Gui Ling Wu Wei Gan Cao Tang

Cinnamon Twig, Poria, Schisandra, and Licorice Decoction · 桂苓五味甘草湯

Also known as: Fu Ling Gui Zhi Wu Wei Zi Gan Cao Tang (茯苓桂枝五味甘草湯), Ling Gui Wei Gan Tang (苓桂味甘湯)

A classical formula used to warm Yang, subdue rebellious Qi rushing upward from the lower abdomen, and resolve congested fluid accumulation. It is typically used in the aftermath of a cold disorder (often after Xiao Qing Long Tang), when underlying Kidney Yang deficiency allows Qi to surge upward, causing dizziness, palpitations, flushing, and cold extremities.

Origin Jin Gui Yao Lue (Essential Prescriptions from the Golden Cabinet) by Zhang Zhongjing — Hàn dynasty, ~200 CE
Composition 4 herbs
Gui Zhi
King
Gui Zhi
Fu Ling
Deputy
Fu Ling
Wu Wei Zi
Assistant
Wu Wei Zi
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Ling Wu Wei Gan Cao Tang is designed to correct these specific patterns.

Why Gui Ling Wu Wei Gan Cao Tang addresses this pattern

This formula addresses Kidney Yang deficiency in a specific clinical context: when weakened Kidney Yang fails to anchor Qi in the lower body, allowing it to surge rebelliously upward. The original Jin Gui Yao Lue passage describes this occurring after use of Xiao Qing Long Tang in someone with pre-existing Kidney Yang weakness. The strong dispersing action of that formula destabilizes the Kidney's grasping function, triggering Qi to rush from the lower abdomen to the chest and throat. Gui Zhi warms Yang to restore its descending governance, Fu Ling drains the accumulated fluid that accompanies Yang deficiency, Wu Wei Zi astringes the Kidneys to re-establish their holding function, and Zhi Gan Cao supports the middle burner to regenerate Yang Qi.

A practitioner would look for one or more of these signs

Palpitations

Heart palpitations from Qi surging upward and fluid disturbing the Heart

Cold Extremities

Cold hands and feet reflecting Yang deficiency and misdirected Qi

Dizziness

Dizziness and muddled consciousness from turbid Yin rising to the head

Difficulty Urinating

Difficulty urinating as fluid metabolism is impaired

Facial Flushing

Face flushing hot as if intoxicated, from deficient Yang floating upward

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gui Ling Wu Wei Gan Cao Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic bronchitis with thin, watery sputum and a cold constitution often reflects a pattern where the Lungs are congested with cold fluid (cold-phlegm or cold-fluid retention). The root cause lies deeper: the Kidney Yang (and often Spleen Yang) is too weak to properly transform and move fluid through the body. Instead, fluid stagnates and collects in the chest, impairing the Lung's descending and dispersing functions. This is especially relevant in patients who have had repeated acute episodes treated with strong dispersing therapies, which can further weaken the underlying Yang.

Why Gui Ling Wu Wei Gan Cao Tang Helps

Gui Ling Wu Wei Gan Cao Tang addresses both the branch symptom (fluid congestion in the chest) and the root cause (Yang deficiency allowing Qi and fluid to rebel upward). Gui Zhi warms Yang and transforms cold fluid. Fu Ling drains the accumulated fluid downward through urination. Wu Wei Zi astringes the Lungs to stop the cough cycle and prevents further loss of Lung Qi. Zhi Gan Cao supports the middle burner so it can resume its role in fluid metabolism. Together, these four herbs restore the normal downward movement of Qi and fluid, clearing congestion from the chest.

Also commonly used for

Asthma

Cold-type asthma with watery phlegm and Yang deficiency

Dizziness

Dizziness and vertigo from turbid Yin ascending

Meniere's Disease

When pattern matches fluid accumulation with Yang deficiency

Pulmonary Congestion

Congested fluid in the lungs with cold constitution

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gui Ling Wu Wei Gan Cao Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gui Ling Wu Wei Gan Cao Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gui Ling Wu Wei Gan Cao Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gui Ling Wu Wei Gan Cao Tang works at the root level.

This formula addresses a specific clinical scenario described in the Jin Gui Yao Lue: a patient with pre-existing Kidney Yang deficiency who has been treated with Xiao Qing Long Tang for an external cold pattern with internal fluid accumulation. Xiao Qing Long Tang is a powerful diaphoretic formula, and in a constitutionally weak patient, its pungent, dispersing herbs can over-stimulate and deplete the body's Yang Qi, particularly the Kidney Yang that normally anchors Qi in the lower body.

