Yue Bi Tang

Maidservant from Yue Decoction · 越婢汤

A classical formula from Zhang Zhongjing's Jin Gui Yao Lue used to reduce swelling and edema caused by Wind and water accumulation with internal Heat. It works by opening the Lungs to restore proper water movement in the body while clearing trapped Heat. Commonly applied for sudden-onset generalized swelling, especially when triggered by external exposure to wind.

Origin Jin Gui Yao Lue (《金匮要略》, Essential Prescriptions of the Golden Cabinet) by Zhang Zhongjing — Eastern Han dynasty, circa 200 CE
Composition 5 herbs
Ma Huang
King
Ma Huang
Shi Gao
Deputy
Shi Gao
Sheng Jiang
Assistant
Sheng Jiang
Da Zao
Assistant
Da Zao
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yue Bi Tang is designed to correct these specific patterns.

Why Yue Bi Tang addresses this pattern

Wind-water (feng shui) is the primary pattern this formula was designed for, as stated in the Jin Gui Yao Lue. In this pattern, external Wind invades the surface and disrupts the Lung's regulation of water metabolism, causing sudden generalized edema. The key features that distinguish Wind-water from other types of edema are: the swelling affects the entire body (especially starting at the face and eyelids), the pulse is floating (indicating the pathogen is at the surface), and there is aversion to wind. Yue Bi Tang addresses this directly: Ma Huang powerfully opens the Lung to restore its water-regulating function and expel Wind from the surface, while Shi Gao clears the interior Heat that has developed from the stagnation of Lung Qi. Sheng Jiang reinforces the surface-opening action, and Gan Cao with Da Zao protect the Spleen to support proper water transformation.

A practitioner would look for one or more of these signs

Edema

Sudden generalized swelling, often starting in the face and eyelids

Aversion To Wind

Sensitivity to wind and drafts

Spontaneous Sweating

Continuous mild sweating that does not relieve the condition

Fever

Mild or low-grade fever (described as 'no great Heat')

Floating Pulse

Pulse felt easily at the surface, indicating pathogen at the exterior

Oliguria

Reduced urination due to disrupted water metabolism

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yue Bi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Wind-Water

TCM Interpretation

In TCM, edema is fundamentally a problem of water metabolism gone wrong. The Lung, Spleen, and Kidney all play roles in moving and transforming fluids. When external Wind attacks, the Lung is often the first organ affected because it governs the skin and surface of the body. If Wind blocks the Lung's ability to disperse and descend Qi, the "water passages" become obstructed and fluid spills into the tissues. This type of edema, called Wind-water, is characterized by rapid onset, starting in the upper body (face and eyelids), a floating pulse, and aversion to wind. It differs from Spleen-type edema (which is chronic and starts in the legs) or Kidney-type edema (which is deep and chronic with cold signs).

Why Yue Bi Tang Helps

Yue Bi Tang directly targets the root cause of Wind-water edema. Ma Huang, in its heavy dose, powerfully reopens the Lung's dispersing function, restoring the Lung's ability to regulate the water passages. This promotes both sweating (to expel surface-level fluid) and urination (to drain deeper fluid accumulation). Shi Gao clears the internal Heat that develops when Lung Qi stagnates, preventing the Heat from further disrupting fluid metabolism. The supporting herbs (Sheng Jiang, Da Zao, Gan Cao) protect the digestive system and ensure the Spleen can assist in transforming and transporting the excess water. Modern research has shown Yue Bi Tang can reduce renal microvascular permeability through the Cav-1/eNOS pathway, providing a mechanism for how it may reduce edema in conditions like nephrotic syndrome.

