Yu Ye Tang

Jade Fluid Decoction · 玉液湯

Also known as: Jade Fluid Decoction, Jade Liquid Decoction

A classical formula designed to relieve persistent thirst, frequent urination, and fatigue caused by a combined deficiency of Qi and Yin. It works by strengthening the Spleen to raise vital fluids upward to moisten the Lungs, while nourishing Yin and securing the Kidneys. It is one of the most commonly used traditional formulas for managing symptoms associated with diabetes.

Origin Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录, Records of Heart-Felt Experiences in Medicine with Reference to the West) by Zhang Xichun — Late Qīng dynasty to early Republic of China, first published 1909 CE
Composition 7 herbs
Shan Yao
King
Shan Yao
Huang Qi
King
Huang Qi
Zhi Mu
Deputy
Zhi Mu
Tian Hua Fen
Deputy
Tian Hua Fen
Ge Gen
Assistant
Ge Gen
Ji nei jin
Assistant
Ji nei jin
Wu Wei Zi
Envoy
Wu Wei Zi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yu Ye Tang is designed to correct these specific patterns.

Why Yu Ye Tang addresses this pattern

Yu Ye Tang is the representative formula for Qi and Yin deficiency manifesting as wasting-thirst (xiao ke). When Spleen Qi is too weak to raise clear fluids upward, and Yin is too depleted to moisten the Lungs and Stomach, a vicious cycle develops: the body cannot distribute fluids, thirst intensifies, excessive drinking leads to excessive urination, and the Kidneys cannot retain what little fluid remains. The formula breaks this cycle from multiple angles. Shan Yao and Huang Qi restore the Spleen's Qi to raise fluids upward. Zhi Mu and Tian Hua Fen replenish the depleted Yin and clear the secondary dryness-Heat. Ji Nei Jin helps the Spleen transform nutrients properly rather than losing them in the urine. Wu Wei Zi astringes the Kidneys to retain fluids. The formula thus simultaneously tonifies both Qi and Yin while restoring proper fluid circulation.

A practitioner would look for one or more of these signs

Thirst

Persistent thirst not relieved by drinking water

Frequent Urination

Frequent and copious urination

Eye Fatigue

Fatigue and shortness of breath

Dry Mouth

Dry mouth and throat

Weight Loss

Gradual weight loss despite normal eating

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yu Ye Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands type 2 diabetes as falling within the category of xiao ke (wasting-thirst), a condition involving the Lungs, Spleen/Stomach, and Kidneys. In Zhang Xichun's view, the fundamental problem is that the body's Qi is too weak to rise and carry fluids upward to the Lungs, where they would normally be distributed to moisten the body. This leads to the classic triad of excessive thirst (upper wasting), excessive hunger (middle wasting), and excessive urination (lower wasting). The Spleen's failure to properly transform and transport nutrients means that sugary substances from food are not converted into usable body fluids but instead pass through and are lost in the urine. Underlying Yin deficiency creates internal dryness that further depletes fluids.

Why Yu Ye Tang Helps

Yu Ye Tang addresses the Qi-Yin deficiency pattern that is most commonly seen in type 2 diabetes. Huang Qi and Ge Gen raise the Spleen's clear Yang so that fluids can be distributed rather than lost. Shan Yao strengthens the Spleen, Lung, and Kidney systems that govern fluid metabolism. Ji Nei Jin was specifically chosen by Zhang Xichun because he observed sugar in the urine and believed this herb helps the Spleen transform dietary sugars into usable body fluids. Zhi Mu and Tian Hua Fen cool dryness-Heat and generate fluids to relieve thirst. Wu Wei Zi astringes the Kidneys to reduce the loss of fluids and nutrients through excessive urination. Modern clinical studies have shown that Yu Ye Tang combined with conventional treatment can improve fasting blood glucose and HbA1c levels in type 2 diabetes patients.

