Bi Yu San

Jade Green Powder · 碧玉散

A simple cooling powder used to clear summer heat and dampness from the body, especially when accompanied by signs of irritability, red eyes, sore throat, or mouth sores. It is a variant of the well-known Liu Yi San (Six-to-One Powder), with the addition of indigo pigment to enhance its ability to cool the Liver and clear heat from the blood.

Origin Xuan Ming Lun Fang (宣明论方) by Liu Wansu — Jīn dynasty, ~1172 CE
Composition 3 herbs
Hua Shi
King
Hua Shi
Gan Cao
Deputy
Gan Cao
Qing Dai
Assistant
Qing Dai
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bi Yu San is designed to correct these specific patterns.

Why Bi Yu San addresses this pattern

When Summer Heat invades along with Dampness, the body's fluid metabolism becomes disrupted. Heat steams the fluids, causing thirst and irritability, while Dampness obstructs the Middle and Lower Burners, leading to vomiting, diarrhea, and difficulty urinating. Hua Shi clears the Summer Heat and opens the waterways to drain accumulated Dampness downward through urination. Gan Cao protects the digestive system and prevents fluid depletion. Qing Dai adds extra Heat-clearing power, particularly useful when the trapped Heat produces signs like red eyes or mouth sores alongside the typical Summer Heat presentation.

A practitioner would look for one or more of these signs

Fever

Body heat during summer

Thirst

Thirst with desire for cold drinks

Diarrhea

Vomiting and diarrhea

Painful Urination

Difficult or painful urination with dark urine

Irritability

Restlessness and irritability

Dysentery

Dysentery with red and white stools

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bi Yu San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acute urinary tract infections are often understood as Damp-Heat pouring downward into the Bladder, a condition traditionally called 'Heat Lin' (热淋). During summer, exposure to environmental heat combined with internal dampness can obstruct the Bladder's ability to properly transform and excrete urine. The result is painful, scanty, dark-coloured urination. When the Liver-Gallbladder system is also affected, additional irritability and emotional agitation may accompany the urinary symptoms.

Why Bi Yu San Helps

Hua Shi, the dominant ingredient, directly promotes urination and clears Heat from the waterways, helping to flush out the Damp-Heat accumulation in the Bladder. Its slippery nature helps ease the passage of urine. Gan Cao protects the body's fluids from being overly depleted during this flushing process, while Qing Dai cools any associated Liver Heat that may be contributing to the inflammatory picture. This combination makes Bi Yu San particularly suited for summer-onset UTIs with signs of both dampness and heat.

Also commonly used for

Acute Gastroenteritis

Summer-onset vomiting and diarrhea

Viral Conjunctivitis

Acute red eyes with heat signs

Mouth Ulcers

Oral ulcers due to heat

Dysentery

Acute dysentery with mixed red and white stools

Stomatitis

Oral inflammation with heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bi Yu San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bi Yu San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bi Yu San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bi Yu San works at the root level.

Bi Yu San addresses a pattern in which Summer-Heat and Dampness invade the body, combined with Heat accumulating in the Liver and Gallbladder. In TCM, Summer-Heat is a seasonal pathogen that characteristically injures Qi and body fluids, while simultaneously generating Dampness that clogs the body's waterways. When this happens, fluids become turbid and stagnant rather than flowing freely through the normal channels of urination and sweating.

The Heat component rises upward and flares outward, producing symptoms like fever, irritability, red eyes, sore throat, and mouth ulcers. When this Heat specifically lodges in the Liver and Gallbladder systems, it adds a quality of constraint and frustration to the picture, since the Liver governs the smooth flow of Qi throughout the body. The Dampness component tends to sink downward, obstructing the Bladder's ability to transform and excrete urine, causing dark, scanty, or painful urination. When Damp-Heat pours into the intestines, it produces diarrhea or dysentery with mixed red and white discharge.

