Mai Wei Di Huang Wan

Ophiopogon and Schisandra Rehmannia Pill · 麦味地黄丸

Also known as: Ba Xian Chang Shou Wan (八仙长寿丸, Eight Immortals Longevity Pill), Ba Wei Di Huang Wan (八味地黄丸, Eight-Ingredient Rehmannia Pill)

A classical formula that nourishes the Kidneys and Lungs, used for people with dryness-related symptoms such as chronic dry cough, dry throat, night sweats, dizziness, ringing in the ears, and weak lower back and knees. It builds on the foundational Liu Wei Di Huang Wan by adding two herbs that specifically moisturize the Lungs and help the body retain its fluids. It is sometimes called the "Eight Immortals Longevity Pill" and has a long history of use as a gentle tonic for the elderly.

Origin Shou Shi Bao Yuan (寿世保元) by Gong Tingxian (龚廷贤), 1615 — Míng dynasty, 1615 CE
Composition 8 herbs
Shu Di huang
King
Shu Di huang
Mai Dong
Deputy
Mai Dong
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Assistant
Shan Yao
Wu Wei Zi
Assistant
Wu Wei Zi
Fu Ling
Assistant
Fu Ling
Mu Dan Pi
Assistant
Mu Dan Pi
Ze Xie
Envoy
Ze Xie
Explore composition
Available in our store
View in Store
From $24.00

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Mai Wei Di Huang Wan is designed to correct these specific patterns.

Why Mai Wei Di Huang Wan addresses this pattern

This is the primary pattern this formula was designed for. When Kidney Yin becomes depleted, it fails to send nourishing fluids upward to moisten the Lungs. The Lungs, in turn, lose their ability to descend Qi properly, leading to dry cough, wheezing, and shortness of breath. Meanwhile, the underlying Kidney Yin deficiency produces its own set of symptoms: soreness in the lower back and knees, dizziness, tinnitus, and night sweats. The deficient Yin also generates a relative excess of Yang, creating deficiency Heat that manifests as tidal fever, flushed cheeks, and a dry throat.

Mai Wei Di Huang Wan addresses this pattern comprehensively. Shu Di Huang replenishes the depleted Kidney Yin at the root. Mai Dong directly nourishes Lung Yin and clears mild Lung Heat. Wu Wei Zi astringes Lung Qi to stop coughing and prevents further fluid loss. The remaining herbs from the Liu Wei Di Huang Wan base stabilize the Kidneys, support the Spleen, clear deficiency Heat, and drain turbidity, creating a balanced formula that both restores what has been lost and prevents further depletion.

A practitioner would look for one or more of these signs

Dry Cough

Chronic dry cough with little or no phlegm, sometimes with blood-streaked sputum

Night Sweats

Night sweats due to Yin deficiency failing to anchor Yang at night

Dry Throat

Persistent dryness and soreness of the throat

Tinnitus

Ringing in the ears from insufficient Kidney Yin nourishing the head

Dizziness

Dizziness and lightheadedness from depleted Yin failing to nourish the brain

Lower Back Pain

Weakness and soreness of the lower back and knees, the domain of the Kidneys

Tidal Fever

Afternoon or evening low-grade fever (tidal Heat)

Shortness Of Breath

Shortness of breath, especially on exertion

Thirst

Thirst with a desire to sip water, from depleted body fluids

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Mai Wei Di Huang Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, a chronic dry cough that lingers for weeks or months after the initial illness has resolved often points to damage to the Lungs' moistening fluids (Lung Yin). The Lungs are described as a "delicate organ" that relies on adequate moisture to function smoothly. When this moisture is depleted by prolonged coughing, chronic illness, or aging, the Lungs lose their ability to descend Qi properly, resulting in a persistent dry, ticklish cough with little or no phlegm.

Crucially, TCM recognizes that the Lungs depend on the Kidneys for their deeper nourishment. The Kidneys are the root source of Yin for the whole body, sending fluids upward to moisten the Lungs. When Kidney Yin is also depleted (from aging, overwork, or chronic disease), the Lungs lose their supply line, making the cough stubborn and resistant to simple cough remedies. This is why the formula treats both the Kidneys and the Lungs together rather than focusing on the cough alone.

