Huang Qin Tang

Scutellaria Decoction · 黄芩汤

Also known as: Huang Qin Shao Yao Tang (黄芩芍药汤, Scutellaria and Peony Decoction), Shao Yao Huang Qin Tang (芍药黄芩汤)

A classical four-herb formula used to clear internal Heat from the digestive tract, relieve diarrhea, and ease abdominal pain. It is especially suited for conditions where Heat causes loose, urgent, or foul-smelling stools accompanied by a bitter taste in the mouth and irritability. Historically called the 'ancestral formula for treating diarrhea,' it remains widely used for inflammatory bowel conditions.

Origin Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng — Eastern Hàn dynasty, ~200 CE
Composition 4 herbs
Huang Qin
King
Huang Qin
Bai Shao
Deputy
Bai Shao
Gan Cao
Assistant
Gan Cao
Da Zao
Envoy
Da Zao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huang Qin Tang is designed to correct these specific patterns.

Why Huang Qin Tang addresses this pattern

When pathogenic Heat lodges in the Shaoyang (the 'half-exterior, half-interior' level associated with the Gallbladder), it can descend and disrupt the intestines rather than producing the classic alternating chills and fever. The Gallbladder Fire pours downward into the Large Intestine, causing diarrhea with foul-smelling or sticky stools, abdominal pain, a bitter taste in the mouth, and a wiry, rapid pulse. Huang Qin directly clears this Shaoyang interior Heat, Bai Shao constrains the fluids and eases the cramping, while Zhi Gan Cao and Da Zao protect the Spleen from both the disease process and the cold nature of the chief herb. The formula resolves the interior Heat so the half-exterior level naturally returns to harmony.

A practitioner would look for one or more of these signs

Diarrhea

Heat-type diarrhea with urgent, foul-smelling stools

Abdominal Pain

Cramping abdominal pain, may have a sense of urgency

Bitter Taste In The Mouth

Bitter taste in the mouth, a hallmark of Shaoyang Heat

Irritability

Restlessness and irritability from interior Heat

Burning Anus

Sensation of burning or heat at the anus during bowel movements

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Huang Qin Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Large Intestine Dryness Shaoyang Heat

TCM Interpretation

In TCM, ulcerative colitis is most commonly understood as Damp-Heat accumulating in the Large Intestine, often with underlying Spleen deficiency. During active flares, Heat and Dampness scorch the intestinal lining, causing bloody or mucous diarrhea, urgency, and cramping. The Spleen fails to properly transform and transport, allowing Dampness to linger and generate more Heat. In patients with a constitutional tendency toward internal Heat (often seen in younger women with red mucous membranes and irritability), this is particularly relevant to the Huang Qin Tang pattern.

Why Huang Qin Tang Helps

Huang Qin is the primary agent here. Its active compound baicalin has demonstrated significant anti-inflammatory effects in multiple animal studies of colitis, reducing pro-inflammatory cytokines like TNF-alpha and IL-1beta and modulating intestinal immune balance (regulating Th17/Treg cells). Bai Shao protects the intestinal mucosa and relieves the spasmodic abdominal pain characteristic of UC. Zhi Gan Cao and Da Zao support the Spleen and Stomach, addressing the underlying digestive weakness. Modern research under the name PHY906 has shown that all four herbs must be present in their original ratio for maximum effect, confirming the classical theory that this formula works as an integrated whole.

Also commonly used for

Dysentery

Bacterial dysentery or infectious diarrhea

Irritable Bowel Syndrome

Diarrhea-predominant IBS with heat signs

Gastroenteritis

Acute gastroenteritis with fever and diarrhea

Abdominal Pain

Spasmodic abdominal pain with heat signs

Abnormal Uterine Bleeding

Uterine bleeding due to Blood Heat

Amenorrhea

Heat-type painful menstruation

Threatened Miscarriage

Restless fetus with heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Huang Qin Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Huang Qin Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Huang Qin Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Huang Qin Tang works at the root level.