Also commonly used for

Diabetes Insipidus

Excessive thirst and urination from fluid metabolism dysfunction

Chronic Pharyngitis

Dry, irritated throat from Yin deficiency

Chronic Gastritis

Stomach dryness with poor appetite and thirst

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yu Ye Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yu Ye Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Yu Ye Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yu Ye Tang works at the root level.

Yu Ye Tang addresses a pattern where the body's Qi has become too weak to carry fluids to where they are needed, while Yin (the body's moistening and cooling resources) has also been depleted. This dual deficiency of Qi and Yin is the root mechanism behind the "wasting-thirst" (Xiao Ke 消渴) pattern this formula targets.

In a healthy body, the Spleen generates Qi from food and drink and "raises the clear" — meaning it sends nourishing substances upward to the Lungs, which then distribute moisture throughout the body. The Kidneys, meanwhile, store essence and prevent precious fluids from leaking away in the urine. When the Spleen's Qi becomes weak, it can no longer lift fluids upward to moisten the mouth and throat, resulting in persistent thirst that drinking water alone cannot relieve. At the same time, deficient Yin means there is not enough "raw material" of moisture in the body, and mild internal Heat from this Yin deficiency further dries what little fluid remains. The Kidneys, also weakened, lose their ability to hold fluids in, so urine becomes frequent and copious — sometimes containing a sweet substance (sugar), which Zhang Xichun astutely recognized as a hallmark of what Western medicine calls diabetes.

The vicious cycle is clear: weak Qi fails to distribute fluids → thirst intensifies → more drinking but fluids are not retained → frequent urination depletes fluids further → Yin deficiency worsens → mild Heat arises → more fluid damage. The formula breaks this cycle by simultaneously strengthening the Qi that lifts and distributes fluids, replenishing the Yin that has been consumed, gently clearing the deficiency Heat, and tightening the Kidney gate to reduce fluid loss through excessive urination.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and slightly bitter — sweet from Shan Yao and Huang Qi to tonify and generate fluids, bitter from Zhi Mu to clear Heat, with a sour note from Wu Wei Zi to astringe and retain fluids.

Channels Entered

Ingredients

7 herbs

The herbs that make up Yu Ye Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Shan Yao

Shan Yao

Yam

Dosage 30g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen
Preparation Must be used raw (生), not dry-fried

Role in Yu Ye Tang

Used raw (sheng) at the heaviest dose in the formula. Tonifies the Spleen, benefits the Lungs, and secures the Kidneys. Its rich, nourishing quality generates fluids and moistens dryness, directly addressing the core mechanism of fluid depletion. Zhang Xichun considered raw Shan Yao his single most important herb for wasting-thirst.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 15g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen
Preparation Must be used raw (生)

Role in Yu Ye Tang

Used raw (sheng) to powerfully tonify Qi and raise the clear Yang of the Spleen and Stomach. When Qi is strong enough to rise, it carries fluids upward to the Lungs so they can be distributed throughout the body, relieving thirst. Paired with Ge Gen, its ascending action is amplified.
Deputies — Assists and enhances the King
Zhi Mu

Zhi Mu

Anemarrhena rhizomes

Dosage 18g
Temperature Cold
Taste Bitter, Sweet
Organ Affinity Kidneys, Lungs, Stomach

Role in Yu Ye Tang

Clears Heat, nourishes Yin, and moistens dryness in the Lungs, Stomach, and Kidneys. Balances the warm, ascending nature of Huang Qi so the formula does not become overly drying. Zhang Xichun likened the pairing of Huang Qi (warm, rising Yang) with Zhi Mu (cool, moistening Yin) to the meeting of rising warmth and gathering clouds that produce rain.
Tian Hua Fen

Tian Hua Fen

Snake gourd roots

Dosage 9g
Temperature Cold
Taste Bitter, Sour, Sweet
Organ Affinity Stomach, Lungs

Role in Yu Ye Tang

Clears Heat, generates fluids, and relieves thirst. Works alongside Zhi Mu to nourish true Yin and moisten the Lungs and Stomach. Its cooling, fluid-generating action directly addresses the dryness and thirst symptoms.
Assistants — Supports or moderates other herbs
Ge Gen