Why Mai Wei Di Huang Wan Helps

Mai Wei Di Huang Wan addresses chronic dry cough at two levels simultaneously. At the root level, Shu Di Huang and Shan Zhu Yu replenish depleted Kidney Yin, restoring the deep reservoir of fluids that the Lungs depend upon. At the branch level, Mai Dong directly moistens the Lung tissue and generates fluids, while Wu Wei Zi astringes Lung Qi to physically calm the cough reflex and prevent further fluid loss. This two-pronged approach of moistening from below (Kidney Yin) and above (Lung Yin), combined with Wu Wei Zi's astringent action, is what makes this formula particularly effective for the lingering, dry cough that does not respond to conventional cough suppressants.

Also commonly used for

Chronic Bronchitis

Chronic bronchitis with dry cough and scanty phlegm

Pulmonary Tuberculosis

Supportive care for tuberculosis with Yin deficiency presentation

Night Sweats

Night sweats from Yin deficiency

Chronic Pharyngitis

Chronic sore and dry throat

Bronchial Asthma

Asthma with Yin deficiency pattern, dry wheezing

Tinnitus

Tinnitus from Kidney Yin deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Mai Wei Di Huang Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Mai Wei Di Huang Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Mai Wei Di Huang Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Mai Wei Di Huang Wan works at the root level.

Mai Wei Di Huang Wan addresses a pattern where Kidney Yin deficiency and Lung Yin deficiency occur together, creating a cascade of symptoms across both the lower and upper body. The root of the problem usually starts in the Kidneys. In TCM, the Kidneys store the body's fundamental Yin, which is the deep reservoir of moisture, coolness, and nourishing substance that keeps all the organs properly hydrated and prevents excessive Heat. When Kidney Yin becomes depleted, whether through chronic illness, aging, overwork, or constitutional weakness, there is no longer enough of this cooling, moistening substance to keep the body in balance.

The Lungs and Kidneys have a particularly important relationship in TCM. The Kidneys are said to "grasp" or receive the Qi that the Lungs send downward, and the Kidneys' Yin moisture nourishes the Lungs from below, like a well feeding moisture upward. When Kidney Yin runs dry, the Lungs lose this nourishing supply and become parched. At the same time, the Lungs themselves may be directly damaged by chronic cough, external dryness, or long-term illness (such as tuberculosis). This dual depletion produces dry cough, shortness of breath, a dry and sore throat, and sometimes blood-streaked sputum.

With insufficient Yin to anchor and cool the body's Yang, a kind of "false Heat" called deficiency fire (虚火) flares up. This explains the afternoon low-grade fevers, night sweats, hot palms and soles, flushed cheeks, dizziness, and tinnitus. The lower back and knees become weak and sore because the Kidneys, which govern the bones and lower back, are depleted. The formula works by replenishing both Kidney and Lung Yin simultaneously, quenching this deficiency fire, and preventing further leakage of the body's precious fluids.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and sour, with mild bitterness. The sweetness nourishes Yin and tonifies, the sourness astringes and preserves fluids, and the slight bitterness helps clear deficiency Heat.

Target Organs

Channels Entered

Kidney Lung

Ingredients

8 herbs

The herbs that make up Mai Wei Di Huang Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 24 - 32g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Mai Wei Di Huang Wan

The chief herb of the formula. Shu Di Huang strongly nourishes Kidney Yin and replenishes Essence (Jing), addressing the root deficiency of Kidney Yin that underlies the entire pattern.
Deputies — Assists and enhances the King
Mai Dong

Mai Dong

Dwarf lilyturf roots

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Mai Wei Di Huang Wan

Nourishes Lung Yin, moistens the Lungs, generates fluids, and gently clears Lung Heat. It directly addresses the Lung dryness that produces dry cough, dry throat, and thirst, working in concert with the Kidney Yin replenishment of the King herb.
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 9 - 12g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in Mai Wei Di Huang Wan

Nourishes and astringes the Liver and Kidneys, helping to prevent the leakage of Essence. It supplements Yin and secures the foundation, reinforcing the Kidney-tonifying action of the King herb.
Assistants — Supports or moderates other herbs
Shan Yao

Shan Yao

Yam

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Mai Wei Di Huang Wan

Strengthens the Spleen and benefits the Lungs while also stabilizing the Kidneys. By supplementing the Spleen (the source of postnatal Qi and fluids), it supports the generation of Yin and ensures the tonifying herbs are properly absorbed and utilized.
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 6 - 9g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Mai Wei Di Huang Wan

