Formula

Huang Lian Shang Qing Tang

Coptis Relieve Fire | 黄连上清汤

Also known as:

Huang Lian Shang Qing Wan , Huang Lian Shang Qing Pian

Properties

Heat-clearing formulas · Cold

Key Ingredients

Huang Lian

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to clear excess Heat from the head and face, and relieve symptoms such as toothache, sore throat, mouth ulcers, red eyes, headache, ear pain, and constipation caused by Wind-Heat attacking upward combined with internal Fire in the Lungs and Stomach. It is intended for short-term use during acute flare-ups and is not suitable for people with weak, cold digestion.

Formula Category

Main Actions

  • Disperses Wind-Heat
  • Clears Heat and Drains Fire
  • Resolves Toxicity
  • Purges Heat and Unblocks the Bowels
  • Alleviates Pain

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huang Lian Shang Qing Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Huang Lian Shang Qing Tang addresses this pattern

When Wind-Heat invades and lodges in the head and face, it produces headache, red swollen eyes, sore throat, ear pain, and facial swelling. This formula directly disperses Wind-Heat using its team of light, ascending herbs (Bo He, Ju Hua, Jing Jie Sui, Man Jing Zi, Fang Feng, Bai Zhi) while simultaneously clearing the internal Heat that allows the external pathogen to gain a foothold. The combination of exterior-releasing and interior-clearing herbs makes the formula effective for patterns where Wind-Heat at the surface is compounded by pre-existing internal Fire.

A practitioner would look for one or more of these signs

Headaches

Distending headache, especially frontal or at the vertex

Red Eyes

Sudden onset of red, swollen, painful eyes

Sore Throat

Red, swollen, painful throat

Tinnitus

Ear pain and ringing in the ears

Dizziness

Dizziness and a heavy, distended sensation in the head

How It Addresses the Root Cause

This formula addresses a pattern where Wind-Heat attacks the upper body while excess Heat accumulates in the Lung and Stomach systems. Understanding how this develops helps explain why the symptoms concentrate in the head and face.

In TCM theory, the head is where all the Yang channels converge, making it especially vulnerable to Wind and Heat. When external Wind-Heat invades, or when internal Fire builds up from dietary excess (spicy, greasy, or rich foods) or emotional stress, Heat tends to flare upward along the body's channels. The Stomach channel traverses the gums, face, and forehead. The Lung opens to the nose and governs the throat. When Fire blazes in these organ systems, it rises to the head and face, producing a cluster of "upper body" symptoms: red swollen eyes, throbbing toothache, mouth ulcers, sore throat, ear pain, tinnitus, and headache with a sensation of pressure or heaviness in the head.

Meanwhile, this same Heat dries out the intestinal fluids, causing constipation and dark, scanty urine. The constipation itself worsens the problem because it traps Heat inside the body with no exit route, creating a vicious cycle where Fire keeps flaming upward. The formula works by attacking this pattern from two directions simultaneously: it vents Wind-Heat outward through the body's surface (using aromatic dispersing herbs), and it purges accumulated Heat downward through the bowels (using Rhubarb and other draining herbs). By opening an exit below, the upward pressure of Fire is relieved, and the painful symptoms in the head, eyes, mouth, and throat resolve.

Formula Properties

Temperature

Cold

Taste Profile

Predominantly bitter and acrid (pungent), with the bitter taste predominating to drain Fire and dry Dampness, while the acrid component disperses Wind-Heat from the exterior and head region.

Target Organs
Heart Liver Lungs Stomach Large Intestine
Channels Entered
Lung Large Intestine Stomach Heart Liver

Formula Origin

Sì Hè Tíng Jí Fāng (饲鹤亭集方)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Huang Lian Shang Qing Tang

Detailed information about each herb in Huang Lian Shang Qing Tang and their roles

Huang Lian
Huang Lian

Coptis rhizome

Dosage: 3 - 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Huang Lian Shang Qing Tang

Clears Heart Fire and drains Heat from the middle burner. As the namesake and core herb, it directly addresses the root cause of internal Fire flaring upward to the head and face.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Clears Heat from the upper burner, particularly the Lungs, reinforcing Huang Lian's Fire-draining action in the upper body.

Huang Qi
Huang Qi

Astragalus root

Dosage: 3 - 6g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Drains Damp-Heat from the lower burner, ensuring the formula clears Heat throughout all three burners. Processed with wine (酒炒) to direct its action upward.

Shi Gao
Shi Gao

Gypsum

Dosage: 6 - 9g

Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Parts Used Mineral (矿物 kuàng wù)
Role in Huang Lian Shang Qing Tang

Clears excess Heat from the Lungs and Stomach, addressing the intense internal Heat that drives symptoms like toothache, thirst, and gum swelling.

