San Jin Pai Shi Tang

Three-Gold Stone-Expelling Decoction · 三金排石湯

Also known as: San Jin Tang (三金汤), Three Gold Stone Decoction

A modern formula designed to help the body pass urinary tract stones (kidney stones, ureteral stones, bladder stones) by clearing Heat and Dampness from the lower body, promoting urination, and softening or dissolving stones. It is also used for gallstones. The name 'Three Gold' refers to its three principal stone-dissolving herbs: Jin Qian Cao (Gold Coin Herb), Ji Nei Jin (Chicken Gizzard Lining), and Hai Jin Sha (Japanese Climbing Fern Spores).

Origin Modern clinical experience formula (现代经验方), attributed to Professor Yin Huihe (印会河) and other contemporary practitioners — Modern era (contemporary clinical formula)
Composition 9 herbs
Jin Qian Cao
King
Jin Qian Cao
Ji nei jin
King
Ji nei jin
Hai Jin Sha
Deputy
Hai Jin Sha
Shi Wei
Assistant
Shi Wei
Bian Xu
Assistant
Bian Xu
Che Qian Zi
Assistant
Che Qian Zi
Qu Mai
Assistant
Qu Mai
Hua Shi
Assistant
Hua Shi
+1
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. San Jin Pai Shi Tang is designed to correct these specific patterns.

Why San Jin Pai Shi Tang addresses this pattern

San Jin Pai Shi Tang is specifically designed for Bladder Damp-Heat that has progressed to the point where stones have formed. In TCM understanding, when Damp-Heat lingers in the lower body for a prolonged period, it 'cooks down' the body's fluids like a pot boiling dry, concentrating urine and eventually forming stones (a process described as 煎熬成石). The formula addresses this with a multi-layered approach: the Three Golds (Jin Qian Cao, Ji Nei Jin, Hai Jin Sha) directly dissolve and soften stones while clearing the underlying Heat; the large group of diuretic herbs (Shi Wei, Bian Xu, Che Qian Zi, Qu Mai, Hua Shi, Mu Tong) powerfully drains Damp-Heat and increases urine flow to flush out stone fragments. This combination treats both the root cause (Damp-Heat accumulation) and the branch manifestation (stone formation and obstruction).

A practitioner would look for one or more of these signs

Painful Urination

Sharp, cutting pain during urination, especially as stones pass

Blood in Urine

Caused by stones irritating or scraping the urinary tract lining

Urinary Retention

Sudden interruption of the urine stream when a stone blocks the passage

Lower Back Pain

Colicky pain radiating from the lower back to the lower abdomen and groin

Dark Urine

Concentrated, scanty, dark yellow urine from Damp-Heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider San Jin Pai Shi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

Kidney stones fall under the classical category of 'stone lin' (石淋), a condition recognized since ancient times. TCM understands stone formation as a consequence of Damp-Heat lingering in the lower body over a long period. The Heat 'boils down' and concentrates the fluids, while Dampness provides the stagnant environment for minerals to accumulate and crystallize. Contributing factors include a diet heavy in rich, greasy, or spicy foods; insufficient water intake; and chronic emotional stress that impairs the Liver's smooth flow of Qi (since the Liver channel wraps around the genitourinary area). When the Kidney's water-regulating function is weakened and the Bladder's transforming function is impaired by Damp-Heat, stones can form at any level of the urinary tract.

Why San Jin Pai Shi Tang Helps

San Jin Pai Shi Tang directly targets the pathomechanism of stone lin. The 'Three Golds' (Jin Qian Cao, Ji Nei Jin, Hai Jin Sha) work together to soften and dissolve stones while clearing the Damp-Heat that caused them. The six supporting diuretic herbs dramatically increase urine output, creating the flushing action needed to wash out stone fragments and sediment. Modern clinical reports have shown that Jin Qian Cao can increase ureteral peristalsis (the wave-like muscle contractions that move urine downward), which helps push stones along. Ji Nei Jin has a traditional reputation for dissolving hard accumulations. The formula works best for single, smaller stones (under about 1cm) and during acute episodes. Patients are advised to drink large amounts of warm water and stay physically active while taking it, as movement helps dislodge stones.

