Gua Lou Niu Bang Tang

Trichosanthes and Arctium Decoction · 瓜蒌牛蒡湯

Also known as: Gua Lou Niu Bang Zi Tang, 栝楼牛蒡汤, Trichosanthes and Burdock Seed Decoction

A classical formula for the early stages of breast infection (mastitis) or breast abscess, when the breast is red, swollen, hot, and painful. It works by clearing Heat and toxins from the breast while also addressing the underlying Qi stagnation in the Liver that contributes to the blockage. Most commonly used for breastfeeding mothers who develop a painful, inflamed area in the breast.

Origin Yi Zong Jin Jian (醫宗金鑒), Volume 66, Wai Ke Xin Fa Yao Jue (外科心法要訣). Note: a 2024 textual research study argues the formula may originate earlier from the Ming dynasty text Wai Ke Zheng Zong (外科正宗) by Chen Shigong. — Qīng dynasty, 1742 CE (Yi Zong Jin Jian compilation). Possibly earlier: Míng dynasty, 1617 CE (Wai Ke Zheng Zong)
Composition 12 herbs
Gua Lou Ren
King
Gua Lou Ren
Niu Bang Zi
King
Niu Bang Zi
Jin Yin Hua
Deputy
Jin Yin Hua
Lian Qiao
Deputy
Lian Qiao
Huang Qin
Assistant
Huang Qin
Zhi Zi
Assistant
Zhi Zi
Tian Hua Fen
Assistant
Tian Hua Fen
Zao Jiao Ci
Assistant
Zao Jiao Ci
+4
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gua Lou Niu Bang Tang is designed to correct these specific patterns.

Why Gua Lou Niu Bang Tang addresses this pattern

When Heat-toxin accumulates in the Liver and Stomach channels (which traverse the breast area), it causes localized redness, swelling, heat, and pain. This formula brings together a powerful group of Heat-clearing and toxin-resolving herbs. Jin Yin Hua and Lian Qiao are the primary toxin-clearing pair, supported by Huang Qin and Zhi Zi which drain Heat from the interior. Gua Lou Ren and Niu Bang Zi specifically target Heat and swelling in the breast, while Tian Hua Fen and Zao Jiao Ci promote pus discharge to prevent the toxin from deepening. The formula's strength against this pattern lies in its comprehensive approach: it clears Heat at multiple levels while keeping Qi moving to prevent further stagnation.

A practitioner would look for one or more of these signs

Breast Pain

Red, swollen, hot, and painful breast, especially in early-stage mastitis

Fever

Chills alternating with fever at disease onset

Breast Lumps

Palpable hard or tender lump in the breast

Red Tongue

Red tongue with yellow coating

Rapid Pulse

Rapid, wiry, or slippery pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gua Lou Niu Bang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands mastitis (called 'breast abscess' or 乳痈, rǔ yōng) as a condition arising from the interplay between two organ systems. The Liver channel passes through the nipple, and the Stomach channel passes through the breast body. When Liver Qi becomes stagnant, often from emotional stress, frustration during nursing, or inadequate rest postpartum, the smooth flow of Qi and milk through the breast is disrupted. This stagnation generates Heat, which then combines with any existing Heat in the Stomach channel (often from rich, greasy food). The resulting Heat-toxin blocks the channels, causing the characteristic redness, swelling, heat, and pain. If not resolved early, the Heat congeals the flesh and forms pus. The alternating chills and fever seen at onset reflect the struggle between the body's defensive Qi and the invading toxin.

Why Gua Lou Niu Bang Tang Helps

Gua Lou Niu Bang Tang is designed specifically for the initial stage of mastitis, before an abscess has fully formed. The King herbs Gua Lou Ren and Niu Bang Zi directly target breast swelling and Heat. The Heat-clearing deputies Jin Yin Hua and Lian Qiao, together with assistants Huang Qin and Zhi Zi, aggressively clear the Heat-toxin driving the inflammation. Crucially, the formula also addresses the root stagnation through Chai Hu, Qing Pi, and Chen Pi, which restore the free flow of Liver and Stomach Qi through the breast. Zao Jiao Ci and Tian Hua Fen promote the venting and discharge of any forming pus. This dual strategy of clearing Heat-toxin while simultaneously unblocking Qi stagnation makes the formula particularly effective for early mastitis, when prompt treatment can often resolve the condition and prevent abscess formation entirely. Clinical studies have shown the formula to be highly effective for acute mastitis.