Zhi Zi
Zhi Zi

Gardenia fruit

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Huang Lian Shang Qing Tang

Drains Fire through all three burners and guides Heat downward for elimination via urination. Ginger-processing (姜制) moderates its cold nature to protect the Stomach.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 3 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Purges accumulated Heat downward through the bowels, clearing constipation and providing a critical exit route for internal Fire. Wine-processing moderates its harsh purgative action.

Lian Qiao
Lian Qiao

Forsythia fruit

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Huang Lian Shang Qing Tang

Clears Heat and resolves toxins, particularly effective for swelling, sore throat, and skin eruptions in the head and face area.

Ju Hua
Ju Hua

Chrysanthemum flower

Dosage: 6 - 12g

Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver
Parts Used Flower (花 huā)
Role in Huang Lian Shang Qing Tang

Disperses Wind-Heat from the head and eyes, clearing red, painful, swollen eyes and relieving headache and dizziness.

Bo He
Bo He

Peppermint herb

Dosage: 3 - 6g

Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Huang Lian Shang Qing Tang

Disperses Wind-Heat from the head, clears the throat, and relieves headache. Its light, aromatic nature helps vent Heat outward from the upper body.

Jing Jie
Jing Jie

Schizonepeta

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Huang Lian Shang Qing Tang

Releases the exterior and disperses Wind from the head, helping to vent Wind-Heat pathogens outward and relieve headache.

Fang Feng
Fang Feng

Siler root

Dosage: 3 - 6g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Dispels Wind and relieves pain, working with Jing Jie and Bai Zhi to address the Wind component of the Wind-Heat pattern that drives head and face symptoms.

Bai Zhi
Bai Zhi

Dahurian angelica root

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach, Large Intestine
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Dispels Wind, opens the nasal passages, and relieves pain, particularly frontal headache and toothache in the upper jaw.

Man Jing Zi
Man Jing Zi

Vitex fruit

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Urinary Bladder, Liver, Stomach
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Huang Lian Shang Qing Tang

Disperses Wind-Heat and clears the head and eyes, relieving headache, dizziness, and eye pain. Dry-fried to enhance its ascending action.

Chuan Xiong
Chuan Xiong

Sichuan lovage rhizome

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Huang Lian Shang Qing Tang

Moves Qi and Blood in the head region, relieving headache. As a key head-directing herb, it helps carry other medicinals to the affected area.

Xuan Fu Hua
Xuan Fu Hua

Inula flower

Dosage: 3 - 6g

Temperature Slightly Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Salty (咸 xián)
Organ Affinity Lungs, Spleen, Stomach, Large Intestine
Parts Used Flower (花 huā)
Role in Huang Lian Shang Qing Tang

Descends rebellious Qi in the upper burner, counteracting the upward surging of congested Fire and Qi. Helps direct stagnant Heat downward.

Jie Geng
Jie Geng

Balloon flower root

Dosage: 3 - 6g

Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Opens and diffuses Lung Qi, benefits the throat, and acts as a guiding herb that directs the formula's action upward to the throat, head, and face.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Huang Lian Shang Qing Tang

Harmonizes all the herbs in the formula, moderates the harsh cold nature of the Heat-clearing herbs to protect the Stomach, and clears Heat from the throat.

Modern Research (1 study)

  • In Silico Target Analysis of Treatment for COVID-19 Using Huang-Lian-Shang-Qing-Wan, a Traditional Chinese Medicine Formula (Network Pharmacology Study, 2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

After meals, twice daily, to reduce the risk of gastrointestinal irritation from the bitter-cold and purgative ingredients.

Typical Duration

Short-term acute use only: 3-5 days. If symptoms do not improve within 3 days, seek medical consultation. This formula is not suitable for long-term use.

Dietary Advice

While taking this formula, avoid spicy, hot, greasy, fried, and rich foods, as these generate internal Heat and directly counteract the formula's cooling and Heat-clearing actions. Alcohol and tobacco should also be strictly avoided, as they produce Heat and toxins. Do not take tonifying or supplementing Chinese herbal medicines concurrently, as their warming and enriching properties conflict with this formula's draining strategy. Favor light, easily digestible foods such as clear soups, steamed vegetables, congee (rice porridge), mung beans, and cooling fruits like pear and watermelon. Adequate water intake supports the formula's action of flushing Heat through the urine and bowels.

Special Populations

Pregnancy

Contraindicated during pregnancy. The formula contains Da Huang (Rhubarb, specifically wine-processed), which is a strong purgative that stimulates intestinal peristalsis and can reflexively promote uterine contractions, posing a risk of miscarriage or premature labor. Additionally, the overall formula is intensely cold and draining in nature, which can injure the vital Qi and Blood needed to sustain pregnancy. Several official Chinese Pharmacopoeia labeling sources explicitly state that pregnant women should avoid this formula (孕妇忌服 or 孕妇慎用). The combination of multiple bitter-cold herbs (Huang Lian, Huang Qin, Huang Bai, Zhi Zi) and the purgative Da Huang makes this formula unsuitable at any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. The formula contains multiple bitter-cold and purgative ingredients whose active compounds may transfer into breast milk. Da Huang (Rhubarb) contains anthraquinone glycosides (such as sennosides and emodin) that are known to pass into breast milk and may cause diarrhea or digestive upset in the nursing infant. Huang Lian (Coptis) contains berberine, which has been detected in breast milk in pharmacological studies. The strongly cold and draining nature of the overall formula may also reduce breast milk production by injuring Spleen and Stomach Qi in the mother. Official labeling advises that breastfeeding women should use this formula only under the guidance of a healthcare practitioner. If use is necessary, it should be limited to the shortest possible duration (a few days at most), and the infant should be monitored for any changes in stool or feeding patterns.