Astringes Lung Qi, stops chronic cough, and consolidates Kidney Essence. Its sour and astringent nature prevents the continued leakage of Yin fluids from the Lungs and Kidneys, complementing Mai Dong's moistening action by helping the body retain the fluids being generated.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Mai Wei Di Huang Wan

Strengthens the Spleen and promotes healthy fluid metabolism by gently draining Dampness. This prevents the rich, tonifying herbs in the formula from causing stagnation or Dampness, and supports the Spleen's role in generating postnatal Qi and fluids.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 6 - 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Mai Wei Di Huang Wan

Clears deficiency Heat and cools the Blood, addressing the low-grade Heat that arises when Yin is depleted. It also gently invigorates Blood, preventing stagnation from the heavy tonifying herbs in the formula.
Envoy — Directs the formula to its target
Ze Xie

Ze Xie

Water plantain

Dosage 6 - 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Mai Wei Di Huang Wan

Drains Dampness and clears turbidity from the Kidneys, guiding ministerial fire downward to its proper source. It prevents the accumulation of pathological fluids and balances the heavily enriching nature of the tonifying herbs, ensuring the formula supplements without creating stagnation.

Why This Combination Works

How the herbs in Mai Wei Di Huang Wan complement each other

Overall strategy

Mai Wei Di Huang Wan addresses a pattern where Kidney Yin deficiency has extended upward to deplete Lung Yin, resulting in dryness throughout the body and impaired fluid metabolism. The prescription strategy combines deep Kidney Yin nourishment with direct Lung moistening and astringency, while maintaining the classical "three tonics, three drains" balance inherited from Liu Wei Di Huang Wan to prevent the formula from becoming cloying or stagnating.

King herb

Shu Di Huang (Prepared Rehmannia) serves as the sole King herb, providing the richest Yin nourishment in the materia medica. As a warm, sweet herb that enters the Kidney and Liver channels, it directly replenishes depleted Kidney Yin and Essence, addressing the root of the entire pathomechanism. Its heavy, enriching quality fills the Yin foundation that supports all the other organs, including the Lungs.

Deputy herbs

Mai Dong (Ophiopogon) is sweet and slightly cold, entering the Lung, Heart, and Stomach channels. It targets Lung Yin directly, moistening the Lungs, generating fluids, and clearing mild Lung Heat. This herb is what distinguishes this formula from its parent Liu Wei Di Huang Wan, extending its reach to the upper body. Shan Zhu Yu (Cornus) is sour and warm, entering the Liver and Kidney channels. It reinforces the King herb by nourishing Liver and Kidney Yin while also providing an astringent quality that prevents Essence from leaking away.

Assistant herbs

Wu Wei Zi (Schisandra) is the second herb that distinguishes this formula from Liu Wei Di Huang Wan. It is sour and astringent, entering all five Yin organ channels. It astringes Lung Qi to stop chronic coughing and secures Kidney Essence, preventing the continued loss of Yin fluids. This is a reinforcing assistant that works with Mai Dong in a complementary way: Mai Dong generates fluids while Wu Wei Zi keeps them from escaping. Shan Yao (Chinese Yam) is a reinforcing assistant that supports the Spleen, strengthening the body's ability to produce new Qi and fluids from food. Fu Ling (Poria) is a restraining assistant that prevents Dampness from accumulating by gently promoting urination, keeping the rich tonifying herbs from causing stagnation. Mu Dan Pi (Moutan Bark) is a restraining assistant that clears deficiency Heat from the Blood and mildly invigorates circulation, counteracting the tendency of heavy Yin tonics to produce stasis.

Envoy herb

Ze Xie (Alisma) drains turbid Dampness downward through the Kidneys, guiding ministerial fire back to its proper lower source. It directs the formula's action to the Kidney water system and ensures that the enriching nature of the other herbs does not lead to fluid stagnation or turbid accumulation.

Notable synergies

The pairing of Mai Dong and Wu Wei Zi is the signature of this formula. Mai Dong moistens and nourishes Lung Yin from the outside in, while Wu Wei Zi astringes and secures Lung Qi from the inside out. Together they both replenish and retain Lung fluids, creating a more complete treatment than either herb alone could achieve. The classical "three tonics and three drains" structure inherited from Liu Wei Di Huang Wan (Shu Di Huang, Shan Zhu Yu, Shan Yao as tonics balanced by Ze Xie, Mu Dan Pi, Fu Ling as drains) ensures that supplementation never becomes excessive, keeping the formula gentle enough for long-term use.

