Ji Sheng Shen Qi Wan

Kidney Qi Pill to Aid the Living · 濟生腎氣丸

Also known as: Jia Wei Shen Qi Wan (加味腎氣丸, Supplemented Kidney Qi Pill), Achyranthes and Plantago Formula

A classical formula for people experiencing swelling (especially in the legs and feet), difficulty urinating, lower back heaviness, and feeling cold, all stemming from weakened Kidney function. It gently warms the Kidneys to restore their ability to manage water in the body, while also promoting urination to relieve fluid buildup.

Origin Yan Shi Ji Sheng Fang (嚴氏濟生方, Yan's Formulas for Saving Lives) by Yan Yonghe (嚴用和) — Southern Sòng dynasty, 1253 CE
Composition 10 herbs
Zhi Fu Zi
King
Zhi Fu Zi
Rou Gui
Deputy
Rou Gui
Shu Di Huang
Deputy
Shu Di Huang
Shan Zhu Yu
Assistant
Shan Zhu Yu
Shan Yao
Assistant
Shan Yao
Fu Ling
Assistant
Fu Ling
Ze Xie
Assistant
Ze Xie
Mu Dan Pi
Assistant
Mu Dan Pi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ji Sheng Shen Qi Wan is designed to correct these specific patterns.

Why Ji Sheng Shen Qi Wan addresses this pattern

When Kidney Yang is deficient, the Kidney loses its ability to transform and move fluids (Qi transformation). Water accumulates in the body, overflowing into the tissues as edema, particularly in the lower body. The Bladder, which relies on Kidney Yang to excrete urine, also fails, leading to scanty urination. This formula directly addresses this pattern by warming Kidney Yang with Fu Zi and Rou Gui to restore Qi transformation, while Che Qian Zi, Ze Xie, Fu Ling, and Niu Xi provide multiple pathways for draining the accumulated water through urination. Shu Di Huang, Shan Zhu Yu, and Shan Yao nourish the depleted Kidney Yin and Essence, ensuring that the warming herbs have a material foundation to work with rather than simply dispersing what little Yin remains.

A practitioner would look for one or more of these signs

Edema

Especially in the lower limbs and feet, pitting on pressure

Difficult Urination

Scanty, reduced urine output

Lower Back Pain

Heaviness and aching in the lumbar region

Cold Limbs

Especially cold feet and lower body

Abdominal Distention

Fullness and bloating of the abdomen

Shortness Of Breath

Wheezing or coughing with thin watery phlegm

Eye Fatigue

General tiredness with heaviness of the body

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ji Sheng Shen Qi Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic kidney disease is understood primarily as a progressive decline of Kidney Qi and Yang, falling within the classical disease categories of 'water swelling' (水肿), 'exhaustion taxation' (虚劳), and 'blocked passage' (癃闭). The Kidneys govern water metabolism throughout the body. When Kidney Yang becomes deficient, the vital warmth needed to transform and move fluids disappears. Water stagnates, accumulating as edema and producing turbid waste products that the body can no longer clear. Over time, the Spleen also weakens (since Kidney Yang is the root of all Yang in the body), further impairing fluid transformation and leading to a vicious cycle of declining function.

Why Ji Sheng Shen Qi Wan Helps

Ji Sheng Shen Qi Wan directly targets the core TCM mechanism of CKD by warming Kidney Yang (Fu Zi and Rou Gui) to restore the body's ability to transform and excrete fluids, while simultaneously nourishing the depleted Kidney Yin and Essence (Shu Di Huang, Shan Zhu Yu) to prevent further deterioration of the Kidney's material foundation. The water-draining herbs (Che Qian Zi, Ze Xie, Fu Ling, Niu Xi) help clear accumulated fluid and waste. A large-scale Taiwanese population study found that Ji Sheng Shen Qi Wan was the most commonly prescribed formula for CKD patients, and its use was associated with improved long-term survival. Modern research suggests it may exert anti-inflammatory and anti-fibrotic effects in the kidneys through multiple molecular pathways.

