Shao Yao Tang

Peony Decoction · 芍藥湯

Also known as: Shaoyao Decoction, Peony Combination

A classical formula used to clear Heat and Dampness from the intestines while soothing abdominal pain and regulating Qi and Blood circulation. It is primarily used for inflammatory bowel conditions with symptoms such as abdominal cramping, bloody or mucus-containing stools, and a constant urge to go to the bathroom that brings little relief.

Origin Sù Wèn Bìng Jī Qì Yí Bǎo Mìng Jí (素问病机气宜保命集) by Liú Wánsù (刘完素) — Jīn dynasty, 1186 CE
Composition 9 herbs
Bai Shao
King
Bai Shao
Huang Qin
Deputy
Huang Qin
Huang Lian
Deputy
Huang Lian
Da Huang
Deputy
Da Huang
Dang Gui
Assistant
Dang Gui
Mu Xiang
Assistant
Mu Xiang
Bing Lang
Assistant
Bing Lang
Rou Gui
Assistant
Rou Gui
+1
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shao Yao Tang is designed to correct these specific patterns.

Why Shao Yao Tang addresses this pattern

This is the primary pattern Shao Yao Tang was designed to treat. Damp-Heat accumulates in the Large Intestine, where it clashes with Qi and Blood, causing the intestinal lining to produce pus and blood. The Heat component drives the burning sensation and urgency, while the Dampness component creates the heavy, sticky quality of the stool and the feeling of incomplete evacuation. Bai Shao and Dang Gui harmonise and move Blood so that bloody pus resolves. Huang Qin, Huang Lian, and Da Huang clear Heat and dry Dampness to remove the root cause. Mu Xiang and Bing Lang restore normal Qi flow in the intestines. Rou Gui in small dose prevents the cold herbs from trapping the pathogen, and Gan Cao protects the digestive system while enhancing the pain-relieving effect.

A practitioner would look for one or more of these signs

Dysentery

Dysentery with pus and blood in the stool, mixed red and white

Abdominal Pain

Cramping abdominal pain

Tenesmus

Tenesmus (constant urge to defecate with incomplete relief)

Anal Burning

Burning sensation at the anus

Dark Scanty Urine

Short, dark-yellow urination

Yellow Greasy Tongue Coating

Yellow, greasy tongue coating

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shao Yao Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, ulcerative colitis during acute flare-ups is most commonly understood as Damp-Heat accumulating in the Large Intestine. The Dampness and Heat combine and become trapped in the intestinal lining, where they damage the Blood vessels and tissue, producing the characteristic bloody mucoid stool. The Qi of the intestines becomes blocked, leading to cramping pain and tenesmus. Over time, the Heat can consume Blood and Yin, potentially shifting the pattern toward deficiency. The acute inflammatory stage with bloody diarrhea, abdominal pain, and urgency maps most closely to the Damp-Heat in the Large Intestine pattern.

Why Shao Yao Tang Helps

Shao Yao Tang directly addresses the acute Damp-Heat stage of ulcerative colitis. Huang Qin, Huang Lian, and Da Huang clear intestinal Heat and Dampness, reducing inflammation at its source. Bai Shao and Dang Gui nourish and move Blood, helping to repair damaged intestinal tissue and resolve bloody stool. Mu Xiang and Bing Lang restore Qi flow to relieve cramping and tenesmus. Modern research has shown that this formula can regulate inflammatory signaling pathways (such as TLR4/NF-kB), reduce inflammatory cytokines, and help restore the intestinal mucosal barrier. It is one of the most frequently prescribed classical formulas for ulcerative colitis in Chinese clinical practice.

Also commonly used for

Toxic Dysentery

Amoebic dysentery

Acute Enteritis

Acute enteritis with bloody or mucoid stool

Irritable Bowel Syndrome

IBS with diarrhea and Damp-Heat signs

Allergic Colitis

Allergic colitis with Damp-Heat presentation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shao Yao Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shao Yao Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shao Yao Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shao Yao Tang works at the root level.

Shao Yao Tang addresses a pattern in which Damp-Heat has lodged in the Large Intestine, disrupting both the movement of Qi and the flow of Blood. When Dampness and Heat accumulate in the gut, they obstruct the normal downward passage of intestinal contents. The trapped Heat "simmers" the body's fluids, Blood, and tissue, essentially corrupting them into pus and bloody discharge. This is the mechanism behind the hallmark symptom of mucus-laden, bloody stool with mixed red and white components.

