Qing Xin Lian Zi Yin

Clear the Heart Lotus Seed Drink · 清心蓮子飲

Also known as: Lotus Seed Combination, Qing Xin Lian Zi Yin

A classical formula designed to cool excessive Heart fire while supporting the body's Qi and Yin. It is commonly used for urinary problems such as painful, cloudy, or difficult urination that worsen with overwork, along with irritability, dry mouth, fatigue, and restless sleep. It works by simultaneously clearing internal heat, draining dampness from the lower body, and strengthening the body's underlying vitality.

Origin Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Volume 5 — Sòng dynasty, ~1107 CE
Composition 9 herbs
Che Qian Zi
King
Che Qian Zi
Huang Qin
Deputy
Huang Qin
Di Gu Pi
Deputy
Di Gu Pi
Tian Men Dong
Assistant
Tian Men Dong
Huang Qi
Assistant
Huang Qi
Ren Shen
Assistant
Ren Shen
Fu Ling
Assistant
Fu Ling
Che Qian Zi
Assistant
Che Qian Zi
+1
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Xin Lian Zi Yin is designed to correct these specific patterns.

Why Qing Xin Lian Zi Yin addresses this pattern

This is the primary pattern this formula addresses. When the Heart fire blazes excessively while Qi and Yin are depleted, the normal communication between Heart (fire, above) and Kidney (water, below) breaks down. Heart fire fails to descend and instead flares upward, causing irritability, insomnia, mouth sores, and a bitter dry mouth. Meanwhile, the weakened Qi cannot hold essence and fluids in place, leading to turbid urination, seminal emission, or vaginal discharge. Shi Lian Zi directly clears the Heart fire and restores the Heart-Kidney connection, while Ren Shen, Huang Qi, and Mai Men Dong rebuild the Qi and Yin foundation. The heat-clearing herbs (Huang Qin, Di Gu Pi) control the fire, and the draining herbs (Fu Ling, Che Qian Zi) give damp-heat an exit route through the bladder.

A practitioner would look for one or more of these signs

Irritability

Restlessness and mental agitation from Heart fire

Turbid Urination

Cloudy or milky urine, worse with overwork

Dry Mouth

Dry mouth and tongue from fluid damage

Eye Fatigue

Four-limb weariness from Qi deficiency

Insomnia

Restless sleep from Heart fire disturbing the spirit

Seminal Emission

Nocturnal emission or spermatorrhea

Five-Palm Heat

Heat sensation in palms, soles, and chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Xin Lian Zi Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, recurrent urinary tract infections fall under the category of "lin zheng" (strangury patterns). When these infections keep returning, especially after overwork or stress, this points to an underlying deficiency of Qi and Yin rather than simple excess heat. The Spleen and Kidney are too weak to properly transform and transport fluids, which allows dampness to accumulate. Emotional stress and mental overwork generate Heart fire, which further damages fluids and drives heat downward into the Bladder. This creates a vicious cycle: the more the body is depleted, the more easily damp-heat gathers, triggering another episode. Classical texts specifically describe this as "lao lin" (labor strangury), meaning strangury that recurs with physical or mental exertion.

Why Qing Xin Lian Zi Yin Helps

Qing Xin Lian Zi Yin is specifically designed for recurrent urinary conditions in depleted patients. Shi Lian Zi clears Heart fire at the source while Che Qian Zi and Fu Ling drain the existing damp-heat through urination. Critically, Ren Shen and Huang Qi strengthen the Qi so the body can resist future episodes, breaking the cycle of recurrence. Di Gu Pi cools the lingering deficiency heat that keeps the condition smoldering between acute flares. This dual approach of clearing the active infection while strengthening the underlying constitution is why modern clinical studies have shown improved cure rates and reduced recurrence when this formula is added to standard treatment for chronic pyelonephritis.