How to Prepare

Traditional preparation instructions for Mai Wei Di Huang Wan

The traditional preparation is as a honey pill. The eight herbs are ground into fine powder, sieved, and mixed evenly. For every 100g of powder, 35 to 50g of refined honey and an appropriate amount of water are used to form water-honey pills (水蜜丸), which are then dried. Alternatively, 80 to 110g of refined honey per 100g of powder can be used to form small or large honey pills.

The standard adult dosage for the patent medicine form is 6g of water-honey pills or 9g of small honey pills, taken twice daily with warm water on an empty stomach. When prepared as a decoction, the herbs are used in their standard individual dosage ranges and simmered in water for approximately 30 to 40 minutes.

Common Modifications

How practitioners adapt Mai Wei Di Huang Wan for specific situations

Added
Bai He

15g, to moisten the Lungs and stop coughing

E Jiao

9g (dissolved separately), to nourish Yin and stop bleeding

Bai He strengthens the Lung-moistening action while E Jiao nourishes Blood and Yin, directly addressing the hemoptysis caused by deficiency Heat scorching the Lung collaterals.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Mai Wei Di Huang Wan should not be used or requires extra caution

Avoid

Active common cold or flu with fever. This nourishing formula can trap external pathogens inside the body (a principle known as 'closing the door on the thief'), prolonging or worsening the illness.

Avoid

Phlegm-Dampness obstructing the Lungs, with symptoms such as copious white watery sputum, chest fullness, and a thick greasy tongue coating. The rich, cloying nature of this formula will worsen Dampness.

Avoid

Yang deficiency or internal Cold patterns, such as cold limbs, pale complexion, clear copious urination, and a pale tongue. This Yin-nourishing, cooling formula is inappropriate for Cold patterns.

Caution

Spleen deficiency with loose stools or poor digestion. The heavy, nourishing herbs (especially Shu Di Huang) are difficult to digest and can further impair a weak Spleen, worsening bloating and diarrhea.

Caution

Patients with severe chronic conditions including uncontrolled hypertension, heart disease, liver disease, diabetes, or kidney disease should use this formula only under close medical supervision.

Avoid

Allergy to any of the formula's ingredients. Those with known allergic constitutions should use with caution.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe in pregnancy. None of the eight herbs in this formula are classified among the traditionally contraindicated or cautioned substances for pregnancy. Official Chinese pharmaceutical product labeling states that pregnant women should take this formula under the guidance of a physician, which is standard caution for most Chinese patent medicines rather than a specific safety concern. That said, any use during pregnancy should be supervised by a qualified practitioner to ensure correct pattern differentiation, as taking a Yin-nourishing formula when it is not indicated could impair digestion.

Breastfeeding

Generally considered safe during breastfeeding. The formula contains gentle nourishing herbs with no known toxicity or compounds that would pose a risk through breast milk. Official Chinese pharmaceutical labeling advises that breastfeeding women should use it under the guidance of a physician, which is standard precautionary language. If the breastfeeding mother has weak digestion, the heavy nourishing herbs (particularly Shu Di Huang) could impair appetite or cause loose stools, potentially affecting nutritional status, so professional guidance is advisable.

Children

Official labeling states that children must take this formula under adult supervision and with physician guidance. The formula is not typically used in very young children. For older children with confirmed Lung-Kidney Yin deficiency patterns (such as chronic dry cough after prolonged illness), a qualified practitioner may prescribe it at a reduced dose, typically one-third to one-half of the adult dose depending on the child's age and weight. Because the formula's rich, cloying nature can be hard on immature digestive systems, it is important to monitor for signs of poor appetite, bloating, or loose stools.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Mai Wei Di Huang Wan

No specific drug interactions have been formally documented in the official Chinese Pharmacopoeia monograph for Mai Wei Di Huang Wan. However, based on the known pharmacological properties of its ingredients, the following potential interactions deserve attention:

  • Hypoglycemic medications: The formula has traditionally been used for wasting-thirst syndrome (消渴, related to diabetes), and several of its ingredients (particularly Shan Yao and Shu Di Huang) may have mild blood sugar-lowering effects. Concurrent use with insulin or oral hypoglycemics could theoretically enhance blood sugar reduction, so blood glucose should be monitored more closely.
  • Diuretics: Ze Xie (Alisma) in the formula has mild diuretic properties. When used alongside pharmaceutical diuretics, there may be an additive effect on fluid loss and electrolyte balance.
  • Anticoagulants and antiplatelet agents: Mu Dan Pi (Moutan bark) has mild blood-activating properties. Although the dose in this formula is small, caution is warranted in patients taking warfarin or similar blood-thinning medications.