Also commonly used for

Chronic Nephritis

Acute flare-ups of chronic nephritis with sudden swelling

Nephrotic Syndrome

When edema is the dominant symptom with signs of Wind-Heat

Asthma

When combined with Ban Xia for wheezing with Heat and fluid accumulation

Rheumatoid Arthritis

Joint swelling with Heat signs (Wind-Damp-Heat pattern)

Allergic Skin Conditions

Allergic dermatitis or purpura with edema and Heat

Bronchitis

Acute bronchitis with fluid congestion in the Lungs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yue Bi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yue Bi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Yue Bi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yue Bi Tang works at the root level.

Yue Bi Tang addresses a condition the Jin Gui Yao Lue calls "Wind-water" (风水, feng shui). This develops when external Wind invades the body surface and disrupts the Lung's critical role in regulating the movement and distribution of fluids. In TCM, the Lung is said to govern the skin and control the "water passages" throughout the body. When Wind blocks the Lung, fluid distribution breaks down and water accumulates under the skin, producing sudden, generalized swelling (edema).

What makes this pattern distinctive is the presence of internal Heat alongside the water accumulation. The Wind pathogen becomes trapped, Lung Qi stagnates, and this stagnation generates Heat internally. The signs of this Heat are subtle: there may be spontaneous sweating (the Heat pushes fluids outward through the pores), and a mild feverish sensation rather than a raging fever. The patient is typically not thirsty because the fluids are overflowing rather than depleted, and the pulse is floating because the pathogen is still at the surface level.

The core problem, then, is a three-way tangle: Wind blocking the surface, water flooding the tissues, and Heat smoldering inside. Simply promoting sweating would not work because sweating is already happening spontaneously and more fluid loss could harm the patient. Simply clearing Heat would not address the trapped water. The formula must simultaneously vent the surface (to release Wind), restore the Lung's water-regulating function (to resolve edema), and clear the internal Heat, all without causing excessive fluid loss.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly pungent and sweet, with a cooling undertone from Shi Gao. The pungent quality opens the exterior and disperses stagnation, while the sweet taste supports the middle and moderates the formula's dispersing force.

Channels Entered

Lung Spleen Stomach Bladder

Ingredients

5 herbs

The herbs that make up Yue Bi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Ma Huang

Ma Huang

Ephedra stem

Dosage 12 - 18g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Urinary Bladder
Preparation Decoct first for 10-15 minutes and skim off the foam before adding the other herbs

Role in Yue Bi Tang

The principal herb, used in a heavy dose to powerfully open the Lung Qi, promote sweating to expel Wind from the surface, and restore the Lung's water-regulating function. By opening the surface and the waterways, it allows accumulated fluid to be excreted both through sweat and through urination. Its strong ascending and dispersing nature is the driving force behind the formula's ability to move stagnant water.
Deputy — Assists and enhances the King
Shi Gao

Shi Gao

Gypsum

Dosage 24 - 30g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach

Role in Yue Bi Tang

Used in a dose heavier than Ma Huang (a ratio of roughly 4:3) to clear the Heat trapped in the Lung and Stomach. Its cold, pungent nature both complements the dispersing action of Ma Huang and restrains Ma Huang's warm, drying character, preventing excessive sweating that would damage fluids. Together with Ma Huang, it creates the formula's signature strategy of simultaneously venting the surface and clearing interior Heat.
Assistants — Supports or moderates other herbs
Sheng Jiang

Sheng Jiang

Fresh ginger rhizome

Dosage 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach

Role in Yue Bi Tang

Assists Ma Huang in dispersing and opening the surface, enhancing the formula's ability to expel Wind and move water outward. Its warm, pungent quality also harmonizes the Stomach, helping to prevent nausea from the heavy mineral Shi Gao.
Da Zao

Da Zao

Jujube fruit

Dosage 15 pieces
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart

Role in Yue Bi Tang

Nourishes the Spleen and Stomach and supports the middle Qi. By strengthening the Spleen's water-transforming function, it helps the body properly process and eliminate fluid accumulation. It also protects the Stomach from the cold nature of Shi Gao and moderates the harsh dispersing action of Ma Huang.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Yue Bi Tang

Harmonizes all the herbs in the formula, tonifies the middle Qi to support the Spleen in transforming Dampness, and pairs with Da Zao to protect the Stomach. Also moderates the dispersing force of Ma Huang to prevent over-sweating.