Also commonly used for

Urinary Tract Stones

Ureteral and bladder stones of the Damp-Heat type

Painful Urination

Stone-related painful urination (石淋)

Blood in Urine

Hematuria caused by stone irritation of the urinary tract

Urinary Tract Infection

When concurrent with stone formation and Damp-Heat

Urinary Retention

Intermittent urinary obstruction from stone blockage

What This Formula Does

Every TCM formula has a specific set of actions — here's what San Jin Pai Shi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, San Jin Pai Shi Tang is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how San Jin Pai Shi Tang works at the root level.

San Jin Pai Shi Tang addresses the condition known in TCM as shi lin (石淋, "stone strangury"), which corresponds to urinary tract stones (kidney stones, ureteral stones, bladder stones). The underlying disease mechanism centers on Damp-Heat accumulating in the Lower Burner, combined with impaired Bladder Qi transformation.

The process begins when the Kidneys' ability to separate the clear from the turbid in body fluids becomes compromised. This may stem from excessive consumption of rich, greasy, or overly salty foods, insufficient water intake, or constitutional Kidney weakness. When the Kidneys and Bladder cannot properly transform and discharge fluids, turbid substances stagnate in the lower urinary tract. Over time, this stagnation generates Heat. The combination of lingering Dampness and Heat then "steams" and concentrates the urine, much like boiling seawater produces salt crystals. Mineral deposits gradually solidify into sand and eventually stones. As classical sources explain: "Damp-Heat simmers in the Lower Burner for a long time, the urine is scorched by this Heat, and day after day the impurities in the urine condense into sand and stone."

Once stones have formed, they obstruct the flow of Qi and fluids, causing sharp pain along the urinary tract, difficulty urinating, and potentially blood in the urine from physical damage to the delicate lining of the ureters or bladder. The obstruction itself creates further stagnation, which can worsen the Heat, creating a self-reinforcing cycle. The formula breaks this cycle by simultaneously clearing the Damp-Heat that created the stones, promoting copious urination to flush out the stones, and softening the hardness of the stones themselves to ease their passage.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bland and sweet with salty notes. Bland to promote urination and drain Dampness, sweet to moderate harshness, and salty to soften hardness and dissolve stones.

Channels Entered

Ingredients

9 herbs

The herbs that make up San Jin Pai Shi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Jin Qian Cao

Jin Qian Cao

Gold coin herb

Dosage 60g
Temperature Cool
Taste Salty, Sweet
Organ Affinity Urinary Bladder, Gallbladder, Kidneys, Liver

Role in San Jin Pai Shi Tang

The chief stone-expelling herb. Clears Heat and Dampness from the Liver, Gallbladder, Kidney, and Bladder, promotes urination, and has a well-established action of softening and dissolving both urinary and biliary stones. Its salty taste softens hardness (咸能软坚). Used at a heavy dose to maximize its stone-expelling and Heat-clearing effect.
Ji nei jin

Ji nei jin

Chicken gizzard skins

Dosage 30g
Temperature Neutral
Taste Sweet
Organ Affinity Urinary Bladder, Spleen, Stomach, Small Intestine

Role in San Jin Pai Shi Tang

The second of the 'Three Golds.' Dissolves stones in the urinary and biliary tract and has a traditional reputation for transforming hard accumulations. Also strengthens the Spleen and Stomach, helping to prevent the cold, draining herbs in the formula from damaging digestion.
Deputy — Assists and enhances the King
Hai Jin Sha

Hai Jin Sha

Japanese climbing fern spores

Dosage 20g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Small Intestine
Preparation Wrap in cloth before decocting (包煎)

Role in San Jin Pai Shi Tang

The third of the 'Three Golds.' Clears Damp-Heat, promotes urination, relieves painful urination, and assists in expelling stones. Its salty, cold nature helps soften stones and clear Heat from the Bladder.
Assistants — Supports or moderates other herbs
Shi Wei

Shi Wei

Pyrrosia leaves

Dosage 15g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Urinary Bladder, Lungs

Role in San Jin Pai Shi Tang

Promotes urination and drains Damp-Heat from the lower body. Also helps stop bleeding caused by stone abrasion of the urinary tract, addressing the common complication of blood in the urine.
Bian Xu

Bian Xu

Knotgrass

Dosage 15g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Urinary Bladder

Role in San Jin Pai Shi Tang

Clears Heat and promotes urination, specifically targeting Damp-Heat in the Bladder. Works synergistically with Qu Mai to clear painful urinary dysfunction (lin syndrome).
Che Qian Zi