Also commonly used for

Breast Lumps

Inflammatory breast lumps with Heat signs

Breast Pain

Breast pain due to Heat-toxin and Qi stagnation

Chest Distension

Breast engorgement with blocked milk ducts and Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gua Lou Niu Bang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gua Lou Niu Bang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gua Lou Niu Bang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gua Lou Niu Bang Tang works at the root level.

In TCM theory, different parts of the breast are governed by different organ systems. The nipple is linked to the Liver (through the Jue Yin channel), while the breast tissue itself is linked to the Stomach (through the Yang Ming channel). This dual relationship is the key to understanding how breast abscess (known as "ru yong," 乳痈) develops.

The typical scenario begins with emotional frustration or stress that causes the Liver's Qi to stagnate. The Liver is responsible for maintaining the smooth flow of Qi throughout the body. When it becomes constrained, Qi cannot circulate freely, and this stagnation generates Heat over time. Simultaneously, the Stomach may accumulate Heat from dietary or other causes. When Liver constraint and Stomach Heat combine, they block the breast's channels and collaterals. The nutritive Qi — which normally flows smoothly to nourish the tissues — becomes obstructed, and this obstruction transforms into a localized swelling with redness, heat, and pain. In breastfeeding women, milk flow is also impeded, and the stagnant milk further contributes to the toxic accumulation.

The formula addresses this pathomechanism on two fronts: it clears the accumulated Heat-toxin from the Stomach channel that is fueling the inflammation, while simultaneously restoring the Liver's ability to move Qi freely so that the underlying stagnation is resolved. This dual approach — clearing Heat while coursing Qi — prevents the condition from progressing to full abscess formation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and acrid — bitter to clear Heat and drain Fire, acrid to disperse stagnation and promote the movement of Qi, with a sweet undertone from Gan Cao to harmonize.

Channels Entered

Ingredients

12 herbs

The herbs that make up Gua Lou Niu Bang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Gua Lou Ren

Gua Lou Ren

Snake gourd seeds

Dosage 9 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Stomach, Large Intestine, Lungs

Role in Gua Lou Niu Bang Tang

Clears Heat, reduces swelling, dissipates nodules, and promotes the discharge of pus. As the primary herb targeting the breast, it moistens, opens, and unblocks stagnation in the chest and breast tissue. Its ability to clear Phlegm-Heat and disperse lumps directly addresses the core pathology of breast abscess.
Niu Bang Zi

Niu Bang Zi

Greater burdock fruits

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Lungs, Stomach
Preparation Dry-fried and crushed (炒、研)

Role in Gua Lou Niu Bang Tang

Disperses Wind-Heat, clears toxins, relieves swelling, and promotes the venting of rashes and sores. It has a strong dispersing and descending action that helps vent toxic Heat outward. Works synergistically with Gua Lou Ren to form the core therapeutic pair for clearing Heat-toxin and reducing breast swelling.
Deputies — Assists and enhances the King
Jin Yin Hua

Jin Yin Hua

Honeysuckle flowers

Dosage 9 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Gua Lou Niu Bang Tang

A premier Heat-clearing and toxin-resolving herb. Strongly supports the King herbs in clearing the Heat-toxin that drives breast abscess formation. Has a particular affinity for treating sores and carbuncles at all stages.
Lian Qiao

Lian Qiao

Forsythia fruits

Dosage 9 - 12g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine
Preparation Remove the core (去心)

Role in Gua Lou Niu Bang Tang

Clears Heat, resolves toxins, and dissipates clumps. Known as the key herb for treating sores and carbuncles, it reinforces Jin Yin Hua in clearing toxic Heat while also having a dispersing quality that helps break up accumulations.
Assistants — Supports or moderates other herbs
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 9 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Gua Lou Niu Bang Tang

Clears Heat and dries Dampness, particularly in the upper body. Assists the deputies in clearing internal Heat from the Liver and Stomach channels that underlies breast abscess formation.
Zhi Zi

Zhi Zi

Cape jasmine fruits

Dosage 9 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Lungs, Sanjiao, San Jiao (Triple Burner)
Preparation Used raw (生), crushed (研)

Role in Gua Lou Niu Bang Tang

Clears Heat, reduces irritability, and cools the Blood. Drains Heat from all three Burners and guides Fire downward, helping to resolve the feverish feeling and redness associated with early-stage breast abscess.
Tian Hua Fen

Tian Hua Fen

Snake gourd roots

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Sour, Sweet
Organ Affinity Stomach, Lungs

Role in Gua Lou Niu Bang Tang

Clears Heat, generates fluids, and promotes pus discharge and tissue healing. Works alongside Gua Lou Ren (both from the same plant) to reinforce the action of reducing swelling and expelling pus from the breast.
Zao Jiao Ci

