Gua Lou Niu Bang Zi Tang

Trichosanthes and Arctium Decoction · 瓜蒌牛蒡子湯

Also known as: Gua Lou Niu Bang Tang, Kua Lou Niu Bang Tang, 栝楼牛蒡汤,

A classical formula used to treat early-stage breast infection (mastitis) and breast abscess, particularly when there is redness, swelling, heat, and pain. It works by clearing the Heat and toxin causing the inflammation while also moving stagnant Qi through the breast channels to reduce swelling and restore normal milk flow. Originally developed for the early stage of breast abscess before pus has formed.

Origin Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Medicine) by Chen Shigong (陈实功) — Míng dynasty, 1617 CE
Composition 12 herbs
Gua Lou Ren
King
Gua Lou Ren
Niu Bang Zi
King
Niu Bang Zi
Jin Yin Hua
Deputy
Jin Yin Hua
Lian Qiao
Deputy
Lian Qiao
Huang Qin
Deputy
Huang Qin
Tian Hua Fen
Assistant
Tian Hua Fen
Zhi Zi
Assistant
Zhi Zi
Zao Jiao Ci
Assistant
Zao Jiao Ci
+4
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gua Lou Niu Bang Zi Tang is designed to correct these specific patterns.

Why Gua Lou Niu Bang Zi Tang addresses this pattern

In TCM, the breast tissue is governed by the Stomach channel (the breast itself) and the Liver channel (the nipple). When Liver Qi becomes stagnant, often from emotional frustration or stress, it loses its normal smooth-flowing nature. This stagnation can transform into Heat, which combines with Stomach Heat to accumulate in the breast, blocking the channels and causing painful, red, hot swelling. Gua Lou Niu Bang Zi Tang directly addresses this dual mechanism: the Qi-moving herbs (Chai Hu, Qing Pi, Chen Pi) resolve Liver constraint, while the Heat-clearing herbs (Jin Yin Hua, Lian Qiao, Huang Qin, Zhi Zi) drain Stomach Heat and toxin. The King herbs (Gua Lou Ren and Niu Bang Zi) bridge both actions by simultaneously clearing Heat and dispersing the resulting nodules.

A practitioner would look for one or more of these signs

Breast Pain

Red, hot, swollen, and painful breast with hardened lumps

Fever

Alternating chills and fever or sustained fever

Breast Lumps

Hard, painful nodules in the breast tissue

Chest Distension

Distention and fullness of the breast

Irritability

Irritability and emotional frustration

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gua Lou Niu Bang Zi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Qi Stagnation Heat Toxin Accumulation

TCM Interpretation

TCM understands acute mastitis (乳痈) as arising primarily from two interconnected organ systems. The nipple is governed by the Liver channel, while the breast tissue itself belongs to the Stomach channel. When Liver Qi stagnates, often triggered by emotional stress, frustration, or difficulty with breastfeeding, the normal free flow of Qi and milk through the breast becomes blocked. This stagnation generates Heat, which combines with Stomach channel Heat to create a toxic accumulation in the breast tissue. The result is the characteristic redness, swelling, heat, and pain. If untreated, the Heat-toxin intensifies and the accumulation suppurates, forming pus. The condition is considered most treatable in its earliest stage, before pus has formed, which is precisely when this formula is indicated.

Why Gua Lou Niu Bang Zi Tang Helps

Gua Lou Niu Bang Zi Tang addresses acute mastitis from multiple angles simultaneously. The King herbs, Gua Lou Ren and Niu Bang Zi, directly target the breast swelling by clearing Heat and dispersing nodules. The strong Heat-clearing team of Jin Yin Hua, Lian Qiao, Huang Qin, and Zhi Zi neutralizes the inflammatory Heat-toxin that drives the condition. Crucially, the formula also treats the root cause: Chai Hu, Qing Pi, and Chen Pi course Liver Qi and regulate Stomach Qi, restoring the free flow through the channels that supply the breast. Zao Jiao Ci penetrates into the hardened tissue to draw out toxin and prevent abscess formation. Clinical studies have shown that modified versions of this formula can achieve effectiveness rates above 95% in treating acute mastitis, comparable to or exceeding antibiotic treatment.

Also commonly used for

Breast Abscess

Early-stage breast abscess with redness, swelling, heat, and pain

Breast Pain

Acute breast pain due to Heat-toxin and Qi stagnation

Chest Distension

Breast engorgement with blocked milk ducts

Mastitis

Lactational and non-lactational mastitis with Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gua Lou Niu Bang Zi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gua Lou Niu Bang Zi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gua Lou Niu Bang Zi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gua Lou Niu Bang Zi Tang works at the root level.