Why This Combination Works

How the herbs in Yue Bi Tang complement each other

Overall strategy

The formula addresses a pattern where Wind traps water under the skin while Heat brews internally. The prescription must open the surface, restore the Lung's water-moving function, and clear Heat simultaneously, without over-sweating a patient who already has spontaneous sweating. This is achieved through the masterful pairing of Ma Huang and Shi Gao at a carefully calibrated dosage ratio.

King herbs

Ma Huang is the King herb, used at a notably heavy dose (6 liang in the original text, approximately 12-18g in modern practice). Its role here is not primarily to induce heavy sweating but to powerfully open and disseminate Lung Qi, restoring the Lung's function of regulating the water passages. By opening the pores and activating the Lung's dispersing and descending functions, it allows trapped water to be expelled both through mild sweating and through increased urination. It also disperses the Wind pathogen from the body surface.

Deputy herbs

Shi Gao serves as Deputy, dosed even heavier than Ma Huang (half a jin in the original, roughly 24-30g modern). This is a deliberate design choice. Shi Gao's cold, pungent nature clears the internal Heat that has built up from Lung Qi stagnation while simultaneously moderating Ma Huang's warm, dispersing tendency. The Ma Huang-to-Shi Gao ratio of roughly 3:4 means the formula disperses strongly but does not overheat the body, making it suitable for a condition that is fundamentally warm in nature.

Assistant herbs

Sheng Jiang (fresh Ginger) is a reinforcing Assistant that supports Ma Huang's surface-opening action, enhancing the expulsion of Wind and water through the skin. Da Zao (Jujube) is a restraining Assistant that nourishes the Spleen and protects the Stomach, strengthening the body's ability to transform and transport water while cushioning against the harsh dispersing and cold properties of the King and Deputy.

Envoy herbs

Gan Cao harmonizes the entire formula, bridging the warm-dispersing herbs (Ma Huang, Sheng Jiang) with the cold-clearing Shi Gao. Together with Da Zao, it supports the middle Qi to ensure the Spleen can participate in water metabolism and prevents the strong medicinals from injuring the Stomach.

Notable synergies

The Ma Huang and Shi Gao pairing is the signature of this formula and one of Zhang Zhongjing's most important herb combinations. At a ratio of 3:4 (Ma Huang to Shi Gao), the combination disperses Lung Qi and clears Heat without causing profuse sweating. This ratio differs meaningfully from Da Qing Long Tang (where Ma Huang dominates 2:1 over Shi Gao for stronger sweating) and Ma Xing Shi Gan Tang (where Shi Gao dominates 2:1 over Ma Huang for stronger Heat-clearing). The Sheng Jiang and Da Zao pairing regulates the protective (Wei) and nutritive (Ying) layers, supporting the surface-releasing action while protecting the body's vital substances.

How to Prepare

Traditional preparation instructions for Yue Bi Tang

The classical preparation from the Jin Gui Yao Lue instructs:

  1. Combine all five ingredients. Use approximately 1,200 mL of water (six sheng in ancient measure).
  2. First, decoct Ma Huang (Ephedra) separately and skim off the foam that rises to the surface. This step reduces the harshness of Ma Huang and removes impurities that can cause nausea or restlessness.
  3. Add the remaining herbs (Shi Gao, Sheng Jiang, Gan Cao, and Da Zao) to the pot.
  4. Continue boiling until the liquid is reduced to approximately 600 mL (three sheng).
  5. Divide into three portions and take warm, three times per day.

In modern practice, approximate dosages are: Ma Huang 12–18 g, Shi Gao (Gypsum, crushed and wrapped in cloth) 24–25 g, Sheng Jiang (fresh Ginger) 9 g, Gan Cao (Licorice) 6 g, Da Zao (Jujube) 5–15 pieces. The formula is typically decocted as a standard water decoction taken warm.