Also commonly used for

Chronic Prostatitis

With irritability, turbid urination, and fatigue

Urethral Syndrome

Non-infectious urinary frequency and discomfort

Diabetes

Early-stage thirst and frequent urination pattern (消渴)

Leukorrhea

Vaginal discharge from damp-heat with Qi deficiency

Nocturnal Emission

Spermatorrhea with Heart-Kidney disharmony

IgA Nephropathy

Qi and Yin deficiency type

Chyluria

Milky or cloudy urine

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Xin Lian Zi Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Xin Lian Zi Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Xin Lian Zi Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Xin Lian Zi Yin works at the root level.

This formula addresses a mixed pattern of deficiency and excess that develops through a specific chain of events. The root cause is depletion of Qi and Yin, often brought on by chronic emotional stress (excessive worry, anxiety, depression), overwork, prolonged illness, or overindulgence in alcohol and sexual activity. When Qi and Yin become depleted, the body loses its ability to keep Fire properly contained and directed downward. Heart Fire, normally controlled by sufficient Yin fluids, begins to flare upward unchecked.

This creates what classical texts describe as "excess above and deficiency below" (上盛下虚). The rising Heart Fire "restrains" the Lungs (Heart Fire punishing Metal), causing dry mouth, dry tongue, and thirst. At the same time, the Heart and Kidneys lose their normal communication: Heart Fire can no longer descend to warm the Kidneys, and Kidney Water can no longer ascend to cool the Heart. With this Heart-Kidney disconnection, Damp-Heat accumulates and pours downward into the Bladder, disrupting its Qi-transforming function. This produces the characteristic urinary symptoms: turbid urine, painful urination, urinary dribbling, or strangury that worsens with exertion. In men this may manifest as nocturnal emissions or cloudy discharge; in women, as abnormal vaginal discharge.

The complexity of this pattern means that simply draining the Fire with bitter-cold herbs would further damage the already weakened Qi and Yin, making the situation worse. Likewise, purely tonifying would leave the pathogenic Heat untreated. The formula must simultaneously clear Heart Fire, drain Damp-Heat downward through the urinary tract, and rebuild the Qi and Yin foundation, which is exactly the strategy the formula employs.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and bland with a bitter undertone. Sweet from Ren Shen, Huang Qi, Gan Cao, and Lian Zi to tonify; bland from Fu Ling and Che Qian Zi to drain Dampness; bitter from Huang Qin and Di Gu Pi to clear Heat.

Channels Entered

Heart Lung Kidney Spleen Bladder

Ingredients

9 herbs

The herbs that make up Qing Xin Lian Zi Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Che Qian Zi

Che Qian Zi

Plantago seed

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs, Small Intestine
Preparation Remove the heart (去心) of the seed

Role in Qing Xin Lian Zi Yin

Clears Heart fire while also nourishing the Spleen and securing essence. It bridges the Heart and Kidney to restore their communication, and drains damp-heat from the lower body. As the core herb, it directly addresses the primary pathomechanism of Heart fire flaring upward with loss of essence downward.
Deputies — Assists and enhances the King
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 6 - 10g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Qing Xin Lian Zi Yin

Clears heat from the upper burner, especially the Heart and Lungs. Reinforces the King herb's heat-clearing action, helping to cool the Heart fire that is damaging the Lung's purifying and descending function.
Di Gu Pi

Di Gu Pi

Lycium root bark

Dosage 6 - 10g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Lungs, Liver, Kidneys

Role in Qing Xin Lian Zi Yin

Clears deficiency heat and cools the Kidney and Liver. Works alongside Huang Qin to clear heat at different levels of the body: Huang Qin targets the upper burner while Di Gu Pi addresses the lower burner and deficiency heat.
Assistants — Supports or moderates other herbs
Tian Men Dong

Tian Men Dong

Asparagus tuber

Dosage 6 - 10g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Kidneys
Preparation Remove the heart (去心)

Role in Qing Xin Lian Zi Yin

Nourishes Yin and generates fluids, especially benefiting the Heart and Lung. Clears Heart heat while replenishing the fluids damaged by internal fire, and calms the spirit.
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Preparation Honey-prepared (蜜炙)

