Sheng Yu Tang

Sage-like Healing Decoction · 聖愈湯

Also known as: Holy Healing Decoction, Sacred Cure Decoction

A classical formula for restoring Qi and Blood after excessive blood loss or chronic depletion. It addresses fatigue, restlessness, insomnia, pale complexion, and irregular menstruation caused by combined Qi and Blood deficiency. Built on the principle that replenishing Qi helps generate new Blood, it combines potent Qi-tonifying herbs with a strong Blood-nourishing foundation.

Origin Lan Shi Mi Cang (兰室秘藏, Secrets from the Orchid Chamber) by Li Dongyuan (李东垣) — Jīn dynasty (金朝), c. 1276 CE
Composition 6 herbs
Huang Qi
King
Huang Qi
Ren Shen
King
Ren Shen
Dang Gui
Deputy
Dang Gui
Shu Di Huang
Deputy
Shu Di Huang
Shu Di Huang
Assistant
Shu Di Huang
Chuan Xiong
Assistant
Chuan Xiong
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sheng Yu Tang is designed to correct these specific patterns.

Why Sheng Yu Tang addresses this pattern

This is the primary pattern Sheng Yu Tang addresses. When both Qi and Blood are depleted, typically following excessive blood loss from wounds, surgery, heavy menstruation, or chronic illness, the body enters a state where Qi is too weak to generate or contain Blood, and Blood is too scarce to anchor Qi. This creates a vicious cycle of mutual depletion. Ren Shen and Huang Qi directly replenish Qi, restoring its ability to produce and hold Blood. Dang Gui, Shu Di Huang, and Sheng Di Huang nourish the depleted Blood. Chuan Xiong ensures the newly generated Blood circulates properly. The formula breaks the cycle by simultaneously addressing both deficiencies based on the principle that Qi and Blood are interdependent.

A practitioner would look for one or more of these signs

Eye Fatigue

Pronounced exhaustion and physical weakness

Dull Pale Complexion

Pale or sallow face from blood depletion

Palpitations

Heart palpitations from insufficient Blood nourishing the Heart

Insomnia

Difficulty sleeping, restlessness at night

Shortness Of Breath

Shortness of breath on exertion

Dizziness

Dizziness or lightheadedness

Irritability

Irritability and mental restlessness from deficiency-Heat

Postmenstrual Bleeding

Menstrual periods arriving early, heavy flow with pale, thin blood

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Sheng Yu Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands anemia primarily as a deficiency of Blood, the vital substance that nourishes all tissues and organs. However, Blood does not exist in isolation: it depends on Qi for its production (the Spleen transforms food into Blood with the help of Qi) and for its circulation (Qi drives Blood through the vessels). When Blood is depleted, whether from chronic blood loss, poor nutrition, or prolonged illness, Qi inevitably weakens as well because it has lost the substance it relies on. This creates the Qi and Blood deficiency pattern. The Liver, which stores Blood, and the Heart, which governs Blood circulation and the spirit, are the two organs most immediately affected. Symptoms like fatigue, pallor, dizziness, palpitations, and insomnia all reflect the failure of Blood to nourish these organs properly.

Why Sheng Yu Tang Helps

Sheng Yu Tang addresses anemia by tackling both Qi and Blood deficiency simultaneously. Ren Shen and Huang Qi strongly replenish Qi, reviving the Spleen's ability to generate new Blood from food and supporting the overall metabolic processes needed for blood production. Dang Gui and Shu Di Huang are powerful Blood-nourishing herbs that directly replenish the depleted Blood stores, while Sheng Di Huang adds a Yin-nourishing and cooling dimension. Chuan Xiong keeps the Blood moving so that the heavy tonic herbs do not cause stagnation. Modern pharmacological research has shown that this formula can increase hemoglobin levels and improve hematopoietic function in animal models of anemia.