Zao Jiao Ci

Gleditsia thorns

Dosage 3 - 9g
Temperature Warm
Taste Pungent
Organ Affinity Stomach, Liver, Lungs

Role in Gua Lou Niu Bang Tang

Draws out toxins, promotes the discharge of pus, invigorates Blood, and reduces swelling. A specialist herb for treating abscesses and sores, it helps vent pus and toxins outward before an abscess can fully form, supporting the formula's strategy of early-stage dispersal.
Chai Hu

Chai Hu

Bupleurum roots

Dosage 3 - 6g
Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver

Role in Gua Lou Niu Bang Tang

Courses the Liver and resolves stagnation. In TCM, the nipple belongs to the Liver channel. Chai Hu directly addresses the Liver Qi stagnation that is a root cause of breast abscess, helping to restore the free flow of Qi through the breast area.
Qing Pi

Qing Pi

Green tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Gallbladder, Stomach, Liver

Role in Gua Lou Niu Bang Tang

Spreads Liver Qi, breaks up stagnation, and reduces accumulations. It has a stronger Qi-moving action than Chen Pi and specifically targets Liver channel stagnation, making it well suited for breast conditions driven by Qi blockage.
Chen Pi

Chen Pi

Tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen

Role in Gua Lou Niu Bang Tang

Regulates Qi, harmonizes the Middle Burner, and dries Dampness. Complements Qing Pi by smoothing Qi flow in the Stomach and Spleen, helping to address the Stomach channel component of the pathology (the breast body belongs to the Stomach channel in TCM).
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Used raw (生)

Role in Gua Lou Niu Bang Tang

Used raw (Sheng Gan Cao) to clear Heat and resolve toxins while harmonizing all the other herbs in the formula. Moderates the bitter-cold properties of the Heat-clearing herbs and protects the Stomach from their harshness.

Why This Combination Works

How the herbs in Gua Lou Niu Bang Tang complement each other

Overall strategy

This formula simultaneously clears Heat-toxin from the Stomach channel and courses stagnant Qi in the Liver channel, the two pathological factors that converge to produce breast abscess. The combination of Heat-clearing with Qi-regulating herbs ensures that the toxin is dispersed before it can congeal into pus.

King herbs

Gua Lou Ren and Niu Bang Zi together form the core therapeutic pair. Gua Lou Ren is sweet, cold, and has a particular affinity for the chest and breast area. It clears Heat, loosens Phlegm, and disperses lumps. Niu Bang Zi is pungent and cold, excelling at venting Heat-toxin outward through the surface and reducing swelling. Together they address the local Heat, swelling, and nodulation in the breast.

Deputy herbs

Jin Yin Hua and Lian Qiao are the classical pair for clearing Heat and resolving toxins in sores and carbuncles. They powerfully reinforce the King herbs' toxin-clearing action and help prevent the progression from initial inflammation to full abscess formation.

Assistant herbs

The assistants work in two distinct groups. The Heat-clearing assistants (Huang Qin, Zhi Zi, Tian Hua Fen) further drain internal Heat. Tian Hua Fen also promotes pus drainage and tissue healing. Zao Jiao Ci draws out toxins and promotes the venting of pus, functioning as a reinforcing assistant. The Qi-moving assistants (Chai Hu, Qing Pi, Chen Pi) address the root cause of Liver Qi stagnation. Chai Hu courses the Liver directly, Qing Pi breaks up Qi accumulation in the Liver channel, and Chen Pi harmonizes the Stomach. This Qi-moving group ensures the formula does not merely suppress Heat but also resolves the underlying stagnation.

Envoy herbs

Sheng Gan Cao (raw Licorice) harmonizes all the herbs, moderates the bitter-cold tendency of the formula, and contributes its own mild Heat-clearing and toxin-resolving action.

Notable synergies

The Gua Lou Ren and Tian Hua Fen pairing is notable as both come from the Trichosanthes plant. Together they create a strong breast-targeted effect for clearing Heat, reducing swelling, and promoting pus discharge. The Chai Hu and Qing Pi pairing specifically targets the Liver channel to course Qi stagnation in the breast, while Jin Yin Hua and Lian Qiao form a classical toxin-clearing pair. The overall design balances Heat-clearing with Qi-movement, which is the formula's distinctive strategic feature.

How to Prepare

Traditional preparation instructions for Gua Lou Niu Bang Tang

Decoct all herbs in approximately 400 ml of water. Bring to a boil, then simmer until approximately 320 ml of liquid remains. Strain the decoction, then add a small cup (approximately 30-50 ml) of heated rice wine or cooking wine and mix well. Take the decoction on an empty stomach, between meals.