Also commonly used for

Diabetic Neuropathy

Kidney Yang deficiency pattern with edema and declining function

Chronic Glomerulonephritis

With proteinuria, edema, and kidney deficiency

Urinary Retention

Including neurogenic bladder in diabetes

Chronic Renal Failure

With fluid retention and edema

Hypothyroidism

With Kidney Yang deficiency presentation

Cirrhosis

With ascites and edema due to Yang deficiency

Chronic Bronchitis

With phlegm-fluid retention and wheezing

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ji Sheng Shen Qi Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ji Sheng Shen Qi Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ji Sheng Shen Qi Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ji Sheng Shen Qi Wan works at the root level.

Ji Sheng Shen Qi Wan addresses a pattern where Kidney Yang has become depleted, leading to a failure of the body's water metabolism. In TCM theory, the Kidneys are the root of all Yin and Yang in the body, and Kidney Yang in particular provides the warming, activating force (sometimes called "Ming Men Fire" or the "fire of the Gate of Vitality") that drives the transformation and movement of fluids throughout the body.

When this warming force weakens, the Kidneys can no longer properly govern water. The Urinary Bladder, which depends on Kidney Yang to transform fluids into urine, loses its ability to separate clean from turbid. Water accumulates in the lower body, producing edema of the legs and feet, heaviness in the lower back, and reduced or difficult urination. Because the Spleen also relies on Kidney Yang to "steam" and warm it (a concept described by Yan Yonghe as "the fire of the Dan Tian steaming upward to warm Spleen Earth"), Spleen function is secondarily impaired, further contributing to fluid stagnation. In severe cases, accumulated water can "flood upward" to the Lungs, causing coughing, wheezing, and breathlessness.

The tongue is typically pale and swollen with tooth marks and a white slippery coating, reflecting both Yang deficiency (pale) and water accumulation (swollen, slippery). The pulse is deep and slow, indicating the weakness has settled deep in the body's core. The formula works by gently reigniting Kidney Yang while simultaneously opening the water pathways downward, treating both the root cause (Yang deficiency) and the branch symptom (fluid accumulation) at the same time.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet, sour, and pungent. Sweet to tonify and nourish (from Shu Di Huang, Shan Yao, Fu Ling), sour to astringe Essence (from Shan Zhu Yu), and pungent to warm Yang and promote circulation (from Rou Gui and Fu Zi), with bland flavors to drain Dampness through urination.

Channels Entered

Kidney Bladder Spleen Liver

Ingredients

10 herbs

The herbs that make up Ji Sheng Shen Qi Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Zhi Fu Zi

Zhi Fu Zi

Prepared aconite lateral root

Dosage 3 - 6g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Kidneys, Spleen
Preparation Must use the processed (制) form; decoct first for 30-60 minutes to reduce toxicity (先煎)

Role in Ji Sheng Shen Qi Wan

Powerfully warms Kidney Yang and dispels cold, restoring the Kidney's ability to transform and move water. As the strongest Yang-warming herb in the formula, it addresses the root cause of Kidney Yang deficiency.
Deputies — Assists and enhances the King
Rou Gui

Rou Gui

Cinnamon bark

Dosage 3 - 6g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys

Role in Ji Sheng Shen Qi Wan

Warms the Kidney and fortifies the Gate of Vitality (命门). Works with Fu Zi to warm Yang and promote Bladder Qi transformation, enabling the body to properly process and excrete water.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 15 - 24g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Ji Sheng Shen Qi Wan

Nourishes Kidney Yin and replenishes Essence. Used in the largest dosage in the formula, it provides the material (Yin) foundation so that Yang can be generated, embodying the principle of 'seeking Yang within Yin.'
Assistants — Supports or moderates other herbs
Shan Zhu Yu

Shan Zhu Yu

Asiatic cornelian cherry fruit

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys

Role in Ji Sheng Shen Qi Wan

Nourishes and astringes the Liver and Kidneys, secures Essence and prevents its leakage. Supports the Kidney's storing function and complements Shu Di Huang in replenishing Yin.
Shan Yao

Shan Yao

Chinese yam

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Ji Sheng Shen Qi Wan

Tonifies the Spleen and benefits the Kidneys. Strengthens the Spleen's role in transforming and transporting fluids, supporting the formula's water-regulating strategy from the digestive system.
Fu Ling

Fu Ling

Poria

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Ji Sheng Shen Qi Wan

Strengthens the Spleen and promotes urination to drain Dampness. Assists the formula's diuretic action while supporting the Spleen to prevent further accumulation of pathological fluid.
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Ji Sheng Shen Qi Wan