In TCM theory, the breast has a dual relationship to two organ systems: the nipple connects to the Liver channel (foot Jue Yin), while the breast flesh itself belongs to the Stomach channel (foot Yang Ming). This dual governance explains why breast problems almost always involve both organs working together — or, in the case of disease, failing together.

Breast abscess (ru yong, 乳痈) develops through a chain of events. It typically begins with emotional stress, frustration, or anger that causes the Liver's Qi to stagnate. When Liver Qi stops flowing smoothly, it can no longer perform its job of regulating the smooth distribution of breast milk. At the same time, rich or greasy foods, or the metabolic demands of breastfeeding, can generate Heat in the Stomach. When this Stomach Heat combines with stagnant Liver Qi, the result is a blockage in the breast's channels and network vessels. Milk and Qi accumulate locally, Heat builds up, and the tissue becomes red, swollen, hot, and painful — the hallmarks of early-stage mastitis. If untreated, the trapped Heat "cooks" the flesh, and pus forms.

Gua Lou Niu Bang Zi Tang addresses this pathomechanism on both fronts simultaneously. It clears the accumulated Heat and toxins from the Stomach channel with its cooling, detoxifying herbs, while also coursing and unbinding the stagnant Liver Qi with its regulating herbs. By restoring flow in both organ systems at once, it resolves the root cause (Qi stagnation plus Heat accumulation) while also treating the local manifestation (swelling, pain, and blocked milk).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and acrid with a sweet undertone — bitter to clear Heat and dry Dampness, acrid to disperse stagnation and promote movement, sweet from Licorice to harmonize.

Target Organs

Channels Entered

Ingredients

12 herbs

The herbs that make up Gua Lou Niu Bang Zi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Gua Lou Ren

Gua Lou Ren

Snake gourd seeds

Dosage 9 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Stomach, Large Intestine, Lungs

Role in Gua Lou Niu Bang Zi Tang

Clears Heat, resolves Phlegm, disperses swelling, and dissipates nodules in the breast. As the primary herb, it directly targets the Heat-toxin and Phlegm accumulation causing the breast abscess, and also moistens and unblocks the channels to promote milk flow.
Niu Bang Zi

Niu Bang Zi

Greater burdock fruits

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Lungs, Stomach
Preparation Dry-fried (炒) and lightly crushed before decocting

Role in Gua Lou Niu Bang Zi Tang

Disperses Wind-Heat, clears Heat-toxin, relieves swelling, and benefits the throat. Works synergistically with Gua Lou Ren to clear Heat and dissipate nodules, and helps vent pathogenic Heat outward through the exterior.
Deputies — Assists and enhances the King
Jin Yin Hua

Jin Yin Hua

Honeysuckle flowers

Dosage 9 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Gua Lou Niu Bang Zi Tang

Strongly clears Heat and resolves toxin, a key herb for treating all types of sores and abscesses. Reinforces the Heat-clearing and toxin-resolving action of the King herbs.
Lian Qiao

Lian Qiao

Forsythia fruits

Dosage 9 - 12g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine
Preparation Remove the inner core (去心)

Role in Gua Lou Niu Bang Zi Tang

Clears Heat, resolves toxin, and dissipates clumps and nodules. Known as the 'sage of sores' (疮家圣药), it supports the King herbs in reducing swelling and dispersing accumulation.
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 6 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Gua Lou Niu Bang Zi Tang

Clears Heat and dries Dampness, especially in the upper burner. Assists the formula's Heat-clearing actions and helps reduce inflammation and abscess formation.
Assistants — Supports or moderates other herbs
Tian Hua Fen

Tian Hua Fen

Snake gourd roots

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Sour, Sweet
Organ Affinity Stomach, Lungs

Role in Gua Lou Niu Bang Zi Tang

Clears Heat, generates Fluids, and resolves swelling and expels pus. Particularly useful in the early stages of breast abscess to reduce swelling before pus has formed.
Zhi Zi

Zhi Zi

Cape jasmine fruits

Dosage 6 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Lungs, Sanjiao, San Jiao (Triple Burner)
Preparation Used raw (生栀子), lightly crushed

Role in Gua Lou Niu Bang Zi Tang

Clears Heat from all three burners and drains Fire, helping to cool the intense inflammatory Heat. Also resolves Dampness and directs Heat downward for elimination.
Zao Jiao Ci

