Li Zhong An Hui Tang

Regulate the Middle and Calm Roundworms Decoction · 理中安蛔湯

Also known as: An Hui Tang (安蛔汤), Li Zhong An Hui Wan (理中安蛔丸)

A warming formula designed to strengthen the digestive system and calm roundworms. It addresses situations where a weak, cold digestive system allows intestinal parasites to become active, causing abdominal pain, vomiting of worms, and loose stools. By warming the Spleen and Stomach while simultaneously pacifying the worms, the formula treats both the underlying weakness and the parasitic disturbance.

Origin Wan Bing Hui Chun (万病回春, Restoration of Health from Myriad Diseases) by Gong Tingxian (龚廷贤), Volume 2 — Míng dynasty, 1587 CE
Composition 6 herbs
Ren Shen
King
Ren Shen
Bai Zhu
Deputy
Bai Zhu
Gan Jiang
Deputy
Gan Jiang
Fu Ling
Assistant
Fu Ling
Wu Mei
Assistant
Wu Mei
Hua Jiao
Assistant
Hua Jiao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Li Zhong An Hui Tang is designed to correct these specific patterns.

Why Li Zhong An Hui Tang addresses this pattern

This is the primary pattern addressed by the formula. When the Spleen and Stomach Yang is deficient, the Middle Jiao becomes cold. This leads to poor digestion, loose stools with clear urine, abdominal pain with rumbling, and cold extremities. In this weakened, cold environment, intestinal roundworms become agitated and active, migrating upward to cause vomiting of worms or passing worms in the stool. The formula's core of Ren Shen, Bai Zhu, Gan Jiang, and Fu Ling directly warms and tonifies the Spleen and Stomach, while Wu Mei and Hua Jiao calm the worms that have become disturbed by the cold environment.

A practitioner would look for one or more of these signs

Abdominal Pain

Cramping abdominal pain with intestinal rumbling (肠鸣腹痛)

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting of roundworms or passing worms in stool

Diarrhea

Loose, clear stools (便清)

Cold Limbs

Cold hands and feet (手足不温)

Loss Of Appetite

Poor appetite and reduced food intake

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Li Zhong An Hui Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Spleen and Stomach Qi Deficiency Roundworms due to Cold in the Middle Jiao

TCM Interpretation

In TCM understanding, biliary ascariasis occurs when roundworms dwelling in the intestines become disturbed and migrate upward into the bile duct. This is triggered by internal Cold in the Middle Jiao. The Spleen and Stomach lose their warming and transporting function, creating a cold internal environment. Roundworms, which in classical theory prefer warmth and become restless in cold, begin to move erratically and may ascend into the biliary system. The resulting condition presents with sudden, severe upper abdominal pain that comes and goes, nausea, vomiting (sometimes vomiting worms), cold limbs, and a pale tongue with a white coating. The underlying deficiency of Spleen Yang is both the cause and the maintaining factor.

Why Li Zhong An Hui Tang Helps

Li Zhong An Hui Tang addresses biliary ascariasis from both angles. Ren Shen and Bai Zhu tonify the Spleen Qi and restore the Middle Jiao's functional capacity. Gan Jiang (dry-fried black) warms the interior and dispels the Cold that triggered the worm migration. Fu Ling supports the Spleen and resolves accumulated Dampness. The critical antiparasitic pair of Wu Mei (sour, to pacify the worms) and Hua Jiao (pungent, to repel and paralyze them) directly calms the worms so they retreat from the bile duct back into the intestine. Clinical studies have reported the formula's effectiveness in treating biliary ascariasis, with one series of 32 cases showing symptom resolution within 1 to 6 doses.

Also commonly used for

Abdominal Pain

Colicky abdominal pain due to intestinal parasites in a cold, deficient constitution

Chronic Gastritis

When presenting with Spleen-Stomach deficiency Cold pattern

Chronic Diarrhea

Loose stools with clear urine and cold limbs due to Middle Jiao deficiency Cold

What This Formula Does

Every TCM formula has a specific set of actions — here's what Li Zhong An Hui Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Li Zhong An Hui Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Li Zhong An Hui Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Li Zhong An Hui Tang works at the root level.

This formula addresses a condition where the Spleen and Stomach Yang is insufficient, leading to internal cold in the Middle Jiao. Under normal circumstances, the Spleen and Stomach maintain a warm environment in the digestive tract. When this warmth declines, the interior becomes cold, digestion falters, and the body produces symptoms such as abdominal pain with rumbling, cold hands and feet, clear watery stools and urine, a pale tongue with white coating, and a weak pulse.