Huang Qin Tang addresses a specific situation where two of the body's defensive layers become disrupted at the same time. In TCM terms, this is called a "combined disease" (合病) of the Tai Yang and Shao Yang stages. Normally, when a pathogen (such as a febrile illness) enters the body, it progresses through stages in sequence. In this pattern, however, the exterior (Tai Yang) and the pivot between exterior and interior (Shao Yang) are both affected simultaneously.

The key problem is Heat from the Shao Yang level, which is associated with the Liver and Gallbladder. When Shao Yang Heat becomes constrained and cannot be properly vented through the normal pivot mechanism, it pushes downward into the intestines, forcing fluids to rush through the bowel and causing diarrhea. This is not a Cold-type diarrhea with watery stools; rather, the stools tend to be urgent, may feel burning at the anus, and can contain mucus or even traces of blood. The person typically has a bitter taste in the mouth, may feel feverish or irritable, and has a wiry or rapid pulse. Because the Heat is the primary driver, the treatment principle is to clear the interior Heat first. Once the Heat is cleared from the Shao Yang, the intestines calm down, normal fluid metabolism is restored, and the exterior condition can also resolve as the body's pivot mechanism returns to balance.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and sour with underlying sweetness. Bitter clears Heat, sour astringes and stops diarrhea, and sweet harmonizes the middle and moderates the bitter-cold nature.

Ingredients

4 herbs

The herbs that make up Huang Qin Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Huang Qin

Huang Qin

Baical skullcap root

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Huang Qin Tang

The chief herb, bitter and cold, directly clears Heat from the Shaoyang and intestines, stops diarrhea caused by Heat descending into the bowels, and dries Dampness.
Deputy — Assists and enhances the King
Bai Shao

Bai Shao

White peony root

Dosage 6 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Huang Qin Tang

Sour and slightly cold, nourishes Yin and Blood, softens the Liver, and relieves abdominal cramping pain. It restrains the astringent loss of fluids due to diarrhea and supports the nutritive (Ying) level to protect against damage from Heat.
Assistant — Supports or moderates other herbs
Gan Cao

Gan Cao

Licorice root

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Huang Qin Tang

Sweet and neutral, tonifies the middle, protects the Stomach and Spleen from the bitter-cold nature of Huang Qin, and works with Bai Shao to relax spasms and ease abdominal pain.
Envoy — Directs the formula to its target
Da Zao

Da Zao

Jujube fruit

Dosage 4 - 12 pieces
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart

Role in Huang Qin Tang

Sweet and warm, nourishes the Spleen and Stomach, generates fluids, and harmonizes the actions of the other herbs. Together with Zhi Gan Cao, it protects the middle Jiao from being overly drained by the cold, bitter nature of the formula.

Why This Combination Works

How the herbs in Huang Qin Tang complement each other

Overall strategy

The formula targets Heat that has entered the Shaoyang level and descended into the intestines, causing diarrhea and abdominal pain. The prescription pairs a strong bitter-cold Heat-clearing herb with sour-sweet substances that protect the middle and ease pain, achieving a clean resolution of interior Heat without damaging the body's fluids or digestive function.

King herbs

Huang Qin (Scutellaria) is the sole King herb. Bitter and cold, it enters the Gallbladder and Large Intestine channels and directly clears the Shaoyang interior Heat that is driving diarrhea. Classical texts note it specifically treats 'intestinal discharge and diarrhea' (肠澼泄利). Its dosage is the largest in the formula, reflecting its primary therapeutic role.

Deputy herbs

Bai Shao (Peony root), sour and astringent, serves two key functions. First, it constrains Yin and body fluids being lost through diarrhea. Second, it softens the Liver and relaxes cramping in the intestines. In the context of Shaoyang Heat flaring, Bai Shao prevents the Heat from further consuming the nutritive level and Blood.

Assistant herbs

Zhi Gan Cao (honey-fried Licorice) is a reinforcing assistant that tonifies the Spleen and Stomach, protecting the middle Jiao from the harsh bitter-cold quality of Huang Qin. Paired with Bai Shao, it forms the well-known Shao Yao Gan Cao Tang combination, which strongly relieves abdominal cramping and urgency.

Envoy herbs

Da Zao (Jujube) harmonizes the formula, nourishes the Spleen, and generates fluids. Together with Zhi Gan Cao, it forms a sweet pair that anchors the middle, preventing the formula's cold nature from overwhelming the digestive system.

