Ling Gui Zhu Gan Tang

Poria, Cinnamon Twig, Atractylodes, and Licorice Decoction · 苓桂术甘汤

Also known as: Fu Ling Gui Zhi Bai Zhu Gan Cao Tang (茯苓桂枝白术甘草汤, Poria, Cinnamon Twig, White Atractylodes, and Licorice Decoction), Gui Ling Gan Zhu Tang (桂苓甘术汤)

A classical four-herb formula used to address dizziness, heart palpitations, chest fullness, and shortness of breath caused by a weak digestive system failing to properly process fluids. It gently warms the body and helps move excess fluid accumulation, particularly when someone feels heavy, waterlogged, or dizzy upon standing.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing — Eastern Hàn dynasty, ~200 CE
Composition 4 herbs
Fu Ling
King
Fu Ling
Gui Zhi
Deputy
Gui Zhi
Bai Zhu
Assistant
Bai Zhu
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ling Gui Zhu Gan Tang is designed to correct these specific patterns.

Why Ling Gui Zhu Gan Tang addresses this pattern

Phlegm-Fluid retention (痰饮) is the primary pattern this formula was designed for. When the Spleen's Yang is weak, it cannot properly transform and transport body fluids. These fluids collect and stagnate, forming what TCM calls "thin fluid" (饮) in the chest and upper abdomen. Fu Ling directly drains this accumulated fluid through urination, Gui Zhi warms Yang to transform it, and Bai Zhu strengthens the Spleen to prevent it from reforming. The formula embodies Zhang Zhongjing's guiding principle for phlegm-fluid disorders: use warm medicinals to gently resolve them.

A practitioner would look for one or more of these signs

Dizziness

Especially upon standing or changing position, caused by turbid fluid clouding the head

Palpitations

Heart palpitations from fluid disturbing the Heart

Exertional Dyspnea

Shortness of breath from fluid pressing on the Lungs

Chest Stiffness

Fullness and distension in the chest and hypochondrium

Nausea

Nausea or sensation of Qi rushing upward to the chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ling Gui Zhu Gan Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM has long recognized that dizziness and vertigo can result from turbid fluid (or phlegm) rising to obscure the head, a concept captured in the classical teaching "no phlegm, no dizziness." When the Spleen's warming and transporting function is weak, body fluids fail to be properly processed and instead accumulate as pathological "thin fluid" in the middle burner. This fluid is unstable and tends to surge upward with changes in posture, blocking the clear Yang Qi from reaching the head. The result is dizziness that is typically worse upon standing, often accompanied by a heavy-headed feeling, nausea, and a sensation of the world spinning. The pattern is characterized by a pale, swollen tongue with a white, slippery coating and a wiry or slippery pulse.

Why Ling Gui Zhu Gan Tang Helps

Ling Gui Zhu Gan Tang directly targets the mechanism of fluid-related dizziness. Fu Ling drains the accumulated fluid downward through urination, physically removing the turbid substance that clouds the head. Gui Zhi warms Yang Qi and subdues the upward surging of fluid and Qi, countering the mechanism that pushes fluid toward the head. Bai Zhu dries dampness and strengthens the Spleen to prevent fluid from reaccumulating. This formula is regarded as a primary treatment for Meniere's disease and benign positional vertigo in clinical TCM practice, and is often combined with Ze Xie Tang (Alisma Decoction) for more severe cases.

Also commonly used for

Asthma

Bronchial asthma in remission phase, used to address root phlegm-fluid retention

Congestive Heart Failure

Mild congestive heart failure with fluid retention and palpitations

Edema

Cardiac or renal edema with Spleen Yang deficiency pattern

Chronic Gastritis

Chronic gastritis with epigastric fullness and splashing sounds

Obesity

Obesity related to fluid and phlegm-dampness accumulation

Fatty Liver

Non-alcoholic fatty liver disease with phlegm-dampness pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ling Gui Zhu Gan Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ling Gui Zhu Gan Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ling Gui Zhu Gan Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ling Gui Zhu Gan Tang works at the root level.

This formula addresses a condition where the body's middle region (the Spleen and Stomach system) has become too cold and weak to properly manage fluids. In TCM, the Spleen is the primary organ responsible for transforming and transporting water and dampness throughout the body. When Spleen Yang (the warming, activating aspect of the Spleen) becomes deficient, this transport function falters. Fluids that should be distributed and utilized instead collect and stagnate internally, forming what TCM calls "phlegm-fluid" (痰饮, tan yin), a thin, watery pathological accumulation distinct from normal body fluids.