Also commonly used for

Irregular Menstruation

Early periods with heavy, pale flow from Qi and Blood deficiency

Insomnia

Insomnia following blood loss or in the context of Blood deficiency

Prostate Disorders

Postpartum weakness and blood loss recovery

Palpitations

Functional palpitations from Qi and Blood deficiency

Wound Healing Difficulties

Chronic non-healing wounds or ulcers with profuse thin discharge

Dizziness

Dizziness and lightheadedness from blood depletion

What This Formula Does

Every TCM formula has a specific set of actions — here's what Sheng Yu Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Sheng Yu Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Sheng Yu Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Sheng Yu Tang works at the root level.

Sheng Yu Tang addresses a condition where both Qi and Blood have become depleted, and as a consequence, Qi can no longer perform one of its critical jobs: keeping Blood flowing inside the vessels. In TCM theory, Blood does not circulate on its own. It relies on Qi to both propel it through the channels and to contain it within the vessels, like water held in place by the banks of a river. When Qi becomes severely weakened, it loses this holding power, and Blood begins to leak out, whether as heavy menstrual bleeding, prolonged wound oozing, or other forms of abnormal bleeding.

This sets up a vicious cycle. Blood loss further depletes Blood, which in turn weakens Qi (since the two are deeply interdependent). The Heart, which relies on adequate Blood to nourish the spirit (Shen), becomes unsettled. This produces the characteristic symptoms described in the original text: restlessness, mental agitation, and inability to sleep. Meanwhile, the Liver, which stores Blood, becomes depleted, and the Spleen, the source of new Qi and Blood production, is too weak to replenish what has been lost.

Li Dongyuan, the formula's creator, understood that in these situations, simply stopping the bleeding or tonifying Blood alone would be insufficient. The root cause is Qi deficiency failing to control Blood, so the treatment must simultaneously rebuild Qi (to restore its holding function) and nourish Blood (to replenish what has been lost). The inclusion of both raw and prepared Rehmannia in the original formula also reflects the understanding that some residual Heat from Blood deficiency may be present, requiring cooling alongside tonification.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and slightly bitter. The sweet herbs (Huang Qi, Ren Shen, Dang Gui, Shu Di Huang) tonify and nourish, while the mildly acrid Chuan Xiong and the slightly bitter-sweet Di Huang ground the formula and ensure Blood circulates smoothly.

Channels Entered

Ingredients

6 herbs

The herbs that make up Sheng Yu Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Huang Qi

Huang Qi

Astragalus root

Dosage 15 - 30g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Sheng Yu Tang

Powerfully tonifies Qi, raises the Yang, and secures the exterior. As the herb used in the largest dosage in the original formula, it is the primary force for replenishing Qi so that Qi can command and generate Blood. It also supports wound healing and tissue regeneration in cases of sore and ulcer bleeding.
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 10g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Sheng Yu Tang

Greatly tonifies the source Qi, strengthens the Spleen and Lung, generates fluids, and calms the spirit. Works together with Huang Qi to form a powerful Qi-tonifying pair, addressing the root mechanism that Qi deficiency underlies blood loss and Blood depletion.
Deputies — Assists and enhances the King
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 15g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Sheng Yu Tang

Tonifies and invigorates Blood, the chief Blood-nourishing herb in this formula. The body portion (shen) of Dang Gui is used specifically to emphasize Blood tonification over Blood-moving. It enters the Heart and Liver to replenish depleted Blood stores.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Sheng Yu Tang

Nourishes Blood and enriches Yin. As a rich, sweet, and warm substance, it strongly replenishes the Liver and Kidney Yin-Blood, providing the material foundation for Blood regeneration after loss.
Assistants — Supports or moderates other herbs
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Sheng Yu Tang

Clears Heat, cools Blood, and nourishes Yin. Balances the warming nature of the other tonifying herbs. Specifically addresses the deficiency-Heat (irritability, thirst, heat in the palms and soles) that arises from Blood and Yin depletion after blood loss.
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Sheng Yu Tang

Invigorates Blood and promotes Qi movement. Prevents the rich, cloying Blood-tonifying herbs from causing stagnation. Known as the 'Qi herb within the Blood', it ensures smooth circulation so that newly generated Blood can reach where it is needed.