When Kidney Yang becomes too weak to "hold down" the body's Qi, a distinctive pathological movement occurs: Qi rushes rebelliously upward from the lower abdomen toward the chest and throat. This is related to what classical texts call "running piglet" (Ben Tun) Qi. At the same time, because Yang is deficient, fluids are no longer being properly transformed and transported. Cold watery fluids (yin pathogenic fluids) accumulate internally, compounding the upward counterflow. The patient may experience cold extremities, dizziness, facial flushing (from the rebellious Yang floating upward), difficulty urinating, palpitations, and a sensation of Qi surging from below.

The core disease mechanism is therefore twofold: (1) Kidney Yang deficiency failing to anchor Qi downward, leading to counterflow surging, and (2) cold fluid accumulation due to impaired Yang transformation of water. The formula must simultaneously warm and restore Yang, subdue the upward-surging Qi, drain accumulated fluids, and astringe the depleted Lung and Kidney Qi to prevent further leakage.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and sour, with mild pungency. The sweet taste (from Fu Ling, Zhi Gan Cao, and Wu Wei Zi) tonifies and harmonizes, the sour taste (from Wu Wei Zi) astringes and contains leaking Qi, and the pungent taste (from Gui Zhi) warms Yang and promotes circulation.

Channels Entered

Lung Heart Kidney Bladder Spleen

Ingredients

4 herbs

The herbs that make up Gui Ling Wu Wei Gan Cao Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Gui Zhi

Gui Zhi

Cinnamon twigs

Dosage 9 - 12g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Gui Ling Wu Wei Gan Cao Tang

Warms Heart Yang and subdues rebellious Qi surging upward from the lower abdomen. By restoring Yang's governing function in the upper body, it calms the upward rushing of cold water Qi. Paired with Zhi Gan Cao, it forms the core of Gui Zhi Gan Cao Tang, which specifically warms and supports Heart Yang.
Deputy — Assists and enhances the King
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Gui Ling Wu Wei Gan Cao Tang

Strengthens the Spleen and promotes water metabolism by draining accumulated fluid downward through the urinary pathway. Calms the Heart and settles palpitations caused by water Qi disturbing the Heart. Supports Gui Zhi in resolving the underlying fluid stagnation.
Assistant — Supports or moderates other herbs
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 6 - 12g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Gui Ling Wu Wei Gan Cao Tang

Astringes Lung Qi and contains the Kidneys to prevent further leakage and upward surging of Qi. Its sour and warm nature restrains dispersed Kidney Qi that has been destabilized (e.g. by prior use of Xiao Qing Long Tang). Prevents the warming and dispersing herbs from over-scattering the body's Qi.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 6 - 9g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Gui Ling Wu Wei Gan Cao Tang

Tonifies the middle burner and harmonizes the other herbs. Together with Gui Zhi, creates a sweet-acrid combination that generates Yang Qi. Moderates the formula and protects the Stomach.

Why This Combination Works

How the herbs in Gui Ling Wu Wei Gan Cao Tang complement each other

Overall strategy

This formula addresses a scenario where Kidney Yang is deficient and Qi surges rebelliously upward from the lower abdomen, often after an externally-contracted cold disorder has been treated with strong dispersing formulas like Xiao Qing Long Tang. The strategy is to warm Yang to re-establish its governing and descending function, drain accumulated fluid, and astringe the Kidneys to prevent further Qi from escaping upward.

King herbs

Gui Zhi (Cinnamon Twig) is the King herb. It warms Heart Yang and powerfully directs rebellious Qi downward. In the classical context, the patient's Qi surges from the lower abdomen up to the chest and throat. Gui Zhi restores the downward-governing function of Yang, calming this upward counterflow. Its warm, acrid nature also assists in transforming accumulated cold fluid.

Deputy herbs

Fu Ling (Poria) serves as Deputy. It promotes urination to drain the congested fluid that underlies the upward surging, while also calming the Heart to address palpitations. By draining fluid through the Bladder pathway, it removes the material basis of the pathology and supports Gui Zhi's warming action from below.

Assistant herbs

Wu Wei Zi (Schisandra) acts as a restraining Assistant. Its sour, astringent nature collects and stabilizes Lung and Kidney Qi that has been scattered or destabilized. It prevents the warming, dispersing action of Gui Zhi from further dissipating the body's already weakened Qi, and specifically contains the Kidneys so that Qi no longer escapes upward. This creates a crucial balance: warming without over-dispersing.

Envoy herbs

Zhi Gan Cao (honey-prepared Licorice) harmonizes the formula and tonifies the middle burner. Paired with Gui Zhi, it forms the well-known acrid-sweet Yang-generating combination (Gui Zhi Gan Cao Tang). It also moderates the other herbs and protects the digestive system.

