Du Qi Wan

Capital Qi Pill · 都氣丸

Also known as: Qi Wei Du Qi Wan (七味都氣丸, Seven-Ingredient Capital Qi Pill), Du Qi Wan (都炁丸)

A classical formula that nourishes the Kidneys and helps the body hold onto its breath. Built on the famous Liu Wei Di Huang Wan with the addition of Schisandra fruit, it is used for chronic cough, shortness of breath, wheezing, and lower back soreness caused by weakness of both the Lungs and Kidneys.

Origin Yi Fang Ji Jie (醫方集解, Collected Explanations of Medical Formulas) by Wang Ang (汪昂), 1682 CE — Qīng dynasty, 1682 CE
Composition 7 herbs
Shu Di huang
King
Shu Di huang
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Wu Wei Zi
Deputy
Wu Wei Zi
Fu Ling
Assistant
Fu Ling
Mu Dan Pi
Assistant
Mu Dan Pi
Ze Xie
Assistant
Ze Xie
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Du Qi Wan is designed to correct these specific patterns.

Why Du Qi Wan addresses this pattern

When Kidney Yin becomes depleted, the Kidneys lose their ability to 'grasp' or anchor the Qi that descends from the Lungs during breathing. Normally, the Lungs govern inhalation and send Qi downward, while the Kidneys receive and hold this Qi in the lower body. When the Kidneys are too weak to perform this anchoring function, Qi rebels upward, producing shortness of breath, wheezing, and difficulty inhaling deeply. Du Qi Wan addresses this by using Shu Di Huang, Shan Zhu Yu, and Shan Yao to restore Kidney Yin, while Wu Wei Zi astringes Lung Qi downward and helps the Kidneys grasp it. The draining herbs (Fu Ling, Ze Xie, Mu Dan Pi) keep the waterways open so the descending mechanism functions smoothly.

A practitioner would look for one or more of these signs

Shortness Of Breath

Worse on exertion, difficulty inhaling deeply

Wheezing

Chronic wheezing with weak, shallow breathing

Chronic Coughing

Dry or minimally productive cough

Lower Back Pain

Soreness and weakness in the lumbar region

Night Sweats

Due to underlying Yin deficiency

Tinnitus

Ringing in ears from Kidney weakness

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Du Qi Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, asthma that has become chronic typically involves the Kidneys. While acute asthma attacks often relate to the Lungs being obstructed by Wind, Cold, or Phlegm, long-standing asthma gradually depletes the Kidneys. The Kidneys are said to 'grasp Qi' from the Lungs, meaning they anchor the breath in the lower body. When this function weakens, breathing becomes shallow, inhalation is difficult, and wheezing occurs on minimal exertion. The underlying Kidney Yin deficiency also fails to nourish the Lungs, leading to dryness and further vulnerability.

Why Du Qi Wan Helps

Du Qi Wan targets the root of chronic asthma by rebuilding Kidney Yin with Shu Di Huang as the foundation, supported by Shan Zhu Yu and Shan Yao. Wu Wei Zi is the critical herb for asthma specifically: it astringes Lung Qi to reduce wheezing and helps the Kidneys receive Qi, restoring the downward anchoring of breath. Modern research has shown that this formula may help reduce airway hyperreactivity by inhibiting mast cell degranulation, providing a pharmacological basis for its traditional anti-asthmatic use.

Also commonly used for

Chronic Bronchitis

Chronic cough with weak breathing and Yin depletion

Emphysema

Shortness of breath from impaired Qi grasping

Nocturnal Emission

Due to Kidney Yin deficiency and Essence insecurity

Diabetes

With Kidney Yin deficiency as the underlying pattern

Chronic Coughing

Persistent dry cough from Lung-Kidney Yin deficiency

Hiccups

Chronic hiccups from deficiency-type Qi rebellion

Frequent Urination

From Kidney Qi insecurity

What This Formula Does

Every TCM formula has a specific set of actions — here's what Du Qi Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Du Qi Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Du Qi Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Du Qi Wan works at the root level.

In TCM, the Kidneys and Lungs share a critical functional relationship in managing respiration. The Lungs govern inhalation and send Qi downward, while the Kidneys are responsible for "grasping" or "receiving" (纳气 nà qì) that descending Qi and anchoring it in the lower body. When Kidney Yin becomes depleted through chronic illness, overwork, aging, or excessive sexual activity, the Kidneys lose their capacity to anchor Qi. The inhaled Qi floats upward instead of being drawn down, producing shortness of breath, wheezing, and a characteristic pattern where exhalation is longer than inhalation.

