Lian Mei An Hui Tang

Picrorhiza and Mume Decoction to Calm Roundworms · 連梅安蛔湯

Also known as: Lian Mei An Hui Tang, 連梅安蛔湯

A classical formula designed to address roundworm disturbances caused by Heat in the Liver and Stomach. It combines bitter, cold herbs that clear internal Heat with sour and pungent herbs that calm and expel roundworms, making it suitable for abdominal pain with vomiting of worms accompanied by signs of Heat such as irritability, facial flushing, dry mouth, and a red tongue.

Origin Chóng Dìng Tōng Sú Shāng Hán Lùn (重订通俗伤寒论, Revised Popular Treatise on Febrile Diseases) — Yu Genchu's experience formula (俞氏经验方) — Qīng dynasty, original text compiled 1776 CE, revised edition 1916 CE
Composition 6 herbs
Hu Huang Lian
King
Hu Huang Lian
Wu Mei
Deputy
Wu Mei
Huang Qi
Deputy
Huang Qi
Hua Jiao
Assistant
Hua Jiao
Pei Lan
Assistant
Pei Lan
Bing Lang
Envoy
Bing Lang
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Lian Mei An Hui Tang is designed to correct these specific patterns.

Why Lian Mei An Hui Tang addresses this pattern

When Liver Fire flares and invades the Stomach, it creates a hot, turbid environment in the digestive tract. Roundworms, which in TCM theory prefer a warm but not excessively hot environment, become agitated and restless when the Stomach heats up excessively. They move upward against the normal downward flow, leading to vomiting of worms. The Liver Fire also causes irritability, facial flushing, and restlessness. Hu Huang Lian and Huang Bai clear the Liver and Stomach Heat at the root, while Wu Mei and Chuan Jiao calm the worms, and Lei Wan and Bing Lang kill and expel them.

A practitioner would look for one or more of these signs

Abdominal Pain

Epigastric and abdominal cramping pain triggered by worm agitation

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting of roundworms, especially after eating

Loss Of Appetite

Hungry but unable to eat, or food triggers vomiting

Irritability

Restlessness and irritability, even confusion in severe cases

Facial Flushing

Red face with sensation of body heat

Dry Mouth

Dry mouth with a red tongue and rapid pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Lian Mei An Hui Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, intestinal parasites (particularly roundworms) are understood as organisms that inhabit the digestive tract and are normally kept in check by the balanced function of the Spleen and Stomach. When internal Heat develops, particularly Liver Fire invading the Stomach, the worms become agitated and move upward or erratically, causing sudden cramping pain, vomiting, and restlessness. The classical texts describe roundworms as loving warmth but being repelled by cold, attracted to sweetness but stilled by sourness and bitterness. This understanding directly informs the treatment strategy.

Why Lian Mei An Hui Tang Helps

Lian Mei An Hui Tang specifically targets the Heat-type presentation of roundworm disease. Hu Huang Lian and Huang Bai clear the Liver and Stomach Heat that agitates the worms, while Wu Mei's sour flavor directly calms them based on the classical principle that worms are stilled by acid. Chuan Jiao's pungent flavor stuns the worms and works synergistically with Wu Mei. Lei Wan and Bing Lang then kill and expel the parasites through the bowels. This comprehensive approach addresses both the root (internal Heat) and the branch (worm activity).

Also commonly used for

Abdominal Pain

Worm-related abdominal colic with Heat signs

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting of roundworms triggered by eating

Intestinal Obstruction

Ascariasis-related intestinal obstruction with Heat presentation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Lian Mei An Hui Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Lian Mei An Hui Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Lian Mei An Hui Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Lian Mei An Hui Tang works at the root level.

This formula addresses a specific and dangerous condition known as Hui Jue (蛔厥), or "roundworm reversal," caused by Liver Fire invading the Stomach in the presence of intestinal roundworm infestation.