Notable synergies

The Gui Zhi and Zhi Gan Cao pairing is the core of Gui Zhi Gan Cao Tang, specifically targeting Heart Yang deficiency and calming upward surging Qi. The contrast between dispersing Gui Zhi and astringent Wu Wei Zi creates a dynamic balance: one warms and moves, the other collects and contains, ensuring Qi is directed downward without being lost. Fu Ling and Gui Zhi together form a warming-plus-draining strategy that transforms cold fluid from two angles simultaneously.

How to Prepare

Traditional preparation instructions for Gui Ling Wu Wei Gan Cao Tang

Combine the four herbs with approximately 1600 ml of water. Bring to a boil and simmer until the liquid is reduced to about 600 ml. Strain to remove the dregs. Divide into three equal portions and take warm, three times daily.

The original text states: "Right four ingredients, use eight sheng of water, cook down to three sheng, remove the dregs, divide into three warm doses" (右四味,以水八升,煮取三升,去滓,分温三服).

Common Modifications

How practitioners adapt Gui Ling Wu Wei Gan Cao Tang for specific situations

Added
Gan Jiang

9g, warms the Lungs and Spleen to transform cold phlegm-fluid

Xi Xin

3-6g, disperses cold from the Lungs and resolves stagnant fluid

Removed
Gui Zhi

Removed because the Qi surging has already been subdued; Gui Zhi's ascending nature is no longer needed

This is the classical modification described in the Jin Gui Yao Lue. Once the rebellious Qi is calmed, the remaining problem is cold phlegm-fluid lodged in the Lungs causing cough and chest fullness. Removing Gui Zhi and adding Gan Jiang and Xi Xin redirects the formula toward warming the Lungs and expelling cold fluid. This modified formula is known as Ling Gan Wu Wei Jiang Xin Tang.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gui Ling Wu Wei Gan Cao Tang should not be used or requires extra caution

Avoid

Yin deficiency with Heat signs. This formula is warming in nature and uses astringent herbs. It should not be used when there is true Yin deficiency fire with dry mouth, night sweats, red tongue with little coating, and rapid pulse.

Avoid

Exterior Wind-Cold patterns that have not been resolved. Although this formula was designed as a follow-up after Xiao Qing Long Tang, it should not be used while the original external pathogen remains active on the body surface.

Avoid

Phlegm-Heat or Damp-Heat conditions. The warming nature of Gui Zhi and the astringent quality of Wu Wei Zi would trap Heat and worsen the condition.

Caution

Patients with uncontrolled hypertension. Gan Cao (Licorice) has mineralocorticoid-like effects that can promote sodium and water retention, potentially raising blood pressure with prolonged use.

Caution

Patients with hypokalemia or those on potassium-depleting medications. Gan Cao can further lower potassium levels.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Gui Zhi (Cinnamomi Ramulus) is a warming, circulation-promoting herb that could theoretically increase uterine activity. Gan Cao (Glycyrrhizae Radix) has mineralocorticoid-like effects that may contribute to fluid retention and blood pressure elevation; some research suggests it may have estrogenic activity and could increase the risk of preterm birth. While none of the four herbs in this formula are classified as strictly forbidden in pregnancy, the combination should only be used under professional supervision if clearly indicated, and alternative approaches should be considered where possible.

Breastfeeding

No specific contraindication during breastfeeding has been established for this formula. All four ingredients (Fu Ling, Gui Zhi, Wu Wei Zi, Zhi Gan Cao) are considered relatively mild. However, Gan Cao (Licorice) in sustained or high doses may affect fluid balance and electrolytes, which could theoretically influence milk composition. Gui Zhi's warming properties are unlikely to be problematic at standard doses. As with any herbal formula during breastfeeding, use should be guided by a qualified practitioner and limited to the shortest effective duration.

Children

This formula may be used in children when the pattern clearly matches, but dosage must be significantly reduced according to age and body weight. A general guideline is one-third to one-half of the adult dose for children aged 6 to 12, and one-quarter for children under 6. Because the formula was designed for a specific post-treatment complication scenario (after Xiao Qing Long Tang), pediatric use should be supervised by an experienced practitioner. The Gan Cao (Licorice) component should be monitored, as children may be more sensitive to its mineralocorticoid-like effects on fluid and electrolyte balance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gui Ling Wu Wei Gan Cao Tang

Gan Cao (Glycyrrhizae Radix) is the primary source of drug interaction concern in this formula:

  • Cardiac glycosides (e.g. digoxin): Gan Cao's glycyrrhizin component can cause potassium depletion (pseudoaldosteronism), which increases the heart's sensitivity to digoxin and may precipitate digoxin toxicity with dangerous arrhythmias. Concurrent use should be avoided.
  • Antihypertensive medications: Gan Cao promotes sodium and water retention, which can directly counteract the effects of blood pressure-lowering drugs. Blood pressure should be monitored if concurrent use is unavoidable.
  • Potassium-depleting diuretics (e.g. furosemide, hydrochlorothiazide): Combined potassium loss from both Gan Cao and these diuretics may lead to clinically significant hypokalemia.
  • Corticosteroids: Gan Cao inhibits the metabolic clearance of hydrocortisone and prednisolone, increasing their blood levels and potentially worsening side effects such as edema, hypertension, and glucose elevation.
  • Warfarin and anticoagulants: Gan Cao may reduce warfarin's effectiveness, potentially increasing clotting risk.
  • Hypoglycemic agents (insulin, sulfonylureas): Gan Cao's glucocorticoid-like activity can raise blood sugar, antagonizing diabetes medications.