Because Kidney Yin is the root of all Yin in the body, its deficiency also generates deficiency Heat, which rises and harasses the Lungs (the Metal organ). This "floating Fire assailing Metal" dries out Lung fluids, causing dry throat, hoarseness, and chronic dry cough. At the same time, the Kidney's storage and consolidation functions weaken: Essence leaks out (seminal emission, night sweats), and urination becomes frequent because the Kidney's gating function is impaired. The core problem is therefore a depletion of Kidney Yin that simultaneously undermines the Kidney's Qi-grasping function and disturbs the Lung-Kidney axis responsible for smooth respiration.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet, sour, and slightly bland. Sweet to nourish and tonify, sour to astringe and consolidate, bland to gently drain Dampness and prevent stagnation.

Channels Entered

Kidney Lung Liver Spleen

Ingredients

7 herbs

The herbs that make up Du Qi Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 24g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Du Qi Wan

The chief herb of the formula. Shu Di Huang richly nourishes Kidney Yin and replenishes Essence (Jing), directly addressing the root deficiency that underlies the entire pattern. Its heavy, sweet, and slightly warm nature makes it the most powerful Yin-nourishing substance in the formula.
Deputies — Assists and enhances the King
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 12g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in Du Qi Wan

Nourishes and astringes the Liver and Kidneys, helping to contain Essence and prevent its leakage. It works alongside the King herb to secure the Kidney's storing function and prevent Essence from dispersing improperly through the Liver.
Shan Yao

Shan Yao

Yam

Dosage 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Du Qi Wan

Tonifies the Spleen and stabilizes the Kidneys. By strengthening Spleen function (the source of postnatal Qi and Essence), it ensures a continuous supply of nourishment to replenish the Kidneys. It also has an astringent quality that helps secure Kidney Essence.
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 6g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Du Qi Wan

The distinguishing addition to the Liu Wei Di Huang Wan base. Wu Wei Zi astringes Lung Qi to stop cough and wheezing, while also tonifying the Kidneys and securing Essence to prevent seminal emission. Its sour and astringent nature helps the Kidneys grasp and hold Qi that descends from the Lungs, making it the key herb that transforms this formula from a general Kidney Yin tonic into one specifically for Kidney failing to receive Qi.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Du Qi Wan

Leaches Dampness from the Spleen and promotes urination. It balances the heavy, cloying nature of Shu Di Huang and prevents Dampness from accumulating due to the formula's rich tonifying herbs. Also supports Shan Yao in strengthening the Spleen.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Du Qi Wan

Clears deficiency Heat from the Liver and cools the Blood. It counterbalances the warming and astringent properties of Shan Zhu Yu, preventing the formula from generating internal Heat. As part of the draining trio, it ensures the formula supplements without stagnating.
Ze Xie

Ze Xie

Water plantain

Dosage 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Du Qi Wan

Clears and drains Kidney Fire downward through urination. It prevents the rich, heavy nature of Shu Di Huang from congesting the Kidneys and creating turbid Dampness. Together with Fu Ling and Mu Dan Pi, it forms the draining trio that ensures the formula tonifies without causing stagnation.

Why This Combination Works

How the herbs in Du Qi Wan complement each other

Overall strategy

Du Qi Wan is built on the 'three tonifying, three draining' (三补三泻) architecture of Liu Wei Di Huang Wan, with the addition of Wu Wei Zi to create a formula that both nourishes Kidney Yin and astringes Lung Qi. The strategy addresses the root cause (Kidney Yin depletion) while simultaneously treating the branch symptom (Qi failing to be grasped by the Kidneys, causing cough and wheezing).

King herbs

Shu Di Huang serves as the sole King herb, using its rich, sweet nature to deeply replenish Kidney Yin and Essence. At 24g, it comprises the largest share of the formula, reflecting its role as the primary force addressing the fundamental Yin deficiency that leads to the Kidneys' inability to anchor Qi.

Deputy herbs

Three herbs serve as Deputies. Shan Zhu Yu nourishes and astringes the Liver and Kidneys, preventing Essence from leaking. Shan Yao strengthens the Spleen to support postnatal generation of Essence and stabilizes the Kidneys. Wu Wei Zi is the critical addition that transforms this formula: its sour, astringent nature simultaneously constrains Lung Qi (preventing its upward rebellion as cough and wheezing) and secures Kidney Essence (preventing seminal emission). Together with Shan Zhu Yu, its astringent quality creates a strong 'grasping' effect that anchors Qi in the lower body.

Assistant herbs

Fu Ling (restraining assistant) leaches Dampness to prevent Shu Di Huang's cloying nature from generating stagnation, while also supporting the Spleen. Mu Dan Pi (restraining assistant) clears deficiency Heat from the Liver, offsetting any warming tendency from Shan Zhu Yu's astringent nature. Ze Xie (restraining assistant) drains Kidney turbidity downward, preventing the rich tonifying herbs from congesting the waterways. These three 'draining' herbs are essential to maintaining the formula's balance, ensuring supplementation without stagnation.