Promotes urination and drains Dampness from the lower body. Prevents the rich, cloying nature of Shu Di Huang from generating further Dampness, and helps clear turbid fluids through the Bladder.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Ji Sheng Shen Qi Wan

Clears deficiency Heat and cools the Blood. Prevents the warming herbs (Fu Zi and Rou Gui) from generating excessive Heat, and restrains Liver ministerial Fire that could flare from the warming tonification.
Niu Xi

Niu Xi

Achyranthes root

Dosage 6 - 9g
Temperature Neutral
Taste Bitter (苦 kǔ), Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Ji Sheng Shen Qi Wan

Tonifies the Liver and Kidneys, strengthens the lower back and knees, and promotes urination. Crucially, it guides the formula's action downward to the lower body where edema concentrates, and helps direct water out through the Bladder.
Che Qian Zi

Che Qian Zi

Plantago seed

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs, Small Intestine
Preparation Wrap in cloth before decocting (包煎) to prevent seeds from making the decoction turbid

Role in Ji Sheng Shen Qi Wan

Promotes urination and clears Dampness. Works synergistically with Fu Ling and Ze Xie to strengthen the formula's water-draining capacity, making it more effective for edema and urinary difficulty than the parent formula.

Why This Combination Works

How the herbs in Ji Sheng Shen Qi Wan complement each other

Overall strategy

The core problem is Kidney Yang deficiency leading to failure of Qi transformation, which causes water and fluids to accumulate rather than being properly metabolized and excreted. The formula addresses both the root (warming Kidney Yang) and the branch (draining accumulated water), embodying the classical approach of 'warming Yang to promote water transformation.'

King herb

Zhi Fu Zi (Prepared Aconite) serves as King because Kidney Yang deficiency is the root pathomechanism. Fu Zi is the most powerful Yang-warming herb in the Chinese pharmacopoeia, and it directly restores the Kidney's fire at its source, reigniting the Qi transformation function that governs water metabolism throughout the body.

Deputy herbs

Rou Gui (Cinnamon Bark) reinforces Fu Zi's warming action while specifically stoking the Gate of Vitality and promoting Bladder Qi transformation, directly supporting the excretion of accumulated water. Shu Di Huang (Prepared Rehmannia) provides the Yin and Essence foundation that Yang needs in order to function. Without adequate Yin substance, warming Yang alone would be like lighting a fire with no fuel. This pairing embodies the principle of 'seeking Yang within Yin' (阴中求阳).

Assistant herbs

Three herbs nourish and secure: Shan Zhu Yu astringes Liver and Kidney Essence (reinforcing assistant), Shan Yao tonifies the Spleen to support the postnatal source of Essence (reinforcing assistant), and Fu Ling strengthens the Spleen while promoting urination (reinforcing assistant that also drains). Three herbs prevent stagnation: Ze Xie and Che Qian Zi promote urination to drain the accumulated water (counteracting assistants addressing the secondary symptom of edema), while Mu Dan Pi clears residual Heat to prevent the warming herbs from generating excess Fire (restraining assistant). Niu Xi tonifies the Liver and Kidneys while directing the formula's action downward to the lower body, where edema typically manifests.

Notable synergies

The pairing of Fu Zi and Rou Gui creates a powerful Yang-warming combination that is greater than either herb alone, generating Kidney fire without excessive dryness. The trio of Ze Xie, Fu Ling, and Che Qian Zi work together to drain water through different mechanisms, creating a comprehensive diuretic effect. The balance between the three tonifying herbs (Shu Di Huang, Shan Zhu Yu, Shan Yao) and three draining herbs (Ze Xie, Fu Ling, Mu Dan Pi) ensures the formula nourishes without causing stagnation, a hallmark of the original Shen Qi Wan design. The addition of Niu Xi and Che Qian Zi to this parent structure is precisely what distinguishes this formula, strengthening its water-draining and downward-directing capacity.

How to Prepare

Traditional preparation instructions for Ji Sheng Shen Qi Wan

The original formula is prepared as honey pills. All ten herbs are ground into fine powder, mixed with honey, and formed into pills. The standard dose is 9g of pills (roughly 80 small pills), taken 1 to 2 times daily on an empty stomach, swallowed with warm rice water.

