Qing Re Tiao Xue Tang

Heat-Clearing Blood-Regulating Decoction · 清熱調血湯

Also known as: Qing Re Si Wu Tang (清热四物汤)

A gynaecological formula used to clear internal Heat and move stagnant Blood, primarily for menstrual pain, heavy or dark periods, and pelvic discomfort caused by Heat accumulating in the Blood and obstructing its free flow. It is one of the most commonly used formulas for painful periods associated with signs of Heat such as a burning sensation, dark clotted menstrual blood, and a red tongue.

Origin 万病回春 (Wàn Bìng Huí Chūn) by Gong Tingxian (龚廷贤) — Míng dynasty, 1587 CE
Composition 11 herbs
Mu Dan Pi
King
Mu Dan Pi
Shu Di Huang
King
Shu Di Huang
Huang Lian
Deputy
Huang Lian
Dang Gui
Deputy
Dang Gui
Bai Shao
Deputy
Bai Shao
Chuan Xiong
Assistant
Chuan Xiong
Tao Ren
Assistant
Tao Ren
Hong Hua
Assistant
Hong Hua
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Re Tiao Xue Tang is designed to correct these specific patterns.

Why Qing Re Tiao Xue Tang addresses this pattern

This is the primary pattern this formula was designed to treat. When Heat accumulates in the Blood level, it 'scorches' and thickens the Blood, causing it to stagnate. In the uterus, this manifests as painful periods with dark, clotted menstrual blood, burning sensations, and cyclical lower abdominal pain. The formula addresses this by cooling the Blood with Mu Dan Pi and Sheng Di Huang, draining Heat with Huang Lian, and actively breaking up stasis with Tao Ren, Hong Hua, E Zhu, and Chuan Xiong. Meanwhile, Dang Gui and Bai Shao nourish and harmonize the Blood to support regeneration, while Yan Hu Suo and Xiang Fu relieve the resulting pain.

A practitioner would look for one or more of these signs

Amenorrhea

Menstrual pain that is intense, burning, or stabbing in character, worsening with pressure

Dark Menstrual Clots

Dark-coloured menstrual blood with clots

Postmenstrual Bleeding

Heavy or prolonged periods with dark-red blood

Abdominal Pain

Lower abdominal pain and distension before or during menstruation

Red Tongue

Red tongue with yellow coating, wiry-rapid pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Re Tiao Xue Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM views menstrual pain as a disruption in the free flow of Qi and Blood through the uterus and its connecting channels. In the specific type of dysmenorrhea this formula addresses, Heat (from emotional constraint, dietary factors, or constitutional tendency) enters the Blood level and 'bakes' it, making it thick and sluggish. This stagnant, overheated Blood blocks the uterine vessels, and the resulting obstruction produces pain that is typically sharp or burning, worse with pressure, and accompanied by dark, clotted menstrual flow. The Liver is often involved, as its role in ensuring smooth Qi flow directly governs menstrual regularity.

Why Qing Re Tiao Xue Tang Helps

The formula targets the two interconnected causes of this type of menstrual pain: the Heat and the Blood stasis. Mu Dan Pi and Sheng Di Huang cool the Blood so it can flow more freely, while Huang Lian drains excess Heat. Tao Ren, Hong Hua, and E Zhu actively break up the clotted, stagnant Blood that is causing the obstruction. Yan Hu Suo provides direct pain relief by moving both Qi and Blood, and Xiang Fu directs the formula's action to the uterus while ensuring Liver Qi flows smoothly. Dang Gui and Bai Shao nourish the Blood to support recovery and prevent the strongly moving herbs from causing depletion.

Also commonly used for

Irregular Menstruation

Menstrual irregularity with Heat signs

Uterine Fibroids

With Heat signs and Blood stasis

Ovarian Cysts

Functional cysts with pelvic pain and Heat signs

Postmenstrual Bleeding

When caused by Heat forcing Blood out of the vessels

Abnormal Uterine Bleeding

With dark, clotted blood and Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Re Tiao Xue Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Re Tiao Xue Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Re Tiao Xue Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Re Tiao Xue Tang works at the root level.

