Tou Nong San

Discharge Pus Powder · 透脓散

Also known as: Tou Nong Tang (透脓汤)

A classical surgical formula used to help the body expel pus from abscesses and boils that have formed internally but cannot break through on their own. It works by strengthening the body's Qi and Blood while actively promoting the discharge of pus, making it a key formula for sores and infections that are 'ripe' but stuck.

Origin Wai Ke Zheng Zong (《外科正宗》), Volume 1, by Chen Shigong (陈实功) — Ming dynasty, 1617 CE
Composition 5 herbs
Huang Qi
King
Huang Qi
Dang Gui
Deputy
Dang Gui
Chuan Xiong
Deputy
Chuan Xiong
Ch
Assistant
Chuan Shan Jia
Zao Jiao Ci
Assistant
Zao Jiao Ci
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tou Nong San is designed to correct these specific patterns.

Why Tou Nong San addresses this pattern

This is the primary pattern for Tou Nong San. When Qi and Blood are insufficient, the body cannot muster enough force to push accumulated toxic pus to the surface. The formula's heavy dose of Huang Qi directly addresses the Qi deficiency that is the root cause of the stalled healing process, while Dang Gui and Chuan Xiong replenish and move Blood. The penetrating action of Chuan Shan Jia and Zao Jiao Ci directly addresses the local toxin accumulation by breaking through the hardened tissue barrier. The overall effect is that the body's renewed strength, combined with the formula's piercing power, forces the pus to erupt and drain, allowing the healing process to resume.

A practitioner would look for one or more of these signs

Abscess

Soft, ripe abscess with pus formed inside but unable to break through the surface

Swelling

Diffuse swelling without a defined head (man zhong wu tou)

Fatigue

General fatigue and weakness reflecting underlying Qi deficiency

Pain

Aching, distending pain at the lesion site with a sense of heat

Pale Complexion

Pale face and pale tongue reflecting Blood deficiency

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Tou Nong San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Qi and Blood deficiency with toxin accumulation

TCM Interpretation

In TCM, skin abscesses are understood as localized accumulations of toxic Heat in the flesh. When external pathogens or internal Heat toxins lodge in the tissue, the struggle between the body's righteous Qi and the pathogen generates intense local Heat. This Heat 'cooks' the surrounding flesh and Blood, transforming it into pus. In healthy individuals, strong Qi and Blood naturally push this pus to the surface, where it erupts, drains, and healing follows. When the patient's constitution is weak, Qi and Blood are insufficient to complete this expulsive process. The abscess becomes trapped: ripe with pus inside but unable to break through, presenting as a diffuse, soft, aching swelling without a clear head.

Why Tou Nong San Helps

Tou Nong San directly addresses the failure to expel pus by tackling both the weakness and the blockage simultaneously. Sheng Huang Qi, the King herb at the highest dose, powerfully boosts Qi to restore the body's expulsive force. Dang Gui and Chuan Xiong replenish and invigorate Blood so that circulation to the lesion improves, bringing healing nutrients while clearing stagnant debris. Chuan Shan Jia and Zao Jiao Ci physically penetrate through the hardened abscess wall, creating a pathway for the pus to drain. Modern research suggests the formula promotes tissue repair, modulates immune function, and has anti-inflammatory and antibacterial effects.

Also commonly used for

Boils And Carbuncles

Deep boils and carbuncles at the suppurative stage

Tonsillitis

Suppurative (pus-forming) tonsillitis

Perianal Abscess

Post-surgical recovery from perianal abscess

Diabetic Neuropathy

Diabetic peripheral neuropathy (modern extended application)

Inflammatory Bowel Disease

Crohn's disease and ulcerative colitis (modern research application)

What This Formula Does

Every TCM formula has a specific set of actions — here's what Tou Nong San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Tou Nong San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Tou Nong San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Tou Nong San works at the root level.

This formula addresses abscesses and boils (known as yong yang in TCM) that have reached the middle stage of development: pus has already formed inside the lesion, but the body is too weak to push it out. In TCM theory, when toxic pathogens invade the body and lodge in the flesh, the struggle between the body's righteous Qi and the invading toxin produces Heat. This Heat cooks the local flesh and Blood into pus. In a person with strong Qi and Blood, the body naturally pushes this pus to the surface, where the abscess breaks open, drains, and begins to heal.