In modern clinical practice, the rice wine is often omitted or reduced. The formula may also be prepared as a standard water decoction without wine, taken warm twice daily.

Common Modifications

How practitioners adapt Gua Lou Niu Bang Tang for specific situations

Added
Lu Jiao Shuang

9g, warms channels and promotes milk flow

Lou Lu

9g, clears Heat and promotes lactation

Wang Bu Liu Xing

9g, invigorates Blood and promotes milk flow

Lu Lu Tong

9g, opens channels and promotes milk flow

When milk stasis is a significant contributing factor, these four herbs work together to warm and open the milk ducts, invigorate Blood circulation through the breast, and actively promote the flow of milk to relieve engorgement.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gua Lou Niu Bang Tang should not be used or requires extra caution

Caution

Breast abscess (mastitis) that has already ruptured and is actively draining pus. Once an abscess has broken open, the formula composition needs to be adjusted, as the strategy shifts from dispersing and resolving to supporting healing and draining residual toxin.

Caution

Spleen and Stomach deficiency cold (poor appetite, loose stools, cold limbs). The formula is predominantly cold in nature with many bitter and cold herbs such as Huang Qin, Zhi Zi, and Lian Qiao, which can further injure a weak digestive system. If the formula must be used, warming herbs like dry ginger (Gan Jiang) and Bai Zhu should be added.

Avoid

Yin-type breast lumps without Heat signs (pale complexion, no redness or warmth at the lesion, deep and slow pulse). This formula is designed for Heat-toxin patterns and would be inappropriate for cold or deficiency-type breast masses.

Caution

Pregnancy. The formula contains Zao Jiao Ci (Gleditsia spine), which has blood-moving and pus-expelling properties, and Gua Lou Ren (Trichosanthes seed), which may stimulate uterine smooth muscle. Both are classified as cautioned during pregnancy.

Caution

Continuous use beyond 7 days without reassessment. If there is no clear improvement after one week, the formula should be re-evaluated and the treatment strategy reconsidered.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. The formula contains Zao Jiao Ci (Gleditsia spine), which has blood-moving and pus-drawing properties that are traditionally cautioned in pregnancy. Additionally, Gua Lou Ren (Trichosanthes seed) has been shown in animal studies to potentially stimulate intestinal and uterine smooth muscle, which could theoretically increase the risk of miscarriage or premature labor. Niu Bang Zi (Arctium seed) is also slippery in nature. This formula is not typically indicated in pregnant women (its primary use is for postpartum or breastfeeding mastitis), but if needed during pregnancy, it should only be used under close supervision by a qualified practitioner with dosage adjustments.

Breastfeeding

This formula is specifically designed for use during breastfeeding, as its primary indication is early-stage mastitis (breast abscess) in nursing mothers. It is generally considered safe and appropriate for breastfeeding women when prescribed by a qualified practitioner. The herbs in the formula are predominantly Heat-clearing and Qi-regulating, and several (such as Gua Lou Ren and Niu Bang Zi) actually help promote milk flow. However, the formula's cold nature means it should not be used for prolonged periods, as excessive cold can potentially reduce milk production. If the condition resolves, the formula should be discontinued promptly. Infants should be monitored for any changes in stool consistency, as the cold herbs may theoretically affect breast milk quality.

Children

This formula is primarily indicated for adult breastfeeding women and is not a standard pediatric prescription. However, in pediatric external medicine, modified versions have occasionally been used for Heat-toxin swellings in children under close practitioner supervision. For children, dosages must be significantly reduced — typically to one-third to one-half of adult doses depending on age and body weight. The cold and bitter nature of many ingredients (Huang Qin, Zhi Zi, Lian Qiao) makes this formula unsuitable for young children with weak digestive systems. Not recommended for infants under 1 year of age.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gua Lou Niu Bang Tang

Gan Cao (Licorice root) in this formula may interact with several pharmaceutical drugs. Glycyrrhizin in licorice can cause sodium retention and potassium loss, potentially interacting with diuretics (especially thiazides and loop diuretics), cardiac glycosides (such as digoxin, where hypokalemia increases toxicity risk), corticosteroids (additive mineralocorticoid effects), and antihypertensive medications (counteracting blood pressure lowering effects).

Huang Qin (Scutellaria root) contains baicalin, which has demonstrated effects on cytochrome P450 enzymes in laboratory studies. It may theoretically alter the metabolism of drugs processed through these pathways, including certain antibiotics and anti-inflammatory medications. Patients already taking antibiotics for mastitis should inform their practitioner.

