Qi Wei Du Qi Wan

Seven-Ingredient Capital Qi Pill · 七味都氣丸

Also known as: Du Qi Wan (都氣丸), Du Qi Wan (都炁丸), Capital Qi Pill,

A classical formula that strengthens the Kidneys' ability to anchor breathing and control the body's vital fluids. It is used for chronic shortness of breath, wheezing, cough, night sweats, and frequent urination caused by Kidney weakness. Built on the famous Liu Wei Di Huang Wan with the addition of Schisandra fruit to help the Kidneys "grasp" Qi during inhalation.

Origin Zhang Shi Yi Tong (張氏醫通) by Zhang Lu (張璐) — Qīng dynasty, 1695 CE
Composition 7 herbs
Shu Di huang
King
Shu Di huang
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Wu Wei Zi
Deputy
Wu Wei Zi
Ze Xie
Assistant
Ze Xie
Fu Ling
Assistant
Fu Ling
Mu Dan Pi
Assistant
Mu Dan Pi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qi Wei Du Qi Wan is designed to correct these specific patterns.

Why Qi Wei Du Qi Wan addresses this pattern

Kidney Yin deficiency is the root cause that Qi Wei Du Qi Wan addresses. When Kidney Yin is depleted, the Kidneys lose their capacity to store essence and anchor Qi. Shu Di Huang directly replenishes the depleted Kidney Yin, while Shan Zhu Yu and Shan Yao support the Liver and Spleen respectively to generate and secure essence. The three draining herbs (Ze Xie, Fu Ling, Mu Dan Pi) prevent the formula from becoming overly heavy and cloying, ensuring that the Yin nourishment is properly absorbed. Wu Wei Zi adds a critical astringent layer that prevents the ongoing leakage of Yin fluids through sweating, emission, and frequent urination.

A practitioner would look for one or more of these signs

Lower Back Pain

Soreness and weakness of the lower back and knees

Night Sweats

Night sweats from Yin deficiency failing to contain fluids

Nocturnal Emission

Seminal emission due to Kidney failing to store essence

Tinnitus

Ringing in the ears from Kidney deficiency

Dry Throat

Dryness of throat from insufficient Yin fluids

Frequent Urination

Frequent urination from Kidney failing to control the water passages

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qi Wei Du Qi Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Kidney Not Grasping Qi Lung and Kidney Yang Deficiency

TCM Interpretation

In TCM, chronic asthma is often understood as a disorder of the Lung-Kidney axis. While acute attacks may involve the Lungs primarily, the root of chronic, recurrent asthma frequently lies in the Kidneys. The Kidneys are said to "grasp" Qi: they receive the Qi that the Lungs send downward during inhalation and anchor it in the lower body. When Kidney Yin is depleted (from chronic illness, aging, or constitutional weakness), this anchoring function fails. Qi floats upward, creating dyspnea that characteristically worsens with exertion and features more exhalation than inhalation. The Kidney deficiency also impairs fluid metabolism, leading to dry airways and a tendency toward recurrent episodes.

Why Qi Wei Du Qi Wan Helps

Qi Wei Du Qi Wan targets the root mechanism of chronic asthma by rebuilding Kidney Yin (via Shu Di Huang) and restoring the Kidneys' ability to grasp Qi (via Wu Wei Zi). Wu Wei Zi astringes Lung Qi and helps anchor it downward, directly addressing the impaired Qi reception that drives the dyspnea. Modern research has shown that Qi Wei Du Qi Wan can inhibit mast cell degranulation, suggesting a mechanism by which it may reduce airway hyperreactivity in allergic asthma. The formula works best for chronic, deficiency-type asthma rather than acute attacks driven by external pathogens.

Also commonly used for

Chronic Bronchitis

Chronic bronchitis with weak, persistent cough

Emphysema

Emphysema with shortness of breath on exertion

Night Sweats

Night sweats from Yin deficiency

Frequent Urination

Urinary frequency from Kidney Qi insufficiency

Chronic Coughing

Chronic cough with deficiency pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qi Wei Du Qi Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qi Wei Du Qi Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qi Wei Du Qi Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qi Wei Du Qi Wan works at the root level.