However, when Qi and Blood are deficient, the body lacks the driving force to push the pus outward. The abscess becomes a diffuse, soft swelling without a defined head, aching and distending but unable to rupture. The pus sits trapped inside, toxins cannot be expelled, and healing stalls. The tongue is typically pale (reflecting Qi and Blood deficiency), and the pulse is thin and weak. The fundamental problem is therefore twofold: the toxic pathogen has already done its damage and produced pus, yet the body's Qi is too weak to complete the natural process of expelling it.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and pungent — sweet from Huang Qi to tonify Qi and support the body, pungent from Chuan Xiong, Zao Jiao Ci, and Chuan Shan Jia to move Blood, penetrate obstruction, and push toxins outward.

Ingredients

5 herbs

The herbs that make up Tou Nong San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Preparation Must be used raw (sheng), not honey-prepared (zhi). The raw form retains its toxin-expelling action, while the prepared form loses this function.

Role in Tou Nong San

The chief herb, used raw (sheng) and in the highest dose. Raw Huang Qi powerfully tonifies Qi and lifts Yang, enabling the body's vital force to push toxins and pus outward through the skin surface. It is traditionally called the 'holy herb for sores' (chuang jia sheng yao) because of its unique ability to support the body's expulsive power when it is too weak to resolve an abscess on its own.
Deputies — Assists and enhances the King
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Tou Nong San

Nourishes and invigorates Blood, supporting the King herb's Qi-tonifying action so that both Qi and Blood are replenished. Adequate Blood flow is essential for tissue repair and for carrying toxins away from the abscess site. Also helps resolve stagnant blood that has accumulated around the swelling.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 6 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Tou Nong San

A powerful Blood-invigorating herb that promotes circulation and breaks through Blood stasis around the abscess. It works closely with Dang Gui to ensure smooth Blood flow to the lesion, helping to generate new tissue while clearing old, stagnant material. Its ascending and dispersing nature supports the outward movement of pus.
Assistants — Supports or moderates other herbs
Ch

Chuan Shan Jia

Pangolin scales

Dosage 3 - 6g
Temperature Slightly Cool
Taste Salty (咸 xián)
Organ Affinity Liver, Stomach
Preparation Stir-baked until puffed (chao), then ground into powder before adding to the decoction. Note: due to conservation concerns, modern substitutes such as Wang Bu Liu Xing (Vaccariae Semen) are often used.

Role in Tou Nong San

A strongly penetrating substance that travels through channels and network vessels to reach deep-seated lesions. It softens hardness, disperses swelling, and actively promotes the discharge of pus. Its piercing, unblocking nature helps break through the abscess wall so that the accumulated pus can drain outward. Must be stir-baked (chao) and powdered before use.
Zao Jiao Ci

Zao Jiao Ci

Chinese Honeylocust Spine

Dosage 3 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Stomach

Role in Tou Nong San

Sharp and penetrating in nature, it pierces through swollen tissue and directs the formula's power straight to the abscess site. Working synergistically with Chuan Shan Jia, it softens hardened lumps and promotes the eruption and discharge of pus. Its searching, dispersing quality helps break up local stagnation in the channels.

Why This Combination Works

How the herbs in Tou Nong San complement each other

Overall strategy

Since the core problem is Qi deficiency preventing pus discharge, the formula simultaneously tonifies the body's Qi and Blood while using penetrating medicinals to break through the abscess and force the pus outward. This is the classical 'supporting the righteous to expel toxins' (tuo du) approach in TCM surgery.

King herbs

Sheng Huang Qi (raw Astragalus) serves as the sole King, used at the highest dose. It powerfully tonifies Qi and lifts Yang, providing the upward and outward driving force needed to push pus through the skin. Crucially, it must be used raw (sheng), because raw Astragalus retains its toxin-expelling property. The honey-prepared form (zhi) would simply tonify without pushing outward.

Deputy herbs

Dang Gui and Chuan Xiong together form the Blood-nourishing and Blood-moving pair. Dang Gui replenishes Blood and resolves old stagnant blood around the abscess. Chuan Xiong invigorates Blood circulation and has an ascending, dispersing quality. Together they ensure that fresh Blood reaches the lesion while stagnant material is cleared, complementing Huang Qi's Qi-level action with Blood-level support.

Assistant herbs

Chuan Shan Jia (pangolin scales) and Zao Jiao Ci (gleditsia thorns) are the penetrating pair. Both are sharp, searching substances that physically pierce through hardened tissue and direct the formula's power deep into the abscess. They soften hardness and promote the actual eruption of pus. These are reinforcing assistants that amplify the King herb's toxin-expelling function from a different angle, adding a mechanical 'breaking through' quality that Huang Qi alone cannot provide.