Role in Qing Xin Lian Zi Yin

Tonifies Qi and raises the Yang, strengthening the Spleen and Lung. Helps consolidate the body's holding function to stop leakage of essence and fluids downward, and prevents the floating Yang that causes false heat on the surface.
Ren Shen

Ren Shen

Ginseng root

Dosage 3 - 6g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Qing Xin Lian Zi Yin

Powerfully tonifies the source Qi, generates fluids, and calms the spirit. Works with Huang Qi to address the underlying Qi deficiency and supports the body's transformative functions so that dampness can be properly metabolized.
Fu Ling

Fu Ling

Poria

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Qing Xin Lian Zi Yin

Promotes urination and drains dampness, strengthens the Spleen, and calms the spirit. Provides a pathway for heart fire to exit via the urine, similar in principle to the Dao Chi San (Guide Out the Red Powder) approach.
Che Qian Zi

Che Qian Zi

Plantago seed

Dosage 6 - 10g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs, Small Intestine
Preparation Wrap in cloth for decoction (包煎)

Role in Qing Xin Lian Zi Yin

Clears heat and promotes urination, helping to separate dampness from heat and guide them out through the bladder. Directly addresses the urinary symptoms of painful and turbid urination.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Qing Xin Lian Zi Yin

Tonifies the Spleen Qi, harmonizes all the other herbs in the formula, and moderates the cold nature of the heat-clearing herbs to prevent damage to the Stomach.

Why This Combination Works

How the herbs in Qing Xin Lian Zi Yin complement each other

Overall strategy

This formula addresses a complex pattern where Heart fire flares upward while Qi and Yin are deficient below, causing damp-heat to accumulate in the lower body. The prescription strategy is to simultaneously clear the Heart fire at its source, drain damp-heat downward through urination, and tonify the Qi and Yin to address the root deficiency. It is neither purely clearing nor purely tonifying, but carefully balances both approaches.

King herbs

Shi Lian Zi (lotus seed) is the sole King herb, and the formula is named after it. It has the unique ability to clear Heart fire while also nourishing the Spleen and securing essence. This dual action is critical because the condition involves both excess (Heart fire) and deficiency (Qi and Yin weakness). By clearing fire from the Heart and helping the Heart communicate downward with the Kidney, Shi Lian Zi addresses the core disruption of the Heart-Kidney axis.

Deputy herbs

Huang Qin clears heat from the upper burner, especially from the Heart and Lungs, reinforcing the fire-clearing action from a different angle. Di Gu Pi clears deficiency heat from the Kidney and Liver in the lower burner. Together they ensure that pathological heat is addressed at multiple levels of the body, preventing the Heart fire from overwhelming the Lung's descending function (a pattern described classically as Heart fire attacking Metal).

Assistant herbs

The assistant herbs divide into two functional groups. The tonifying group consists of Ren Shen, Huang Qi (honey-prepared), and Mai Men Dong. Ren Shen and Huang Qi powerfully boost Qi, raise the clear Yang, and consolidate the body's holding capacity so that essence and fluids stop leaking downward. Mai Men Dong nourishes Yin, generates fluids, and cools the Heart, replenishing the substances that fire has consumed. The draining group consists of Fu Ling and Che Qian Zi, which promote urination and guide damp-heat out through the bladder, providing a direct exit route for the turbid pathogenic factors causing the urinary symptoms.

Envoy herbs

Zhi Gan Cao (honey-prepared licorice) harmonizes the formula, tonifies the middle burner, and moderates the cold nature of the heat-clearing herbs so they do not injure the Stomach. It ties together the clearing and tonifying actions into a unified whole.

Notable synergies

The pairing of Fu Ling and Che Qian Zi mirrors the classical approach of guiding Heart fire out through the urine, a strategy shared with Dao Chi San. The combination of Ren Shen and Huang Qi with the heat-clearing herbs creates a "supplement the root while clearing the branch" dynamic: they ensure that clearing fire does not further deplete an already deficient body. The balance of Shi Lian Zi above with the diuretic herbs below creates a top-down clearing pathway that restores Heart-Kidney communication.