Pediatric Use

This formula should be used in children only under the guidance of a qualified healthcare practitioner. Official labeling specifically notes that children should use this formula with medical supervision. Key considerations: - Generally not recommended for very young children (under 3 years) due to the strongly cold and purgative nature of the formula. - For older children (roughly 6 years and above), the dose must be significantly reduced, typically to one-third to one-half of the adult dose, adjusted by age and body weight. - Da Huang (Rhubarb) can cause diarrhea, abdominal cramping, and fluid loss, which children are more vulnerable to than adults. Electrolyte imbalance from excessive purging is a greater risk in pediatric patients. - Duration should be strictly limited to 2-3 days, and the child should be monitored for excessive loose stools or abdominal pain. - Children's digestive systems are considered physiologically immature in TCM (脾常不足), making them more susceptible to damage from bitter-cold formulas.

Drug Interactions

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which has well-documented interactions with several drug classes:

  • Digoxin and cardiac glycosides: Licorice can cause potassium depletion, which increases the toxicity of digoxin and raises the risk of dangerous cardiac arrhythmias.
  • Potassium-depleting diuretics (thiazides, furosemide): Combined use may lead to excessive potassium loss, causing muscle weakness and cardiac rhythm disturbances.
  • Antihypertensives: Licorice promotes sodium and water retention, potentially reducing the effectiveness of blood pressure medications.
  • Warfarin and anticoagulants: Licorice may interfere with warfarin metabolism, potentially reducing its anticoagulant effect.
  • Corticosteroids: Licorice may potentiate the side effects of corticosteroids through additive mineralocorticoid activity.

Da Huang (Rhubarb) contains anthraquinone glycosides that stimulate bowel movement:

  • Other laxatives: Combined use increases the risk of dehydration and electrolyte imbalance.
  • Cardiac glycosides (digoxin): Chronic use of Rhubarb can also deplete potassium, compounding the risk alongside Licorice.
  • Oral medications in general: Rhubarb's purgative effect may accelerate intestinal transit and reduce absorption of concurrently taken oral drugs.

Huang Lian (Coptis) and Huang Bai (Phellodendron) contain berberine and related alkaloids, which have been shown to inhibit certain cytochrome P450 enzymes (particularly CYP3A4 and CYP2D6), potentially affecting the metabolism of drugs processed through these pathways, including some statins, immunosuppressants (cyclosporine), and certain antidepressants.

Bo He (Mentha) may have mild CYP enzyme interactions, though these are generally not clinically significant at the doses used in this formula.

Patients taking any prescription medications should consult their physician or pharmacist before using this formula.

Contraindications

Avoid

Spleen and Stomach deficiency Cold (脾胃虚寒): This formula is strongly cold in nature and contains purgative herbs like Da Huang (Rhubarb). People with a constitutionally weak and cold digestive system, loose stools, poor appetite, or cold abdominal pain should not use this formula, as it will further damage Spleen and Stomach Yang.

Avoid

Yin deficiency with Empty Fire: When symptoms like mouth sores or sore throat arise from Yin deficiency rather than genuine excess Heat, this formula's cold and draining nature will further deplete Yin and body fluids without addressing the root cause.

Avoid

Pregnancy: The formula contains Da Huang (Rhubarb), which stimulates intestinal peristalsis and may promote uterine contractions, and other cold bitter herbs that are unsuitable during pregnancy. Official labeling states pregnant women should either avoid or use with extreme caution.

Avoid

Known allergy or hypersensitivity to any of the 17 ingredients in the formula. Allergic individuals should exercise caution.

Caution

Chronic conditions such as hypertension, heart disease, liver disease, diabetes, or kidney disease require medical supervision before using this formula.

Caution

Elderly and physically weak individuals: The formula's strongly purging and cold nature can easily injure the body's righteous Qi. Dosage should be reduced and duration limited.

Caution

Should not be taken concurrently with tonifying or supplementing Chinese herbal formulas, as the formula's cold purgative actions will counteract their warming and nourishing effects.

Caution

Diarrhea or loose stools during use: If bowel movements become excessively frequent or watery, the dose should be reduced or the formula discontinued.

Cautions & Warnings

Huang Lian Shang Qing Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Liu Wei Di Huang Wan.

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Granules

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