The key pathological dynamic is the combination of Heat steaming above and Dampness blocking below, with the Liver-Gallbladder axis caught in the middle, unable to perform its normal spreading and coursing function. The formula works by giving both the Heat and the Dampness a downward exit route through the urine, while simultaneously cooling the Liver-Gallbladder fire that keeps the cycle of constraint going.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bland and sweet with a cool, slightly bitter quality. The bland taste from Talc promotes drainage of Dampness through urination, the sweet from Licorice harmonizes and protects the Stomach, and the salty-cold quality of Indigo directs the cooling action toward the Liver and Blood.

Channels Entered

Ingredients

3 herbs

The herbs that make up Bi Yu San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Hua Shi

Hua Shi

Talc

Dosage 18 - 30g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Stomach, Urinary Bladder

Role in Bi Yu San

The principal herb in the formula, Hua Shi clears Summer Heat and facilitates the downward drainage of Dampness through the urinary tract. Its cold, heavy, and slippery nature allows it to open the waterways and clear pathogenic Heat from all three Burners. It also relieves irritability and thirst caused by Summer Heat.
Deputy — Assists and enhances the King
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Bi Yu San

Gan Cao harmonizes the Middle Burner and mildly clears Heat and resolves toxicity. Critically, it protects the Stomach and generates body fluids, preventing Hua Shi's strong draining action from injuring Qi or Yin. The 6:1 ratio of Hua Shi to Gan Cao ensures effective dampness drainage without depleting the body.
Assistant — Supports or moderates other herbs
Qing Dai

Qing Dai

Indigo Naturalis

Dosage 1 - 3g
Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Liver, Lungs

Role in Bi Yu San

Qing Dai clears Heat from the Liver and cools the Blood. This is the key ingredient that distinguishes Bi Yu San from its parent formula Liu Yi San. By adding Qing Dai, the formula gains the ability to address Liver and Gallbladder Heat, treating symptoms such as red eyes, sore throat, mouth sores, and irritability that accompany Summer Heat with Liver-Gallbladder constraint.

Why This Combination Works

How the herbs in Bi Yu San complement each other

Overall strategy

Bi Yu San is designed for situations where Summer Heat and Dampness become trapped in the body and, at the same time, Heat stagnates in the Liver and Gallbladder system. The formula clears Heat downward through urination while simultaneously cooling the Liver, addressing both the dampness and the fire components of this pattern.

King herbs

Hua Shi (Talc) is the undisputed King, comprising the vast majority of the formula by weight. Its cold, sweet, and bland nature clears Summer Heat while its heavy, slippery quality directs pathogenic Heat downward and out through the urine. It can also release Heat outward through the skin pores, making it effective whether the Heat is trapped internally or at the surface.

Deputy herbs

Gan Cao (Licorice) plays a crucial protective role. While Hua Shi powerfully drains Dampness downward, Gan Cao ensures the Stomach is not harmed and body fluids are not depleted. It also adds mild Heat-clearing and toxin-resolving properties. The classic 6:1 ratio between Hua Shi and Gan Cao achieves a balance of clearing without injuring, draining without depleting.

Assistant herbs

Qing Dai (Natural Indigo) is a reinforcing assistant that expands the formula's range beyond what Liu Yi San can achieve alone. Qing Dai enters the Liver channel and has strong abilities to clear Liver Fire, cool the Blood, and resolve toxicity. This targets the secondary but important Liver-Gallbladder Heat dimension of the pattern, addressing symptoms like red eyes, mouth sores, sore throat, and emotional irritability.

Notable synergies

The pairing of Hua Shi and Gan Cao is one of the most elegant in Chinese medicine: together they clear Heat without trapping Dampness, and drain Dampness without injuring fluids. The addition of Qing Dai to this base creates a formula that addresses both the Lower Burner (urinary drainage) and the Upper Burner (eyes, throat, mouth) simultaneously, giving Bi Yu San a broader therapeutic scope than its parent formula.