In TCM theory, the Kidneys and Lungs share a vital partnership in breathing. The Lungs govern inhalation and exhalation, but the Kidneys are responsible for "grasping" or "receiving" the inhaled Qi and drawing it downward. When Kidney Yin becomes depleted, this grasping function weakens. Qi that should descend and be anchored by the Kidneys instead rebels upward, creating a pattern of shallow breathing where exhalation is long but inhalation is short and labored. This is the core concept of "Kidney failing to receive Qi" (肾不纳气).

As Kidney Yin declines, the body loses its ability to nourish and moisten. Deficiency Heat may arise, producing dry throat, night sweats, and a flushed face. The Kidney's role as the root of the body's consolidating function also weakens: Essence leaks out as seminal emission, fluids are poorly held leading to frequent urination, and the Lung's own Qi scatters because it has lost its anchor below. The result is a cluster of symptoms including chronic cough, wheezing, shortness of breath, chest tightness, night sweats, dry throat, and seminal emission, all stemming from the same root of depleted Kidney Yin failing to perform its grasping and consolidating duties.

This formula addresses the problem by deeply nourishing Kidney Yin to restore the root, while simultaneously using astringent herbs to pull scattered Qi back down and lock it in place. Rather than simply treating the cough or wheezing at the Lung level, the strategy goes to the source: replenish the Kidney, re-establish the downward pull on Qi, and secure what is leaking.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and sour, with mild bitterness. Sweet to nourish and tonify, sour to astringe and consolidate, with a bland undertone from Fu Ling and Ze Xie to gently drain excess moisture.

Channels Entered

Kidney Lung Liver Spleen

Ingredients

7 herbs

The herbs that make up Qi Wei Du Qi Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 24 - 30g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Qi Wei Du Qi Wan

Richly nourishes Kidney Yin and fills the essence (Jing). As the herb with the largest dosage in the formula, it directly addresses the root deficiency of Kidney Yin, providing the material foundation that the Kidneys need to anchor Qi and support their storing function.
Deputies — Assists and enhances the King
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 9 - 12g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in Qi Wei Du Qi Wan

Nourishes and astringes the Liver and Kidneys, securing the essence and preventing leakage. Reinforces the King herb by consolidating the Kidney Yin that Shu Di Huang generates, while also addressing seminal emission and excessive sweating.
Shan Yao

Shan Yao

Yam

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Qi Wei Du Qi Wan

Tonifies the Spleen and Kidneys simultaneously. By strengthening the Spleen, it ensures ongoing production of postnatal essence to replenish the Kidneys. Its mild astringent quality also helps stabilize the Kidneys' holding function.
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 6 - 9g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs
Preparation Vinegar-processed (醋制) form is standard

Role in Qi Wei Du Qi Wan

The distinguishing addition to Liu Wei Di Huang Wan. Astringes Lung Qi and supplements the Kidneys, helping the Kidneys grasp the Qi that the Lungs send downward during inhalation. Its sour and astringent nature also helps stop seminal emission, night sweats, and chronic cough.
Assistants — Supports or moderates other herbs
Ze Xie

Ze Xie

Water plantain

Dosage 6 - 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Qi Wei Du Qi Wan

Drains Kidney turbidity and promotes urination to clear dampness. Prevents the rich, cloying nature of Shu Di Huang from creating stagnation, ensuring the formula tonifies without generating pathological dampness.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 6 - 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Qi Wei Du Qi Wan

Strengthens the Spleen and leaches dampness. Works alongside Shan Yao to support Spleen function and alongside Ze Xie to prevent dampness accumulation, keeping the formula balanced between tonification and drainage.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 6 - 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Qi Wei Du Qi Wan

Clears deficiency Heat from the Liver and cools the Blood. Prevents the warm, tonifying herbs from generating unwanted Heat, and specifically addresses the Liver Fire that can arise from Kidney Yin deficiency. Complements Shan Zhu Yu by clearing what the Liver cannot regulate when Yin is depleted.