Che Qian Zi

Plantain seeds

Dosage 15g
Temperature Cool
Taste Sweet
Organ Affinity Kidneys, Liver, Lungs, Small Intestine
Preparation Wrap in cloth before decocting (包煎)

Role in San Jin Pai Shi Tang

Strongly promotes urination and clears Heat. Increases urine volume to help flush out small stones and sediment. Also clears Heat from the Liver, which can benefit cases where Liver channel involvement causes radiating pain to the groin and lower abdomen.
Qu Mai

Qu Mai

Chinese pink herbs

Dosage 12g
Temperature Cold
Taste Bitter
Organ Affinity Urinary Bladder, Heart, Small Intestine

Role in San Jin Pai Shi Tang

Encourages urination and expels Damp-Heat from the Bladder. Also has a secondary action of moving Blood, which supports the overall strategy of clearing obstruction in the urinary tract.
Hua Shi

Hua Shi

Talc

Dosage 12g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Stomach

Role in San Jin Pai Shi Tang

Promotes urination and clears Damp-Heat from the Bladder. Its slippery nature (as the name 'Sliding Stone' implies) helps lubricate the urinary passage to facilitate the smooth passage of stones.
Envoy — Directs the formula to its target
Mu Tong

Mu Tong

Akebia stems

Dosage 10g
Temperature Cold
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine

Role in San Jin Pai Shi Tang

Promotes urination and directs Heat downward to be discharged through the urine. Helps open the water passages and guides the formula's action into the urinary system. Also smoothes the flow of Blood in the channels.

Why This Combination Works

How the herbs in San Jin Pai Shi Tang complement each other

Overall strategy

San Jin Pai Shi Tang addresses urinary stones caused by Damp-Heat accumulating in the lower body. The strategy is twofold: dissolve and soften the stones while simultaneously flushing them out by clearing Heat, promoting strong urination, and ensuring the urinary passages are open and unobstructed.

King herbs

Jin Qian Cao (Gold Coin Herb) and Ji Nei Jin (Chicken Gizzard Lining) form the core stone-dissolving pair. Jin Qian Cao, used at a heavy 60g dose, is the foremost stone-expelling herb in the Chinese materia medica. It clears Damp-Heat from the Liver, Gallbladder, Kidney, and Bladder while its salty taste softens hardness, helping break down and dissolve stones. Ji Nei Jin is renowned for its ability to transform hard accumulations and dissolve stones, while also protecting the Spleen and Stomach from the heavily draining nature of the other herbs in the formula.

Deputy herbs

Hai Jin Sha (Japanese Climbing Fern Spores) completes the 'Three Golds' trio and powerfully reinforces the stone-expelling action. It clears Damp-Heat, promotes urination, and helps relieve the painful, burning urination that accompanies stone passage. Together, the Three Golds create a focused stone-dissolving and stone-expelling effect that is greater than any single herb could achieve alone.

Assistant herbs

Six herbs form the assistant tier, working primarily as reinforcing assistants. Shi Wei, Bian Xu, Che Qian Zi, Qu Mai, and Hua Shi collectively clear Damp-Heat and dramatically increase urine output, creating the hydraulic pressure needed to flush stones out. Shi Wei doubles as a restraining assistant by stopping bleeding from stone-irritated urinary tissue. Hua Shi's naturally slippery quality lubricates the urinary tract to ease stone passage.

Envoy herbs

Mu Tong guides the formula's action into the Heart and Small Intestine channel, directing Heat downward to be eliminated through urination. It opens the water passages throughout the body and ensures the combined draining action of all the herbs is focused on the urinary system.

Notable synergies

The 'Three Golds' pairing (Jin Qian Cao, Ji Nei Jin, Hai Jin Sha) is the signature combination: Jin Qian Cao and Hai Jin Sha soften and dissolve while Ji Nei Jin transforms hard accumulations, creating a three-pronged attack on stones. Bian Xu and Qu Mai form a classical paired duo (often seen together in formulas like Ba Zheng San) that powerfully drains Damp-Heat from the Bladder. Che Qian Zi and Hua Shi together maximize urine volume and lubrication of the urinary tract.