Ge Gen

Kudzu roots

Dosage 4.5g
Temperature Cool
Taste Pungent, Sweet
Organ Affinity Spleen, Stomach

Role in Yu Ye Tang

Raises the clear Yang of the Spleen and Stomach, promoting the upward distribution of fluids to relieve thirst. Assists Huang Qi in elevating Qi so that fluids can reach the Lungs. Also generates fluids and clears mild Heat.
Ji nei jin

Ji nei jin

Chicken gizzard skins

Dosage 6g
Temperature Neutral
Taste Sweet
Organ Affinity Urinary Bladder, Spleen, Stomach, Small Intestine
Preparation Crush finely (捣细) before adding, or grind into powder and stir into the strained decoction

Role in Yu Ye Tang

Strengthens the Spleen and Stomach's digestive and transformative capacity. Zhang Xichun specifically noted that in wasting-thirst the urine contains sugar, and this herb helps the Spleen and Stomach transform the sugary substances in food into usable fluids. Also assists in reducing frequent urination.
Envoy — Directs the formula to its target
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 9g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Yu Ye Tang

Its sour, astringent nature secures the Kidney gate, preventing fluids from leaking downward as excessive urination. Assists Shan Yao in consolidating the Kidneys and retaining Yin fluids, ensuring the generated fluids are not immediately lost.

Why This Combination Works

How the herbs in Yu Ye Tang complement each other

Overall strategy

Yu Ye Tang addresses wasting-thirst (xiao ke) caused by Qi failing to rise and carry fluids upward, combined with underlying Yin deficiency. The formula simultaneously raises Qi to restore proper fluid distribution and nourishes Yin to replenish the depleted fluid reserves, while securing the Kidneys to prevent ongoing fluid loss through excessive urination.

King herbs

Sheng Shan Yao and Sheng Huang Qi together form the core of the formula. Shan Yao, used at the heaviest dose (30g), tonifies the Spleen, benefits the Lungs, and secures the Kidneys, directly replenishing the body's fluid-generating capacity across all three organ systems involved in water metabolism. Huang Qi (15g) powerfully raises Qi upward, restoring the Spleen's ability to "scatter essence to the Lungs" so that fluids can be distributed to moisten the mouth and upper body. Together they address both the root (Qi and Yin deficiency) and the branch (inability to distribute fluids).

Deputy herbs

Zhi Mu and Tian Hua Fen reinforce the Yin-nourishing side of the formula. Zhi Mu clears deficiency-Heat, moistens the Lungs and Kidneys, and critically balances the warm, ascending nature of Huang Qi so the formula does not overshoot into dryness. Zhang Xichun described the pairing of Huang Qi with Zhi Mu as like warm rising air meeting cool gathering clouds, creating the conditions for rain. Tian Hua Fen adds further cooling, fluid-generating power directed at relieving thirst.

Assistant herbs

Ge Gen (reinforcing assistant) works with Huang Qi to raise the clear Yang of the Spleen and Stomach, amplifying the upward transport of fluids. Its own mild fluid-generating quality adds to the thirst-relieving effect. Ji Nei Jin (reinforcing assistant) strengthens the Spleen and Stomach's transformative function from a different angle. Zhang Xichun specifically noted it helps transform sugary substances in food into usable body fluids rather than allowing them to pass through as sugar in the urine.

Envoy herbs

Wu Wei Zi, with its sour and astringent nature, secures the Kidney gate and prevents fluid from rushing downward as excessive urination. It directs the formula's consolidating action to the lower body, ensuring that the fluids generated and raised by the other herbs are retained rather than lost.