Common Modifications

How practitioners adapt Yue Bi Tang for specific situations

Added
One piece (approximately 6-9g), processed (炮). Warms Yang and stops sweating caused by Yang deficiency

When excessive sweating has damaged the body's Yang Qi, Fu Zi (Aconite) is added to warm and restore Yang, stop pathological sweating, and prevent further fluid loss. This is the modification specified in the original Jin Gui Yao Lue text.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yue Bi Tang should not be used or requires extra caution

Avoid

Yin deficiency with internal Heat (a person who is constitutionally dry, flushed, and overheated). Ma Huang (Ephedra) is a powerful diaphoretic that further depletes fluids and Yin, which would worsen the condition.

Avoid

Severe sweating or spontaneous profuse sweating from Qi deficiency. The formula already addresses mild self-sweating from Heat, but if sweating is profuse due to underlying Qi or Yang exhaustion, using heavy-dose Ma Huang risks collapse.

Avoid

Edema due to Spleen Yang deficiency or Kidney Yang deficiency without any exterior pathogenic factor. This formula is designed for 'Wind-Water' edema with external Wind involvement. Internal-origin edema from organ deficiency requires tonifying formulas instead.

Caution

People with high blood pressure or cardiovascular disease. Ma Huang contains ephedrine alkaloids that can raise blood pressure and heart rate, posing a risk to these individuals.

Caution

People with thirst and scanty urine indicating significant fluid depletion. The original text specifically warns that those who are thirsty with frequent urination and loose stools should not be given diaphoretic treatment.

Caution

People with a weak constitution or the elderly. The heavy dose of Ma Huang (the chief herb) is vigorous and dispersing, and may be too harsh for those with weak Qi. Dosage should be significantly reduced or an alternative formula considered.

Caution

Warm or hot weather conditions. The diaphoretic action of the formula is amplified in summer heat, increasing the risk of excessive sweating and fluid loss. Dosages of Ma Huang and Shi Gao should be adjusted according to the season.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Ma Huang (Ephedra) is the chief herb in this formula at a high dose (up to 18 g). Ephedrine and pseudoephedrine in Ma Huang are sympathomimetic agents that can raise blood pressure, increase heart rate, and potentially affect uterine blood flow. The strong diaphoretic and dispersing nature of the formula may also cause excessive sweating and fluid loss, which is undesirable during pregnancy. This formula should generally be avoided unless a qualified practitioner determines that the clinical need outweighs the risk, and dosages should be significantly reduced.

Breastfeeding

Use with caution during breastfeeding. Ma Huang (Ephedra) contains ephedrine and pseudoephedrine, which are known to pass into breast milk. These sympathomimetic alkaloids may cause irritability, poor sleep, or elevated heart rate in a nursing infant. If the formula is clinically necessary, the mother should be advised to monitor the infant for signs of restlessness or feeding difficulties. The other ingredients (Gypsum, Ginger, Licorice, Jujube) are generally considered safe, but the Licorice component may theoretically affect electrolyte balance with prolonged use. Short-term use under practitioner supervision is preferred.

Children

Yue Bi Tang can be used in pediatric cases, and in fact the variant Yue Bi Jia Ban Xia Tang has been reported to be particularly effective for childhood bronchial asthma. However, dosages must be substantially reduced according to the child's age and weight. As a rough guide: children under 6 may use one-quarter to one-third of the adult dose; children 6-12 may use one-third to one-half. Ma Huang dosage requires special caution in children, as they are more sensitive to its stimulant effects (restlessness, rapid heartbeat, difficulty sleeping). It should be avoided in infants under 1 year. A qualified practitioner should always supervise use in children, and the formula should only be used for the acute phase of illness, not for extended periods.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yue Bi Tang