Patients taking any prescription medications should consult their physician or pharmacist before using this formula concurrently.

Usage Guidance

Practical advice for getting the most out of Mai Wei Di Huang Wan

Best time to take

Twice daily, 30 minutes before meals on an empty stomach for optimal absorption.

Typical duration

Often taken for 4 to 8 weeks as an initial course, then reassessed by a practitioner. May be used for several months for chronic conditions.

Dietary advice

Avoid greasy, oily, and heavy foods while taking this formula, as they can impair absorption and burden the digestive system already challenged by the formula's rich, nourishing herbs. Also avoid raw, cold foods and iced drinks, which can further weaken digestion. Spicy, hot, and drying foods (such as chili peppers, fried foods, and alcohol) should be minimized because they consume Yin fluids, working against the formula's purpose. Favor light, easily digestible meals with naturally moistening foods such as pears, lily bulb, white wood ear fungus, congee, and lightly steamed vegetables.

Mai Wei Di Huang Wan originates from Shou Shi Bao Yuan (寿世保元) by Gong Tingxian (龚廷贤), 1615 Míng dynasty, 1615 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Mai Wei Di Huang Wan and its clinical use

From the Huang Di Nei Jing (Su Wen):

「阴精所奉其人寿,阳精所降其人夭」 — "Those who are nourished by Yin essence enjoy longevity; those depleted of it suffer premature decline." This principle from the Nei Jing underlies the formula's philosophy: as people age, Yin naturally declines, and replenishing Yin essence is the foundation for preserving health and extending life.

From the Huang Di Nei Jing (Su Wen):

「年四十而阴气自半也,起居衰矣」 — "At forty, the body's Yin is already half depleted, and daily vitality begins to decline." This teaching motivated ancient physicians to develop Yin-nourishing formulas like Mai Wei Di Huang Wan for middle-aged and elderly patients.

Historical Context

How Mai Wei Di Huang Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Mai Wei Di Huang Wan originated during the Ming dynasty, first recorded under the name Ba Xian Chang Shou Wan (八仙长寿丸, "Eight Immortals Longevity Pill") in the Shou Shi Bao Yuan (寿世保元, "Achieving Longevity by Guarding the Source"), written by the physician Gong Tingxian (龚廷贤) and published in 1615. The formula was conceived by adding just two herbs, Mai Men Dong (Ophiopogon) and Wu Wei Zi (Schisandra), to the famous Liu Wei Di Huang Wan, which itself traces back through the Song dynasty pediatrician Qian Yi to Zhang Zhongjing's Kidney Qi Pill. A version also appears in the Dan Xi Xin Fa (丹溪心法) attributed to the Yuan dynasty master Zhu Danxi, with minor differences in dosage. Other sources cite the Yi Ji (医级) by Dong Xiyuan and the Yang Ke Xin De Ji (疡科心得集) supplement section.

The poetic name "Eight Immortals Longevity Pill" reflects the cultural reverence for this formula: the eight herbs were likened to the Eight Immortals of Daoist mythology, each contributing its own unique power to promote long life. The formula was especially valued for elderly patients, as Ming dynasty physicians recognized that age-related decline was rooted in Yin depletion, following the Nei Jing teaching that Yin is half depleted by age forty. Over the centuries, the formula has remained remarkably stable in composition and has become one of the most widely used Liu Wei Di Huang Wan variants, now produced as a standard over-the-counter Chinese patent medicine listed in the Chinese Pharmacopoeia.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Mai Wei Di Huang Wan

1

A Meta-Analysis of the Clinical Efficacy of TCM Decoctions Made from Formulas in the Liuwei Dihuang Wan Categorized Formulas in Treating Diabetic Nephropathy Proteinuria (Meta-Analysis, 2018)

Yuan Y, et al. Evidence-Based Complementary and Alternative Medicine, 2018, Article ID 1394689

This meta-analysis pooled data from 14 randomized controlled trials with 918 patients to evaluate Liu Wei Di Huang Wan category formulas (including Mai Wei Di Huang Wan) as add-on therapy for diabetic nephropathy. The results showed significantly better overall efficacy than standard treatment alone, with reduced 24-hour urinary protein and microalbumin excretion, and no serious adverse reactions were reported.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.