Notable synergies

The Huang Qi and Zhi Mu pairing is the hallmark of this formula: Huang Qi warms and raises, Zhi Mu cools and moistens, and together they create a dynamic balance where Qi ascends while Yin responds, likened to clouds forming rain. The Shan Yao and Wu Wei Zi pairing addresses the Kidneys from two angles: Shan Yao nourishes Kidney Yin substantively, while Wu Wei Zi astringes and locks the gate so Yin substance is not leaked away. The Huang Qi and Ge Gen pairing amplifies the upward-raising action, making a small dose of Ge Gen (4.5g) highly effective at lifting fluids to the upper body.

How to Prepare

Traditional preparation instructions for Yu Ye Tang

Add all seven herbs to approximately 600-800 mL of water. Bring to a boil, then reduce heat and simmer for 30-40 minutes. Note that the Ji Nei Jin (chicken gizzard lining) should be finely crushed before adding to the decoction, or alternatively ground into powder and stirred into the strained decoction (taken as a draft). Strain and divide into two portions, taken warm in the morning and evening. One decoction per day.

Common Modifications

How practitioners adapt Yu Ye Tang for specific situations

Added
Ren Shen

6-9g, or substitute Xi Yang Shen (American Ginseng) 9-12g for dual Qi and Yin support

When Qi deficiency is the dominant feature, adding Ren Shen or Xi Yang Shen powerfully supplements the Qi-raising action of Huang Qi. Zhang Xichun himself added wild Tai Shan Shen (野台参) in his case records when the pulse was extremely faint and thin.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yu Ye Tang should not be used or requires extra caution

Avoid

Damp-Heat accumulation or excess Heat patterns (湿热内蕴, 实热证). This formula tonifies and moistens, which can worsen conditions where Dampness or excess pathogenic Heat is the primary problem. Signs include a greasy yellow tongue coating, a slippery rapid pulse, and a feeling of heaviness in the body.

Avoid

Cold-Dampness obstructing the Spleen and Stomach. When the digestive system is bogged down by Cold and Dampness (loose stools, heavy sensation, thick white greasy tongue coating), the Yin-nourishing and cooling herbs in this formula may further impair digestive function.

Caution

Excess-type Xiao Ke (wasting-thirst) due to Lung-Stomach blazing Heat. When vigorous pathogenic Heat is the dominant factor with a strong, forceful pulse, this formula's gentle tonifying approach is insufficient and inappropriate. Formulas that strongly clear Heat and drain Fire should be used instead.

Caution

Severe Kidney Yang deficiency with cold limbs, clear profuse urine, and a deep slow pulse. This formula primarily addresses Qi and Yin deficiency and contains cooling herbs (Zhi Mu, Tian Hua Fen) that may further damage Yang. Kidney Yang-warming formulas like Jin Gui Shen Qi Wan are more appropriate.

Caution

Active diarrhea or loose stools from Spleen deficiency. The large dose of Shan Yao and the cold nature of Zhi Mu may aggravate weak digestion in some patients. Dosages should be adjusted or Spleen-strengthening herbs added.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy based on its ingredient profile. None of the seven herbs (Shan Yao, Huang Qi, Zhi Mu, Tian Hua Fen, Ge Gen, Wu Wei Zi, Ji Nei Jin) are classified as strongly contraindicated in pregnancy. However, Tian Hua Fen (Trichosanthes root) has historically been noted for potential abortifacient effects when used in concentrated injectable preparations (Tian Hua Fen protein), though this concern does not apply to the standard oral decoction doses used in this formula. As a precaution, pregnant women should only take this formula under the guidance of a qualified practitioner, and the Tian Hua Fen dosage should be kept moderate.

Breastfeeding

No specific safety concerns have been identified for breastfeeding mothers. The formula's seven herbs are food-grade or commonly used tonics (Shan Yao is a food, Huang Qi is a widely consumed tonic, Ji Nei Jin is an animal product). None are known to produce toxic metabolites that transfer through breast milk in clinically significant amounts. The formula's gentle Qi-tonifying and Yin-nourishing actions are unlikely to negatively affect milk production or quality. However, the cooling nature of Zhi Mu and Tian Hua Fen means the formula should be discontinued if the infant develops loose stools or digestive upset. Use under practitioner guidance is recommended.