In TCM understanding, the Liver's Qi naturally flows freely and helps coordinate digestion. When excess Heat (Fire) builds up in the Liver, it can "invade" the Stomach, disrupting its normal downward-directing function. The Stomach becomes excessively hot. Roundworms, which normally reside quietly in the intestines, are highly sensitive to their environment: they are disturbed by Heat and become agitated, moving upward against the normal flow. This creates a vicious cycle where the patient feels hungry (because the Stomach still demands food), but eating triggers the worms to move, causing vomiting of worms. The worms' erratic movement produces severe cramping pain in the upper abdomen. In extreme cases, the patient becomes profoundly irritable, confused, and their limbs turn cold, despite having a flushed face and a hot body. This pattern of simultaneous Heat signs above (red face, thirst, dry mouth, red tongue, rapid pulse) and cold limbs below is characteristic of the Heat being trapped internally while failing to reach the extremities.

The key distinction is that this is a Heat-predominant roundworm condition. Unlike the more famous Wu Mei Wan (乌梅丸) from the Shang Han Lun, which treats roundworm reversal from a mixed cold-and-heat pattern, Lian Mei An Hui Tang is specifically designed for cases where Liver Fire and Stomach Heat are the dominant pathology driving the worms' agitation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and sour with acrid notes. The bitterness (Hu Huang Lian, Huang Bai) drains Heat downward, the sourness (Wu Mei) constrains and quiets the worms, and the pungency (Chuan Jiao) causes worms to retreat and hide.

Ingredients

6 herbs

The herbs that make up Lian Mei An Hui Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Hu Huang Lian

Hu Huang Lian

Picrorhiza rhizomes

Dosage 3g
Temperature Cool
Taste Bitter
Organ Affinity Stomach, Large Intestine, Liver

Role in Lian Mei An Hui Tang

The primary Heat-clearing herb in this formula. Bitter and cold, it enters the Liver and Stomach to clear Damp-Heat and drain Liver Fire, directly addressing the root cause of the worm disturbance. By clearing the Heat that agitates the roundworms, it creates conditions for the worms to settle.
Deputies — Assists and enhances the King
Wu Mei

Wu Mei

Chinese plums

Dosage 2 pieces (approximately 6g)
Temperature Neutral
Taste Sour
Organ Affinity Large Intestine, Liver, Lungs, Spleen
Preparation Use the flesh only (乌梅肉), pit removed

Role in Lian Mei An Hui Tang

Sour and astringent, Wu Mei is the classical herb for calming roundworms. Roundworms are repelled by sour flavors and become still when exposed to acidity. Wu Mei generates fluids and restrains the worms, working alongside the bitter cold herbs to pacify the parasites from a complementary angle.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 2.4g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen
Preparation Used raw (生)

Role in Lian Mei An Hui Tang

Bitter and cold, raw Huang Bai reinforces the Heat-clearing action of Hu Huang Lian, particularly in the Lower Burner. It clears Damp-Heat from the Liver and Intestines, supporting the overall strategy of eliminating the Heat environment that provokes worm agitation.
Assistants — Supports or moderates other herbs
Hua Jiao

Hua Jiao

Sichuan pepper

Dosage 10 pieces (approximately 2g)
Temperature Warm
Taste Pungent
Organ Affinity Kidneys, Spleen, Stomach
Preparation Dry-fried (炒)

Role in Lian Mei An Hui Tang

Pungent and warm, Chuan Jiao is a classical antiparasitic that stuns and paralyzes roundworms. Its warmth also moderates the heavy cold nature of Hu Huang Lian and Huang Bai, preventing excessive cold from damaging the Spleen and Stomach. The combination of sour Wu Mei and pungent Chuan Jiao follows the classical principle of using sour and pungent flavors together to subdue worms.
Pei Lan

Pei Lan

Eupatorium herbs

Dosage 9g
Temperature Neutral
Taste Pungent
Organ Affinity Spleen, Stomach, Lungs

Role in Lian Mei An Hui Tang

A dedicated antiparasitic herb that directly kills and expels roundworms. Lei Wan strengthens the worm-expelling action of the formula beyond simply calming the worms, ensuring that the parasites are eliminated rather than merely pacified.
Envoy — Directs the formula to its target
Bing Lang

Bing Lang

Areca nuts

Dosage 2 pieces (approximately 10g)
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Large Intestine, Stomach
Preparation Grind into juice and stir into the strained decoction (磨汁冲服)

Role in Lian Mei An Hui Tang

Bing Lang moves Qi downward through the digestive tract and expels parasites. It directs the formula's action downward through the intestines, facilitating the expulsion of the paralyzed or killed worms. Its Qi-moving action also helps relieve the abdominal distension and pain caused by the worm obstruction.