In classical TCM understanding, roundworms (hui, 蛔) are restless creatures that prefer a warm environment and are repelled by cold. When the Middle Jiao becomes cold, the worms become agitated and move erratically, sometimes ascending to be vomited out through the mouth or descending to appear in the stool. The cold environment essentially destabilizes the worms, causing them to wander and provoke further abdominal pain and distress. This is distinct from the mixed Heat-Cold roundworm pattern (as treated by Wu Mei Wan), because here the problem is purely one of deficiency cold without significant upper Heat.

The treatment principle is therefore twofold: restore warmth and strength to the Middle Jiao so the digestive environment normalizes, and simultaneously calm the roundworms using sour and acrid flavors that subdue and pacify them. Once the Spleen Yang is revived and the middle is warm again, the worms settle down and the associated symptoms of pain, vomiting, and intestinal disturbance resolve.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid and sour with underlying sweetness — acrid to warm and dispel cold, sour to calm roundworms, sweet to tonify the Spleen.

Ingredients

6 herbs

The herbs that make up Li Zhong An Hui Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Ren Shen

Ren Shen

Ginseng

Dosage 6 - 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Li Zhong An Hui Tang

Strongly tonifies the Qi of the Middle Jiao, reinforcing Spleen and Stomach function. As the primary herb, it addresses the root cause of middle Yang deficiency that allows parasites to become active.
Deputies — Assists and enhances the King
Bai Zhu

Bai Zhu

Atractylodes rhizomes

Dosage 6 - 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Spleen, Stomach

Role in Li Zhong An Hui Tang

Strengthens the Spleen and dries Dampness, working with Ren Shen to restore the Spleen's transforming and transporting functions. Helps solidify the digestive system so it can resist parasitic disturbance.
Gan Jiang

Gan Jiang

Dried ginger

Dosage 3 - 4.5g
Temperature Hot
Taste Pungent
Organ Affinity Heart, Kidneys, Lungs, Stomach
Preparation Dry-fried until black (炒黑)

Role in Li Zhong An Hui Tang

Warms the Middle Jiao and dispels interior Cold. Dry-fried until black (炒黑), which moderates its pungency while retaining its warming nature, making it suited for a deficiency-cold condition with parasites. Works with Ren Shen to restore Spleen Yang.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 6 - 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Li Zhong An Hui Tang

Strengthens the Spleen and promotes the drainage of Dampness. Assists Bai Zhu in resolving the Dampness that accumulates when Spleen Yang is deficient, and supports overall digestive function.
Wu Mei

Wu Mei

Chinese plums

Dosage 3 - 6g
Temperature Neutral
Taste Sour
Organ Affinity Large Intestine, Liver, Lungs, Spleen

Role in Li Zhong An Hui Tang

Sour in flavour, it pacifies and calms roundworms (安蛔). Roundworms are repelled by sour taste and become still when exposed to acidity. Wu Mei is the key herb for this antiparasitic action and pairs with Hua Jiao to subdue worm activity.
Hua Jiao

Hua Jiao

Sichuan pepper

Dosage 2 - 3g
Temperature Warm
Taste Pungent
Organ Affinity Kidneys, Spleen, Stomach
Preparation Remove the seeds (去目)

Role in Li Zhong An Hui Tang

Pungent and warm, it warms the Middle Jiao and kills or paralyzes roundworms. Combined with Wu Mei, the sour-pungent pairing (酸辛伏虫) is a classical strategy for subduing worms. Also helps warm the Spleen and Stomach to address internal Cold.

Why This Combination Works

How the herbs in Li Zhong An Hui Tang complement each other

Overall strategy

This formula addresses a situation where Spleen and Stomach Yang deficiency creates internal Cold, which in turn agitates roundworms in the intestines. The prescription strategy is twofold: warm and tonify the Middle Jiao to correct the root deficiency, while simultaneously calming the worms with sour and pungent herbs. By restoring the digestive system's warmth and strength, the environment becomes inhospitable to parasitic activity.

King herbs

Ren Shen (Ginseng) serves as the King herb, powerfully tonifying the Qi of the Spleen and Stomach. The core problem is middle Yang deficiency, and Ren Shen directly addresses this root cause by reinforcing the body's vital Qi and restoring the Spleen's capacity to transform and transport.

Deputy herbs

Bai Zhu strengthens the Spleen and dries Dampness, complementing Ren Shen's Qi-tonifying action by addressing the Dampness that accumulates when the Spleen fails to function properly. Gan Jiang (dry-fried black) warms the Middle Jiao and disperses Cold, directly targeting the internal Cold that disturbs the worms. Together with Ren Shen, these two herbs restore Spleen Yang.