Notable synergies

The Huang Qi + Chuan Shan Jia + Zao Jiao Ci trio is the signature synergy: Huang Qi provides the driving Qi force, while the two penetrating substances provide the pathways for that force to reach the abscess and break it open. Without Huang Qi, the penetrating herbs lack power; without them, Huang Qi's push has no direction. The Dang Gui + Chuan Xiong pair ensures Blood support so that after pus is discharged, new tissue can grow and the wound can heal.

How to Prepare

Traditional preparation instructions for Tou Nong San

The original text prescribes 5 herbs. Use approximately 400 ml of water. Soak the herbs first, then decoct until reduced to about 200 ml. Strain the decoction, then re-decoct the dregs with fresh water and combine the two batches. Serve warm in divided doses. A small amount of rice wine (huang jiu) may be added just before drinking to enhance the formula's ability to invigorate Blood circulation and drive the medicinals to the affected area.

Common Modifications

How practitioners adapt Tou Nong San for specific situations

Added
Pu Gong Ying

15 - 30g, clears Heat and resolves toxins, especially effective for breast and skin abscesses

Zi Hua Di Ding

15 - 30g, clears Heat toxins and reduces swelling

The base formula focuses on tonifying and expelling but lacks strong Heat-clearing action. Adding these two powerful Heat-clearing, toxin-resolving herbs addresses cases where toxic Heat is particularly intense.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Tou Nong San should not be used or requires extra caution

Avoid

Abscess or swelling in the early stage (initial onset) when pus has not yet formed. This formula is specifically designed to discharge pus that has already accumulated, and using it prematurely could worsen the condition by driving toxins deeper or promoting tissue breakdown before it is ready to drain.

Avoid

Yin-type sores (阴疽) that are cold, pale, flat, and non-inflamed without signs of heat or active suppuration. Tou Nong San is intended for Yang-type abscesses with local heat and ripened pus. Yin-type sores require warming and tonifying strategies instead.

Caution

Ulcerated sores that have already broken open and are draining pus freely. Once the abscess has spontaneously ruptured and drainage is established, this formula's pus-discharging action is no longer needed and could over-disperse, hindering wound closure and tissue regeneration.

Caution

Severe Qi and Blood deficiency with marked exhaustion. While the formula does tonify Qi and Blood, patients who are extremely weak may not tolerate its strong pus-expelling ingredients (Chuan Shan Jia and Zao Jiao Ci). In such cases, stronger tonification should be given first.

Avoid

Pregnancy. The formula contains Chuan Shan Jia (Pangolin Scales) and Zao Jiao Ci (Gleditsia Thorn), both of which have strong Blood-moving and penetrating actions that may pose risk to the fetus.

Caution

Patients with bleeding disorders or on anticoagulant therapy, as the formula contains Blood-activating herbs (Dang Gui, Chuan Xiong) and penetrating agents (Chuan Shan Jia) that may increase bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Chuan Shan Jia (Pangolin Scales) and Zao Jiao Ci (Gleditsia Thorn), both of which have strong penetrating and Blood-moving properties. Chuan Xiong (Szechuan Lovage) and Dang Gui (Chinese Angelica) also actively move Blood. These combined actions may stimulate uterine contractions or promote bleeding, posing a risk of miscarriage. Pregnant women who develop abscesses should seek alternative treatment strategies under professional guidance.

Breastfeeding

Caution is advised during breastfeeding. While the formula has historically been used to treat mastitis and even to promote lactation (with modifications), its Blood-moving and penetrating ingredients (particularly Chuan Shan Jia and Chuan Xiong) may transfer bioactive compounds into breast milk. If used for breastfeeding-related conditions such as breast abscess, it should only be taken under professional supervision with careful monitoring of the nursing infant for any adverse effects. Dosage and duration should be kept to the minimum effective level.

Children

Tou Nong San is not commonly used in young children. In older children and adolescents, dosage should be reduced to approximately one-third to one-half of the adult dose depending on age and body weight, and the formula should only be used under professional supervision. The strong penetrating and Blood-moving nature of ingredients like Chuan Shan Jia (Pangolin Scales) and Zao Jiao Ci (Gleditsia Thorn) warrants particular caution in pediatric populations. For children under 6, alternative approaches for managing abscesses should generally be preferred. Note that Chuan Shan Jia is a controlled substance in many jurisdictions and may be substituted with other penetrating herbs in modern practice.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Tou Nong San