This fluid stagnation creates a cascade of symptoms depending on where it pools. When it collects below the heart (the upper digestive region), it causes a sensation of fullness and stuffiness in the chest and flanks. Because the clear Yang Qi of the Spleen can no longer rise upward to nourish the head and sensory organs, dizziness and visual blurring result. When fluid surges upward to harass the Heart and Lungs, the person experiences palpitations, shortness of breath, and sometimes coughing. The classical texts describe this as "Qi surging upward into the chest" (气上冲胸). The tongue coating becomes white and slippery (a hallmark sign of internal cold fluid), and the pulse tends to be slippery or deep and tight, both indicating fluid accumulation driven by Yang deficiency.

Zhang Zhongjing's principle for treating this condition is captured in his famous teaching: "For diseases of phlegm-fluid retention, use warm medicinals to harmonize them." The logic is straightforward: since the fluid accumulation arises from cold and weakness, warming the center restores the Spleen's ability to transform and transport fluids, while simultaneously guiding excess water downward and out through urination. The formula does not forcefully drain, but gently warms and restores normal fluid metabolism from within.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and bland with mild pungency. Sweet from Gan Cao and Fu Ling tonifies the Spleen; bland from Fu Ling drains dampness through urination; pungent from Gui Zhi warms Yang and promotes Qi movement.

Channels Entered

Spleen Heart Lung Bladder

Ingredients

4 herbs

The herbs that make up Ling Gui Zhu Gan Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Fu Ling

Fu Ling

Poria

Dosage 12 - 20g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Ling Gui Zhu Gan Tang

Strengthens the Spleen and promotes urination to drain accumulated fluid from the middle burner. As the highest-dosed herb, it directly addresses the core problem of fluid retention by channeling excess water downward through the urinary tract while simultaneously supporting the Spleen's ability to process fluids.
Deputy — Assists and enhances the King
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 9 - 15g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Ling Gui Zhu Gan Tang

Warms the Yang and transforms Qi to resolve fluid retention. Its warm, acrid nature acts like sunlight evaporating stagnant water, helping the body's Yang Qi to reassert control over fluid metabolism. It also calms the upward surging of Qi (descends counterflow), directly relieving the sensation of Qi rushing up to the chest, dizziness, and palpitations.
Assistant — Supports or moderates other herbs
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 6 - 10g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Ling Gui Zhu Gan Tang

Strengthens the Spleen and dries Dampness, addressing the root cause of fluid accumulation. By restoring the Spleen's transporting function, it prevents new fluid from pooling. Works synergistically with Fu Ling to bolster the Spleen and with Gui Zhi to warm and mobilize the middle burner.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Ling Gui Zhu Gan Tang

Tonifies Spleen Qi and harmonizes the other herbs in the formula. Combined with Gui Zhi, it generates Yang through the classical 'acrid-sweet transforming into Yang' mechanism. It also moderates Fu Ling's draining action to prevent excessive fluid loss that might damage normal body fluids.

Why This Combination Works

How the herbs in Ling Gui Zhu Gan Tang complement each other

Overall strategy

This formula treats phlegm-fluid retention (痰饮, tán yǐn) caused by weakness of the middle burner's warming and transporting functions. The classical principle guiding its design is from the Jin Gui Yao Lue: "For those with phlegm-fluid disorders, treat with warm medicinals." The formula simultaneously warms Yang to transform accumulated fluids, drains what has already collected, and strengthens the Spleen to prevent recurrence.

King herb

Fu Ling (Poria) is used in the largest dose because it directly targets the accumulated fluid, the most immediate problem. Its bland, seeping nature gently draws retained water downward and out through urination, while its Spleen-strengthening action supports the organ most responsible for proper fluid metabolism. It also calms the Heart, helping to settle palpitations caused by fluids disturbing the Heart.

Deputy herb

Gui Zhi (Cinnamon Twig) is the essential warming partner. Fluid retention in this pattern is a cold, Yin-type pathogen that cannot be resolved by drainage alone. Gui Zhi provides the warmth needed to "evaporate" the stagnant fluid and restore the flow of Yang Qi. It also has a specific action of subduing upward-surging Qi, which directly addresses the symptoms of Qi rushing to the chest and dizziness upon standing. Together, Fu Ling and Gui Zhi form one of the most celebrated herb pairings in TCM: one drains from below while the other warms from above.