Why This Combination Works

How the herbs in Sheng Yu Tang complement each other

Overall strategy

Sheng Yu Tang addresses the fundamental interdependence of Qi and Blood. When excessive bleeding depletes Blood, Qi also becomes unmoored because it has nothing to attach to. The formula simultaneously rebuilds Qi (so it can generate and hold Blood) and nourishes Blood (so Qi has a substance to anchor to), following the classical principle that 'when Blood is lost, generating new Blood requires first tonifying Qi'.

King herbs

Huang Qi and Ren Shen together form a powerful Qi-tonifying pair. Huang Qi, used at the highest dosage in the original formula, raises Yang Qi, consolidates the body's defensive exterior, and supports tissue healing. Ren Shen strongly replenishes the source Qi and stabilizes the spirit, directly addressing the restlessness and insomnia that follow severe blood loss. Together they embody the principle that 'when Yang generates, Yin grows' and provide the driving force for new Blood production.

Deputy herbs

Dang Gui Shen (the body portion of Dang Gui) and Shu Di Huang are the core Blood-nourishing pair. Dang Gui enters the Heart and Liver to tonify and gently invigorate Blood, while Shu Di Huang deeply enriches Yin-Blood at the Kidney level. Together they replenish the depleted Blood stores from two complementary angles: active Blood circulation (Dang Gui) and deep Yin-Blood nourishment (Shu Di Huang).

Assistant herbs

Sheng Di Huang (raw Rehmannia) serves as a restraining assistant, its cool and Yin-nourishing nature counterbalancing the warm tonifying herbs and specifically targeting the deficiency-Heat symptoms (irritability, thirst, feverish sensation) that emerge when Blood and Yin are severely depleted. Chuan Xiong serves as a reinforcing assistant with a different angle: rather than adding more tonification, it invigorates Blood circulation and moves Qi, preventing the rich, heavy tonic herbs from causing stagnation. This ensures the formula 'tonifies without clogging'.

Notable synergies

The Huang Qi and Ren Shen pairing exemplifies mutual reinforcement in Qi tonification, one lifting Yang and securing the exterior while the other stabilizes the source Qi internally. The Dang Gui and Chuan Xiong pairing (a classical 'Blood pair') ensures Blood is both nourished and kept flowing. The combination of Sheng Di Huang and Shu Di Huang (raw and prepared Rehmannia together) creates a balance between cooling and warming, Yin-clearing and Blood-enriching, that neither herb achieves alone.

How to Prepare

Traditional preparation instructions for Sheng Yu Tang

The original text instructs to coarsely chop (㕮咀) the herbs to the size of hemp seeds (如麻豆大), combine as a single dose, add approximately 600 mL of water (水二大盏), and decoct down to approximately 300 mL (煎至一盏). Strain and remove the residue (去滓), then take warm (稍热) at any time of day (无时服).

In modern clinical practice, standard dosages are significantly larger than the original formula's tiny amounts (which were for a coarse-powder decoction). The herbs are typically decocted in 600–800 mL of water, brought to a boil, then simmered on low heat for 30–40 minutes until reduced to approximately 200–300 mL. The decoction is strained and divided into two portions, taken warm in the morning and evening.

Common Modifications

How practitioners adapt Sheng Yu Tang for specific situations

Added
Di Gu Pi

9-15g, clears deficiency-Heat and cools Blood

Mu Dan Pi

6-9g, cools Blood and clears steaming bone Heat

When Blood and Yin depletion generates significant deficiency-Heat, Di Gu Pi and Mu Dan Pi cool Blood-level Heat without damaging the Yin, complementing Sheng Di Huang's cooling action.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Sheng Yu Tang should not be used or requires extra caution

Avoid

Excess Heat or true Fire patterns. The warming, tonifying nature of this formula can worsen conditions driven by excess Heat or Fire, not deficiency.

Avoid

Active external pathogenic invasion (common cold, flu, acute febrile illness). Tonifying formulas can trap pathogens inside the body, worsening the illness. The formula should not be used until the external condition has resolved.

Avoid

Bleeding caused by Blood Heat (excess type). This formula treats bleeding due to Qi failing to hold Blood (deficiency type). If bleeding is caused by reckless movement of Hot Blood, with signs like bright red blood, a red tongue, and a rapid forceful pulse, this formula is inappropriate.