  • Anticoagulants and antiplatelet drugs (e.g. warfarin, aspirin, clopidogrel): Dang Gui (Chinese Angelica) and Chuan Xiong (Szechuan Lovage) both activate Blood circulation. Combined use may potentiate anticoagulant effects and increase the risk of bleeding. Close monitoring of coagulation parameters (e.g. INR) is recommended if co-administration is unavoidable.
  • Immunosuppressants: Huang Qi (Astragalus) has well-documented immunomodulatory effects. In patients taking immunosuppressive medications (e.g. cyclosporine, tacrolimus), concurrent use may alter immune function in unpredictable ways. Professional supervision is advised.
  • Hypoglycemic agents: Huang Qi has been reported to have blood glucose-lowering effects. Patients on insulin or oral hypoglycemics should monitor blood sugar levels carefully to avoid hypoglycemia when taking this formula.
  • Antibiotics: When used alongside antibiotics for suppurative infections, the formula's pus-expelling action may theoretically complement antibiotic therapy. However, there is no formal interaction data, and concurrent use should be coordinated by a qualified healthcare professional.

Usage Guidance

Practical advice for getting the most out of Tou Nong San

Best time to take

Between meals (on a relatively empty stomach). The original text notes it may be taken with a small cup of warm rice wine to enhance the formula's penetrating action.

Typical duration

Acute use: 3–7 days, taken until the abscess ruptures and drains; reassess promptly if no improvement after 3–5 doses.

Dietary advice

While taking this formula, avoid cold and raw foods (such as salads, iced drinks, and raw seafood) as these can impair Spleen and Stomach function, weakening the body's ability to generate Qi and Blood needed for healing. Also avoid greasy, heavy, and overly rich foods that produce Dampness and may obstruct the flow of Qi. Spicy and hot foods (such as chili, pepper, and deep-fried items) should be limited, as excess internal Heat can worsen inflammation. Instead, favor easily digestible, nourishing foods such as congee, cooked vegetables, lean proteins, and mild soups to support the Spleen and Stomach during recovery.

Tou Nong San originates from Wai Ke Zheng Zong (《外科正宗》), Volume 1, by Chen Shigong (陈实功) Ming dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Tou Nong San and its clinical use

  • 《外科正宗》卷一 (Wai Ke Zheng Zong, Volume 1):
    Original: 「治痈疽诸毒,内脓已成,不穿破者,服之即破。」
    Translation: "Treats all manner of abscesses and toxic swellings in which pus has already formed internally but has not broken through the surface. Taking this formula will cause it to rupture promptly."
  • 《外科正宗》方歌 (Formula verse):
    Original: 「透脓散治毒成脓,服此能成速溃功;川芎归芪甲片皂,加芷蒡银力更雄。」
    Translation: "Tou Nong San treats toxins that have formed pus; taking it achieves the merit of swift rupture. Chuan Xiong, Dang Gui, Huang Qi, Shan Jia, and Zao Jiao are its core; adding Bai Zhi, Niu Bang, and Jin Yin Hua makes its power even greater."
  • 《外科正宗》方义 (Formula analysis):
    Original: 「方中的黄芪益气升阳,托毒外泄;当归、川芎养血活血;穿山甲、皂刺软坚透脓。全方共奏补虚托毒,溃疮透脓之效。」
    Translation: "In this formula, Huang Qi boosts Qi, raises Yang, and pushes toxins outward. Dang Gui and Chuan Xiong nourish and invigorate the Blood. Chuan Shan Jia and Zao Jiao Ci soften hardness and penetrate to discharge pus. Together, the whole formula achieves the effect of supplementing deficiency, expelling toxins, and causing abscesses to rupture and drain."

Historical Context

How Tou Nong San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Tou Nong San originates from the Wai Ke Zheng Zong (《外科正宗》, "Orthodox Manual of External Medicine"), written by the renowned Ming dynasty surgeon Chen Shigong (陈实功, 1555–1636) and published in 1617. Chen Shigong was from Chongchuan (modern-day Nantong, Jiangsu Province) and is considered the leading figure of the "Orthodox School" (正宗派) of Chinese external medicine. He practiced surgery for over forty years, and his book was lauded by later generations as having "the most detailed case descriptions and the most precise treatments" (列症最详,论治最精). The formula reflects Chen's signature clinical philosophy of "supporting the righteous and expelling toxins" (扶正托毒), which prioritized bolstering the patient's constitution so the body could push pus and toxins outward on its own, rather than relying solely on harsh draining or cold-clearing medicines.