Notable synergies

The Bai Shao and Zhi Gan Cao pairing (the 'Peony-Licorice' combination) is one of the most celebrated herb pairs in Chinese medicine, specifically addressing spasmodic abdominal pain. The overall structure has been described as 'sour and bitter combined to preserve Yin' (酸苦相济, 调中以存阴), using the sour of Peony and the bitter of Scutellaria together to clear Heat while protecting body fluids.

How to Prepare

Traditional preparation instructions for Huang Qin Tang

Combine the four herbs with approximately 2000 mL (one dǒu) of water. Bring to a boil, then simmer and reduce to approximately 600 mL (three shēng). Strain out the dregs. Take one warm dose of approximately 200 mL, three times daily (twice during the day and once in the evening).

If the patient also has vomiting, add Bàn Xià (半夏, Pinellia) half shēng (~9 g) and Shēng Jiāng (生薑, Fresh Ginger) 1.5 liǎng (~5 g), turning the formula into Huáng Qín Jiā Bàn Xià Shēng Jiāng Tāng.

Common Modifications

How practitioners adapt Huang Qin Tang for specific situations

Added
Ban Xia

9g, descends rebellious Stomach Qi and stops vomiting

Sheng Jiang

5-9g, harmonizes the Stomach and assists Ban Xia

This is the classical modification from the Shang Han Lun itself, creating Huang Qin Jia Ban Xia Sheng Jiang Tang. When Gallbladder Heat rebels upward into the Stomach causing vomiting, Ban Xia and Sheng Jiang descend the counterflow and harmonize the Stomach.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Huang Qin Tang should not be used or requires extra caution

Avoid

Diarrhea due to Spleen Yang deficiency or internal Cold (虚寒泄泻). The bitter-cold nature of Huang Qin will further damage the Yang and worsen the condition. Signs include watery stools without odor, cold limbs, and a pale tongue with white coating.

Avoid

Chronic diarrhea from Spleen Qi deficiency without Heat signs. This formula clears Heat rather than tonifying Qi, and would weaken the Spleen further.

Caution

Patients with significant exterior Cold symptoms (strong aversion to cold, floating tight pulse) without interior Heat. The formula lacks exterior-releasing herbs and the bitter-cold Huang Qin may drive the pathogen deeper.

Caution

Patients with weak digestion or poor appetite due to Stomach Cold. Gan Cao and Da Zao provide some middle-supporting action, but the cold nature of the main herb may still impair digestion. Reduce dosage or add warming herbs with caution.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered compatible with short-term use in pregnancy, but requires caution. Huang Qin (Scutellaria) is traditionally regarded as a fetus-calming herb (安胎药) and has been included in many classical pregnancy formulas. Bai Shao (Peony) and Gan Cao (Licorice) are also generally safe. However, the bitter-cold nature of Huang Qin in large doses could theoretically impair Spleen function, which is critical for nourishing the fetus. Pregnant individuals should only use this formula under professional guidance, at appropriate dosages, and for the shortest duration necessary. Not contraindicated, but supervision is recommended.

Breastfeeding

No specific contraindications during breastfeeding have been identified for this formula. Huang Qin, Bai Shao, Gan Cao, and Da Zao are all commonly used herbs with long histories of clinical application, including in postpartum women. The bitter-cold nature of Huang Qin is moderated by the sweet herbs in the formula. However, because Gan Cao (Licorice) can affect hormonal balance in large doses and prolonged use, breastfeeding individuals should keep the course of treatment short and dosage moderate. Use under practitioner supervision is advisable.