Caution

Spleen and Stomach weakness with significant Dampness or food stagnation. The rich, cloying herbs (especially Shu Di Huang and Sheng Di Huang) can worsen digestive sluggishness, leading to bloating, loose stools, and poor appetite. If Dampness is present, the formula should be modified or a different approach used.

Caution

Yin deficiency with vigorous Fire. While the formula contains Yin-nourishing herbs, its Qi-tonifying warm ingredients (Ren Shen, Huang Qi) may aggravate pronounced deficiency-Fire symptoms such as strong night sweats, five-palm heat, and a rapid thin pulse.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy, as the formula contains no known abortifacient or strongly Blood-moving herbs. However, Chuan Xiong (Szechuan lovage root) is a mild Blood-invigorating herb and should be used cautiously in the first trimester. The formula's overall Qi-tonifying and Blood-nourishing actions may actually support a healthy pregnancy when genuine Qi and Blood deficiency is present, but it should only be used under the supervision of a qualified practitioner who can assess the individual situation. Dosage adjustments are typically needed during pregnancy.

Breastfeeding

Generally considered compatible with breastfeeding. All six herbs are commonly used tonifying substances without known toxicity concerns for nursing infants. Ren Shen (Ginseng) and Huang Qi (Astragalus) are traditionally used postpartum to support recovery, and the Blood-nourishing herbs may help support lactation by replenishing the mother's Qi and Blood. As with any herbal formula during breastfeeding, it should be taken under the guidance of a qualified practitioner.

Children

Sheng Yu Tang can be used in children with appropriate dosage reduction. The original Lan Shi Mi Cang does not include specific pediatric dosing for this formula, but a related formula in the same text notes that children should receive half the adult dose. As a general guideline: - Children under 6: approximately one-quarter to one-third of the adult dose - Children 6-12: approximately one-half of the adult dose - Adolescents 12+: approximately two-thirds to full adult dose The formula is suitable for children with confirmed Qi and Blood deficiency patterns, such as those recovering from prolonged illness, chronic bleeding conditions, or anaemia. It is not appropriate for acute febrile conditions in children. A qualified practitioner should always assess the child's pattern before prescribing.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Sheng Yu Tang

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Dang Gui and Chuan Xiong have mild Blood-invigorating properties and may theoretically potentiate the effects of blood-thinning medications, increasing bleeding risk. Concurrent use requires close monitoring of coagulation parameters.

Antihypertensive medications: Ren Shen (Ginseng) may modestly raise blood pressure in some individuals or interfere with the effects of certain antihypertensive drugs. Patients on blood pressure medication should use this formula with caution and monitor blood pressure regularly.

Hypoglycaemic medications (insulin, metformin, sulfonylureas): Both Ren Shen and Huang Qi have demonstrated blood glucose-lowering effects in pharmacological studies. Combined use with diabetes medications could theoretically lead to hypoglycaemia, requiring blood sugar monitoring and possible dose adjustment.

Immunosuppressants: Huang Qi and Ren Shen are known to modulate immune function. Patients taking immunosuppressive medications (e.g. post-organ transplant, autoimmune conditions) should consult their physician before using this formula, as it may counteract immunosuppressive effects.

Usage Guidance

Practical advice for getting the most out of Sheng Yu Tang

Best time to take

Between meals (about 1 hour before or 2 hours after eating), taken warm. The original text specifies 'take slightly warm, at any time' (稍热无时服), meaning it can be taken at flexible times throughout the day rather than being tied to a specific meal schedule.

Typical duration

Typically taken for 2-8 weeks for acute blood loss recovery; may be used for 1-3 months for chronic Qi and Blood deficiency, reassessed periodically by a practitioner.

Dietary advice

While taking this formula, favour warm, easily digestible, nourishing foods such as bone broths, congee, dark leafy greens, red dates, goji berries, and iron-rich foods like liver or black sesame. These foods support the formula's blood-building and Qi-tonifying actions. Avoid cold and raw foods (ice water, salads, raw fruits in excess), greasy or heavy fried foods, and excessively spicy foods. Cold foods can impair the Spleen's ability to transform nutrients into Qi and Blood, directly undermining the formula's purpose. As the original text states, the formula should be taken slightly warm (稍热服).