Notable synergies

Wu Wei Zi and Shan Zhu Yu work together as a powerful astringent pair: Wu Wei Zi constrains the Lungs above while Shan Zhu Yu secures the Kidneys below, creating a top-and-bottom containment that prevents Qi and Essence from escaping. Shu Di Huang and Ze Xie form a classic tonic-draining pair: Shu Di Huang enriches Yin while Ze Xie clears turbidity, preventing the formula from becoming heavy and stagnant. The overall three-tonify, three-drain architecture plus Wu Wei Zi ensures the formula nourishes without cloying and astringes without trapping pathogenic factors.

How to Prepare

Traditional preparation instructions for Du Qi Wan

Grind all seven herbs into a fine powder. Mix with refined honey and form into small pills the size of Chinese parasol tree seeds (about 6mm). Take 9g per dose (approximately 50 to 70 pills) on an empty stomach, swallowed with lightly salted warm water in the morning or with warm rice wine before bed.

For modern use: available as honey pills, taking 9g per dose two to three times daily. May also be prepared as a decoction by simmering the herbs in water.

Common Modifications

How practitioners adapt Du Qi Wan for specific situations

Added
Tian Men Dong

9-12g, nourishes Lung Yin and moistens dryness

Tian Men Dong

9-12g, enriches Kidney and Lung Yin

When Lung dryness is severe, adding Mai Men Dong and Tian Men Dong enhances the formula's ability to moisten the Lungs and clear deficiency Heat, while Wu Wei Zi prevents the added moistening herbs from being too dispersing.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Du Qi Wan should not be used or requires extra caution

Avoid

Exterior pathogen cough or common cold/flu: This formula is tonifying and astringent. Using it during an acute external invasion (wind-cold or wind-heat) would trap the pathogen inside and worsen the condition.

Avoid

Excess-type cough or wheezing with abundant Phlegm: The formula's astringent nature (especially Wu Wei Zi and Shan Zhu Yu) can trap Phlegm and exacerbate congestion. Not suitable when thick, copious sputum is the dominant feature.

Caution

Spleen deficiency with loose stools or poor appetite: The formula contains Shu Di Huang, which is heavy, cloying, and difficult to digest. People with weak digestion may experience bloating, loose stools, or reduced appetite.

Caution

Kidney Yang deficiency with prominent cold signs: This formula nourishes Kidney Yin and is slightly cool in nature. If the patient shows marked cold limbs, pale complexion, watery stools, and a pale tongue, a Yang-warming formula would be more appropriate.

Caution

Dampness or Phlegm-Damp accumulation: The rich, moistening herbs (particularly Shu Di Huang) can aggravate Dampness. Patients with heavy limbs, greasy tongue coating, or edema should use this formula with caution or modification.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe for short-term use under professional guidance, as the formula contains no directly abortifacient or uterine-stimulating herbs. However, Shu Di Huang (prepared Rehmannia) is heavy and cloying, and Ze Xie (Alisma) promotes fluid drainage, both of which require consideration during pregnancy. The astringent nature of Wu Wei Zi and Shan Zhu Yu may also affect fluid dynamics. Pregnant women should only use this formula under the supervision of a qualified practitioner who can adjust the dosage and composition as needed.

Breastfeeding

No specific safety concerns have been documented for breastfeeding. The formula's herbs are mild tonics and astringents without known toxicity or known transfer of harmful constituents through breast milk. Shu Di Huang's cloying nature could theoretically affect digestion in both mother and infant if the mother's Spleen function is already weak. Practitioners should monitor for any digestive disturbance in the nursing infant. Use under professional guidance is recommended.

Children

Du Qi Wan can be used in children, as its parent formula Liu Wei Di Huang Wan was originally designed for pediatric use. However, dosage must be significantly reduced based on age and body weight. For children aged 6-12, roughly one-third to one-half of the adult dose is typical. For children under 6, one-quarter of the adult dose or less is used, and professional supervision is essential. The cloying nature of Shu Di Huang may be especially problematic for children, who often have relatively weaker digestive function. The formula should be discontinued if the child develops loose stools, bloating, or poor appetite.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Du Qi Wan

Diuretics: Ze Xie (Alisma) and Fu Ling (Poria) have mild diuretic properties. Concurrent use with pharmaceutical diuretics (furosemide, hydrochlorothiazide) may have additive effects on fluid loss and electrolyte balance, particularly potassium levels.

Antidiabetic medications: Several herbs in this formula (Shan Yao, Shu Di Huang, Shan Zhu Yu) have demonstrated mild blood-glucose-lowering effects in animal studies. Patients taking insulin or oral hypoglycemics should monitor blood glucose more closely, as additive effects are theoretically possible.

Anticoagulant/antiplatelet drugs: Mu Dan Pi (Moutan bark) contains paeonol, which has demonstrated mild antiplatelet activity. Patients on warfarin, heparin, or other anticoagulants should be monitored for any changes in clotting parameters.