This formula addresses a pattern where Heat lodges in the Blood level of the Uterus (Chong and Ren channels), causing the Blood to become both agitated and stagnant. In TCM theory, Heat in the Blood has a paradoxical effect: it makes the Blood "reckless" (forcing it to move erratically) while simultaneously "scorching" it into thick, sluggish clots. This combination of Heat and stasis creates a vicious cycle. As the menstrual period approaches, Qi and Blood naturally surge downward toward the Uterus. When they encounter the existing obstruction of Heat and stasis in the lower abdomen, the flow is blocked, producing the characteristic intermittent cramping pain described in the classical indication.

Emotional frustration or chronic stress can compound this mechanism. When Liver Qi becomes constrained, it generates internal Heat (Qi stagnation transforming into Fire), and this Heat is readily transmitted into the Blood level via the Liver's close relationship with Blood storage and the Chong channel. The stagnant Qi also impairs Blood circulation directly, worsening the stasis. This is why the original text specifies "Qi and Blood both in excess" — it is not a deficiency problem but rather an excess condition of Heat congesting the Blood combined with Qi stagnation driving the pain.

In modern clinical practice, this pathomechanism is commonly seen in conditions such as endometriosis-related dysmenorrhea, chronic pelvic inflammatory disease, and uterine fibroids where the presenting pattern involves Heat signs (dark red or purplish menstrual blood with clots, burning sensations, yellow tongue coating) alongside stasis signs (fixed stabbing pain, clotted flow).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and pungent — bitter to clear Heat and drain Fire downward, pungent to move Qi and Blood and dispel stasis, with a secondary sour-sweet note from the Blood-nourishing herbs.

Channels Entered

Liver Heart Spleen Chong Mai (冲脉) Penetrating Vessel

Ingredients

11 herbs

The herbs that make up Qing Re Tiao Xue Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Qing Re Tiao Xue Tang

Clears Heat from the Blood level, cools the Blood, and activates Blood circulation to dispel stasis. As King herb it directly addresses the core pathomechanism of Heat accumulating in the Blood layer of the uterus.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Qing Re Tiao Xue Tang

Clears Heat, cools the Blood, and nourishes Yin. Works alongside Mu Dan Pi to clear Heat from the Blood level while protecting Yin fluids from being consumed by Heat.
Deputies — Assists and enhances the King
Huang Lian

Huang Lian

Coptis rhizome

Dosage 5 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Qing Re Tiao Xue Tang

Clears Heat and dries Dampness, particularly in the Lower Burner. Powerfully drains excess Fire-Heat that has accumulated alongside Blood stasis, reinforcing the Heat-clearing action of the King herbs from a different angle.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Qing Re Tiao Xue Tang

Nourishes and harmonizes the Blood while also gently activating Blood circulation. Prevents the cold, bitter Heat-clearing herbs from damaging the Blood and ensures that new Blood is generated as stasis is resolved.
Bai Shao

Bai Shao

White peony root

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Preparation Some traditions specify wine-processed (jiu zhi) Bai Shao to enhance its Blood-moving quality

Role in Qing Re Tiao Xue Tang

Nourishes the Blood, softens the Liver, and alleviates pain. Works with Dang Gui to nourish Blood while its sour-astringent quality helps contain Blood within the vessels.
Assistants — Supports or moderates other herbs
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Qing Re Tiao Xue Tang

Invigorates Blood and promotes the movement of Qi within the Blood. As the key 'Qi-within-Blood' herb, it ensures that Blood circulates freely and does not stagnate, amplifying the stasis-resolving effect of the formula.
Tao Ren

Tao Ren

Peach kernel

Dosage 6 - 9g
Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine

Role in Qing Re Tiao Xue Tang

Breaks up Blood stasis and promotes Blood circulation. Directly targets established Blood stasis in the lower abdomen, working with Hong Hua to form the classical Blood-moving pair.
Hong Hua

Hong Hua

Safflower

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver

Role in Qing Re Tiao Xue Tang

Invigorates Blood, dispels stasis, and unblocks the channels. Pairs with Tao Ren to provide powerful stasis-dispelling action directed at menstrual Blood stagnation.
E Zhu