Sheng Yu Tang originates from Lan Shi Mi Cang (兰室秘藏, Secrets from the Orchid Chamber) by Li Dongyuan (李东垣) Jīn dynasty (金朝), c. 1276 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Sheng Yu Tang and its clinical use

Lán Shì Mì Cáng《兰室秘藏》by Lǐ Dōngyuán (Li Gao), Jin Dynasty

Original: 圣愈汤 治诸恶疮,血出多而心烦不安,不得睡眠,亡血故也,以此药主之。

Translation: Sheng Yu Tang (Sage-like Healing Decoction): Treats all manner of malignant sores with profuse bleeding causing irritability, restlessness, and inability to sleep. This is due to the loss of Blood, and this formula is the governing treatment.


Yī Zōng Jīn Jiàn《医宗金鉴》(Golden Mirror of the Medical Tradition), Qing Dynasty

The Yi Zong Jin Jian later adopted Sheng Yu Tang and broadened its clinical scope to include gynaecological conditions, particularly menstrual disorders from Qi and Blood deficiency. In this context, the formula was indicated for early menstruation with heavy, pale flow, fatigue, and weakness, a pattern where Qi fails to hold Blood within the vessels.

Historical Context

How Sheng Yu Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Sheng Yu Tang was created by Lǐ Dōngyuán (Li Gao, 1180–1251), one of the four great masters of the Jin-Yuan medical era and the founder of the Earth-Tonifying (Bǔ Tǔ) school. It first appeared in his Lán Shì Mì Cáng (Secrets of the Orchid Chamber), published around 1276 after his death. The formula name literally means "Sage-like Healing Decoction," reflecting the author's confidence in its remarkable efficacy. Li Dongyuan placed this formula in the chapter on sores and wounds (疮疡), where its original indication was for excessive bleeding from malignant sores leading to mental distress and insomnia.

Li Dongyuan's insight was to take the classical Si Wu Tang (Four Substances Decoction), the standard Blood-tonifying formula, and add Ren Shen (Ginseng) and Huang Qi (Astragalus) to powerfully reinforce Qi. This reflected his core clinical philosophy that the Spleen and Stomach are the root of all Qi and Blood production, and that tonifying Qi is essential for generating and controlling Blood. Later, the Qing Dynasty text Yi Zong Jin Jian (Golden Mirror of the Medical Tradition) expanded its application to gynaecology, especially early menstruation with heavy pale bleeding from Qi and Blood deficiency. In 2018, China's National Medical Products Administration included Sheng Yu Tang in its first catalogue of classical prescriptions approved for simplified drug development, recognizing it as a historically significant and clinically reliable formula.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Sheng Yu Tang

1

Neuroprotective mechanisms of Sheng Yu Decoction on ischemic stroke mice (Preclinical study, 2014)

Shen YC, et al. Journal of Traditional and Complementary Medicine, 2014, 4(3), 165-175

This animal study investigated the neuroprotective effects of Sheng Yu Tang in mice subjected to acute ischemic stroke. The formula significantly extended survival compared to vehicle treatment, with efficacy comparable to the standard clot-dissolving drug rt-PA. Transcriptome analysis revealed that the formula worked through unique molecular mechanisms including regulation of inflammatory pathways and cell survival genes, distinct from those of rt-PA.

PubMed
2

Sheng-Yu-Tang for post-hematopoietic stem cell transplantation leukemia patients: pilot trial and protocol (Pilot clinical trial, 2018)

Fleischer T, et al. Global Advances in Health and Medicine, 2018, 7, 1-12

This pilot study enrolled 18 leukemia patients after stem cell transplantation at China Medical University Hospital. Patients received Sheng Yu Tang for up to 6 months alongside standard care, with monthly immune reconstitution monitoring. The study explored the formula's potential to support immune recovery after transplantation. An in vitro component showed a possible trend toward decreased TNF-alpha, a cytokine central to graft-versus-host disease. The results were used to design a larger randomized controlled trial.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.