Zao Jiao Ci

Gleditsia thorns

Dosage 6 - 9g
Temperature Warm
Taste Pungent
Organ Affinity Stomach, Liver, Lungs

Role in Gua Lou Niu Bang Zi Tang

Draws out toxin, expels pus, invigorates Blood, and reduces swelling. Particularly important for directing the formula to penetrate through blockages and disperse hardened masses in the breast tissue.
Chai Hu

Chai Hu

Bupleurum roots

Dosage 3 - 6g
Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver

Role in Gua Lou Niu Bang Zi Tang

Spreads Liver Qi and resolves constraint. Since the nipple pertains to the Liver channel, Chai Hu specifically addresses Liver Qi stagnation, one of the root causes of breast abscess. Also vents Heat from the Shaoyang level.
Qing Pi

Qing Pi

Green tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Gallbladder, Stomach, Liver

Role in Gua Lou Niu Bang Zi Tang

Breaks Qi stagnation, soothes the Liver, and disperses accumulation. Pairs with Chai Hu and Chen Pi to powerfully move Liver and Stomach Qi, addressing the underlying stagnation that leads to breast lumps.
Chen Pi

Chen Pi

Tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen

Role in Gua Lou Niu Bang Zi Tang

Regulates Qi and harmonizes the Stomach. Works with Qing Pi to move Qi through the middle burner, ensuring the other herbs can circulate freely and preventing Qi stagnation from worsening the accumulation.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Used raw (生甘草)

Role in Gua Lou Niu Bang Zi Tang

Harmonizes all the herbs in the formula, clears Heat-toxin, and protects the Stomach from the cold, bitter herbs. Used raw (生甘草) to maximize its Heat-clearing and detoxifying function.

Why This Combination Works

How the herbs in Gua Lou Niu Bang Zi Tang complement each other

Overall strategy

Breast abscess (乳痈) arises from Liver Qi stagnation and Stomach Heat accumulating in the breast, blocking the channels and causing swelling, redness, and pain. This formula simultaneously clears Heat-toxin, dissipates nodules, and moves stagnant Qi through the Liver and Stomach channels to restore the free flow of Qi and milk through the breast.

King herbs

Gua Lou Ren (Trichosanthes Seed) and Niu Bang Zi (Arctium Fruit) together form the core therapeutic pair. Gua Lou Ren clears Heat, resolves Phlegm, and disperses clumps, directly targeting the swollen, hardened breast tissue. Niu Bang Zi disperses Wind-Heat and resolves toxin, venting pathogenic Heat outward while reducing swelling. Together, they address both the toxic Heat and the physical mass.

Deputy herbs

Jin Yin Hua (Honeysuckle), Lian Qiao (Forsythia), and Huang Qin (Scutellaria) powerfully reinforce the Heat-clearing and toxin-resolving action. Jin Yin Hua and Lian Qiao are the classical pair for treating sores and abscesses, while Huang Qin specifically clears Heat from the upper burner where the breast is located.

Assistant herbs

This formula has a particularly large and varied assistant tier reflecting the complexity of the condition. Tian Hua Fen (Trichosanthes Root) and Zhi Zi (Gardenia) reinforce Heat-clearing and help reduce swelling before pus forms. Zao Jiao Ci (Gleditsia Thorn) serves a unique penetrating role: it draws out toxin and expels pus, pushing the formula's action deep into hardened tissue. Chai Hu, Qing Pi, and Chen Pi form a Qi-moving trio that addresses the root cause of Liver constraint and Stomach Qi stagnation. Chai Hu specifically courses Liver Qi (the nipple pertains to the Liver channel), while Qing Pi breaks accumulation and Chen Pi harmonizes the middle burner.

Envoy herbs

Raw Gan Cao (Licorice) harmonizes the formula's many ingredients, adds its own mild Heat-clearing and detoxifying action, and protects the Stomach from the accumulation of cold, bitter herbs in the prescription.

Notable synergies

Gua Lou Ren and Niu Bang Zi together are more effective at dispersing breast nodules than either alone, as one works from within (moistening and loosening Phlegm) while the other vents Heat outward. The Chai Hu, Qing Pi, Chen Pi trio comprehensively addresses Qi stagnation across the Liver and Stomach channels, which is essential because simply clearing Heat without moving Qi would leave the root cause untreated. Zao Jiao Ci paired with the Heat-clearing herbs ensures that toxin is actively expelled rather than merely cooled in place.