E Zhu

Zedoary rhizome

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Spleen

Role in Qing Re Tiao Xue Tang

Breaks Blood stasis and promotes the movement of Qi. Particularly effective for stubborn, fixed abdominal masses or severe menstrual clotting where Blood stasis has become entrenched.
Yan Hu Suo

Yan Hu Suo

Corydalis tuber

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen

Role in Qing Re Tiao Xue Tang

Moves both Qi and Blood and is one of Chinese medicine's most important pain-relieving herbs. Directly addresses the menstrual pain that is the primary symptom this formula targets.
Envoy — Directs the formula to its target
Xiang Fu

Xiang Fu

Nutgrass rhizome

Dosage 6 - 9g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Preparation Vinegar-processed (cu zhi) Xiang Fu is preferred to enhance its pain-relieving and Liver-entering qualities

Role in Qing Re Tiao Xue Tang

Moves Liver Qi and alleviates pain, particularly in gynaecological conditions. Known as the 'commander of Qi within Blood-level disorders,' it directs the formula's action to the Liver channel and uterus, and ensures smooth Qi flow so that Blood can circulate freely.

Why This Combination Works

How the herbs in Qing Re Tiao Xue Tang complement each other

Overall strategy

This formula addresses the intertwined pathomechanism of Heat in the Blood and Blood stasis in the uterus. The prescription simultaneously clears Heat, cools the Blood, invigorates Blood circulation, and moves Qi to relieve pain, following the treatment principle of clearing Heat and regulating Blood (清热调血).

King herbs

Mu Dan Pi (Moutan Bark) and Sheng Di Huang (raw Rehmannia) jointly serve as King herbs. Mu Dan Pi is uniquely suited because it both cools the Blood and activates circulation, directly addressing both the Heat and the stasis without being one-sided. Sheng Di Huang powerfully clears Heat from the Blood level while nourishing Yin, protecting fluids from being consumed by the pathological Heat. Together, they cool the Blood without causing it to congeal, and move it without further agitating the Heat.

Deputy herbs

Huang Lian reinforces the Heat-clearing strategy from the standpoint of draining Fire and drying Dampness, particularly effective for Damp-Heat accumulation in the Lower Burner. Dang Gui and Bai Shao form a nourishing pair that harmonizes and supplements the Blood. This is crucial because the many Blood-moving and Heat-clearing herbs in the formula could otherwise deplete or scatter the Blood. Dang Gui also gently activates circulation, while Bai Shao softens the Liver and alleviates cramping pain.

Assistant herbs

Chuan Xiong (reinforcing assistant) moves Qi within the Blood to prevent stagnation, amplifying the effects of the King herbs. Tao Ren and Hong Hua (reinforcing assistants) form a classical Blood-stasis-breaking pair, targeting established stasis in the lower abdomen. E Zhu (reinforcing assistant) adds further stasis-breaking power for cases with palpable masses or severe clotting. Yan Hu Suo (reinforcing assistant with a secondary restraining role) is the formula's chief analgesic, moving both Qi and Blood to directly relieve menstrual pain.

Envoy herbs

Xiang Fu directs the entire formula to the Liver channel and uterus. As the premier Qi-regulating herb for gynaecological conditions, it ensures that Qi flows smoothly through the Blood level, creating the conditions for Blood to circulate freely. Its ability to 'lead' Blood-moving herbs to the reproductive organs makes it an ideal Envoy.

Notable synergies

Mu Dan Pi paired with Sheng Di Huang creates a powerful Blood-cooling axis that addresses Heat without freezing Blood movement. Tao Ren paired with Hong Hua (the classical 'Tao Hong' pair) provides synergistic stasis-breaking action. Yan Hu Suo paired with Xiang Fu addresses both the Qi and Blood aspects of pain simultaneously, ensuring complete analgesia. The overall design balances clearing (Mu Dan Pi, Sheng Di, Huang Lian), moving (Tao Ren, Hong Hua, E Zhu, Chuan Xiong), and nourishing (Dang Gui, Bai Shao), preventing the formula from being excessively draining.