Usage Guidance

Practical advice for getting the most out of Gui Ling Wu Wei Gan Cao Tang

Best time to take

Divided into 3 doses per day, taken warm, between meals (about 30 to 60 minutes before or after eating).

Typical duration

Short-term use for the specific acute or subacute condition: typically 3 to 14 days, reassessed as symptoms evolve, since the original text describes a sequential treatment approach.

Dietary advice

Avoid cold, raw, and icy foods and beverages, which can worsen internal cold and fluid stagnation. Limit greasy, rich, and dairy-heavy foods that tend to generate more phlegm and dampness. Favour warm, easily digestible meals such as congee, cooked vegetables, and lightly seasoned soups. Small, frequent meals are preferable to large ones. Moderate intake of mildly warming foods like ginger, cinnamon, and small amounts of lamb may support the formula's warming action.

Gui Ling Wu Wei Gan Cao Tang originates from Jin Gui Yao Lue (Essential Prescriptions from the Golden Cabinet) by Zhang Zhongjing Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gui Ling Wu Wei Gan Cao Tang and its clinical use

Jin Gui Yao Lue (金匮要略), Chapter 12 — Phlegm-Fluids, Cough and Upper Qi Counterflow (痰饮咳嗽病脉证并治):

青龙汤下已,多唾口燥,寸脉沉,尺脉微,手足厥逆,气从小腹上冲胸咽,手足痹,其面翕热如醉状,因复下流阴股,小便难,时复冒者,与茯苓桂枝五味甘草汤,治其气冲。

"After taking Qing Long Tang [Xiao Qing Long Tang], there is copious salivation with dry mouth, a deep cun pulse and faint chi pulse, counterflow cold of the hands and feet, Qi surging upward from the lower abdomen to the chest and throat, numbness of the limbs, a face flushing hot as if drunk, then flowing downward to the inner thighs, difficulty urinating, and periodic episodes of muddled consciousness. Give Fu Ling Gui Zhi Wu Wei Gan Cao Tang to treat the surging Qi."

冲气即低,而反更咳、胸满者,用桂苓五味甘草汤去桂加干姜、细辛,以治其咳满。

"Once the surging Qi has been subdued, but there is renewed coughing with chest fullness, use Gui Ling Wu Wei Gan Cao Tang minus Gui Zhi, plus Gan Jiang and Xi Xin, to treat the cough and fullness."

Historical Context

How Gui Ling Wu Wei Gan Cao Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gui Ling Wu Wei Gan Cao Tang (桂苓五味甘草汤), also known as Fu Ling Gui Zhi Wu Wei Gan Cao Tang (茯苓桂枝五味甘草汤) or Ling Gui Wei Gan Tang (苓桂味甘汤), originates from Zhang Zhongjing's Jin Gui Yao Lue (Essentials from the Golden Cabinet, c. 220 CE), in the chapter on phlegm-fluids, cough, and upper Qi counterflow (痰饮咳嗽病脉证并治). It is closely related to the more famous Ling Gui Zhu Gan Tang (苓桂术甘汤), differing only in the substitution of Wu Wei Zi (Schisandra) for Bai Zhu (Atractylodes). This single herb swap shifts the formula's strategy from strengthening the Spleen to drain dampness (Bai Zhu's role) toward astringent containment of the Lungs and Kidneys to stop the rebellious upward surging of Qi.

The formula appears in a famous sequential treatment passage in the Jin Gui Yao Lue, where Zhang Zhongjing demonstrates step-by-step management of complications arising after the use of Xiao Qing Long Tang. This passage became a foundational teaching text for understanding how to handle iatrogenic (treatment-induced) imbalances. The renowned modern Shang Han Lun scholar Liu Duzhou (刘渡舟) was particularly well-known for his clinical mastery of the "Ling Gui" formula family, and his writings on water-pattern diseases (水证论) significantly advanced the modern clinical understanding of this formula group. Qing dynasty physician Ye Tianshi (叶天士) also reportedly used this formula for elderly patients with lower Jiao deficiency causing phlegm-fluids to surge upward, adding Ginger and Dates for a gentle, warm approach to resolving counterflow cough.