How to Prepare

Traditional preparation instructions for San Jin Pai Shi Tang

Take one dose (one full set of herbs) per day. Add approximately 800ml of water and decoct down to about 500ml. Strain and divide into two portions, taken warm morning and evening. A course of treatment is typically 6 consecutive days, after which a 3-day rest period is observed before continuing with the next course if needed.

Special preparation notes: Hai Jin Sha (Japanese Climbing Fern Spores) should be wrapped in cloth before decocting (包煎) to prevent the fine spores from floating in the liquid. Che Qian Zi (Plantain Seeds) should also be wrapped in cloth (包煎) for the same reason. Patients are strongly advised to drink plenty of warm water after taking the decoction and to engage in physical activity (such as jumping or brisk walking) to help facilitate the movement and passage of stones.

Common Modifications

How practitioners adapt San Jin Pai Shi Tang for specific situations

Added
Yan Hu Suo

12g, to move Qi and Blood and relieve spasmodic pain

Hu Po

3g ground to powder and dissolved in the strained decoction (冲服), to invigorate Blood, relieve pain, and promote urination

Yan Hu Suo is one of the strongest pain-relieving herbs in TCM, with a specific action of moving both Qi stagnation within Blood and Blood stagnation within Qi. Hu Po (Amber) invigorates Blood, disperses stasis, and is classified as a key herb for promoting water metabolism and resolving turbidity, making it ideal for stone-related pain with urinary obstruction.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where San Jin Pai Shi Tang should not be used or requires extra caution

Avoid

Pregnancy. Several herbs in this formula (such as Qu Mai/Dianthus and Bian Xu/Polygonum) promote urination and move downward forcefully, and may adversely affect pregnancy.

Avoid

Large urinary stones (generally over 1 cm in diameter). This formula is suitable for small or sand-like stones. Larger stones require surgical or lithotripsy intervention and attempting herbal expulsion alone risks dangerous obstruction.

Caution

Severe Kidney Qi or Kidney Yang deficiency without modification. The formula is predominantly cold in nature and strongly draining. In patients with underlying Kidney deficiency, prolonged use without tonifying herbs can further damage the Kidneys. Practitioners typically add warming or tonifying herbs (such as Du Zhong or Lu Jiao Shuang) in these cases.

Caution

Spleen and Stomach deficiency with loose stools or poor appetite. The cold, draining nature of the formula can further weaken digestive function. In debilitated or elderly patients, formula modifications or concurrent Spleen-supporting herbs are advisable.

Avoid

Complete urinary tract obstruction or acute renal failure. Attempting to force stone passage with diuretic herbs when there is complete blockage may worsen the condition. Urgent urological intervention is required.

Caution

Not suitable for long-term continuous use without reassessment. The formula's cold and draining properties can deplete Yin and Qi if taken for extended periods. Treatment is typically given in 6-day courses with rest periods between them.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Multiple herbs in this formula pose risks: Qu Mai (Dianthus) and Bian Xu (Polygonum aviculare) are traditionally considered to promote downward movement and could potentially stimulate uterine activity. Mu Tong (Akebia stem), present in the basic version, has documented nephrotoxicity concerns and is avoided in pregnancy. Hua Shi (Talcum) is a slippery, downward-draining mineral that is traditionally cautioned against in pregnancy. The overall strongly cold, draining, and downward-directing nature of the entire formula makes it inappropriate for use during any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While no specific adverse effects on nursing infants have been documented for this formula, its strongly cold and draining nature could theoretically affect the quality or quantity of breast milk by depleting the mother's fluids and Qi. Mu Tong (Akebia stem), if present in the formula version used, has been associated with nephrotoxicity due to aristolochic acid content in certain species (Aristolochia manshuriensis), and potential transfer of harmful compounds through breast milk is a concern. If stone treatment is urgently needed during breastfeeding, a qualified practitioner should carefully select the safest version of the formula, adjust dosages, and monitor the mother closely. The short-course treatment protocol (6 days on, 3 days rest) helps limit exposure.