How to Prepare

Traditional preparation instructions for Qing Re Tiao Xue Tang

Decoct in water. Add all herbs to approximately 600ml of water, bring to a boil, then simmer on low heat for 25-30 minutes until reduced to about 200-250ml. Strain and divide into two portions. Take warm, one portion in the morning and one in the evening. Traditionally taken in the days before and during menstruation when used for dysmenorrhea.

Common Modifications

How practitioners adapt Qing Re Tiao Xue Tang for specific situations

Added
San Leng

6-9g, strongly breaks Blood stasis and disperses accumulations

Dan Shen

9-15g, invigorates Blood and calms the mind

San Leng paired with E Zhu (already in the formula) forms a classical mass-breaking pair that intensifies the stasis-dispelling action for cases with palpable abdominal masses or severe clotting.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Re Tiao Xue Tang should not be used or requires extra caution

Avoid

Pregnancy. The formula contains several strong Blood-moving and stasis-breaking herbs (Tao Ren, Hong Hua, E Zhu, Mu Dan Pi) that may stimulate uterine contractions and risk miscarriage.

Avoid

Heavy menstrual bleeding (menorrhagia) without Blood stasis. The formula's Blood-invigorating herbs can increase bleeding volume when there is no underlying stasis pattern.

Avoid

Cold-deficiency type dysmenorrhea (pain improved by warmth, pale complexion, cold limbs, pale tongue). This formula is cooling in nature and designed for Heat patterns; using it for Cold patterns would worsen the condition.

Caution

Qi and Blood deficiency patterns without Heat or stasis signs. The formula's cooling and moving nature may further deplete Qi and Blood in already weakened patients.

Caution

Spleen and Stomach deficiency with poor digestion. Several herbs (Huang Lian, Sheng Di Huang, Mu Dan Pi) are cold in nature and may impair digestive function. Dosage reduction or addition of Spleen-supporting herbs may be needed.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains multiple herbs that strongly move Blood and break stasis: - Tao Ren (Peach Kernel) and Hong Hua (Safflower) are well-known for promoting Blood circulation and are traditionally contraindicated in pregnancy due to risk of uterine stimulation. - E Zhu (Curcuma Zedoary) is a powerful stasis-breaking herb that can stimulate uterine contractions. - Mu Dan Pi (Moutan Bark) activates Blood and is traditionally listed among pregnancy-caution herbs. The combined effect of these ingredients poses a significant risk of miscarriage or premature labor. This formula must not be used during any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While none of the individual herbs are specifically documented as toxic through breast milk, the formula contains potent Blood-moving herbs (Tao Ren, Hong Hua, E Zhu) whose effects on the nursing infant have not been well studied. Huang Lian (Coptis) is very bitter and cold, and its alkaloids (particularly berberine) are known to pass into breast milk in small amounts, potentially causing digestive upset in the infant. If the formula is clinically necessary, a practitioner should monitor for signs of loose stools or fussiness in the nursing infant and consider reducing the Huang Lian dosage.

Children

This formula is designed for gynecological conditions in adult women and is not indicated for pediatric use. The Blood-moving and stasis-breaking herbs (Tao Ren, Hong Hua, E Zhu) are generally too strong for children. Adolescent girls experiencing severe dysmenorrhea with clear Heat-stasis signs may be prescribed a modified version by an experienced practitioner, with significantly reduced dosages (typically one-third to one-half of adult doses) and with E Zhu either reduced or removed. Not suitable for children under 12.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Re Tiao Xue Tang

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): The formula contains multiple Blood-activating herbs — Tao Ren (Peach Kernel), Hong Hua (Safflower), Chuan Xiong (Ligusticum), Dan Pi (Moutan Bark), and E Zhu (Curcuma Zedoary) — all of which have demonstrated antiplatelet or anticoagulant activity in pharmacological studies. Concurrent use may significantly increase the risk of bleeding. Coagulation parameters (INR, PT) should be monitored closely if concurrent use is unavoidable.