Children

Huang Qin Tang has historical use in pediatric practice. The formula's simple composition and relatively mild action make it suitable for children with Heat-type diarrhea. Dosage should be adjusted by age and body weight: typically one-quarter to one-third of the adult dose for infants (under 3 years), one-third to one-half for young children (3-7 years), and one-half to two-thirds for older children (7-14 years). Because children's Spleen function tends to be immature (脾常不足), the bitter-cold Huang Qin should not be used at high doses or for prolonged courses. Stop the formula once diarrhea resolves. Ensure adequate fluid intake, as diarrhea in children carries higher dehydration risk.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Huang Qin Tang

Gan Cao (Licorice) interactions: Glycyrrhiza (licorice) contains glycyrrhizin, which can cause potassium depletion and sodium retention with prolonged use. It may interact with corticosteroids (potentiating their effects and side effects), digoxin and cardiac glycosides (hypokalemia increases toxicity risk), diuretics (especially thiazide and loop diuretics, compounding potassium loss), and antihypertensive medications (counteracting blood pressure lowering effects through fluid retention).

Huang Qin (Scutellaria) interactions: Baicalin and baicalein, major active compounds in Huang Qin, have been shown to inhibit certain CYP450 enzymes and drug transporters in vitro. This could theoretically affect the metabolism of drugs processed through CYP2C9 or CYP3A4 pathways. However, the Yale PHY906 studies specifically tested interactions with multiple chemotherapy agents (irinotecan, 5-FU, capecitabine, gemcitabine, sorafenib) and found that the formula did not alter their pharmacokinetics in animal or clinical studies.

Bai Shao (White Peony) interactions: Paeoniflorin has mild anticoagulant properties. Patients on warfarin or other anticoagulants should use this formula with monitoring.

Usage Guidance

Practical advice for getting the most out of Huang Qin Tang

Best time to take

Three times daily (twice during the day and once at night), taken warm, between meals or on an empty stomach.

Typical duration

Acute use: 3-7 days for febrile diarrhea, reassessed once stools normalize. Discontinue promptly when Heat signs resolve.

Dietary advice

While taking this formula, avoid greasy, fried, and spicy foods, which can aggravate intestinal Heat and worsen diarrhea. Cold and raw foods (salads, ice cream, cold drinks) should also be minimized, as they may impair Spleen transport even though the formula itself addresses Heat. Light, easily digestible foods are best: plain rice porridge (congee), steamed vegetables, and mild soups. Avoid alcohol, dairy products, and excessively sweet foods during acute diarrhea. The classical text instructs to take the decoction warm (温服), which aids absorption and gentles the formula's cold nature on the Stomach.

Huang Qin Tang originates from Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Huang Qin Tang and its clinical use

Shang Han Lun (《伤寒论》), Clause 172:
「太阳与少阳合病,自下利者,与黄芩汤;若呕者,黄芩加半夏生姜汤主之。」
"When Tai Yang and Shao Yang are simultaneously affected [combined disease], and spontaneous diarrhea occurs, give Huang Qin Tang. If there is also vomiting, Huang Qin Jia Ban Xia Sheng Jiang Tang governs."

Yi Fang Ji Jie (《医方集解》) by Wang Ang, Qing Dynasty:
Wang Ang classified Huang Qin Tang under the harmonizing formulas (和解之剂) and praised it as 「万世治利之祖方」, meaning "the ancestral formula for treating diarrhea through all ages."

Yi Zong Jin Jian (《医宗金鉴》), Qing Dynasty, commentary by Cheng Yingmao:
The commentary explains that the combined disease involves symptoms of both Tai Yang and Shao Yang appearing simultaneously, including headache, chest fullness, bitter taste in the mouth, dry throat, and dizziness, and that once Shao Yang's interior Heat fails to maintain order, diarrhea results from Heat forcing downward.

Historical Context

How Huang Qin Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Huang Qin Tang was first recorded in the Shang Han Lun (Treatise on Cold Damage) by Zhang Zhongjing during the late Eastern Han Dynasty (circa 200 CE). It appears in Clause 172, where it treats the combined disease of Tai Yang and Shao Yang presenting with spontaneous diarrhea. Despite containing only four herbs, the formula has had an outsized influence on later medical practice.

The Qing Dynasty physician Wang Ang (汪昂), in his influential Yi Fang Ji Jie (Medical Formulas Collected and Explained, 1682), classified Huang Qin Tang among the harmonizing formulas and famously called it "the ancestral formula for treating diarrhea through all ages" (万世治利之祖方). The later celebrated formula Shao Yao Tang, widely used for dysentery, is considered to have evolved directly from Huang Qin Tang by adding Blood-moving and Qi-regulating herbs. Some scholars have also noted the close resemblance between Huang Qin Tang and the "Small Yin Dawn Decoction" (小阴旦汤) recorded in the Fu Xing Jue Zang Fu Yong Yao Fa Yao, a Dunhuang manuscript attributed to Tao Hongjing, which adds fresh ginger to a nearly identical base.

