang governs."


Wu Jutong, Wen Bing Tiao Bian, Formula Commentary on Hua Ban Tang:

「此热淫于内,治以咸寒,佐以苦甘法也。前人悉用白虎汤作化斑汤者,以其为阳明证也。阳明主肌肉,斑家遍体皆赤,自内而外。」

"This follows the principle of treating internal excess Heat with salty-cold substances, assisted by bitter and sweet. Previous physicians all used Bai Hu Tang as the formula for resolving maculae, because it is a Yangming pattern. Yangming governs the flesh, and those with maculae show redness covering the entire body, manifesting from inside outward."


Wu Jutong, Wen Bing Tiao Bian, Formula Commentary (continued):

「本论独加元参、犀角者,以斑色正赤,木火太过,其变最速……故加元参启肾经之气,上交于肺,庶水天一气,上下循环,不致泉源暴绝也。犀角咸寒,救肾水以济心火,托斑外出,而又败毒辟瘟也。再病至发斑,不独在气分矣,故加二味凉血之品。」

"This text uniquely adds Xuan Shen and Xi Jiao because the maculae are bright red, indicating excessive Wood-Fire, and the changes progress extremely rapidly... Therefore Xuan Shen is added to activate Kidney channel Qi and direct it upward to communicate with the Lungs, so that the Water-Heaven Qi circulates above and below without the source being suddenly exhausted. Xi Jiao, salty and cold, rescues Kidney Water to counterbalance Heart Fire, pushes the maculae outward, and also resolves toxins and repels pestilence. Moreover, when illness reaches the point of producing maculae, it is no longer confined to the Qi level alone, hence the addition of these two Blood-cooling substances."

Historical Context

How Hua Ban Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Hua Ban Tang was created by Wu Jutong (吴鞠通, 1758–1836), one of the four great masters of Warm Disease theory during the Qing Dynasty, and published in his landmark work Wen Bing Tiao Bian (《温病条辨》, Systematic Differentiation of Warm Diseases), completed in 1798 and first printed in 1813. The formula represents Wu Jutong's refinement of earlier approaches to treating Heat-induced maculae. As Wu himself noted, "previous physicians all used Bai Hu Tang as the formula for resolving maculae," treating it purely as a Yangming Qi-level problem. Wu's innovation was recognizing that when maculae appear, the disease has already penetrated beyond the Qi level into the Blood, requiring the addition of Blood-cooling agents.

Wu Jutong built Hua Ban Tang on the foundation of Bai Hu Tang (White Tiger Decoction, from Zhang Zhongjing's Shang Han Lun), adding Xuan Shen and Xi Jiao (rhinoceros horn) to create a formula that simultaneously clears Qi-level Heat and cools the Blood. This dual-level approach reflects Wu's integration of the Yangming six-channel framework with the Wei-Qi-Ying-Xue (defensive-Qi-nutritive-Blood) four-level theory pioneered by Ye Tianshi. The original formula used Xi Jiao (rhinoceros horn), which has been internationally banned since 1993 due to the endangered status of rhinoceros species. Modern practice universally substitutes Shui Niu Jiao (Water Buffalo Horn) at significantly higher doses to approximate the original therapeutic effect.

Clinicians have since expanded Hua Ban Tang's application well beyond its original warm disease context. Reports include its use in allergic purpura, pityriasis rosea, and even as part of treatment strategies for subcutaneous hemorrhage in leukemia patients, typically with additional Blood-cooling and toxin-clearing herbs added to the base formula.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Hua Ban Tang

1

Network pharmacology and experimental study on Hua-ban decoction in acute lung injury (2023)

Zhou W, Hu Z, Wu X, Zhang S, Jiang Y, Tian L, Huang X, Ma Z, Qiu L, Zheng P, Zhang S, Lu Z. Molecular Immunology, 2023, Volume 156, Pages 85-97.

This preclinical study used a lipopolysaccharide-induced acute lung injury (ALI) mouse model to investigate Hua Ban Tang's anti-inflammatory mechanism. The study found that the decoction reduced pulmonary injury by downregulating pro-inflammatory cytokines (IL-6 and TNF-alpha), decreasing macrophage infiltration, and inhibiting macrophage M1 polarization. In vitro experiments on LPS-stimulated macrophages confirmed that bioactive compounds from the formula suppressed inflammatory cytokine secretion.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.