Gua Lou Ren (Trichosanthes seed) is classically listed as incompatible with Wu Tou (Aconitum) preparations. This is one of the "Eighteen Incompatibilities" (十八反) of Chinese medicine. Patients taking any aconite-containing formulas or preparations must avoid this formula.

Usage Guidance

Practical advice for getting the most out of Gua Lou Niu Bang Tang

Best time to take

Traditionally taken on an empty stomach (空腹) with a small amount of warm rice wine mixed into the decoction, typically twice daily — once in the morning before breakfast and once in the evening before dinner.

Typical duration

Acute use: 3–7 days. If no improvement within 7 days, the formula and diagnosis should be reassessed.

Dietary advice

While taking this formula, avoid spicy, greasy, and fried foods, as these generate internal Heat and can worsen the inflammatory condition. Rich meats, alcohol, and shellfish should also be avoided. Cold and raw foods should be consumed in moderation to protect the Spleen and Stomach, which are already burdened by the cooling nature of the formula. Light, easily digestible foods are preferred, such as congee, steamed vegetables, and mild soups. Foods that gently promote milk flow, such as crucian carp soup or papaya, may be beneficial if milk stagnation is present. Avoid strongly warming spices like chili, black pepper, and cinnamon.

Gua Lou Niu Bang Tang originates from Yi Zong Jin Jian (醫宗金鑒), Volume 66, Wai Ke Xin Fa Yao Jue (外科心法要訣). Note: a 2024 textual research study argues the formula may originate earlier from the Ming dynasty text Wai Ke Zheng Zong (外科正宗) by Chen Shigong. Qīng dynasty, 1742 CE (Yi Zong Jin Jian compilation). Possibly earlier: Míng dynasty, 1617 CE (Wai Ke Zheng Zong)

Classical Texts

Key passages from the classical Chinese medical texts that first described Gua Lou Niu Bang Tang and its clinical use

Formula song verse from the Yi Zong Jin Jian (《医宗金鉴》, Golden Mirror of Medicine):

瓜蒌牛蒡芩栀翘,花粉柴胡青陈饶,银花角刺与甘草,疏肝清热乳痈消。

Translation: Gua Lou and Niu Bang with Huang Qin, Zhi Zi, and Lian Qiao; Hua Fen, Chai Hu, Qing Pi, and Chen Pi are generously included; Jin Yin Hua, Zao Jiao Ci, and Gan Cao complete the formula — it courses the Liver, clears Heat, and resolves breast abscess.


From the Yi Zong Jin Jian · Wai Ke Xin Fa Yao Jue (《医宗金鉴·外科心法要诀》):

乳头属肝,乳房属胃,乳痈是由于肝郁气滞、疏泄失职,脾胃失和,胃热壅滞,致使经络阻隔,营气不和而发病。

Translation: The nipple pertains to the Liver; the breast pertains to the Stomach. Breast abscess arises from Liver constraint and Qi stagnation with failure of free coursing, disharmony of Spleen and Stomach, and congestion of Stomach Heat, leading to blockage of the channels and disharmony of nutritive Qi, which causes the disease.

Historical Context

How Gua Lou Niu Bang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gua Lou Niu Bang Tang originates from the Yi Zong Jin Jian (《医宗金鉴》, Golden Mirror of Medicine), a monumental medical compendium compiled in the Qing Dynasty (1742) under the editorship of Wu Qian (吴谦) and his colleagues, commissioned by imperial decree during the reign of Emperor Qianlong. The formula appears in the Wai Ke Xin Fa Yao Jue (外科心法要诀, Essentials of External Medicine) section. Some sources trace the formula's conceptual roots to the Ming Dynasty surgeon Chen Shigong (陈实功) and his Wai Ke Zheng Zong (《外科正宗》, True Lineage of External Medicine, 1617), where principles for treating breast abscess were extensively developed.

A notable historical modification was made by Gu Xiaoyan (顾筱岩), a famous external medicine specialist from Shanghai. Gu found that while the original formula effectively reduced redness and heat, lumps were sometimes slow to resolve in postpartum women whose Qi and Blood had not yet recovered. He modified the formula by removing the strongly cold herbs (Jin Yin Hua, Lian Qiao, Huang Qin, Shan Zhi) and adding wind-dispersing and blood-moving herbs such as Jing Jie, Fang Feng, Zi Su Geng, Lu Jiao Shuang, and Liu Xing Zi. He replaced the cold-natured heat-clearing herbs with Pu Gong Ying, a gentler alternative. Gu used this modified version for decades, treating tens of thousands of cases with significantly improved early resolution rates.