Why This Combination Works

How the herbs in Lian Mei An Hui Tang complement each other

Overall strategy

This formula addresses roundworm disturbances arising from Liver Fire invading the Stomach. The strategy combines clearing the internal Heat that agitates the worms with directly calming, killing, and expelling the parasites, following the classical principle of treating both the root (Heat) and the branch (worm activity) simultaneously.

King herbs

Hu Huang Lian serves as the King herb. Bitter and cold, it enters the Liver, Stomach, and Large Intestine channels to clear Damp-Heat and drain Liver Fire. By eliminating the Heat that makes the Stomach environment intolerable for roundworms (causing them to move upward and be vomited), it addresses the root pathomechanism. The name "Lian Mei" in the formula title refers to this herb paired with Wu Mei.

Deputy herbs

Wu Mei (Mume fruit) is the classical sour herb for calming roundworms, based on the principle that worms are stilled by sour flavors. It complements Hu Huang Lian by directly pacifying the worms while the King herb clears the Heat driving their agitation. Huang Bai reinforces the Heat-clearing strategy, targeting Damp-Heat in the Lower Burner and Large Intestine to create a hostile environment for the parasites.

Assistant herbs

Chuan Jiao is a restraining assistant: its warmth moderates the heavy cold of Hu Huang Lian and Huang Bai, protecting the Spleen and Stomach from cold damage. It also has direct antiparasitic action, and its pungent flavor pairs with Wu Mei's sour flavor in the classical "sour and pungent" combination for subduing worms. Lei Wan is a reinforcing assistant that adds powerful direct worm-killing action, ensuring the parasites are eliminated rather than merely calmed.

Envoy herbs

Bing Lang directs the formula's action downward through the intestinal tract. Its Qi-moving and descending properties facilitate expulsion of the paralyzed worms through the bowels. It also relieves the abdominal pain and distension that accompany worm obstruction.

Notable synergies

The Hu Huang Lian and Wu Mei pairing is the formula's signature combination (hence the name "Lian Mei"): the bitter cold of Hu Huang Lian clears the Heat driving worm agitation, while the sour astringency of Wu Mei directly calms the worms. The Wu Mei and Chuan Jiao pairing echoes the classical Shang Han Lun strategy from Wu Mei Wan, using sour and pungent flavors together to pacify roundworms. Lei Wan and Bing Lang together form a strong expelling pair that kills the worms and moves them out of the body.

How to Prepare

Traditional preparation instructions for Lian Mei An Hui Tang

Decoct Hu Huang Lian, Chuan Jiao, Lei Wan, Wu Mei, and Huang Bai together in water. Grind the Bing Lang (betel nut) separately into a juice and stir it into the strained decoction just before drinking. Take the decoction warm.

Common Modifications

How practitioners adapt Lian Mei An Hui Tang for specific situations

Added
Jin Yin Hua

15g, clears Heat and resolves toxicity

Lian Qiao

15g, clears Heat and disperses swelling

When worm disease is complicated by infection (fever, elevated white blood cells), adding Jin Yin Hua and Lian Qiao strengthens the formula's ability to clear toxic Heat and combat the secondary infection.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Lian Mei An Hui Tang should not be used or requires extra caution

Avoid

Spleen and Stomach Yang deficiency with cold signs (cold limbs, pale tongue, loose stools without Heat signs). This formula is designed for roundworm conditions with predominant Heat and should not be used when the underlying pattern is cold. Li Zhong An Hui Tang (理中安蛔汤) is more appropriate for cold-type roundworm presentations.

Avoid

Pregnancy. Bing Lang (Areca seed) promotes downward movement of Qi in the intestines, and Lei Wan (Omphalia) has antiparasitic properties with unclear safety in pregnancy. Chuan Jiao (Sichuan pepper) is also warming and stimulating. The combination poses potential risks during pregnancy.

Avoid

Patients without confirmed parasitic infection. This formula's bitter, cold, acrid, and sour composition is specifically targeted at roundworm conditions with Heat. Using it for general abdominal pain without worm involvement could damage Spleen and Stomach Qi.

Caution

Severe Yin deficiency or Blood deficiency. The bitter-cold herbs (Hu Huang Lian, Huang Bai) can further deplete Yin fluids if the patient is already severely depleted. Use with caution and modify accordingly.