Children

Yu Ye Tang is not a formula traditionally associated with pediatric use, as wasting-thirst (Xiao Ke) with Qi-Yin deficiency is primarily an adult condition. In rare cases where it may be considered for adolescents with diabetes showing clear Qi-Yin deficiency signs, dosages should be reduced to approximately one-third to one-half of adult doses depending on age and body weight. Zhi Mu (Anemarrhena) is cold in nature and should be used cautiously in children, whose digestive systems are inherently more delicate. The formula is generally not suitable for children under 12 without specific practitioner guidance. For younger children with thirst or frequent urination, simpler and milder approaches should be considered first.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yu Ye Tang

Oral hypoglycemic agents and insulin: Yu Ye Tang has demonstrated blood-glucose-lowering effects in both animal studies and clinical practice. When combined with pharmaceutical diabetes medications (metformin, sulfonylureas, insulin, etc.), there is a potential for additive hypoglycemic effects. Blood glucose should be monitored closely and medication dosages may need adjustment.

Anticoagulant and antiplatelet drugs: Huang Qi (Astragalus) and Ge Gen (Pueraria) have mild effects on blood circulation. Patients taking warfarin, aspirin, or other blood-thinning medications should use this formula with caution and have their clotting parameters monitored.

Immunosuppressants: Huang Qi is known to modulate immune function (generally upregulating it). This could theoretically interfere with immunosuppressive therapy in transplant patients or those on such medications for autoimmune conditions.

Usage Guidance

Practical advice for getting the most out of Yu Ye Tang

Best time to take

30 minutes before meals, twice daily (morning and evening), to optimize absorption and the formula's Qi-raising action.

Typical duration

Often taken for 4–12 weeks as a course of treatment, then reassessed. Chronic conditions like diabetes may require intermittent long-term use with periodic practitioner review.

Dietary advice

Avoid sugary, greasy, and rich foods that burden the Spleen and generate Dampness or Heat, as these directly worsen the wasting-thirst pattern this formula treats. Favour whole grains, light vegetables, yams, mung beans, and foods that gently nourish Yin such as pears, lily bulb, and white fungus (Tremella). Alcohol and spicy foods should be minimized, as they generate Heat and damage Yin. Cold and raw foods should be eaten in moderation to protect the Spleen's transforming function. Regular, moderate-sized meals are preferable to large or irregular eating patterns.

Yu Ye Tang originates from Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录, Records of Heart-Felt Experiences in Medicine with Reference to the West) by Zhang Xichun Late Qīng dynasty to early Republic of China, first published 1909 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yu Ye Tang and its clinical use

Zhang Xichun (张锡纯), Yi Xue Zhong Zhong Can Xi Lu (《医学衷中参西录》), section on treating Xiao Ke (消渴):

「消渴一证,多由于元气不升,此方乃升元气以止渴者也。方中以黄芪为主,得葛根能升元气。而又佐以山药、知母、花粉以大滋真阴,使之阳升而阴应,自有云行雨施之妙也。用鸡内金者,因此证尿中皆含有糖质,用之以助脾胃强健,化饮食中糖质为津液也。用五味者,取其酸收之性,大能封固肾关,不使水饮急于下趋也。」

"The condition of wasting-thirst mostly arises from the failure of source Qi to ascend. This formula raises the source Qi to stop thirst. Huang Qi is the chief herb, and with Ge Gen it can raise the source Qi. It is assisted by Shan Yao, Zhi Mu, and Tian Hua Fen to greatly nourish the true Yin, so that when Yang ascends, Yin responds — like clouds forming and rain falling, a wondrous effect. Ji Nei Jin is used because in this condition the urine contains sugar; it helps strengthen the Spleen and Stomach so they can transform the sugar in food into body fluids. Wu Wei Zi is used for its sour astringent nature, which is excellent for sealing and securing the Kidney gate, preventing water and fluids from rushing downward."