For clinical use as a decoction, the pill dosages are proportionally reduced to standard decoction amounts. Decoct all herbs together in water for approximately 30 minutes, strain, and take in two divided doses per day. Che Qian Zi (Plantain Seed) should be wrapped in cloth (包煎) before decocting to prevent the small seeds from making the liquid murky.

Common Modifications

How practitioners adapt Ji Sheng Shen Qi Wan for specific situations

Added
Da Fu Pi

9-15g, promotes Qi movement and reduces water accumulation in the abdomen

Zhu Ling

9-12g, strengthens the diuretic action

Da Fu Pi moves Qi in the abdomen to reduce distension, while Zhu Ling adds another powerful water-draining pathway to address severe fluid retention.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ji Sheng Shen Qi Wan should not be used or requires extra caution

Avoid

Yin Deficiency with vigorous Fire (signs such as night sweats, five-palm heat, dry mouth, red tongue with little coating). The warming herbs in this formula would further deplete Yin and aggravate Heat.

Avoid

Excess Heat or interior Fire patterns. The formula contains Fu Zi (aconite) and Rou Gui (cinnamon bark), which are hot in nature and will worsen any condition driven by excess Heat.

Avoid

Damaged Body Fluids or Fluid Deficiency with dry mouth, dry stool, and scanty urine from a dryness pattern rather than Yang deficiency. The diuretic herbs may further deplete fluids.

Avoid

Acute external pathogen invasion (common cold, flu, acute febrile illness). Tonifying the interior during an active exterior condition may trap the pathogen inside the body.

Avoid

Damp-Heat accumulation or edema caused by Damp-Heat (with dark scanty urine, yellow greasy tongue coat). This formula warms Yang and would aggravate Damp-Heat conditions.

Caution

Wind-Water pattern edema (acute-onset edema with exterior symptoms like aversion to wind, facial puffiness). This requires an exterior-releasing approach, not interior warming.

Caution

Pregnancy. The formula contains Fu Zi (processed aconite), Niu Xi (achyranthes), and Mu Dan Pi (moutan bark), all of which carry pregnancy risks. Use only with extreme caution under specialist guidance.

Caution

Prolonged or excessive use. Due to the toxic potential of Fu Zi (aconite), even in its processed form, this formula should not be taken in large doses or for extended periods without practitioner supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with extreme caution during pregnancy, and only under direct supervision of a qualified practitioner. The formula contains several herbs of concern: - Fu Zi (processed aconite): classified as toxic even in its prepared form. Aconitine alkaloids can potentially affect the developing fetus and stimulate uterine activity. - Niu Xi (achyranthes root): traditionally listed as a pregnancy-caution herb because it invigorates Blood and directs movement downward, which may promote uterine contractions or vaginal bleeding. - Mu Dan Pi (moutan bark): moves Blood and clears Heat from the Blood level; its Blood-moving property carries theoretical risk of disrupting pregnancy. - Rou Gui (cinnamon bark): hot in nature and moves Blood, which may contribute to uterine stimulation. Most Chinese pharmacopoeia references list pregnancy as a caution (慎用) rather than absolute prohibition, but given the combined risk profile of these four ingredients, most practitioners would avoid this formula during pregnancy unless no safer alternative exists.

Breastfeeding

Use with caution during breastfeeding. The formula contains Fu Zi (processed aconite), which contains trace aconitine alkaloids that could theoretically transfer into breast milk. While processed aconite has greatly reduced toxicity compared to its raw form, the safety margin for nursing infants is unknown and no clinical studies have confirmed safety during lactation. Rou Gui (cinnamon bark) is warm and pungent and may alter the taste of breast milk or cause mild warming effects in the infant. The diuretic herbs (Ze Xie, Che Qian Zi, Fu Ling) could theoretically reduce fluid volume and potentially affect milk production, though this has not been formally studied. If a nursing mother requires this formula for significant Kidney Yang deficiency with edema, a practitioner should monitor the infant for any signs of irritability, digestive upset, or feeding difficulties, and use the lowest effective dose for the shortest necessary duration.