  • Ma Huang (Ephedra) and sympathomimetic drugs or stimulants: Ephedrine in Ma Huang can potentiate the effects of pseudoephedrine, caffeine, amphetamines, and other stimulants, increasing the risk of hypertension, tachycardia, and cardiac arrhythmia.
  • Ma Huang and MAO inhibitors (MAOIs): Concurrent use of ephedrine-containing herbs with MAO inhibitors (such as phenelzine or tranylcypromine) can cause a dangerous hypertensive crisis. This is an absolute contraindication.
  • Ma Huang and antihypertensive medications: Ephedrine may counteract the effects of blood-pressure-lowering drugs such as beta-blockers, ACE inhibitors, or calcium channel blockers, reducing their efficacy.
  • Gan Cao (Licorice) and diuretics or cardiac glycosides (digoxin): Glycyrrhizin in Licorice can cause potassium depletion and sodium retention, which may worsen hypokalemia in patients taking thiazide or loop diuretics, and increase the toxicity of digoxin.
  • Gan Cao and corticosteroids: Licorice may potentiate the effects of corticosteroids by inhibiting cortisol metabolism, potentially increasing the risk of side effects such as edema and hypertension.
  • Ma Huang and anesthetics: Ephedrine may interact with volatile anesthetics (such as halothane), increasing the risk of cardiac arrhythmias. The formula should be discontinued well before any planned surgery.

Usage Guidance

Practical advice for getting the most out of Yue Bi Tang

Best time to take

Warm, divided into 2–3 doses per day, ideally between meals. For acute edema with exterior symptoms, taking a dose before bed may enhance the diaphoretic effect.

Typical duration

Acute use: 3–7 days. This is a strong dispersing formula for acute conditions and should not be taken long-term without reassessment.

Dietary advice

While taking this formula, avoid cold and raw foods (such as ice cream, cold salads, and raw fish) as they can impair the Spleen's ability to transform dampness, which the formula is trying to resolve. Also avoid greasy, oily, and heavily fried foods, as these generate more Dampness and burden the Spleen and Stomach. Salty and heavily seasoned foods should be limited, especially if there is significant edema, since excess salt promotes fluid retention. Light, warm, and easily digestible foods are best, such as plain rice porridge (congee), lightly cooked vegetables, and mild soups. Avoid alcohol, which generates Dampness and Heat internally and may interfere with the formula's action. The classical tradition also advises caution with wind-provoking foods (such as shellfish and certain fermented foods) when treating Wind-related conditions.

Yue Bi Tang originates from Jin Gui Yao Lue (《金匮要略》, Essential Prescriptions of the Golden Cabinet) by Zhang Zhongjing Eastern Han dynasty, circa 200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yue Bi Tang and its clinical use

Original Formula Passage

《金匮要略·水气病脉证并治第十四》 (Jin Gui Yao Lue, Chapter 14: Water-Qi Disease)

风水恶风,一身悉肿,脉浮不渴,续自汗出,无大热,越婢汤主之。

"Wind-water [edema] with aversion to wind, generalized swelling of the whole body, a floating pulse, absence of thirst, continuous spontaneous sweating, and no great heat: Yue Bi Tang governs this."

Modifications Noted in the Original Text

恶风者,加附子一枚(炮);风水,加术四两。

"For those with [pronounced] aversion to wind, add one piece of Fuzi (prepared Aconite). For wind-water [with more severe fluid retention], add four liang of Zhu (Atractylodes)."

Commentary from Yi Fang Ji Jie (《医方集解》)

此足太阳药也,风水在肌肤之间,用麻黄之辛热以泻肺;石膏之甘寒以清胃;甘草佐之,使风水从毛孔中出;又以姜枣为使,调和营卫,不使其太发散耗津液也。

"This is a Foot Taiyang formula. Wind-water lodges between the skin and flesh. Ma Huang's pungent warmth drains the Lungs; Shi Gao's sweet coldness clears the Stomach. Gan Cao assists them, causing the wind-water to exit through the pores. Ginger and Jujube serve as envoys, harmonizing the Ying and Wei, preventing excessive dispersal and fluid exhaustion."