Meanwhile, the stagnation of Qi in the intestines creates a sensation of incomplete evacuation and cramping, the distressing feeling known as tenesmus (li ji hou zhong, 里急后重). The Qi cannot flow freely, so the intestines spasm and strain. At the same time, the Heat drives Blood out of the vessels, producing the bloody component. The combination of obstructed Qi and damaged Blood is what makes this pattern so uncomfortable: the person feels a burning urgency to use the toilet but gets little relief, accompanied by sharp abdominal pain. Other signs such as scanty dark urine, a yellow greasy tongue coating, and a rapid pulse all reflect the Damp-Heat saturating the interior.

The key therapeutic insight, famously summarized by Liu Wansu as "mobilize the Blood and the pus heals; regulate the Qi and the tenesmus resolves," is that this is not a problem to be treated by simply stopping the diarrhea. Instead, the root causes (Heat, Dampness, Blood stasis, and Qi stagnation) must be addressed simultaneously. Suppressing the discharge without clearing the pathogenic factors would trap the problem inside.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter with secondary sour and acrid notes. Bitter to clear Heat and dry Dampness, sour to astringe and regulate Blood, acrid to move Qi and disperse stagnation.

Ingredients

9 herbs

The herbs that make up Shao Yao Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Bai Shao

Bai Shao

White peony root

Dosage 15 - 30g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Shao Yao Tang

Used at the highest dose in the formula, Bai Shao softens the Liver, harmonises Blood, and relieves the cramping abdominal pain that characterises dysentery. It is the key herb for treating dysentery-related pain.
Deputies — Assists and enhances the King
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Shao Yao Tang

Bitter and cold, Huang Qin enters the Large Intestine to clear Heat and dry Dampness, addressing the root cause of the dysentery. Works with Huang Lian and Da Huang to clear intestinal Heat-toxin.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 5 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Shao Yao Tang

Strongly clears Heat and dries Dampness in the intestines. Together with Huang Qin, these two bitter-cold herbs eliminate the Damp-Heat that causes dysentery and bloody stool.
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Shao Yao Tang

Purges Heat, dispels Blood stasis, and pushes accumulated toxins and stagnation out through the bowels. Embodies the classical principle of 'tong yin tong yong' (using purgation to treat diarrhea) by clearing the intestinal blockage that causes dysentery.
Assistants — Supports or moderates other herbs
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 15g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Shao Yao Tang

Nourishes and moves Blood, supporting Bai Shao in harmonising Blood circulation. Combined with Da Huang, it helps dispel Blood stasis in the intestines, embodying the principle 'moving Blood makes pus and bloody stool resolve on its own'.
Mu Xiang

Mu Xiang

Costus root

Dosage 5 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, San Jiao (Triple Burner), Gallbladder

Role in Shao Yao Tang

Moves Qi and relieves stagnation in the intestines. Paired with Bing Lang, it addresses Qi stagnation to relieve tenesmus (the constant urge to defecate), embodying the principle 'regulating Qi makes tenesmus resolve on its own'.
Bing Lang

Bing Lang

Areca seed

Dosage 5 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Stomach, Large Intestine

Role in Shao Yao Tang

Promotes downward movement of Qi and guides out intestinal stagnation. Works with Mu Xiang to relieve Qi blockage and with Da Huang to expel accumulated waste and toxins from the intestines.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 2 - 5g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys

Role in Shao Yao Tang

Used in a small dose as a 'reverse assistant' (fan zuo). Its warm, acrid nature serves three purposes: it helps Dang Gui and Bai Shao move Blood and warm the channels; it prevents the large amount of bitter-cold herbs from injuring the Stomach or causing the Damp-Heat to become 'frozen' and harder to expel; and it helps prevent nausea from the bitter-cold herbs.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 5 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Shao Yao Tang

Harmonises all the herbs in the formula and protects the Stomach. Paired with Bai Shao, it enhances the ability to relax spasms and relieve abdominal pain, echoing the classical Shao Yao Gan Cao Tang combination.

Why This Combination Works

How the herbs in Shao Yao Tang complement each other

Overall strategy

This formula targets Damp-Heat lodged in the Large Intestine that has disrupted both Qi movement and Blood circulation, producing dysentery with pus, blood, and cramping pain. The prescription simultaneously clears Heat, dries Dampness, moves Qi, and harmonises Blood, following Liu Wansu's guiding principle: "moving Blood makes bloody pus resolve on its own; regulating Qi makes tenesmus resolve on its own."