Why This Combination Works

How the herbs in Qi Wei Du Qi Wan complement each other

Overall strategy

This formula addresses Kidney Yin deficiency that has compromised the Kidneys' ability to "grasp" (receive) Qi during inhalation, leading to breathing difficulties and loss of essence. The prescription strategy combines rich Yin tonification with astringent herbs to both replenish what has been lost and prevent further leakage, while three drainage herbs keep the formula from becoming overly cloying.

King herbs

Shu Di Huang (prepared Rehmannia root) serves as King with the largest dosage, directly filling the depleted Kidney Yin and essence. Its rich, sweet, slightly warm nature enters the Kidney channel and provides the substantial material basis that the Kidneys require to perform their storing and anchoring functions.

Deputy herbs

Three Deputies support the King from complementary angles. Shan Zhu Yu nourishes the Liver and Kidneys while astringently securing essence, preventing the ongoing leakage of vital substances. Shan Yao tonifies the Spleen to ensure the postnatal source of essence remains productive, supporting the Kidneys indirectly through the Spleen's transformative function. Wu Wei Zi is the signature addition that distinguishes this formula from Liu Wei Di Huang Wan: its sour, astringent nature enters both the Lung and Kidney channels, directly helping the Kidneys grasp the Qi that descends from the Lungs during breathing, while also stabilizing sweating and reducing seminal loss.

Assistant herbs

Ze Xie (restraining assistant) drains Kidney turbidity and dampness, preventing Shu Di Huang's rich, cloying nature from creating stagnation. Fu Ling (reinforcing assistant) strengthens the Spleen and leaches dampness, working alongside Shan Yao to maintain healthy Spleen function. Mu Dan Pi (restraining assistant) clears deficiency Heat from the Liver, addressing the secondary heat that commonly arises when Kidney Yin is depleted and preventing the tonifying herbs from generating excessive warmth.

Notable synergies

The classical "three tonifying, three draining" (三补三泻) structure of Liu Wei Di Huang Wan is preserved: Shu Di Huang nourishes Kidney Yin while Ze Xie drains Kidney turbidity; Shan Zhu Yu nourishes the Liver while Mu Dan Pi clears Liver Heat; Shan Yao tonifies the Spleen while Fu Ling leaches Spleen dampness. Wu Wei Zi adds a powerful astringent dimension that bridges the Lung-Kidney axis, ensuring the Kidneys can anchor Qi received from the Lungs. The pairing of Wu Wei Zi with Shan Zhu Yu creates a particularly strong astringent effect that addresses both respiratory symptoms (cough, wheezing) and essence loss (emission, sweating) simultaneously.

How to Prepare

Traditional preparation instructions for Qi Wei Du Qi Wan

Grind all seven herbs into a fine powder, sift, and mix evenly. For every 100g of powder, combine with 30g of refined honey and an appropriate amount of water to form pills. Dry the pills thoroughly. The standard dosage is 9g taken orally, twice daily. Store sealed in a cool, dry place.

The formula may also be prepared as a decoction (water-based brew) using the standard proportions: Shu Di Huang 24g, Shan Zhu Yu 12g, Shan Yao 12g, Ze Xie 9g, Fu Ling 9g, Mu Dan Pi 9g, Wu Wei Zi 6g. Decoct in water and take in two divided doses daily.

Common Modifications

How practitioners adapt Qi Wei Du Qi Wan for specific situations

Added
Zi Su Zi

9g, descends Lung Qi and resolves phlegm

Bai Qian

9g, redirects Qi downward and expels phlegm

Chen Pi

6g, regulates Qi and dries dampness

Ban Xia

9g, dries dampness and transforms phlegm

When chronic cough is accompanied by abundant phlegm, the base formula's astringent nature could trap phlegm inside. These herbs descend Qi, dry dampness, and help expel phlegm before the astringent herbs close the gate.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qi Wei Du Qi Wan should not be used or requires extra caution

Avoid

External pathogenic invasion (common cold, flu, or acute febrile illness). Using tonifying and astringent herbs during an exterior pattern can trap the pathogen inside the body and worsen the condition.

Avoid

Kidney Yang deficiency with pronounced Cold signs such as cold limbs, pale complexion, watery stools, and clear profuse urination. This formula nourishes Yin and does not warm Yang, so it may aggravate Yang deficiency patterns.