How to Prepare

Traditional preparation instructions for Bi Yu San

Grind Hua Shi (Talc) and Gan Cao (Licorice root) into a fine powder. Add Qing Dai (Natural Indigo) in sufficient quantity to tint the powder a jade-green (碧青) colour. Mix thoroughly. For each dose, take approximately 9 grams of the powder, add a small amount of honey, and stir into warm water or freshly drawn cool water. Take three times daily. If the person craves cold drinks, the powder may be mixed with cold water instead.

Common Modifications

How practitioners adapt Bi Yu San for specific situations

Added
Zhu Sha

Zhu Sha (Cinnabar), 1-2g, wrapped in cloth for decoction — this variant is traditionally called Yi Yuan San

Removed
Qing Dai

Qing Dai is removed, reverting to Liu Yi San base before adding Cinnabar

Adding Cinnabar sedates the Heart and calms the spirit when Summer Heat has disturbed the Heart, causing severe restlessness and insomnia. This creates the formula Yi Yuan San.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bi Yu San should not be used or requires extra caution

Avoid

Pregnancy. Hua Shi (Talc) has a slippery, downward-draining nature that could theoretically promote descent and affect the fetus. Avoid use during pregnancy.

Avoid

Spleen and Stomach deficiency with cold. This formula is cold in nature and promotes drainage. Using it when digestive function is already weak and cold will further injure the middle burner, potentially worsening diarrhea and poor appetite.

Caution

Yin deficiency without Dampness or Summer-Heat. The diuretic action of this formula can further deplete body fluids in a person whose Yin is already deficient, unless significant Damp-Heat is also present.

Caution

Excessive or prolonged use. Talc (Hua Shi) should not be taken long-term. Discontinue after symptoms resolve.

Caution

Pre-existing liver dysfunction. Qing Dai (Indigo) in compound formulas has been associated with rare cases of liver enzyme elevation. Those with existing liver conditions should use with caution and monitoring.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Hua Shi (Talc), the chief ingredient at the highest dose, has a descending and slippery nature that promotes downward drainage. This property raises concern for fetal safety. Qing Dai (Indigo) is cold and could potentially contribute to uterine instability by over-cooling the lower abdomen. There is no established safety data for this formula in pregnancy. Pregnant individuals should avoid this formula entirely.

Breastfeeding

Limited safety data exists for Bi Yu San during breastfeeding. Hua Shi (Talc) is a mineral substance with low systemic absorption when taken orally, so transfer through breast milk is likely minimal. Qing Dai (Indigo) contains indigo and indirubin, which are biologically active compounds. While serious adverse effects through breast milk are not well documented, the formula's strongly cold nature could theoretically affect the infant's digestion if used in significant doses. Gan Cao (Licorice) can influence hormone levels with prolonged use. Short-term use under professional guidance may be acceptable, but caution is advised. Avoid prolonged use while breastfeeding.

Children

Bi Yu San has historical use in pediatric settings. Classical texts mention its use for children with summer fever (潮热) that persists for several days. Dosage should be significantly reduced for children: typically one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children aged 3-6. For infants under 3 years, use only under direct practitioner supervision. The powder form makes dosage adjustment straightforward. Externally, Liu Yi San (the base formula without Qing Dai) has a folk tradition of being dusted on children's skin after bathing to prevent prickly heat and summer eczema. However, internal use of Bi Yu San in very young children should be cautious, as the cold nature may injure the developing digestive system. Monitor for loose stools or poor appetite as signs of over-cooling.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bi Yu San

Gan Cao (Licorice root): Glycyrrhizin in Gan Cao may interact with several drug classes. It can reduce the effectiveness of antihypertensive medications by promoting sodium retention and potassium excretion. It may potentiate the effects of corticosteroids. It can cause dangerous hypokalemia when combined with potassium-depleting diuretics (thiazides, loop diuretics), and this hypokalemia in turn increases the risk of digoxin toxicity. Those taking warfarin or other anticoagulants should be aware that Gan Cao may have mild effects on clotting parameters.