King herb

Bai Shao (White Peony Root) is used at the highest dose (up to 30g). Its sour-bitter, slightly cool nature softens the Liver, relaxes spasm in the intestinal wall, harmonises Blood, and directly relieves the cramping abdominal pain of dysentery. It is traditionally regarded as a key herb for treating dysentery.

Deputy herbs

Huang Qin, Huang Lian, and Da Huang form the Heat-clearing core. Huang Qin and Huang Lian are bitter and cold, entering the Large Intestine channel to clear Heat-toxin and dry Dampness, addressing the root cause of the disease. Da Huang purges accumulated Heat and stagnation downward and out through the bowels, using the classical strategy of "tong yin tong yong" (treating diarrhea with purgation). Together with Huang Qin and Huang Lian, it clears while also draining.

Assistant herbs

Dang Gui (reinforcing) nourishes and activates Blood, supporting Bai Shao's Blood-harmonising action while also helping Da Huang dispel Blood stasis. Mu Xiang and Bing Lang (reinforcing) move Qi and guide out stagnation, directly relieving tenesmus. Rou Gui (restraining/reverse assistant) is used in a very small dose. Its warm, acrid nature prevents the predominant bitter-cold herbs from injuring the Stomach or causing the Damp-Heat to become trapped. It also supports the Blood-moving herbs in warming and circulating Blood through the channels.

Envoy herb

Zhi Gan Cao harmonises the formula and protects the Middle Burner. Its combination with Bai Shao recreates the classical Shao Yao Gan Cao Tang pairing, powerfully relaxing spasm and relieving abdominal pain.

Notable synergies

The Bai Shao and Zhi Gan Cao pairing (from Shao Yao Gan Cao Tang) is a well-known combination for relieving cramping and pain. The Dang Gui and Da Huang pairing simultaneously moves stagnant Blood and purges Heat, so that old Blood stasis is cleared while fresh Blood is nourished. The combination of cooling herbs (Huang Qin, Huang Lian, Da Huang) with a small amount of warming Rou Gui exemplifies the strategy of "combining cold and warm herbs, with emphasis on cooling" to prevent either extreme from dominating.

How to Prepare

Traditional preparation instructions for Shao Yao Tang

Roughly chop all herbs. In the original text, take half a liǎng (approximately 15g) of the mixed herbs per serving, add two cups of water (approximately 400ml), and decoct down to one cup (approximately 200ml). Strain and take warm after meals.

In modern practice, decoct the full formula in approximately 600-800ml of water. Bring to a boil, then simmer on low heat for 20-30 minutes until the liquid reduces to roughly 300ml. Strain, divide into two doses, and take warm after meals.

Common Modifications

How practitioners adapt Shao Yao Tang for specific situations

Added
Mu Dan Pi

9-12g, cools Blood and disperses stasis

Di yu

9-12g, cools Blood and stops bleeding in the Lower Burner

When Blood-level Heat predominates, indicated by stool that is predominantly bloody, adding Mu Dan Pi and Di Yu strengthens the formula's ability to cool Blood and stop bleeding.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shao Yao Tang should not be used or requires extra caution

Avoid

Chronic dysenteric disorders caused by Spleen and Kidney Yang deficiency (Cold from Deficiency). This formula is designed for acute Damp-Heat patterns, and its cold, draining herbs would further damage the already weakened Yang Qi.

Avoid

Pregnancy. The formula contains Da Huang (Rhubarb), which promotes bowel movement and may stimulate uterine contractions, and Bing Lang (Areca Seed), which has downward-driving properties.

Avoid

Dysentery with concurrent exterior symptoms (fever with chills, body aches). The exterior condition should be resolved first before using this interior-directed formula.

Avoid

Chronic or recurrent anal bleeding from hemorrhoids or other structural causes. This formula targets acute Damp-Heat dysentery, not chronic bleeding conditions.

Caution

Patients with significant Qi and Blood deficiency or those who are debilitated. The draining and purging herbs (Da Huang, Huang Lian, Huang Qin) may further weaken someone already depleted. Use only with significant modification.

Caution

Patients on anticoagulant or antiplatelet therapy. Da Huang (Rhubarb) and Dang Gui (Angelica sinensis) have blood-moving properties and may increase bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Da Huang (Rhubarb), which has purgative action and can stimulate uterine contractions. Bing Lang (Areca Seed) has strong downward-directing properties. Dang Gui (Angelica sinensis) and Rou Gui (Cinnamon Bark) promote blood circulation, which may increase the risk of uterine bleeding. Pregnant women with dysenteric symptoms should seek practitioner guidance for safer alternatives.