Caution

Spleen deficiency with significant Dampness, loose stools, or poor appetite. The formula contains rich, cloying Yin-nourishing herbs (especially Shu Di Huang) that can burden weak digestion.

Avoid

Cough or wheezing due to Phlegm-Heat or Wind-Cold obstruction in the Lungs. The astringent nature of Wu Wei Zi and Shan Zhu Yu can trap pathogenic factors, making this formula inappropriate for excess-type respiratory conditions.

Caution

Patients with excessive Dampness or edema. The Yin-nourishing herbs may worsen fluid accumulation, though the formula does contain some draining herbs (Ze Xie, Fu Ling).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy as it contains no known abortifacient or strongly moving herbs. All seven ingredients are mild tonifying, draining, or astringent substances without uterine-stimulating properties. However, the richly cloying nature of Shu Di Huang (prepared Rehmannia) may aggravate nausea or digestive discomfort in pregnancy. Use should be guided by a qualified practitioner who can assess whether the pattern fits and adjust the formula as needed.

Breastfeeding

No specific concerns have been documented for use during breastfeeding. The formula's ingredients are standard tonifying and astringent herbs without known toxicity or compounds likely to adversely affect breast milk composition or infant health. Shu Di Huang (prepared Rehmannia) is rich and cloying and may occasionally cause digestive upset in the mother, which could indirectly affect breastfeeding comfort. A practitioner should confirm the diagnosis before use and monitor for any digestive symptoms.

Children

Qi Wei Du Qi Wan can be used in children, as its parent formula Liu Wei Di Huang Wan was originally developed as a pediatric medicine by the Song dynasty physician Qian Yi. Dosage should be reduced according to the child's age and weight, typically to one-third to one-half of the adult dose. For young children, the pills can be crushed and dissolved in warm water for easier administration. It is most appropriate for older children showing clear signs of Kidney Yin deficiency with respiratory symptoms such as chronic cough or asthma with a deficiency pattern. It is not suitable for acute respiratory infections in children. A practitioner should confirm the diagnosis before use.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qi Wei Du Qi Wan

Diuretics: The formula contains Ze Xie (Alisma) and Fu Ling (Poria), both of which promote urination. Concurrent use with pharmaceutical diuretics (e.g. furosemide, hydrochlorothiazide) may have an additive diuretic effect, potentially increasing the risk of dehydration or electrolyte imbalance.

Antidiabetic medications: Some studies on Liu Wei Di Huang Wan and its derivatives suggest a mild blood-sugar-lowering effect. Patients taking insulin or oral hypoglycemic agents should monitor blood glucose carefully, as combined use may increase the risk of hypoglycemia.

Immunosuppressants: Research on the Liu Wei Di Huang Wan family shows immune-modulating properties. Patients on immunosuppressive therapy (e.g. cyclosporine, tacrolimus) should use this formula with caution, as it may alter immune function in ways that interact with their medication regimen.

Usage Guidance

Practical advice for getting the most out of Qi Wei Du Qi Wan

Best time to take

Traditionally taken on an empty stomach with lightly salted warm water (淡盐汤送下), typically in the morning and evening, 30 minutes before meals.

Typical duration

Often taken as a course of 4 to 8 weeks for chronic conditions, then reassessed by a practitioner. May be used longer-term for deeply rooted Kidney Yin deficiency patterns.

Dietary advice

Avoid cold, raw, and greasy foods while taking this formula, as these can burden the Spleen and impair absorption of the rich Yin-nourishing herbs. Limit excessively spicy or hot foods, which can further deplete Yin and counteract the formula's cooling, moistening action. Foods that gently support the Kidneys and Yin are beneficial, such as black sesame seeds, walnuts, goji berries, yam, and pears. Adequate hydration is encouraged. Avoid excessive caffeine and alcohol, both of which can further dry and heat the system.