In the modern era, this formula gained remarkable international attention when Professor Yung-Chi Cheng at Yale University developed a pharmaceutical-grade preparation of Huang Qin Tang called PHY906 (later renamed YIV-906). Beginning in the early 2000s, this preparation underwent multiple phase I and II clinical trials as an adjuvant to cancer chemotherapy, particularly to reduce the gastrointestinal side effects of irinotecan (CPT-11) treatment. This represents one of the most rigorous modern investigations of any classical Chinese formula through Western clinical trial methodology.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Huang Qin Tang

1

Phase I clinical study of PHY906 as a modulator of irinotecan-based chemotherapy in advanced colorectal cancer (Phase I RCT, 2011)

Saif MW, Lansigan F, Ruta S, et al. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine. 2010;17(3-4):161-169.

A multicenter, double-blind, randomized, placebo-controlled dose-escalation study at Yale and other US institutions tested PHY906 (standardized Huang Qin Tang) alongside irinotecan/5-FU/leucovorin chemotherapy for advanced colorectal cancer. The study found PHY906 did not alter the pharmacokinetics of the chemotherapy drugs, showed no formula-related toxicity, and provided preliminary evidence of reduced gastrointestinal side effects.

PubMed
2

PHY906 reduces chemotherapy-induced gastrointestinal toxicity (Preclinical, 2010)

Lam W, Bussom S, Guan F, et al. The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Science Translational Medicine. 2010;2(45):45ra59.

Yale University researchers demonstrated in a mouse model that PHY906 (Huang Qin Tang) protected against intestinal damage from irinotecan chemotherapy. The formula promoted intestinal stem cell regeneration through Wnt signaling, reduced inflammation, and enhanced antitumor activity without interfering with the chemotherapy drug's effectiveness.

3

Huangqin-Tang ameliorates TNBS-induced colitis by regulating effector and regulatory CD4+ T cells (Preclinical, 2015)

Zou Y, Li WY, Wan Z, et al. Huangqin-Tang ameliorates TNBS-induced colitis by regulating effector and regulatory CD4+ T cells. BioMed Research International. 2015;2015:102021.

This animal study found that Huang Qin Tang significantly reduced the severity of chemically induced colitis in rats in a dose-dependent manner. The formula reduced Th1 and Th17 inflammatory cells while increasing protective Th2 and regulatory T cells, outperforming mesalazine (a standard ulcerative colitis drug) on several measures including weight loss, bleeding, and intestinal inflammation.

4

Review: Huangqin-Tang and ingredients in modulating the pathogenesis of ulcerative colitis (Review, 2017)

Wang Y, Zhang Q, Chen Y, et al. Huangqin-Tang and ingredients in modulating the pathogenesis of ulcerative colitis. Evidence-Based Complementary and Alternative Medicine. 2017;2017:7016468.

A comprehensive review of pharmacological studies on Huang Qin Tang and its individual ingredients in treating ulcerative colitis. The review found that HQT modulates the intestinal environment, corrects immune imbalances, suppresses inflammatory pathways (particularly NF-kB), and reduces oxidative stress. Multiple active compounds were identified including baicalin, paeoniflorin, and glycyrrhizic acid.

5

Mechanism Based Quality Control (MBQC) of YIV-906 (PHY906) (Phase I/II summary, 2018)

Lam W, Jiang Z, Guan F, et al. Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906). Frontiers in Pharmacology. 2018;9:1324.

This study summarized results from seven phase I/II clinical trials using YIV-906 (PHY906, standardized Huang Qin Tang) on 140 evaluable cancer patients at Yale University and other US institutions. The findings showed no formula-related toxicity, and suggested decreased grade 3/4 diarrhea and nausea compared to chemotherapy alone, with potential improvement in quality of life.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.