Immunosuppressants: The formula has demonstrated immunomodulatory effects in preclinical research. Patients taking immunosuppressive medications should use this formula with caution and under professional guidance.

Usage Guidance

Practical advice for getting the most out of Du Qi Wan

Best time to take

On an empty stomach, ideally 30 minutes before meals, morning and evening. Classical instructions suggest taking with lightly salted warm water in the morning and warm rice wine at bedtime.

Typical duration

Medium to long-term use, typically 4-12 weeks, with periodic reassessment by a practitioner. May be used for several months in chronic conditions.

Dietary advice

Avoid cold, raw, and greasy foods, which can impair Spleen function and hinder the absorption of this tonifying formula. Limit excessively spicy or drying foods, which can further deplete Yin and counteract the formula's moistening effects. Favor warm, easily digestible foods such as congee, steamed vegetables, yams, and lightly cooked lean proteins. Foods that gently nourish Yin, such as pears, black sesame, walnuts, and goji berries, are supportive. Avoid excessive alcohol and caffeine, which can generate Heat and damage Yin.

Du Qi Wan originates from Yi Fang Ji Jie (醫方集解, Collected Explanations of Medical Formulas) by Wang Ang (汪昂), 1682 CE Qīng dynasty, 1682 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Du Qi Wan and its clinical use

《医方集解》(Yī Fāng Jí Jiě):
"益肺之源,以生肾水。"
"Benefits the source of the Lungs in order to generate Kidney Water."

《中药成方配本》(Zhōng Yào Chéng Fāng Pèi Běn):
"补肾纳气。"
"Tonifies the Kidneys and helps them receive Qi."

《饲鹤亭集方》(Sì Hè Tíng Jí Fāng):
"都气丸主治元阴亏损,浮火乘金,咳嗽失音,浮肿喘促,一切气不归纳之病。"
"Du Qi Wan treats depletion of primordial Yin, floating Fire assailing the Lungs (Metal), cough, loss of voice, edema, wheezing, and all conditions where Qi fails to be received and anchored."

《张氏医通》(Zhāng Shì Yī Tōng):
"肾水不固,咳嗽精滑。"
"When Kidney Water is not secured, there will be cough and seminal leakage."

《医钞类编》(Yī Chāo Lèi Biān):
"伤肾咳嗽,气逆烦冤,牵引腰痛,俯仰不利。"
"Kidney-injuring cough with rebellious Qi and vexation, pulling pain in the lower back, and difficulty bending forward or backward."

Historical Context

How Du Qi Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Du Qi Wan is a direct derivative of Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill), the foundational Kidney Yin-nourishing formula created by the Song Dynasty pediatrician Qian Yi (钱乙) and recorded in his Key to Therapeutics of Children's Diseases (小儿药证直诀). Du Qi Wan adds a single herb, Wu Wei Zi (Schisandra fruit), to that six-herb base, transforming its focus from general Yin nourishment to specifically addressing the Kidney's failure to receive Qi.

The formula is recorded in the Zheng Yin Mai Zhi (《症因脉治》, Symptoms, Causes, Pulses, and Treatments), authored by the late Ming Dynasty physician Qin Jingming (秦景明, also known as Qin Changyu 秦昌遇), with later supplementation by Qin Huangshi (秦皇士) during the Qing Dynasty. The text was completed around 1641. Some sources also attribute discussion of the formula to the Qing Dynasty text Yi Zong Yi Ren Pian (《医宗已任编》) by Yang Chengliu. The formula's alternate name, Du Qi Yin (都气饮), appears in the Pan Zhu Ji (《盘珠集》). Classical case records in the Jing Xiang Lou Yi An (《静香楼医案》) describe modifications of Du Qi Wan for treating chronic Yin-deficiency cough and nocturnal emission, illustrating how later physicians adapted the base formula by adding herbs like Nu Zhen Zi, Gou Qi Zi, Tian Dong, Niu Xi, and Rou Gui for specific clinical presentations.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Du Qi Wan

1

Qi-Wei-Du-Qi-Wan and its major constituents exert an anti-asthmatic effect by inhibiting mast cell degranulation (Preclinical study, 2020)

Lin LJ, Wu CJ, Wang SD, Kao ST. Journal of Ethnopharmacology, 2020, 254, 112403.

This preclinical study investigated the anti-asthmatic mechanism of Qi Wei Du Qi Wan in a chronic asthma mouse model induced by dust mite allergen. The formula effectively reduced airway hyperresponsiveness, airway inflammation, sputum secretion, and serum IgE levels. Mechanistic analysis using mast cells showed that the formula inhibited IL-4 and IL-13 gene expression and stabilized mast cell membranes, preventing degranulation. The researchers also identified key active compounds responsible for inhibiting ALOX-5 and HDC gene expression.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.