The formula exemplifies the "Tuo" (托, "supporting") method, one of the three core strategies of Chinese external medicine: Xiao (消, dispersing), Tuo (托, supporting), and Bu (补, tonifying). Chen emphasized that during the suppuration stage, it was critical not to damage the Spleen and Stomach with excessive cold or attacking herbs, lest the body lose its ability to generate and expel pus. The later Qing dynasty physician Cheng Guopeng (程国彭) expanded the formula in his Yi Xue Xin Wu (《医学心悟》) by adding Bai Zhi, Niu Bang Zi, and Jin Yin Hua, creating a modified version that added heat-clearing and toxin-resolving power for cases with stronger heat-toxin. This modified version is sometimes referenced in the formula verse alongside the original.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Tou Nong San

1

In vitro anti-proliferative and apoptotic effects of Tou Nong San extract on human lymphoma Raji cells (2012)

Fang LH, Wang RP, Hu SY, Zhang L, Liu SL. Chinese Journal of Integrative Medicine, 2012, 18(7): 522–528.

This laboratory study investigated the effects of Tou Nong San extract (TNSE) on Raji human lymphoma cells. TNSE inhibited cell proliferation in a dose- and time-dependent manner. At various concentrations, it significantly increased apoptosis (programmed cell death) rates compared to controls. The mechanism appeared to involve downregulation of NF-kB and upregulation of Bad, caspase-9, and caspase-3, key proteins in the apoptotic pathway.

DOI
2

In vivo antitumor effects of Tou Nong San on colonic cancer xenografts in nude mice (2015)

Fang LH, Wang RP, Hu SY, Hu Y, Zhang L, Qin KH. Evidence-Based Complementary and Alternative Medicine, 2015, Article ID 518454.

This preclinical animal study tested the ethanol extract of Tou Nong San in athymic mice bearing human colon cancer xenografts. After two weeks of oral administration, the extract significantly reduced both tumor weight and volume compared to controls, with no observable adverse reactions or toxicity. LC-MS analysis identified seven major chemical compounds in the extract. The results supported the potential anticancer properties of the formula previously seen in cell culture studies.

DOI
3

Anti-inflammatory effects of Tou Nong San in TNBS-induced inflammatory bowel disease model via NF-kB pathway (2018)

Hu Z, Yang M, Ye Q, Qin K, Wu M, Gu R, Lu F, Ye Q. Evidence-Based Complementary and Alternative Medicine, 2018, Article ID 6929307.

This animal study explored the anti-inflammatory properties of Tou Nong San (TNS) in a rat model of colitis induced by TNBS (a standard model resembling Crohn's disease). HPLC quality control identified six major chemical constituents in the water extract. TNS administration improved weight loss, food intake, and both macroscopic and microscopic tissue damage scores. Proinflammatory cytokines (IL-17, TNF-alpha, IL-1-beta, IL-6) were significantly reduced, with findings linked to regulation of the NF-kB signaling pathway.

DOI
4

Tou Nong Powder inhibits ulcerative colitis via NF-kB/NLRP3/Caspase-1/GSDMD inflammasome pyroptotic pathway (2023)

Hu Y, Ye Q, Qin K, et al. Journal of Ethnopharmacology, 2023, 317:116782.

This preclinical study investigated whether Tou Nong Powder (TNP) could alleviate TNBS-induced colitis in rats through regulation of the NLRP3 inflammasome and pyroptosis (a type of inflammatory cell death). Network pharmacology and UPLC-Q-TOF/MS were used to identify active compounds and targets. TNP showed a therapeutic effect on colitis by suppressing the NF-kB/NLRP3/Caspase-1/GSDMD pathway and reducing the expression of pro-inflammatory cytokines IL-1-beta and IL-18.

PubMed
5

Modified Tou Nong Powder alleviates ulcerative colitis by regulating autophagy and mitochondrial function via AMPK/PGC-1α (2025)

Li L, Ye Z, Qian H, Chen L, Hu Y, Liu X, Zhu J, Bao T, Ganesan K, Lu F, Wang J, Wen X, Qin K, Ye Q. Journal of Ethnopharmacology, 2025, 340:119220.

This recent study examined a modified version of the formula in TNBS-induced colitis models. The modified Tou Nong Powder triggered autophagy (cellular self-cleaning) and enhanced mitochondrial function, leading to alleviation of ulcerative colitis both in cell cultures and in living animals. These benefits were linked to activation of the AMPK/PGC-1-alpha signaling pathway, suggesting a novel mechanism for the formula's therapeutic effects on mucosal ulceration.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.