How to Prepare

Traditional preparation instructions for Qing Xin Lian Zi Yin

In the original text, the herbs are ground into a coarse powder (锉散). Take 9g of the powder per dose with 10 grains of Mai Men Dong, add approximately 225ml of water, and decoct down to about 180ml. Strain, cool in water until lukewarm or room temperature, and take on an empty stomach before meals.

In modern practice, the formula is typically prepared as a standard decoction: combine all herbs in the listed dosages, soak in cold water for 30 minutes, bring to a boil, then simmer for 25 to 30 minutes. Strain and divide into two doses taken warm, once in the morning and once in the evening, on an empty stomach. Che Qian Zi (plantain seeds) should be wrapped in cloth (包煎) to prevent the decoction from becoming cloudy.

Common Modifications

How practitioners adapt Qing Xin Lian Zi Yin for specific situations

Added
Chai Hu

6 - 9g, disperses constrained heat from the Liver and Gallbladder

Bo He

3 - 6g, added in the last 5 minutes, vents heat from the exterior

This is the original text's own modification. When heat manifests as daytime fever with night-time calm, Chai Hu disperses constrained Liver-Gallbladder heat while Bo He vents heat outward through the surface, preventing heat from being trapped internally.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Xin Lian Zi Yin should not be used or requires extra caution

Caution

Excess Damp-Heat patterns without underlying Qi and Yin deficiency. When urinary symptoms are caused purely by excess pathogenic factors (full-Heat, full-Dampness) without a deficiency root, stronger clearing and draining formulas are more appropriate.

Caution

True Yin deficiency with strong deficiency-Fire and no Dampness. If the pattern is primarily Kidney Yin depletion with vigorous empty Fire but without turbid urination or Damp-Heat signs, a pure Yin-nourishing formula is better suited.

Caution

Spleen-Kidney Yang deficiency with cold signs. The formula's cooling herbs (Huang Qin, Di Gu Pi) and bland-draining herbs (Che Qian Zi, Fu Ling) can further injure Yang Qi in patients with clear, copious urination, cold limbs, and a pale tongue with white coating.

Avoid

Patients with known allergy or hypersensitivity to any ingredient in the formula.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered low-risk, but should be used with caution during pregnancy and only under the guidance of a qualified practitioner. Che Qian Zi (Plantago Seed) promotes urination and has a downward-draining quality, and Huang Qin (Scutellaria), while classically considered a fetus-calming herb, is cold in nature and used here to clear Heat, which may not be appropriate if there is no Heat pattern. Ren Shen (Ginseng) and Huang Qi (Astragalus) are generally safe in pregnancy but may need dose adjustment. No specific abortifacient herbs are present in this formula, but the overall cooling and draining strategy requires careful pattern differentiation before use during pregnancy.

Breastfeeding

No specific safety concerns have been identified for breastfeeding. The formula contains mild, commonly used herbs without known toxicity or strong properties that would be expected to adversely affect breast milk or nursing infants. Ren Shen (Ginseng) and Huang Qi (Astragalus) are Qi tonics generally considered compatible with breastfeeding. Huang Qin (Scutellaria) is bitter and cold, and in theory large doses could affect the digestive comfort of a sensitive infant through breast milk, but this is speculative. As with all herbal formulas during breastfeeding, use under the guidance of a qualified practitioner is recommended.

Children

This formula has been used in pediatric settings, particularly for functional enuresis (bedwetting) in children. Dosages should be reduced proportionally based on the child's age and body weight, typically to one-third to one-half of the adult dose for school-age children. For very young children (under 5 years), use should be guided by a qualified practitioner with pediatric experience. The herbs in this formula are relatively mild, but the cooling and draining properties should be monitored to avoid over-draining in constitutionally weak children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Xin Lian Zi Yin

Gan Cao (Licorice Root): The Zhi Gan Cao (honey-prepared licorice) in this formula contains glycyrrhizin, which can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure) with prolonged use. It may interact with antihypertensive medications (reducing their efficacy), diuretics (particularly potassium-depleting diuretics like furosemide or hydrochlorothiazide, compounding potassium loss), cardiac glycosides such as digoxin (hypokalemia increases the risk of digoxin toxicity), and corticosteroids (additive mineralocorticoid effects).