Assistant herbs

Fu Ling (reinforcing assistant) supports the Spleen and drains Dampness, complementing Bai Zhu's drying action from a different angle through gentle leaching of accumulated fluid. Wu Mei (counteracting assistant) addresses the secondary symptom of active roundworms through its intensely sour flavour, which paralyzes and quiets the worms. Hua Jiao (counteracting assistant) adds pungent warmth that both kills parasites and reinforces the formula's Middle-warming action.

Notable synergies

The Wu Mei and Hua Jiao pairing is the critical antiparasitic combination in this formula. Classical theory holds that roundworms are subdued by sourness and repelled by pungency (蛔得酸则静,得辛则伏). Together they create a sour-pungent environment that calms worms without the need for harsh purgative antiparasitics. This gentle approach is appropriate because the patient is already weak from Spleen deficiency. The Ren Shen, Bai Zhu, and Gan Jiang trio reconstructs the warming core of Li Zhong Tang, ensuring the root deficiency is addressed alongside the parasitic symptoms.

How to Prepare

Traditional preparation instructions for Li Zhong An Hui Tang

Roughly cut (锉) all herbs. Decoct in approximately 300-400 ml of water over medium heat. Bring to a boil, then reduce heat and simmer for 20-30 minutes. Strain and serve warm. Take one dose per day, divided into two servings (morning and evening), ideally on an empty stomach. During treatment, avoid greasy, raw, and cold foods.

Common Modifications

How practitioners adapt Li Zhong An Hui Tang for specific situations

Added
Lai Fu Zi

6-9g (processed), to strongly warm Yang and dispel Cold

When Spleen and Kidney Yang deficiency is severe, adding processed Fu Zi greatly strengthens the formula's warming power and restores Yang, preventing further collapse of the Middle Jiao.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Li Zhong An Hui Tang should not be used or requires extra caution

Avoid

Yin Deficiency with Heat signs. This is a warm, drying formula and will further deplete Yin fluids if used in patients with Yin-deficient constitutions.

Avoid

Roundworm conditions with significant Heat signs (high fever, yellow greasy tongue coating, rapid forceful pulse). This formula addresses roundworms in a cold, deficient context only. For Heat-predominant or mixed Heat-Cold roundworm patterns, Wu Mei Wan (Mume Pill) is more appropriate.

Avoid

External Wind-Cold invasion with fever. The formula's interior-warming action is inappropriate when an exterior pathogen has not yet been resolved.

Avoid

Damp-Heat in the Middle Jiao with bitter taste, yellow greasy tongue coating, and foul-smelling stools. The warming herbs will aggravate internal Heat.

Caution

Patients with a strong constitution who present with roundworms but no signs of Spleen-Stomach deficiency cold. Tonifying and warming herbs are unnecessary and may cause excess Heat.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Hua Jiao (Sichuan Pepper) is acrid and warm with a stimulating nature, and some classical sources list it as a caution herb during pregnancy due to its potential to increase downward-moving activity. Gan Jiang (Dried Ginger) is hot in nature. While neither herb is a strong abortifacient, the overall warming and Qi-moving properties of the formula warrant careful assessment by a qualified practitioner before prescribing to pregnant women. The formula should only be used if the benefits clearly outweigh potential risks, and only under professional supervision.

Breastfeeding

Generally considered acceptable with caution during breastfeeding. The herbs in this formula are food-grade or commonly used medicinal substances. Hua Jiao (Sichuan Pepper) is a culinary spice used widely in Chinese cooking, and Gan Jiang (Dried Ginger) is similarly common. Ren Shen (Ginseng) components may transfer into breast milk in small quantities. There are no well-documented adverse effects on lactation or nursing infants from these herbs at standard medicinal doses, but as with all herbal formulas during breastfeeding, professional guidance is recommended. If the infant shows any signs of irritability, digestive upset, or changes in feeding patterns, the formula should be discontinued.

Children

This formula has historically been used in pediatric practice, as roundworm infestations were particularly common in children. Dosage should be reduced to approximately one-third to one-half of the adult dose for children aged 6–12, and one-quarter for children under 6, adjusted by body weight and constitution. The formula is relatively mild in composition compared to stronger anti-parasitic formulas, making it more suitable for children with weak constitutions showing signs of Spleen deficiency cold. The sour taste of Wu Mei and the numbing quality of Hua Jiao may be challenging for young children to tolerate; the decoction can be sweetened lightly with honey (for children over 1 year of age) to improve compliance. A practitioner should confirm the parasitic diagnosis before prescribing, and modern deworming medications should also be considered as standard care.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Li Zhong An Hui Tang

Ren Shen (Ginseng): May interact with anticoagulant and antiplatelet medications (such as warfarin) by potentially affecting platelet aggregation. May also interact with hypoglycemic agents by independently lowering blood sugar, potentially causing hypoglycemia when combined. Ren Shen may reduce the effectiveness of immunosuppressant drugs.