Children

San Jin Pai Shi Tang is not commonly used in young children, as urinary stones are relatively uncommon in the pediatric population. For adolescents (over 12 years), dosage should be reduced to approximately 50-70% of the adult dose, adjusted by body weight. In younger children (under 12), urinary stones require specialist evaluation, and herbal treatment should only be considered under close supervision by a practitioner experienced in pediatric TCM. The cold, draining nature of this formula can more easily injure the Spleen and Stomach in children, whose digestive systems are still developing. Mu Tong should be used with extra caution or substituted (e.g., with Tong Cao/Rice Paper Plant Pith) in pediatric use due to nephrotoxicity concerns. Adequate hydration during treatment is essential for children, as with adults.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with San Jin Pai Shi Tang

Diuretics (thiazides, loop diuretics, potassium-sparing diuretics): San Jin Pai Shi Tang has strong diuretic effects through multiple herbs (Jin Qian Cao, Che Qian Zi, Hua Shi, Bian Xu, Qu Mai, Mu Tong). Concurrent use with pharmaceutical diuretics may cause excessive fluid loss, electrolyte imbalances (particularly hypokalemia or hyponatremia), and dehydration. Electrolytes should be monitored if combined use is necessary.

Lithium: The formula's potent diuretic action could alter lithium clearance and serum levels, potentially leading to lithium toxicity. Patients on lithium therapy should avoid this formula or have their lithium levels closely monitored.

Nephrotoxic drugs (aminoglycosides, NSAIDs, certain antivirals): If the formula version contains Mu Tong (particularly Guan Mu Tong from Aristolochia manshuriensis, which contains aristolochic acid), there is a risk of additive nephrotoxicity. Even with safer Mu Tong species, caution is warranted when combining with drugs that stress the kidneys.

Anticoagulants and antiplatelet drugs (warfarin, aspirin, clopidogrel): Some expanded versions of this formula include Blood-moving herbs like Dan Shen, Chi Shao, and Wang Bu Liu Xing, which may potentiate anticoagulant effects and increase bleeding risk. Dan Shen in particular has documented interactions with warfarin.

Usage Guidance

Practical advice for getting the most out of San Jin Pai Shi Tang

Best time to take

Twice daily, morning and evening, on an empty or near-empty stomach. Drink copious warm water after each dose, and engage in physical activity such as jumping, walking, or climbing stairs to help dislodge and move stones downward.

Typical duration

6 days per course, with a 3-day rest between courses. Multiple courses may be needed (commonly 2-4 courses). Reassess with imaging after each course.

Dietary advice

Drink large amounts of warm water throughout treatment (aim for at least 2 liters daily) to help flush stones and support the formula's diuretic action. Avoid greasy, fried, and rich foods, as these generate Dampness and Heat. Reduce intake of high-oxalate foods such as spinach, strong tea, nuts, and chocolate. Limit high-purine foods including organ meats, shellfish, sardines, and excessive red meat. Reduce salt intake, as excess sodium increases calcium excretion in the urine. Avoid alcohol and beer in particular, which contain purines and promote dehydration. Eat more fresh vegetables, whole grains, and fruit to maintain alkaline urine balance. Light, easily digestible foods are preferable during treatment to avoid taxing the Spleen and Stomach, which are already challenged by the formula's cold nature.

San Jin Pai Shi Tang originates from Modern clinical experience formula (现代经验方), attributed to Professor Yin Huihe (印会河) and other contemporary practitioners Modern era (contemporary clinical formula)

Classical Texts

Key passages from the classical Chinese medical texts that first described San Jin Pai Shi Tang and its clinical use

While San Jin Pai Shi Tang itself is a modern empirical formula rather than a classical prescription, its theoretical foundation rests on key classical passages about urinary stone disease (石淋, shi lin):

Zhu Bing Yuan Hou Lun (诸病源候论) by Chao Yuanfang

「诸淋者,由肾虚而膀胱热故也。」
"All strangury conditions arise from Kidney deficiency with Bladder Heat."

This passage identifies the root mechanism behind stone formation: an underlying Kidney deficiency allows Damp-Heat to accumulate in the Bladder, which over time concentrates the urine and produces stones.

Dan Xi Xin Fa (丹溪心法) by Zhu Danxi

「淋有五,皆属乎热。」
"There are five types of strangury, and all are rooted in Heat."

This concise statement emphasizes that Heat is the common pathogenic factor across all strangury patterns, which is why clearing Heat and draining Dampness forms the core treatment strategy of this formula.