Breastfeeding

Use with caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinones that may transfer into breast milk and could cause loose stools in the nursing infant. Bing Lang (Areca Seed) contains arecoline, an alkaloid with potential central nervous system effects, and its transfer into breast milk has not been well studied. Huang Lian (Coptis) and Huang Qin (Scutellaria) are generally considered low risk but may impart bitter compounds to the milk. If the formula is clinically necessary, short-term use under practitioner supervision is advised, with monitoring of the infant for digestive disturbance.

Children

Shao Yao Tang may be used in children for acute Damp-Heat dysenteric conditions, but dosages must be substantially reduced according to age and body weight. As a general guideline, children aged 6-12 typically receive one-third to one-half the adult dose, and children under 6 should receive one-quarter or less. The purgative herb Da Huang (Rhubarb) is particularly important to reduce, as children are more sensitive to its cathartic effect and risk of fluid loss. Bing Lang (Areca Seed) should also be used cautiously in young children due to its alkaloid content. This formula is intended for short-term acute use only in pediatric patients. Prolonged use of bitter-cold and purgative herbs can easily damage a child's Spleen and Stomach Qi. A qualified practitioner should supervise any pediatric use.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shao Yao Tang

Da Huang (Rhubarb): May potentiate the effects of anticoagulant and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel) due to its blood-moving properties. Da Huang's purgative action can also reduce absorption of orally administered medications by accelerating intestinal transit. It may lower potassium levels, which could interact with cardiac glycosides (digoxin) and diuretics.

Gan Cao (Licorice): Contains glycyrrhizin, which can cause sodium retention and potassium loss. This may interact with antihypertensive medications, corticosteroids, and diuretics. It can enhance the toxicity of digoxin through hypokalemia. Gan Cao may also affect the metabolism of drugs processed through CYP450 enzymes.

Rou Gui (Cinnamon Bark): Contains coumarin compounds and may have additive effects with blood-thinning medications. May influence blood glucose levels, potentially interacting with antidiabetic drugs.

Huang Lian (Coptis) and Huang Qin (Scutellaria): Berberine from Huang Lian has documented interactions with cyclosporine, metformin, and certain antibiotics. Baicalin from Huang Qin may inhibit CYP enzymes and affect drug metabolism. Both herbs may influence the absorption of concurrently administered oral medications.

Usage Guidance

Practical advice for getting the most out of Shao Yao Tang

Best time to take

After meals (食后温服), as specified in the original text. Taking the warm decoction after eating protects the stomach from the formula's bitter-cold herbs.

Typical duration

Acute use: typically 3-7 days, reassessed once symptoms improve. Not intended for long-term continuous use due to its purgative and bitter-cold components.

Dietary advice

While taking this formula, avoid greasy, fatty, and fried foods, which generate more Dampness and Heat in the intestines. Avoid raw, cold foods (sushi, salads, ice cream, cold drinks) that can contract the intestines and trap pathogens inside. Spicy and heavily seasoned foods should also be limited, as they may aggravate intestinal Heat. Alcohol and dairy are strongly discouraged during acute dysenteric episodes. Favor bland, easily digestible foods such as plain rice porridge (congee), steamed vegetables, and mild soups. Small, frequent meals are preferable to large ones to reduce burden on the inflamed gut.

Shao Yao Tang originates from Sù Wèn Bìng Jī Qì Yí Bǎo Mìng Jí (素问病机气宜保命集) by Liú Wánsù (刘完素) Jīn dynasty, 1186 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shao Yao Tang and its clinical use

Original source text from the Su Wen Bing Ji Qi Yi Bao Ming Ji (《素问病机气宜保命集》), "Diarrhea and Dysentery" chapter:

「芍药汤:下血调气。经曰:溲而便脓血,气行而血止。行血则便脓自愈,调气则后重自除。

"Shao Yao Tang: directs the Blood downward and regulates Qi. The classic says: when there is urination with bloody purulent stool, once Qi moves the bleeding stops. When Blood is mobilized, purulent stool heals naturally; when Qi is regulated, tenesmus resolves on its own."

From the Cheng Fang Bian Du (《成方便读》) by Zhang Bingcheng:

「夫痢之为病,固有寒热之分,然热者多而寒者少,总不离邪滞蕴结,以致肠胃之气不宣,酿为脓血稠粘之属……故刘河间有云:行血则便脓自愈,调气则后重自除,二语足为治痢之大法。」

"In dysentery as a disease, there is certainly a division between Cold and Heat, yet Heat is more common and Cold less so. It always involves pathogenic stagnation and accumulation, obstructing the Qi of the intestines and stomach, which ferments into thick, sticky pus and blood… Thus Liu Hejian said: 'When Blood is mobilized, purulent stool heals naturally; when Qi is regulated, tenesmus resolves on its own.' These two statements suffice as the great method for treating dysentery."