Assistant herb

Bai Zhu (White Atractylodes) is a reinforcing assistant that addresses the root cause. While Fu Ling and Gui Zhi deal with the existing fluid, Bai Zhu strengthens and dries the Spleen to prevent new fluid from accumulating. In TCM terms, it "treats the source where phlegm is generated." It forms effective working pairs with both Fu Ling (Spleen strengthening plus dampness removal) and Gui Zhi (warming plus drying the middle burner).

Envoy herb

Zhi Gan Cao (Honey-prepared Licorice) harmonizes the formula and supports the Spleen. Paired with Gui Zhi, it creates the classical combination of acrid and sweet flavors that generates Yang Qi. It also prevents Fu Ling's draining action from being too aggressive, protecting the body's normal fluids while still allowing excess water to be removed.

Notable synergies

The Fu Ling and Gui Zhi pairing is the most important: one promotes urination to drain fluid downward, the other warms Yang to transform fluid from above. This "one drains, one warms" combination is far more effective than either approach alone. The Gui Zhi and Zhi Gan Cao pairing uses the classical "acrid-sweet generating Yang" principle to gently restore the warmth the body needs. The Fu Ling and Bai Zhu pairing reinforces the Spleen from two angles: Fu Ling drains existing dampness while Bai Zhu dries and prevents its return. Despite having only four ingredients, the formula covers all strategic bases: warming, draining, strengthening, and harmonizing.

How to Prepare

Traditional preparation instructions for Ling Gui Zhu Gan Tang

Place all four herbs in a pot with approximately 1200 ml of water. Bring to a boil, then reduce heat and simmer until the liquid is reduced to approximately 600 ml. Strain out the dregs. Divide into three equal portions and take warm, three times daily.

After taking the decoction, urination should increase noticeably, which is the expected sign that fluid retention is being resolved through the urinary tract. This corresponds to the original text's note: "urination will then become free" (小便则利).

Common Modifications

How practitioners adapt Ling Gui Zhu Gan Tang for specific situations

Added
Ze Xie

15 - 30g, strongly promotes urination to drain fluid from the head

Ze Xie powerfully drains fluid downward and is specifically indicated for dizziness caused by turbid fluid rising to the head. This combination essentially merges Ling Gui Zhu Gan Tang with Ze Xie Tang, a well-established clinical approach for Meniere's disease and severe positional vertigo.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ling Gui Zhu Gan Tang should not be used or requires extra caution

Avoid

Yin deficiency with Heat signs (dry mouth, red tongue with little coating, night sweats). This formula is warming and drying in nature and would further deplete Yin fluids.

Avoid

Phlegm-Heat or Damp-Heat patterns. The warm nature of Gui Zhi (Cinnamon Twig) and the drying quality of Bai Zhu (White Atractylodes) would worsen Heat conditions.

Caution

Severe Kidney Yang deficiency with flooding edema. This formula addresses mild to moderate fluid retention from Spleen Yang deficiency. Severe cases with Kidney Yang collapse require stronger formulas such as Zhen Wu Tang.

Caution

Patients with uncontrolled hypertension. Gan Cao (Licorice) can promote sodium and water retention, potentially raising blood pressure. Use with caution and monitor.

Caution

Patients with hypokalemia or those on potassium-depleting medications. Gan Cao (Licorice) can further lower potassium levels.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Gui Zhi (Cinnamon Twig) is warming and promotes circulation, which is generally acceptable in moderate doses, but Gan Cao (Licorice, specifically glycyrrhizin) has been associated with potential corticosteroid-like and estrogenic effects. Research suggests high-dose or prolonged licorice intake during pregnancy may increase the risk of preterm delivery and may stimulate the fetal hypothalamic-pituitary-adrenal axis. While the dose of Zhi Gan Cao in this formula is relatively small (6g), pregnant women should consult a qualified practitioner before use. Not absolutely contraindicated, but caution is warranted.

Breastfeeding

Generally considered compatible with breastfeeding. The four herbs in this formula (Fu Ling, Gui Zhi, Bai Zhu, Zhi Gan Cao) are mild and commonly used in postpartum care. Fu Ling and Bai Zhu are frequently included in formulas to support Spleen function during lactation. Gan Cao (Licorice) at the low dose in this formula (6g) is unlikely to cause problems, though prolonged high-dose licorice use could theoretically affect electrolyte balance. No specific adverse effects on breast milk or nursing infants have been documented for this formula. As always, use under practitioner guidance.