Hua Jiao (Sichuan Pepper): Contains compounds that may have mild local anesthetic effects on the gastrointestinal tract. Theoretical potential to affect the absorption rate of co-administered oral medications due to its effects on GI motility.

General consideration: As this formula warms the interior and promotes digestive function, it may alter the absorption kinetics of concurrently taken oral pharmaceuticals. Patients on narrow therapeutic index drugs should separate administration times by at least one to two hours.

Usage Guidance

Practical advice for getting the most out of Li Zhong An Hui Tang

Best time to take

On an empty stomach, typically 30–60 minutes before meals in the morning and evening. Empty-stomach administration is classically preferred for anti-parasitic formulas to maximize contact between the herbs and the intestinal parasites.

Typical duration

Acute use: 3–7 days for active roundworm symptoms, reassessed as symptoms resolve. May be continued for 1–2 weeks for underlying Spleen deficiency cold.

Dietary advice

While taking this formula, avoid cold and raw foods (including raw vegetables, salads, cold drinks, ice cream, and chilled fruit) as these worsen the internal cold this formula is treating. Greasy, oily, and heavy foods should also be avoided as they burden the already weakened Spleen. Classical dietary advice for roundworm conditions specifically prohibits fatty meat and strong-smelling fishy foods (荤腥油腻), which may agitate the worms. Favor warm, easily digested foods such as congee (rice porridge), cooked root vegetables, and mild soups. Light, bland food supports the Spleen-strengthening action of the formula.

Li Zhong An Hui Tang originates from Wan Bing Hui Chun (万病回春, Restoration of Health from Myriad Diseases) by Gong Tingxian (龚廷贤), Volume 2 Míng dynasty, 1587 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Li Zhong An Hui Tang and its clinical use

Source Text — Wan Bing Hui Chun (万病回春), Gong Tingxian, Ming Dynasty (1587)

The original text records this formula under the section on roundworm disorders, indicating it for patterns of Middle Yang insufficiency with Spleen-Stomach deficiency cold accompanied by roundworm disturbance. The formula is listed with the composition: Ren Shen (人参), Bai Zhu (白术), Fu Ling (茯苓), Gan Jiang dry-fried black (干姜炒黑), Hua Jiao with eyes removed (花椒去目), and Wu Mei (乌梅).

Baidu Baike entry on Li Zhong Tang (理中汤) variants:

「本方去甘草,加茯苓、川椒、乌梅,名理中安蛔丸,治胃寒吐蛔。」

Translation: "This formula [Li Zhong Tang] with Gan Cao removed and Fu Ling, Chuan Jiao, and Wu Mei added is called Li Zhong An Hui Wan, and treats vomiting of roundworms due to Stomach cold."

Historical Context

How Li Zhong An Hui Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Li Zhong An Hui Tang originates from the Wan Bing Hui Chun (万病回春, "Recovery from Ten Thousand Diseases"), written by the Ming Dynasty physician Gong Tingxian (龚廷贤, 1522–1619). Gong was a celebrated doctor from Jinxi, Jiangxi province, who came from a medical family — his father Gong Xin served in the Imperial Medical Bureau. Gong Tingxian himself earned the extraordinary title "Medical Forest Champion" (医林状元) for his clinical prowess, and practiced medicine for over sixty years. His Wan Bing Hui Chun, published in 1587, became enormously influential both in China and abroad, particularly in Japan where it was adopted by the Kampo medical tradition.

The formula is a creative modification of Zhang Zhongjing's classical Li Zhong Tang (理中汤, "Regulate the Middle Decoction") from the Shang Han Lun. Gong removed Zhi Gan Cao (Honey-Fried Licorice) from the original four-herb formula, added Fu Ling (Poria) to strengthen Spleen function and drain dampness, and crucially added Wu Mei (Mume Fruit) and Hua Jiao (Sichuan Pepper) as anti-parasitic herbs. This adaptation demonstrated Gong's clinical ingenuity: rather than creating an entirely new formula, he built upon the well-established Li Zhong Tang framework while adding targeted herbs to address the specific complication of roundworm infestation in the context of Spleen-Stomach deficiency cold. The formula also appears referenced in the Qing Dynasty text Lei Zheng Zhi Cai (类证治裁) by Lin Peiqin, confirming its continued use across dynasties.