Zhu Bing Yuan Hou Lun (诸病源候论)

「石淋者,淋而出石也,肾主水,水结则化为石,故肾客砂石。」
"Stone strangury means urinating with stones. The Kidneys govern Water; when Water congeals it transforms into stone, hence the Kidneys harbor sand and stones."

This passage directly describes how urinary stones form within the framework of Kidney Water metabolism.

Historical Context

How San Jin Pai Shi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

San Jin Pai Shi Tang is a modern empirical formula (经验方) rather than a classical prescription from the ancient texts. Its name, "Three-Gold Stone-Expelling Decoction," refers to its three principal stone-dissolving herbs, each containing the character 金 (jin, "gold"): Jin Qian Cao (金钱草, Gold Coin Herb), Ji Nei Jin (鸡内金, Chicken Gizzard Lining), and Hai Jin Sha (海金沙, Japanese Climbing Fern Spores). This "Three Golds" combination has become one of the most recognized herbal groupings in Chinese medicine for treating urinary and biliary stones.

Several versions of the formula circulate in clinical literature. A widely cited version attributed to Professor Yin Huihe (印会河), the renowned Beijing TCM educator, focuses on the core nine-herb composition for urinary stone disease (石淋). Another notable version was developed by Professor Tan Xinhua (谭新华) of Hunan University of Chinese Medicine, who added Blood-moving and Kidney-tonifying herbs such as Dan Shen, Chi Shao, Huang Qi, and Sang Ji Sheng, reflecting his clinical philosophy that stone disease involves not only Damp-Heat but also Blood stasis and underlying Kidney deficiency. Other clinicians, such as Ning Xianming, published expanded versions incorporating herbs like Mang Xiao (Glauber's salt) for its stone-softening properties and Niu Xi (Achyranthes) to guide stone fragments downward.

Though the formula itself is modern, the therapeutic principles it embodies trace back to ancient texts. The concept of shi lin (stone strangury) appears in the Shen Nong Ben Cao Jing from the Han Dynasty, and Chao Yuanfang's Zhu Bing Yuan Hou Lun (610 CE) provided the foundational pathology of Kidney deficiency with Bladder Heat. The classical Shi Wei San (石韦散) from Gu Jin Lu Yan (古今录验) already used Shi Wei and Dong Kui Zi as a pair for stone strangury, a combination preserved in San Jin Pai Shi Tang. The formula thus represents a modern synthesis of centuries of accumulated clinical wisdom about treating urinary stones.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of San Jin Pai Shi Tang

1

Clinical study of San Jin Pai Shi Tang combined with ESWL for proximal ureteral stones (RCT, published in Chinese)

Published in a Chinese TCM clinical journal (中医药临床杂志). Details of exact journal volume available through the Taizhou Hospital clinical research group.

A randomized controlled trial of 98 patients with proximal ureteral stones assigned to either ESWL alone or ESWL combined with San Jin Pai Shi Tang. The combined group showed significantly reduced pain scores, shorter time to hematuria resolution, and faster stone clearance compared to ESWL alone. Complication rates were similar between groups.

2

Endothelium Corneum Gigeriae Galli (Ji Nei Jin) extract inhibits calcium oxalate formation and exerts anti-urolithic effects (Preclinical, 2018)

Wang N, et al. Journal of Ethnopharmacology, 2018, 231: 80-89.

This laboratory study investigated the anti-urolithic properties of Ji Nei Jin (chicken gizzard lining), one of the three principal herbs in San Jin Pai Shi Tang. The extract was found to inhibit calcium oxalate crystal formation and aggregation, providing pharmacological support for its traditional use in dissolving and preventing urinary stones.

PubMed
3

Therapeutic effects of Chinese herbal medicines for treatment of urolithiasis: A review (Review article, 2023)

Division of Nephrology, Tianjin University of TCM & University of Alabama at Birmingham. Journal of Ethnopharmacology, 2024, 319: 117098.

A comprehensive review covering clinical trials and pharmacological studies on Chinese herbal medicines for urolithiasis. The review discusses mechanisms including inhibition of stone growth and aggregation, reduction of urine pH, promotion of stone dissolution, increased urine output, and smooth muscle relaxation. Several herbs found in San Jin Pai Shi Tang (Jin Qian Cao, Hai Jin Sha, Shi Wei, Che Qian Zi) are discussed for their anti-urolithic properties.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.