Caution

Young children or the elderly with weak constitution. The antiparasitic herbs (Lei Wan, Bing Lang) can be harsh on a fragile digestive system. Dosage should be significantly reduced and closely monitored.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. Bing Lang (Areca seed) has strong downward-directing and Qi-moving properties in the intestines, which could theoretically stimulate uterine activity. Lei Wan (Omphalia) is an antiparasitic agent whose safety profile in pregnancy has not been established. Chuan Jiao (Sichuan pepper) is acrid and warming, traditionally listed among herbs used with caution in pregnancy. The overall formula strategy of forcefully purging parasites makes it unsuitable for pregnant women. If a pregnant woman has a roundworm condition, a qualified practitioner should be consulted for safer alternatives with appropriate dosage adjustments.

Breastfeeding

Use with caution during breastfeeding. Bing Lang (Areca seed) contains alkaloids such as arecoline that could potentially transfer into breast milk, though specific studies on this are lacking. Lei Wan (Omphalia) has antiparasitic compounds whose safety during lactation is not well documented. Hu Huang Lian (Picrorhiza) and Huang Bai (Phellodendron) are bitter and cold, and excessive use could theoretically affect the nursing infant's digestion through breast milk. If a breastfeeding mother requires treatment for roundworm infestation, a practitioner should weigh the urgency of treatment against these potential risks and consider temporarily suspending breastfeeding during the short course of treatment.

Children

Roundworm infestations historically affected children frequently, and this formula can be considered for pediatric use under qualified practitioner supervision. However, dosages must be significantly reduced based on age and body weight. As a general guide: children under 5 years should receive roughly one-quarter to one-third of the adult dose; children aged 5-10 approximately half the adult dose; and adolescents aged 10-14 roughly two-thirds. Lei Wan (Omphalia) and Bing Lang (Areca seed) are potent antiparasitic herbs that may cause loose stools or mild abdominal cramping, which should be monitored carefully in children. The bitter-cold herbs (Hu Huang Lian, Huang Bai) should be used cautiously in children with weak digestion. In modern practice, roundworm infestations in children are more commonly treated with pharmaceutical anthelmintics, and this formula would typically be reserved for cases where the TCM Heat pattern is clearly present and a practitioner specifically recommends it.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Lian Mei An Hui Tang

Bing Lang (Areca seed) contains arecoline and other alkaloids with cholinergic activity. It may interact with cholinergic or anticholinergic medications, potentially amplifying or counteracting their effects. Caution is advised when used alongside drugs for glaucoma, myasthenia gravis, or Alzheimer's disease that act on the cholinergic system.

Huang Bai (Phellodendron bark) contains berberine, which has documented interactions with several drug classes. Berberine may increase the blood levels of cyclosporine and other drugs metabolized by cytochrome P450 enzymes (particularly CYP3A4). It may also interact with antidiabetic medications by enhancing their hypoglycemic effect, and with anticoagulants or antiplatelet drugs by potentially altering their metabolism.

Hu Huang Lian (Picrorhiza rhizome) has hepatoprotective and immunomodulatory properties. Theoretical interactions exist with immunosuppressants, as it may modulate immune function. Patients on immunosuppressive therapy should use this formula with caution.

As with all herbal formulas containing multiple bioactive compounds, patients taking prescription medications of any kind should consult both their prescribing physician and a qualified TCM practitioner before using this formula.

Usage Guidance

Practical advice for getting the most out of Lian Mei An Hui Tang

Best time to take

On an empty stomach, 30-60 minutes before meals, to maximize direct contact of the medicinals with the intestinal environment where the parasites reside.

Typical duration

Acute use: typically 3-5 days, or until roundworm symptoms resolve. Reassess promptly if no improvement within 3 days.

Dietary advice

While taking this formula, avoid greasy, oily, and rich foods, as these are difficult to digest and may aggravate the worm condition. Cold and raw foods should also be avoided, as they can impair Stomach function that is already compromised. Spicy and heating foods (alcohol, deep-fried dishes, chili) should be limited, since the underlying pattern involves excess Heat. Sweet and sugary foods are traditionally thought to attract roundworms and should be restricted. Light, easily digestible foods such as rice porridge, steamed vegetables, and clear soups are recommended. Sour foods like vinegar or pickled vegetables may complement the formula's sour strategy but should not be overdone.