Children

Ji Sheng Shen Qi Wan is primarily an adult formula, but it has historical precedent for pediatric use. The parent formula (Shen Qi Wan) was adapted by Song dynasty pediatrician Qian Yi into Liu Wei Di Huang Wan specifically because children, being constitutionally warm ("pure Yang bodies"), generally do not need the warming herbs Fu Zi and Rou Gui. If a child genuinely presents with Kidney Yang deficiency (signs may include failure to thrive, delayed fontanelle closure, excessive white in the eyes, pale complexion, cold limbs), Ji Sheng Shen Qi Wan may be considered under specialist supervision with significant dose reduction. General guidance: - Children under 3: generally not recommended; Liu Wei Di Huang Wan is usually more appropriate - Ages 3-6: if indicated, reduce to approximately one-quarter of the adult dose - Ages 7-14: approximately one-third to one-half adult dose - Always use processed (Zhi) Fu Zi and ensure proper decoction time (at least 30-60 minutes of boiling) to reduce aconite toxicity Due to the inclusion of Fu Zi, pediatric use requires careful practitioner monitoring. Discontinue immediately if the child shows signs of aconite sensitivity (numbness of lips/tongue, nausea, palpitations).

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ji Sheng Shen Qi Wan

Potassium-sparing diuretics (spironolactone, triamterene, amiloride): This formula has a relatively high potassium content from its herbal ingredients. Concurrent use with potassium-sparing diuretics may increase the risk of hyperkalemia (dangerously high blood potassium levels). Monitor potassium levels if co-administration is necessary.

Sulfonamide antibiotics: Chinese pharmacopoeia sources advise avoiding concurrent use with sulfonamide drugs, as interactions may reduce drug efficacy or increase adverse effects.

Cardiac glycosides (digoxin): Fu Zi (aconite) contains alkaloids with cardiac activity. Concurrent use with digoxin or other cardiac glycosides could theoretically potentiate cardiac effects and increase arrhythmia risk. Close monitoring is essential.

Antihypertensive medications: The formula's diuretic action (from Fu Ling, Ze Xie, and Che Qian Zi) may have additive effects with conventional antihypertensives, potentially causing excessive blood pressure reduction. Dose adjustment may be needed.

Anticoagulants and antiplatelet drugs (warfarin, aspirin): Niu Xi and Mu Dan Pi both have Blood-moving properties. While the effect in pill form is mild, concurrent use with blood-thinning medications warrants caution and monitoring for signs of bleeding.

Hypoglycemic agents (metformin, insulin): Given research suggesting this formula family may lower blood glucose, concurrent use with diabetes medications should be monitored to avoid hypoglycemia.

Usage Guidance

Practical advice for getting the most out of Ji Sheng Shen Qi Wan

Best time to take

On an empty stomach, ideally in the morning and evening, with warm water or warm rice water (米饮). Traditional instructions specify taking the pill form before meals (空心服) to facilitate absorption.

Typical duration

Chronic condition use: typically 4-8 weeks per course, then reassessed by a practitioner. Not intended for indefinite use due to Fu Zi content.

Dietary advice

Maintain a low-salt diet while taking this formula. Excess salt burdens the Kidneys and worsens water retention, directly counteracting the formula's purpose. Avoid cold and raw foods (salads, iced drinks, raw fish, chilled fruit) as these further weaken Kidney Yang and impair the Spleen's ability to transform fluids. Favor warm, easily digestible, Kidney-nourishing foods: cooked yam, black beans, walnuts, lamb, shrimp, leeks, and warming grains like millet. Goji berry and chestnut congee is a particularly supportive accompaniment. Limit greasy, heavy, and overly sweet foods that generate Dampness and obstruct the Spleen. Avoid alcohol, which generates Damp-Heat and may interact with the warming herbs in the formula. During the course of treatment, eat at regular times and avoid overeating, as Spleen overload impairs fluid metabolism.

Ji Sheng Shen Qi Wan originates from Yan Shi Ji Sheng Fang (嚴氏濟生方, Yan's Formulas for Saving Lives) by Yan Yonghe (嚴用和) Southern Sòng dynasty, 1253 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ji Sheng Shen Qi Wan and its clinical use

《严氏济生方》(Yan Shi Ji Sheng Fang) on the pathology of water swelling:

「夫水肿者,皆由真阳怯少……肾水不流,脾舍堙塞,是以上为喘急,下为肿满。」

"As for water swelling, it all arises from true Yang being timid and deficient... Kidney Water ceases to flow, the dwelling of the Spleen becomes obstructed, and so above there is panting and breathlessness, and below there is swelling and fullness."