Ren Shen (Ginseng): Ginseng has documented interactions with warfarin and other anticoagulants (may reduce anticoagulant effect), hypoglycemic agents and insulin (may potentiate blood sugar lowering, requiring monitoring), and MAO inhibitors (theoretical risk of overstimulation). Huang Qi (Astragalus) may also have mild immunomodulatory effects that could theoretically interact with immunosuppressant medications used in transplant patients or autoimmune conditions.

Huang Qin (Scutellaria): Contains baicalin and baicalein, which have shown effects on cytochrome P450 enzymes in laboratory studies. This could theoretically affect the metabolism of drugs processed through these pathways, though clinical significance is not well established.

Usage Guidance

Practical advice for getting the most out of Qing Xin Lian Zi Yin

Best time to take

On an empty stomach, 30 to 60 minutes before meals, ideally morning and evening. The original text specifies taking the decoction cooled in water (水中沉冷) on an empty stomach before food.

Typical duration

Typically prescribed for 2 to 4 weeks initially, then reassessed. For chronic conditions like recurrent urinary tract issues or chronic nephritis, courses of 4 to 8 weeks or longer may be used with periodic practitioner review.

Dietary advice

Avoid spicy, greasy, fried, and strongly heating foods (such as lamb, chili peppers, and excessive alcohol), as these can aggravate Heart Fire and generate more Damp-Heat, directly working against the formula's therapeutic aims. Also avoid excessively cold and raw foods, which can impair the Spleen's transformative function and worsen Dampness. Favour bland, easily digestible foods such as congee, mung beans, lotus seeds, barley (yi yi ren), winter melon, and cucumber, which gently support the Spleen while helping to clear Heat and drain Dampness. Adequate hydration is important given the formula's diuretic properties. Coffee, strong tea, and other stimulants should be limited as they can aggravate Heart Fire and disturb sleep.

Qing Xin Lian Zi Yin originates from Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Volume 5 Sòng dynasty, ~1107 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Xin Lian Zi Yin and its clinical use

Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》):
"治心中蓄积,时常烦躁,因而思虑劳力,忧愁抑郁,是致小便白浊,或有沙膜,夜梦走泄,遗沥涩痛,便赤如血;或因酒色过度,上盛下虚,心火炎上,肺金受克,口舌干燥,渐成消渴,睡卧不安,四肢倦怠,男子五淋,妇人带下赤白;及病后气不收敛,阳浮于外,五心烦热。药性温平,不冷不热,常服清心养神,秘精补虚,滋润肠胃,调顺血气。"
Translation: "Treats accumulation in the Heart with constant irritability, brought on by excessive thinking, mental exertion, worry, and depression, leading to turbid white urine, sandy sediment, nocturnal emissions, dribbling painful urination, and urine red as blood. Or from overindulgence in alcohol and sexual activity, creating a pattern of excess above and deficiency below, with Heart Fire flaring upward and restraining the Lungs, causing dry mouth and tongue, gradually developing into wasting-thirst, restless sleep, and fatigue of the four limbs, the five types of strangury in men, and red or white vaginal discharge in women. Also for cases after illness where Qi fails to consolidate, with Yang floating outward and heat in the five centres (palms, soles, and chest). The formula's nature is mild and balanced, neither cold nor hot. Regular use clears the Heart and nourishes the Spirit, secures Essence and supplements deficiency, moistens the intestines and stomach, and regulates Blood and Qi."