Children

This formula can be used in children with appropriate dosage reduction. As a general guideline: children aged 6-12 may receive approximately half the adult dose; children aged 2-6 may receive one-quarter to one-third the adult dose. Infants under 2 should only receive this formula under close practitioner supervision. The herbs in this formula are mild and well-tolerated. Gui Zhi (Cinnamon Twig) is warm but not harsh, and Fu Ling is gentle enough for pediatric use. For children who resist the taste, the decoction can be given in small, frequent sips. Monitor for any signs of excessive dryness or thirst, which would indicate the formula may be too warming.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ling Gui Zhu Gan Tang

Gan Cao (Licorice) interactions: The Zhi Gan Cao (honey-processed Licorice) in this formula contains glycyrrhizic acid, which has well-documented drug interactions:

  • Cardiac glycosides (digoxin): Licorice can promote potassium loss, increasing sensitivity to digoxin and raising the risk of digoxin toxicity and cardiac arrhythmias. Concurrent use should be avoided or closely monitored.
  • Potassium-depleting diuretics (furosemide, thiazides): Licorice's mineralocorticoid-like effects compound with these diuretics to increase the risk of hypokalemia. Electrolytes should be monitored if combined.
  • Antihypertensive drugs: Licorice can cause sodium and water retention, potentially reducing the effectiveness of blood pressure medications.
  • Hypoglycemic agents (insulin, metformin, sulfonylureas): Glycyrrhizic acid has glucocorticoid-like activity that can raise blood sugar, potentially counteracting diabetes medications.
  • Warfarin: Licorice may interact with warfarin metabolism, potentially altering its anticoagulant effect. Monitoring of INR is advised.
  • Corticosteroids: Licorice inhibits cortisol metabolism, potentially increasing steroid blood levels and side effects.

Gui Zhi (Cinnamon Twig): Contains cinnamaldehyde, which has mild blood-thinning properties. Theoretically, it may have an additive effect with anticoagulant or antiplatelet drugs, though clinical significance at standard formula doses is uncertain.

Usage Guidance

Practical advice for getting the most out of Ling Gui Zhu Gan Tang

Best time to take

Divide into three doses taken warm throughout the day, ideally 30 minutes before meals or between meals on a relatively empty stomach. The classical instruction specifies "fen wen san fu" (分温三服), meaning to divide into three portions and take warm.

Typical duration

Typically prescribed for 1 to 4 weeks for acute fluid retention episodes, then reassessed. Chronic conditions (recurrent dizziness, palpitations from phlegm-fluid) may require intermittent courses of 4 to 8 weeks with periodic reassessment.

Dietary advice

Avoid cold, raw, and icy foods and beverages, as they further burden the Spleen Yang that this formula is working to restore. Reduce intake of greasy, oily, and heavy foods that promote dampness and phlegm. Minimize dairy products and excessively sweet foods, which can generate dampness. Favor warm, easily digestible foods such as congee (rice porridge), cooked grains, lightly steamed vegetables, ginger tea, and mild soups. Small, frequent meals are better than large heavy ones. The classical instruction after taking this formula notes that "urination should become free," so adequate (but not excessive) warm fluid intake supports the formula's action.

Ling Gui Zhu Gan Tang originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ling Gui Zhu Gan Tang and its clinical use

Shang Han Lun (《伤寒论》), Clause 67

Original: 伤寒,若吐若下后,心下逆满,气上冲胸,起则头眩,脉沉紧,发汗则动经,身为振振摇者,茯苓桂枝白术甘草汤主之。

Translation: In cold damage, after vomiting or purging has been applied, if there is rebellious fullness below the heart, Qi surging upward into the chest, dizziness upon rising, a deep and tight pulse, and if sweating were promoted the channels would be disturbed and the body would tremble and sway, Poria-Cinnamon Twig-White Atractylodes-Licorice Decoction governs.

Jin Gui Yao Lue (《金匮要略》), Chapter 12: Phlegm-Fluid and Cough

Original: 心下有痰饮,胸胁支满,目眩,苓桂术甘汤主之。

Translation: When there is phlegm-fluid below the heart, with distending fullness of the chest and flanks, and dizziness, Ling Gui Zhu Gan Tang governs.

Jin Gui Yao Lue (《金匮要略》), Chapter 12

Original: 夫短气有微饮,当从小便去之,苓桂术甘汤主之。

Translation: When there is shortness of breath with mild fluid retention, it should be eliminated through urination. Ling Gui Zhu Gan Tang governs.