Hua Shi (Talc): As a mineral substance, Talc could theoretically reduce the absorption of concurrently taken oral medications by binding them in the gastrointestinal tract. It is advisable to separate the administration of Bi Yu San from other oral medications by at least 1-2 hours.

Qing Dai (Indigo): Contains indirubin and indigo, which are biologically active. Qing Dai-containing formulas have been associated with rare cases of liver enzyme elevation. Caution is warranted when combining with other hepatotoxic drugs (e.g. methotrexate, statins, acetaminophen). Patients on medications requiring hepatic metabolism should have liver function monitored.

Usage Guidance

Practical advice for getting the most out of Bi Yu San

Best time to take

Three times daily, mixed with a small amount of honey in warm water, or in freshly drawn cool water if the patient craves cold drinks. Can be taken between meals.

Typical duration

Acute use: 3-7 days for summer heat conditions. Discontinue once symptoms resolve; not intended for long-term use.

Dietary advice

While taking Bi Yu San, avoid greasy, fried, and heavily spiced foods, as these generate internal Heat and Dampness that work against the formula's purpose. Cold and raw foods should also be limited despite the formula treating a Heat condition, because excessive cold food can further damage Spleen function that is already burdened by Dampness. Favour light, easily digestible foods such as mung bean soup, watermelon, cucumber, winter melon, and plain rice porridge, which naturally support the clearing of Summer-Heat. Avoid alcohol, which generates Damp-Heat. Stay well hydrated with room-temperature or slightly cool water.

Bi Yu San originates from Xuan Ming Lun Fang (宣明论方) by Liu Wansu Jīn dynasty, ~1172 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bi Yu San and its clinical use

Source text (Huang Di Su Wen Xuan Ming Lun Fang, 《黄帝素问宣明论方》, Liu Wansu):

Original formula record: 「滑石六两,甘草一两,青黛(着令粉呈碧色)」

Translation: "Talc six liang, Licorice one liang, Indigo [added until the powder takes on a jade-green colour]."

The formula name "Bi Yu" (碧玉, Jasper) comes from the distinctive blue-green colour imparted by the Qing Dai, which tints the white Liu Yi San (Six-to-One Powder) base into a colour resembling jasper stone.


From the formula indications:

「主夏伤暑热,身热吐泻,下痢赤白,癃闭淋痛;或兼见目赤咽痛,口舌生疮者」

Translation: "Indicated for summer damage from Summer-Heat, with body heat, vomiting and diarrhea, dysentery with red and white discharge, urinary blockage and painful urination; or accompanied by red eyes, sore throat, and mouth or tongue sores."

Historical Context

How Bi Yu San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Bi Yu San was created by Liu Wansu (刘完素, c. 1110–1200), courtesy name Shouzhen (守真), one of the four great physicians of the Jin-Yuan era and founder of the "Cold and Cool School" (寒凉派) of Chinese medicine. It first appeared in his major clinical work, the Huang Di Su Wen Xuan Ming Lun Fang (《黄帝素问宣明论方》), completed in 1172 CE during the Jin Dynasty. Liu Wansu was known for challenging the prevailing Song Dynasty reliance on warm and drying prescriptions from the Tai Ping Hui Min He Ji Ju Fang (Imperial Grace Formulary), arguing that many diseases of his time were caused by fire and heat, requiring cool and cold treatment strategies.

Bi Yu San is essentially a modification of Liu Yi San (六一散, Six-to-One Powder, also called Tian Shui San or Yi Yuan San), which uses just Talc and Licorice in a 6:1 ratio to clear Summer-Heat and promote urination. By adding Qing Dai (Indigo), the formula gains the additional ability to clear Liver-Gallbladder fire and cool the Blood, extending its range to patients whose Summer-Heat condition includes pronounced signs of Liver Heat such as red eyes, irritability, and mouth sores. Other well-known modifications of Liu Yi San include Yi Yuan San (adding Cinnabar for restlessness and insomnia) and Ji Su San (adding fresh mint for mild exterior symptoms). Together, these variants form a practical family of summer formulas designed to be adjusted to individual presentations.