NSAIDs (e.g. ibuprofen, naproxen): Since both the formula and NSAIDs are commonly used for dysmenorrhea, concurrent use is likely in practice. The combined antiplatelet effects may increase gastrointestinal bleeding risk, particularly given the cold nature of Huang Lian which can already stress the stomach lining.

Antihypertensive medications: Yan Hu Suo (Corydalis) contains alkaloids (notably tetrahydropalmatine) with mild sedative and hypotensive properties. Combined use with antihypertensive drugs could theoretically potentiate blood pressure-lowering effects.

Sedatives and CNS depressants: Yan Hu Suo's analgesic alkaloids have mild sedative properties and could potentially enhance the effects of benzodiazepines or other sedating medications.

Usage Guidance

Practical advice for getting the most out of Qing Re Tiao Xue Tang

Best time to take

30 minutes to 1 hour after meals, twice daily (morning and evening), beginning 5-7 days before the expected menstrual period and continuing through the menstrual phase.

Typical duration

Typically prescribed for 3-6 menstrual cycles, taken during the premenstrual and menstrual phases, with reassessment by a practitioner after each cycle.

Dietary advice

Avoid spicy, greasy, and fried foods, which generate internal Heat and Dampness and may worsen the underlying condition. Reduce consumption of alcohol and coffee, as both can agitate Blood Heat. Cold and raw foods should also be limited, as they can impair Spleen function and hinder the formula's ability to regulate Blood effectively. Favor lightly cooked vegetables, whole grains, and foods that gently support Blood circulation without generating excess Heat, such as small amounts of hawthorn berry, celery, and dark leafy greens. Adequate hydration with warm or room-temperature water is recommended.

Qing Re Tiao Xue Tang originates from 万病回春 (Wàn Bìng Huí Chūn) by Gong Tingxian (龚廷贤) Míng dynasty, 1587 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Re Tiao Xue Tang and its clinical use

Original indication from the Wan Bing Hui Chun (万病回春):

「治妇人经水将来,腹痛,乍作乍止,气血俱实。」

Translation: "Treats women who, as the menstrual period is about to arrive, experience abdominal pain that comes and goes intermittently, with both Qi and Blood in a state of excess."

This concise indication establishes the formula's core application: dysmenorrhea of the excess-Heat and Blood stasis type, occurring in the premenstrual phase, with intermittent cramping pain characteristic of Qi stagnation combined with Blood stasis.

Historical Context

How Qing Re Tiao Xue Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Re Tiao Xue Tang was created by Gong Tingxian (龚廷贤, courtesy name Zi Cai, literary name Yun Lin), one of the most celebrated physicians of the Ming Dynasty. Gong was born in 1522 in Jinxi, Jiangxi Province, into a family of physicians — his father Gong Xin served at the Imperial Medical Academy. Gong Tingxian followed in his father's footsteps and eventually served as an official at the Imperial Medical Academy himself, earning the remarkable title of "Champion of the Medical Forest" (医林状元). He practiced medicine for over 60 years and lived to approximately 90 years of age.

The formula first appeared in Gong's major work Wan Bing Hui Chun (万病回春, "Recovery of Ten Thousand Diseases"), completed in 1587 during the Wanli reign period. This eight-volume comprehensive medical text covers internal medicine, gynecology, pediatrics, and surgical conditions, and was enormously influential both in China and abroad — it was particularly well received in Japan and Korea. The formula is also recorded under the alternate name Qing Re Si Wu Tang (清热四物汤, "Heat-Clearing Four Substance Decoction"), reflecting its structural relationship to the classic Si Wu Tang (Four Substance Decoction), which it expands upon with Heat-clearing and stasis-breaking herbs to treat a more complex excess-type pattern.

The formula exemplifies a broader trend in Ming Dynasty gynecology toward recognizing and treating combined Heat-stasis patterns. Earlier gynecological formulas often addressed Cold-stasis (like Wen Jing Tang) or pure Blood deficiency (like Si Wu Tang), but Gong Tingxian's innovation was to pair Blood-nourishing and Blood-moving herbs with strong Heat-clearing agents for conditions where Heat was a driving pathological factor.