Jin Gui Yao Lue (《金匮要略》), Chapter 12

Original: 病痰饮者,当以温药和之。

Translation: For diseases of phlegm-fluid retention, one should use warm medicinals to harmonize them. (This is the guiding therapeutic principle under which Ling Gui Zhu Gan Tang operates.)

Historical Context

How Ling Gui Zhu Gan Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ling Gui Zhu Gan Tang originates from Zhang Zhongjing's Shang Han Za Bing Lun (Treatise on Cold Damage and Miscellaneous Diseases), written during the Eastern Han dynasty (circa 200 CE). After this masterwork was lost and later reconstructed, the formula appeared in both surviving compilations: the Shang Han Lun (Clause 67 and Clause 243) and the Jin Gui Yao Lue (Chapter 12, on Phlegm-Fluid and Cough). Interestingly, the two texts present slightly different dosages for Bai Zhu: the Shang Han Lun version lists 2 liang, while the Jin Gui Yao Lue version lists 3 liang. The Jin Gui Yao Lue also adds the clinical observation "xiao bian ze li" (小便则利, "urination will then become free") after the dosing instructions, which is absent from the Shang Han Lun version.

This formula is the foundation of the "Ling Gui" family of formulas, a group of closely related prescriptions that share the core pairing of Fu Ling and Gui Zhi. By swapping just one herb, Zhang Zhongjing created distinct formulas for different clinical scenarios: replacing Bai Zhu with Da Zao (jujube) yields Ling Gui Zao Gan Tang for palpitations below the navel with impending running-piglet Qi; replacing Bai Zhu with Sheng Jiang (fresh ginger) yields Ling Gui Jiang Gan Tang (Fu Ling Gan Cao Tang) for water stagnation in the stomach with cold reversal. The Qing dynasty commentator You Zaijing (尤在泾) praised this formula, noting that "phlegm-fluid is a Yin pathogen" that "disperses when warmed" and "can be transported when the Spleen and Stomach are warmed." In modern clinical practice, the formula has been extensively used by the Yanjing Liu School of Shang Han Lun scholarship (燕京刘氏伤寒学派), who developed over 15 variant formulas based on Ling Gui Zhu Gan Tang for treating cardiovascular and fluid metabolism disorders.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Ling Gui Zhu Gan Tang

1

Systematic Review and Meta-Analysis: Linggui Zhugan Decoction for Premature Contraction in Coronary Heart Disease (2022)

Liu L, Zhao Y, Birling Y, Sun Y, Shang Q, Hu ZJ, Liu J, Liu Z. Frontiers in Cardiovascular Medicine. 2022;9:1002378.

This systematic review evaluated randomized controlled trials on Ling Gui Zhu Gan Tang as an adjunct to conventional antiarrhythmic drugs for premature beats in coronary heart disease patients. Results suggested that the combination was more effective than antiarrhythmic drugs alone, with acceptable safety.

2

Clinical Evidence and Potential Mechanisms for Management of Serum Lipids and Obesity: Systematic Review with Network Pharmacology (2022)

Huang J, Zhao L, Sun J, et al. Evidence-Based Complementary and Alternative Medicine. 2022;2022:7714034.

This study combined a meta-analysis of RCTs with network pharmacology to evaluate the formula's effects on blood lipids and obesity. The clinical evidence suggested benefits for reducing triglycerides, total cholesterol, and body weight. Network analysis identified potential targets related to lipid metabolism.

PubMed
3

RCT: Modified Linggui Zhugan Decoction with Very Low Calorie Diets on Cardiovascular Risk Factors in Obese IGT Patients (2012)

Journal of Traditional Chinese Medicine. 2012;32(2):193-198.

An RCT of 85 obese patients with impaired glucose tolerance found that a modified version of the formula combined with short-term calorie restriction improved blood glucose, lipids, blood pressure, BMI, and waist circumference more effectively than basic weight-reduction treatment alone over 6 months.

4

Preclinical: Ling-Gui-Zhu-Gan Decoction Ameliorates NAFLD via Modulating Gut Microbiota (2023)

Microbiology Spectrum (ASM). 2023.

An animal study in high-fat-diet mice demonstrated that the formula significantly improved liver function, reduced lipid accumulation, restored gut microbiota diversity, and modulated bile acid metabolism. The formula activated the PPAR signaling pathway and improved intestinal barrier function.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.