Zhang Xichun further elaborated on the rationale for the formula's approach:

「若肺体非热,因元气不升,不能使津上承,当用升元气以止渴,导之上升,此拙拟玉液汤之义也。」

"If the Lung itself is not hot, but rather the source Qi fails to ascend and cannot carry fluids upward, one should raise the source Qi to stop thirst and guide it upward — this is the meaning behind my Yu Ye Tang."

Historical Context

How Yu Ye Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yu Ye Tang (玉液汤, "Jade Fluid Decoction") was created by Zhang Xichun (张锡纯, 1860–1933), one of the most influential Chinese physicians of the modern era. It appears in his masterwork Yi Xue Zhong Zhong Can Xi Lu (《医学衷中参西录》, "Records of Medicine with Reference to East and West"), under the section on treating wasting-thirst (治消渴方). Zhang lived during the turbulent late Qing and early Republican period, a time when Western medicine was rapidly entering China. He became the leading figure of the "Integrating Chinese and Western Medicine" (衷中参西) school of thought, advocating that TCM should remain the foundation while selectively incorporating useful insights from Western medicine.

What makes Yu Ye Tang historically remarkable is Zhang Xichun's strikingly modern observation that the urine of patients with wasting-thirst "contains sugar" (尿中皆含有糖质). He explicitly designed Ji Nei Jin (chicken gizzard lining) to "transform the sugar in food into body fluids" — a concept that foreshadowed modern understanding of glucose metabolism in diabetes. This blend of classical TCM reasoning with proto-scientific observation is characteristic of Zhang's approach. The formula became one of his most celebrated creations alongside formulas like Zhen Gan Xi Feng Tang and Huo Luo Xiao Ling Dan, and it remains widely used today as a foundational formula for Qi-Yin deficiency type diabetes in Chinese clinical practice.

Zhang Xichun's companion formula for more severe Yin-deficient wasting-thirst is Zi Cui Yin (滋膵饮), which emphasizes deeper Yin nourishment. Together, these two formulas represent his complete approach to treating diabetes from the Qi-Yin deficiency perspective.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Yu Ye Tang

1

Network pharmacology and experimental study on mechanism of Yuye Decoction against T2DM (2023)

Guo F, Yao L, Zhang WX, Chen P, Hao R, Huang X, et al. Journal of Ethnopharmacology, 2023, 308: 116222.

This study used UHPLC-MS/MS analysis combined with network pharmacology and animal experiments to explore how Yuye Decoction works against type 2 diabetes. Using a streptozotocin-induced rat model, the researchers found that the formula could protect pancreatic islet beta-cells from dysfunction and apoptosis, potentially through PI3K/AKT1 and Sirt1/FoxO1 signaling pathways.

DOI
2

Integrated 16S rRNA sequencing and metabolomics analysis of Yu-Ye Tang on T2DM rats (2023)

Ma Z, Sun W, Wang L, Wang Y, Pan B, Su X, Li H, Zhang H, Lv S, Wang H. Frontiers in Endocrinology, 2023, 14: 1159707.

This animal study investigated how Yu-Ye Tang affects gut microbiota and metabolism in diabetic rats. Results showed the formula significantly reduced blood glucose, improved liver and kidney function markers, lowered pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), and beneficially altered gut bacteria composition by increasing Lactobacillus and Bacteroides while decreasing harmful species.

DOI
3

Review of therapeutic effects of Yuye Decoction on diabetes and its complications (2020)

Wan JH, Lam KH, Song TH, Ho PS, Leung LL, Fong TL, et al. Integrative Medicine Research, 2020.

This review compiled 88 studies on the individual herbs in Yuye Decoction and their anti-diabetic mechanisms. It found evidence that the formula's components can improve diabetes through diverse pathways including improving insulin sensitivity, protecting beta-cells, reducing oxidative stress, and modulating lipid metabolism. The authors noted that well-designed randomized controlled trials on the complete formula are still needed.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.