This passage explains the core disease mechanism the formula addresses: when Kidney Yang is insufficient, water metabolism fails, fluids accumulate, the Spleen's transportation function is blocked, and symptoms manifest both above (respiratory distress from water flooding the Lungs) and below (edema of the lower body).


《严氏济生方》, formula indication:

「加味肾气丸,治肾虚腰重脚肿,小便不利。」

"Jia Wei Shen Qi Wan (Supplemented Kidney Qi Pill) treats Kidney deficiency with heaviness of the lower back, swelling of the legs, and difficulty urinating."


Method verse (方歌 fang ge):

「肾气丸补肾阳虚,地黄山药及茱萸,苓泽丹皮合桂附,水中生火在温煦。济生加入车牛膝,温肾利水消肿需。」

"Shen Qi Wan tonifies Kidney Yang deficiency, with Rehmannia, Dioscorea, and Cornus; Poria, Alisma, and Moutan joined with Cinnamon and Aconite, generating Fire within Water for gentle warmth. Ji Sheng adds Plantain Seed and Achyranthes, warming the Kidneys and promoting water drainage to resolve swelling."

Historical Context

How Ji Sheng Shen Qi Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ji Sheng Shen Qi Wan was created by the Southern Song dynasty physician Yan Yonghe (严用和, also known as Yan Yonghuo) and published in his Yan Shi Ji Sheng Fang (《严氏济生方》, "Formulas for Saving Lives"), completed in 1253 CE. The formula's original name was Jia Wei Shen Qi Wan (加味肾气丸, "Supplemented Kidney Qi Pill"), and it was later commonly called Ji Sheng Shen Qi Wan after the source text.

Yan Yonghe studied medicine from age twelve under the physician Liu Kai (刘开), and practiced for over thirty years before compiling his book. In the preface, he explained that ancient formulas could not always be applied unchanged to contemporary patients, because times, climates, and constitutions vary. His approach was to adapt proven classical formulas to fit real clinical needs. The Yuan dynasty scholar Wu Cheng (吴澄) praised the book, commenting that he "most appreciated the formulas in Yan's Ji Sheng Fang for being neither excessive nor redundant, and always effective when applied."

The formula itself is a direct modification of Zhang Zhongjing's original Shen Qi Wan (肾气丸) from the Jin Gui Yao Lue (《金匮要略》). Yan added two key herbs: Chuan Niu Xi (川牛膝, cyathula root, wine-soaked) and Che Qian Zi (车前子, plantain seed, wine-steamed), and specified that Shan Yao be dry-fried. These additions strengthened the formula's ability to drain water downward, making it specifically suited for Kidney Yang deficiency complicated by significant edema. This represented a clinically important evolution: while the original Shen Qi Wan gently warms Kidney Yang, Ji Sheng Shen Qi Wan actively addresses the water accumulation that often accompanies advanced Yang deficiency.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Ji Sheng Shen Qi Wan

1

Evidence and Potential Mechanisms of Jin-Gui Shen-Qi Wan as a Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis (2021)

Guo Q, et al. Frontiers in Pharmacology, 2021, 12: 699932

This systematic review and meta-analysis included 14 randomized controlled trials with 1,586 participants examining the Shen Qi Wan family of formulas (including Ji Sheng Shen Qi Wan variants) for type 2 diabetes. Pooled results showed that combination treatment with conventional medicine led to reductions in glycated hemoglobin (HbA1c) and fasting blood glucose compared to conventional medicine alone. All included studies were judged to be at high risk of bias, so while the results are suggestive, higher-quality evidence is still needed.

PubMed
2

Target Identification of Active Constituents of Shen Qi Wan to Treat Kidney Yang Deficiency Using Computational Target Fishing and Network Pharmacology (2019)

Tao W, et al. Frontiers in Pharmacology, 2019, 10: 680

This network pharmacology study used computational methods to identify the molecular targets and pathways through which Shen Qi Wan (the parent formula) may act in kidney yang deficiency syndrome. The analysis identified multiple active compounds and predicted their interactions with targets related to the hypothalamic-pituitary-adrenal/thyroid/gonadal axes, providing a theoretical basis for the formula's multi-target mechanism.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.