How to Prepare

Traditional preparation instructions for Gua Lou Niu Bang Zi Tang

Use water approximately 400 mL (the classical text specifies two cups, 水二钟). Decoct the twelve herbs together until the liquid is reduced to about 160 mL (roughly 60% reduction, 煎八分). After straining, combine the decoction with approximately 200 mL of rice wine (黄酒) and mix evenly. Take the formula on an empty stomach (空腹服), divided into doses taken throughout the day. The original text specifies three doses per day (一日三次).

In modern clinical practice, the rice wine is often reduced or omitted, and the formula is typically decocted as a standard decoction taken warm twice daily (morning and evening) on an empty stomach or between meals.

Common Modifications

How practitioners adapt Gua Lou Niu Bang Zi Tang for specific situations

Added
Pu Gong Ying

15-30g, strongly clears Heat-toxin from breast tissue

Zi Hua Di Ding

15g, resolves toxin and reduces swelling

Pu Gong Ying (Dandelion) is one of the most important herbs for breast abscesses and strongly clears Heat-toxin from the breast area. Zi Hua Di Ding adds further toxin-resolving power for severe inflammatory presentations.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gua Lou Niu Bang Zi Tang should not be used or requires extra caution

Avoid

Breast abscess that has already fully formed and ruptured (the formula is designed for the initial stage of breast abscess before pus has formed; once pus has collected and broken through, surgical drainage and different formulas are needed).

Avoid

Yin-type sores or chronic Yin-deficiency patterns: this is a cooling, toxin-clearing formula and is inappropriate for cold-type, non-inflammatory breast lumps or deficiency-cold conditions where there is no redness, heat, or swelling.

Caution

Spleen and Stomach deficiency-cold with loose stools or poor appetite: the formula contains multiple cold and bitter herbs (Huang Qin, Zhi Zi, Lian Qiao, Jin Yin Hua) that can damage the digestive function. Reduce cooling herbs or add Spleen-supporting herbs if the patient has a weak digestive system.

Caution

Postpartum women with significant Blood deficiency and incomplete lochia discharge: the formula's cooling nature may impede recovery. Classical modifications call for adding Dang Gui and Yi Mu Cao while reducing the cold herbs.

Caution

Prolonged use beyond the acute phase: once the redness, swelling, and heat have resolved, the formula should be discontinued or modified to avoid excessive cooling that could impair healing.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Several herbs in the formula have properties that raise concern: Zao Jiao Ci (Gleditsia spine) has Blood-moving and pus-expelling actions, and Niu Bang Zi (Arctium seed) and Gua Lou Ren (Trichosanthes seed) are slippery in nature and promote downward movement, which could theoretically affect pregnancy. Chai Hu also has ascending and dispersing properties. While the formula is not classified among the strongly prohibited formulas for pregnancy, it is primarily designed for postpartum or lactating women with acute breast infection. If a pregnant woman develops breast problems, a practitioner should carefully modify the formula or select an alternative approach. Do not self-prescribe during pregnancy.

Breastfeeding

This formula was specifically designed for use during breastfeeding — its primary indication is acute mastitis in lactating women. The herbs are generally considered compatible with continued breastfeeding. In fact, part of the formula's therapeutic strategy is to restore normal milk flow. Breastfeeding or expressing milk from the affected breast should continue during treatment, as milk stasis is a major contributing factor to the condition. The bitter and cold herbs (Huang Qin, Zhi Zi) could theoretically cause mild loose stools in a sensitive infant through breast milk transfer, though this is uncommon at standard doses. If the infant develops digestive upset, consult a practitioner to adjust the formula. Practitioners sometimes add herbs like Lu Jiao Shuang or Lou Lu specifically to promote lactation alongside treatment.

Children

Gua Lou Niu Bang Zi Tang is designed for adult women with breast abscess (mastitis), so pediatric use is uncommon. However, the formula's underlying mechanism of clearing Heat-toxins and dispersing swelling has occasionally been applied by experienced practitioners in modified form for children with similar Heat-toxin patterns (such as swollen lymph nodes or skin infections). For children, dosages should be reduced to approximately one-third to one-half of adult doses depending on age and body weight. The multiple cold and bitter herbs may upset a child's digestion, so Spleen-protecting modifications are advisable. This formula should only be given to children under the direct guidance of a qualified TCM practitioner.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gua Lou Niu Bang Zi Tang

No severe drug interactions have been widely documented for this formula, but several theoretical considerations apply:

  • Gan Cao (Licorice root): May interact with corticosteroids (potentiating their effects), diuretics (increasing potassium loss), cardiac glycosides such as digoxin (due to potential hypokalemia), and antihypertensive medications. Licorice can cause sodium retention and potassium depletion with prolonged use.
  • Huang Qin (Scutellaria): Contains baicalin, which has been shown to inhibit certain cytochrome P450 enzymes in laboratory studies. This could theoretically affect the metabolism of drugs processed through these pathways, though clinical significance at typical herbal doses is not well established.
  • Chai Hu (Bupleurum): Contains saikosaponins that may influence hepatic drug metabolism. Patients taking medications heavily metabolized by the liver should use this formula with practitioner supervision.
  • Antibiotic co-administration: This formula is sometimes used alongside antibiotics for mastitis. No antagonistic interactions are well documented, and some Chinese clinical studies have combined them. However, patients should inform both their TCM and biomedical practitioners about all treatments being used.

Usage Guidance

Practical advice for getting the most out of Gua Lou Niu Bang Zi Tang

Best time to take

On an empty stomach or between meals (the classical instruction specifies 食远服, meaning 'taken away from food'), twice daily, warm.

Typical duration

Acute use: 3–10 days, reassessed every 2–3 days as the condition evolves rapidly.

Dietary advice

Avoid greasy, fried, and rich foods, as these generate Stomach Heat and worsen the underlying condition. Spicy and warming foods (chili, lamb, alcohol, deep-fried dishes) should also be avoided, as they fan internal Heat. Dairy and cold raw foods are best minimized since they can produce Dampness and Phlegm that further obstruct the breast channels. Favor light, easily digestible meals such as porridge, steamed vegetables, and mild soups. Foods traditionally considered beneficial for promoting smooth milk flow include silk gourd (si gua/luffa) soup and cooked leafy greens. Stay well hydrated with warm water or mild herbal teas.

Gua Lou Niu Bang Zi Tang originates from Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Medicine) by Chen Shigong (陈实功) Míng dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gua Lou Niu Bang Zi Tang and its clinical use

From the Yi Zong Jin Jian (《医宗金鉴》, Golden Mirror of Medical Tradition, 1742), Surgical Heart Method chapter:

The formula song (fang ge) reads:
乳痈初起需金银,连翘花草山栀芩,青陈柴胡皂角刺,瓜蒌牛蒡汤最神。
"When breast abscess first arises, use Jin Yin Hua; with Lian Qiao, Hua Fen, Gan Cao, Shan Zhi, and Huang Qin; Qing Pi, Chen Pi, Chai Hu, and Zao Jiao Ci — Gua Lou Niu Bang Tang is most miraculous."

On pathomechanism, from the Zhong Yi Wai Ke Xue (Chinese Surgery textbook) citing classical theory:

乳头属肝,乳房属胃,乳痈是由于肝郁气滞、疏泄失职,脾胃失和,胃热壅滞,致使经络阻隔,营气不和而发病。
"The nipple pertains to the Liver; the breast pertains to the Stomach. Breast abscess arises because Liver Qi stagnation impairs the coursing and discharge function, while the Spleen and Stomach lose harmony and Stomach Heat accumulates, causing the channels to become blocked and the nutritive Qi to lose its harmonious flow."

Historical Context

How Gua Lou Niu Bang Zi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gua Lou Niu Bang Zi Tang originates from the Yi Zong Jin Jian (《医宗金鉴》, Golden Mirror of Medical Tradition), compiled in 1742 under the direction of Wu Qian and commissioned by the Qianlong Emperor of the Qing Dynasty. This massive 90-volume work was intended as the authoritative medical textbook for the entire empire, and the formula appears in its surgical (wai ke) section as the primary treatment for early-stage breast abscess.

The famous Shanghai external medicine specialist Gu Xiaoyan (顾筱岩), whose family practiced for generations, significantly modified this formula based on decades of clinical experience treating thousands of postpartum mastitis cases. Gu found that the original formula was effective at clearing redness and heat but often left behind hard lumps that were slow to resolve. Reasoning that postpartum women have depleted Qi and Blood and should not be over-cooled, he removed the strongly cold herbs (Jin Yin Hua, Lian Qiao, Huang Qin, Shan Zhi) and added wind-dispersing herbs (Jing Jie, Fang Feng, Zi Su Geng) along with milk-promoting herbs (Liu Xing Zi, Si Gua Luo) and the warm Deerhorn Frost (Lu Jiao Shuang). His modified version reportedly achieved faster resolution rates than the original.

In modern clinical practice, the formula remains a standard first-line TCM treatment for acute lactation mastitis in China. It is referenced in current Chinese surgery textbooks as the representative formula for the Qi stagnation and Heat accumulation pattern of breast abscess.