Yi Fang Kao (《医方考》) by Wu Kun:
"劳淋者,此方主之。遇劳即发者,名曰劳淋。此以体弱,故不任劳。然五脏各有劳。劳者动也,动而生阳,故令内热,内热移于膀胱,故令淋闭。是方也,石莲肉泻火于心,麦门冬清热于肺,黄芩泻火于肝,地骨皮退热于肾,黄芪、人参、茯苓、甘草泻火于脾,皆所以疗五脏之劳热也;惟车前子之滑,乃以治淋去着云尔。"
Translation: "This formula governs taxation-strangury [urinary difficulty triggered by exertion]. When it recurs with any exertion, it is called taxation-strangury. This arises from bodily weakness that cannot withstand exertion. Each of the five Zang organs has its own form of taxation. Taxation means movement, and movement generates Yang, which produces internal Heat. This internal Heat shifts to the Bladder, causing urinary blockage. In this formula, Shi Lian Rou (Lotus Seed) drains Fire from the Heart, Mai Men Dong clears Heat from the Lungs, Huang Qin drains Fire from the Liver, Di Gu Pi clears Heat from the Kidneys, and Huang Qi, Ren Shen, Fu Ling, and Gan Cao drain Fire from the Spleen. All of these treat the taxation-Heat of the five Zang organs. Only Che Qian Zi, being slippery, serves to treat the strangury and remove the obstruction."

Historical Context

How Qing Xin Lian Zi Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Xin Lian Zi Yin first appeared in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), compiled during the Song Dynasty (published in its most well-known edition around 1107-1110 CE). This was the first government-sponsored formulary in Chinese history, collecting clinically proven prescriptions for use in public pharmacies across the empire. The formula was originally indicated for a broad range of conditions centering on Heart Fire with Qi-Yin deficiency and Damp-Heat pouring downward.

Over the centuries, the formula was widely adopted and discussed by numerous physicians. Wu Kun's Yi Fang Kao (《医方考》, late Ming Dynasty) provided an influential analysis explaining how the formula addresses taxation-Heat across all five Zang organs. Later texts including the Zheng Zhi Zhun Sheng (《证治准绳》), Jing Yue Quan Shu (《景岳全书》), Wan Bing Hui Chun (《万病回春》), and Zhang Shi Yi Tong (《张氏医通》) all recorded modifications and case studies using this formula. Li Shizhen's Ben Cao Gang Mu also referenced it, noting its use for Heart-Kidney disconnection with taxation-induced turbid urine. Variant versions appeared in texts such as the You You Ji Cheng (《幼幼集成》, a pediatric text) and the Ming Yi Za Zhu (《明医杂著》), each adapting the composition for slightly different presentations. In modern clinical practice, it is frequently applied in nephrology for conditions such as chronic pyelonephritis, chronic glomerulonephritis, IgA nephropathy, and urethral syndrome.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Qing Xin Lian Zi Yin

1

Renoprotective mechanism of Qingxin Lianzi Yin Decoction in db/db mice: network pharmacology and metabolomics study (2024, Preclinical)

Gao WY, Tian MY, Li ML, Gao SR, Wei XL, Gao C, Zhou YY, Li T, Wang HJ, Bian BL, Si N, Zhao W, Zhao HY. Phytomedicine, 2024, 126:155222.

This preclinical study used db/db diabetic mice to investigate how Qingxin Lianzi Yin protects the kidneys in diabetic nephropathy. The researchers found that the formula alleviated diabetes-induced kidney pathological changes by correcting disturbances in amino acid metabolism. Network pharmacology analysis identified key targets and metabolic pathways involved in its renoprotective effects.

2

Chemical profiling and bioactive constituent identification of Qingxin Lianzi Yin Decoction with network pharmacology for diabetic nephropathy targets (2021, Preclinical/Analytical)

Gao WY, Li ML, Gao SR, Tian MY, Wei XL, Zhou YY, Wang HJ, Bian BL, Si N, Zhao HY. Journal of Ethnopharmacology, 2021, 276:114189.

This study systematically characterized the chemical constituents of Qingxin Lianzi Yin using advanced mass spectrometry, identifying 220 compounds in the formula. In animal experiments, 123 components (74 prototypes and 49 metabolites) were found in rat plasma, urine, bile, and feces. Network pharmacology analysis suggested baicalein, liquiritigenin, succinic acid, formononetin, and wogonin as major bioactive constituents for treating diabetic nephropathy.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.