Historical Context

How Yue Bi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yue Bi Tang originates from Zhang Zhongjing's Jin Gui Yao Lue (《金匮要略》, Essential Prescriptions of the Golden Cabinet), written during the Eastern Han dynasty (around 200 CE). It appears in Chapter 14 on Water-Qi diseases, where it is the primary formula for the pattern called feng shui (风水, "Wind-Water" edema).

The name "Yue Bi" (越婢) has been debated for centuries. The Song-dynasty commentator Cheng Wuji argued that "Bi" (婢, meaning a maidservant) refers to the Spleen, which he described as a "humble organ like a servant" that manages water and grain, and that the formula "causes the Spleen-Qi to leap forth" (发越脾气) to move fluids. The Wai Tai Mi Yao (《外台秘要》) indeed records an alternate name, "Yue Pi Tang" (越脾汤, "Spleen-Vaulting Decoction"), supporting this reading. Other scholars such as Fang Youzhi, Yu Jiayan, and Qian Huang offered different interpretations of the name. The formula also appears in the Shang Han Lun in composite form as "Gui Zhi Er Yue Bi Yi Tang" (桂枝二越婢一汤), a combination of two parts Gui Zhi Tang to one part Yue Bi Tang for mild exterior Heat.

Later physicians expanded the formula significantly. Sun Simiao's Bei Ji Qian Jin Yao Fang (《备急千金要方》) records a version adding Bai Zhu and Fu Zi for wind-damp leg weakness. The modern Japanese Kampo tradition has also maintained active use of this formula and its variants. In contemporary clinical practice in China, Yue Bi Tang and its modifications (especially Yue Bi Jia Zhu Tang) are widely used for acute nephritis, nephrotic syndrome edema, urticaria, and respiratory conditions.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Yue Bi Tang

1

Preclinical study: Yue-bi-tang attenuates adriamycin-induced nephropathy edema via Cav-1/eNOS pathway (2023)

Li T, Cheng S, Xu L, Lin P, Shao M. Frontiers in Pharmacology, 2023, 14:1138900.

This animal study used a rat model of nephrotic syndrome induced by Adriamycin. Researchers found that Yue Bi Tang at various doses significantly reduced edema and proteinuria, and decreased renal microvascular permeability. The mechanism was linked to inhibition of the Cav-1/eNOS signaling pathway, which controls vascular endothelial permeability. The study supports the traditional use of this formula for kidney-related edema.

DOI
2

Preclinical study: Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury (2020)

Hu J, Zhang YM, Miao YF, Zhu L, Yi XL, Chen H, et al. World Journal of Gastroenterology, 2020, 26(43): 6810-6821.

This animal study investigated whether Yue Bi Tang could protect against lung and kidney injury in rats with severe acute pancreatitis. Results showed the formula reduced tissue edema in both lung and kidney, lowered the pro-inflammatory cytokine TNF-alpha, and regulated water metabolism by decreasing the expression of aquaporin water channels (AQP1, AQP5 in lungs; AQP1, AQP2 in kidneys). This provides a molecular basis for the formula's traditional edema-clearing action.

DOI
3

Network pharmacology and preclinical study: Exploring the therapeutic mechanism of Yuebi Decoction on nephrotic syndrome (2024)

Yao T, Wang Q, Han S, Xu Y, Chen M, Wang Y. Aging, 2024, 16: doi:10.18632/aging.206116.

This study combined network pharmacology analysis, molecular docking, and an animal experiment using a puromycin aminonucleoside-induced nephrotic syndrome rat model. Researchers identified 124 active ingredients in the formula and 119 overlapping drug-disease targets. The in vivo experiment showed the formula reduced proteinuria and improved renal function, with key targets including AKT1, STAT3, TRPC6, and PPP3CA, supporting the formula's multi-target anti-edema and kidney-protective effects.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.