Qi Wei Du Qi Wan originates from Zhang Shi Yi Tong (張氏醫通) by Zhang Lu (張璐) Qīng dynasty, 1695 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qi Wei Du Qi Wan and its clinical use

Formula song verse (方歌):

「都气五味纳肾气,滋补肺肾麦味续」

"Du Qi [Wan] with Wu Wei Zi draws Qi down to the Kidneys; nourishing the Lungs and Kidneys, adding Mai Dong and Wu Wei Zi continues [the treatment]."

This verse from the traditional formula song of the Liu Wei Di Huang Wan family highlights how adding Wu Wei Zi (Schisandra) to the six-ingredient Rehmannia base specifically addresses the Kidney's failure to grasp Qi, giving the formula its distinctive capacity to anchor rebellious Qi downward.


From the Yi Zong Ji Ren Bian (医宗己任编):

「阴火呃逆,脉两尺洪盛或弦细而数,面时赤」

"Yin-Fire hiccup, with a pulse that is flooding and strong at both chi positions, or wiry-thin and rapid, with intermittent facial flushing."

This passage from Gao Gufen's Qing dynasty text describes one of the formula's classical indications: hiccup caused by deficiency Fire rising from the Kidneys, a pattern where the Kidney Yin is too depleted to anchor Qi and Fire downward.


From the Yi Chao Lei Bian (医钞类编):

「伤肾咳嗽,气逆烦冤,牵引腰痛,俯仰不利」

"Cough from Kidney damage, with rebellious Qi, irritability and constraint, pulling pain in the lower back, and difficulty bending forward or backward."

This passage identifies the formula's use for cough rooted in Kidney deficiency rather than a Lung problem alone, where the inability of the Kidneys to receive Qi manifests as both respiratory and lumbar symptoms.

Historical Context

How Qi Wei Du Qi Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qi Wei Du Qi Wan (Seven-Ingredient Capital Qi Pill) is a member of the famous Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) family. The base formula, Liu Wei Di Huang Wan, was created by the Song dynasty pediatrician Qian Yi (钱乙) in his Xiao Er Yao Zheng Zhi Jue (Key to Therapeutics of Children's Diseases), itself a simplification of Zhang Zhongjing's earlier Jin Gui Shen Qi Wan by removing the warming herbs Gui Zhi and Fu Zi. Du Qi Wan was formed by adding a single herb, Wu Wei Zi (Schisandra fruit), to this six-ingredient base, specifically to enhance the formula's ability to astringe Lung Qi and help the Kidneys grasp Qi.

The formula is recorded in the Qing dynasty text Yi Fang Ji Jie (Collected Explanations of Medical Formulas, 1682) by Wang Ang (汪昂), and also appears in the Yi Zong Ji Ren Bian (Medical Tradition of Personal Responsibility) by the Qing physician Gao Gufen (高鼓峰). It is listed in the modern Chinese Pharmacopoeia as an officially recognized prepared medicine. As a derivative of the Liu Wei Di Huang Wan system, it sits alongside other famous variants such as Zhi Bai Di Huang Wan (adding Zhi Mu and Huang Bai), Qi Ju Di Huang Wan (adding Gou Qi Zi and Ju Hua), and Mai Wei Di Huang Wan (adding Mai Dong and Wu Wei Zi). Each variant targets a different clinical extension of Kidney Yin deficiency, and Du Qi Wan's specific focus on grasping Qi made it particularly valued for chronic respiratory conditions rooted in Kidney weakness.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Qi Wei Du Qi Wan

1

Qi-Wei-Du-Qi-Wan and its major constituents exert an anti-asthmatic effect by inhibiting mast cell degranulation (Preclinical animal study, 2020)

Lin LJ, Wu CJ, Wang SD, Kao ST. Journal of Ethnopharmacology, 2020, 254: 112403.

This study used a mouse model of chronic asthma induced by house dust mite allergen. The researchers found that Qi Wei Du Qi Wan significantly reduced airway hyperreactivity, lowered total and allergen-specific IgE levels in blood, and decreased inflammatory cell infiltration in the lungs. The formula also suppressed the release of multiple inflammatory signaling molecules. Further cell-based experiments identified that quercetin, beta-carotene, and luteolin from the formula's ingredients were key compounds responsible for inhibiting mast cell degranulation, a critical step in allergic reactions.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.