Lian Mei An Hui Tang originates from Chóng Dìng Tōng Sú Shāng Hán Lùn (重订通俗伤寒论, Revised Popular Treatise on Febrile Diseases) — Yu Genchu's experience formula (俞氏经验方) Qīng dynasty, original text compiled 1776 CE, revised edition 1916 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Lian Mei An Hui Tang and its clinical use

From the Chóng Dìng Tōng Sú Shāng Hán Lùn (重订通俗伤寒论), Chapter on Cooling Formulas (清凉剂), by Yu Genchu with annotations by He Xiushan:

「肝火入胃。胃热如沸。饥不欲食。食则吐蛔。甚则蛔动不安。脘痛烦躁。昏乱欲死者。此为蛔厥。」

"When Liver Fire enters the Stomach, the Stomach Heat boils over. The patient is hungry but does not wish to eat. Upon eating, roundworms are vomited. In severe cases the worms become restless and agitated, causing epigastric pain, irritability, and a confused, near-death state. This is called Hui Jue (roundworm reversal)."

「故以连、柏、椒、梅之苦辛酸法。泻肝救胃为君。佐以雷丸、槟榔专治蛔厥。使蛔静伏而不敢蠕动。或竟使蛔从大便泻出。此为清肝安蛔。止痛定厥之良方。」

"Therefore, using the bitter-acrid-sour method of Lian [Hu Huang Lian], Bai [Huang Bai], Jiao [Chuan Jiao], and Mei [Wu Mei] to drain the Liver and rescue the Stomach as sovereign. Assisted by Lei Wan and Bing Lang which specifically treat Hui Jue (roundworm reversal), causing the worms to become still and not dare to wriggle, or even causing them to be expelled through the stool. This is an excellent formula for clearing the Liver, calming roundworms, stopping pain, and settling reversal."

Classical principle referenced in the formula's rationale:

「蛔得酸则静,得辛则伏,得苦则下」

"Roundworms become still when they encounter sourness, hide when they encounter pungency, and descend when they encounter bitterness."

Historical Context

How Lian Mei An Hui Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Lian Mei An Hui Tang (连梅安蛔汤, "Coptis and Mume Decoction to Calm Roundworms") originates from the Chóng Dìng Tōng Sú Shāng Hán Lùn (重订通俗伤寒论, "Revised Popular Treatise on Febrile Diseases"), where it is recorded as an experience formula of Yu Genchu (俞根初, 1734–1799), the Qing dynasty physician from Shaoxing, Zhejiang, who founded the "Shaoxing School of Cold Damage" (绍派伤寒). Yu Genchu's original text was later annotated by He Xiushan (何秀山) and significantly expanded by He Lianchen (何廉臣) in 1916, with further revisions by Cao Bingzhang (曹炳章) and Xu Rongzhai (徐荣斋). The formula appears in the section on cooling formulas (清凉剂) under the treatment strategy called "clearing the Liver to calm roundworms" (清肝安蛔法).

This formula represents an important clinical refinement of the classical approach to roundworm disease. The most famous earlier formula for Hui Jue (roundworm reversal) is Wu Mei Wan (乌梅丸) from Zhang Zhongjing's Shang Han Lun, which addresses a mixed cold-and-heat pattern with warming herbs like Fu Zi, Gui Zhi, and Gan Jiang alongside bitter-cold and sour herbs. Yu Genchu recognized that some patients presented with a clearly Heat-predominant picture where the warming herbs of Wu Mei Wan would be inappropriate. His Lian Mei An Hui Tang stripped away the warming elements and focused purely on clearing Liver Fire while employing the classical "sour-bitter-acrid" strategy against roundworms. This reflects the pragmatic, pattern-specific approach that characterized the Shaoxing school's contribution to Chinese medicine.

The formula also has a sibling: Li Zhong An Hui Tang (理中安蛔汤), from the Wan Bing Hui Chun (万病回春), which treats the opposite pattern of cold-type roundworm disease with warming herbs. Together, these two formulas illustrate the TCM principle of treating the same disease (roundworm infestation) with different approaches depending on whether the underlying pattern is Hot or Cold.