Historical Context

How Shao Yao Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shao Yao Tang was created by Liu Wansu (刘完素, c. 1110–1200), courtesy name Shouzhen, also known as Liu Hejian after his hometown of Hejian in present-day Hebei Province. Liu Wansu was the first of the celebrated "Four Great Masters of the Jin-Yuan Period" (金元四大家) and the founder of the "Cold and Cool School" (寒凉派) of medical thought. He devoted over 35 years to studying the Huang Di Nei Jing Su Wen, and his core insight was that the six climatic factors can all transform into Fire and Heat when pathological. The formula appeared in his late-career synthesis, the Su Wen Bing Ji Qi Yi Bao Ming Ji (《素问病机气宜保命集》), in the chapter on diarrhea and dysentery.

The formula reflects Liu Wansu's characteristic approach: rather than using purely bitter-cold purging methods for Heat diseases, he integrated Blood-level and Qi-level treatments. His famous aphorism for this formula, "mobilize the Blood and pus heals naturally; regulate the Qi and tenesmus resolves on its own" (行血则便脓自愈,调气则后重自除), became one of the most widely cited principles in the treatment of dysenteric illness throughout later Chinese medicine. The formula was included in the Chinese government's official "Catalogue of Classical Famous Formulas" (古代经典名方目录, second batch), recognizing its enduring clinical significance.

In modern times, the formula has been extensively applied beyond its original indication of acute dysentery. It has become one of the most frequently used classical formulas for ulcerative colitis, a condition categorized under the Damp-Heat pattern of the Large Intestine in TCM, and remains a foundation for clinical research in inflammatory bowel disease.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Shao Yao Tang

1

Meta-analysis of Shaoyao Decoction for Ulcerative Colitis (2025)

Zhu Y, Liu Q. Iran J Public Health. 2025;54(3):478-488.

A meta-analysis of 23 randomized controlled trials with 2,068 participants found that Shaoyao Decoction significantly improved clinical effective rates, quality of life scores (IBDQ), and reduced levels of pro-inflammatory markers (TNF-alpha, IL-1-beta, IL-6) in ulcerative colitis patients compared to conventional therapy alone. Adverse reactions and recurrence rates were also lower in the Shaoyao Decoction groups. The authors concluded the formula shows certain advantages and good safety, but noted that higher-quality studies are still needed.

2

Preclinical study: Shaoyao Decoction inhibits inflammation and improves intestinal barrier function in DSS-induced colitis mice (2021)

Chi H, Wang D, Chen M, Lin J, Zhang S, Yu F, Zhou J, Zheng X, Zou Y. Frontiers in Pharmacology. 2021;12:524287.

In a mouse model of colitis induced by dextran sulfate sodium (DSS), Shaoyao Decoction significantly reduced clinical disease signs, suppressed pro-inflammatory cytokines, decreased immune cell infiltration, and improved intestinal mucosal barrier function. The study identified suppression of STAT3 and NF-kB signaling pathways as key mechanisms.

3

Preclinical study: Effect of Shaoyao Tang on ulcerative colitis in rats via TLR4/NF-kB signal pathway (2019)

Zhong Y, Zheng XB, Ye H, Guo M, Wu Q, Zou Y, Chi HG, Zhu YZ. Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica). 2019;44(7):1450-1456.

In a rat model of ulcerative colitis, different doses of Shaoyao Tang improved disease activity scores and inhibited colon shortening and pathological injury. The high-dose group showed the most significant effects. The formula significantly decreased expression levels of MPO, P-selectin, MIF, and TXB2 in both serum and colon tissues, and downregulated TLR4 and NF-kB protein expression in colonic tissue.

4

Preclinical study: Shaoyao Decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines (2014)

Lin X, Yi Z, Diao J, Shao M, Zhao L, Cai H, Fan Q, Yao X, Sun X. Journal of Ethnopharmacology. 2014;153(3):684-693.

Using an AOM/DSS-induced colitis-associated colorectal cancer model in mice, this study found that Shaoyao Decoction reduced tumor number and size, downregulated pro-inflammatory cytokines, and promoted epithelial-mesenchymal transition markers. The results suggest potential chemopreventive effects of the formula in the progression from chronic colitis to colorectal cancer.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.