Formula

Qing Re Tiao Xue Tang

清熱調血湯

Also known as:

Qing Re Si Wu Tang (清热四物汤)

Key Ingredients

Mu Dan Pi, Shu Di Huang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A gynaecological formula used to clear internal Heat and move stagnant Blood, primarily for menstrual pain, heavy or dark periods, and pelvic discomfort caused by Heat accumulating in the Blood and obstructing its free flow. It is one of the most commonly used formulas for painful periods associated with signs of Heat such as a burning sensation, dark clotted menstrual blood, and a red tongue.

Formula Category

Main Actions

  • Clears Heat from the Blood Level
  • Cools the Blood
  • Invigorates Blood and Dispels Stasis
  • Regulates menstruation
  • Moves Qi and Alleviates Pain

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Re Tiao Xue Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Qing Re Tiao Xue Tang addresses this pattern

This is the primary pattern this formula was designed to treat. When Heat accumulates in the Blood level, it 'scorches' and thickens the Blood, causing it to stagnate. In the uterus, this manifests as painful periods with dark, clotted menstrual blood, burning sensations, and cyclical lower abdominal pain. The formula addresses this by cooling the Blood with Mu Dan Pi and Sheng Di Huang, draining Heat with Huang Lian, and actively breaking up stasis with Tao Ren, Hong Hua, E Zhu, and Chuan Xiong. Meanwhile, Dang Gui and Bai Shao nourish and harmonize the Blood to support regeneration, while Yan Hu Suo and Xiang Fu relieve the resulting pain.

A practitioner would look for one or more of these signs

Amenorrhea

Menstrual pain that is intense, burning, or stabbing in character, worsening with pressure

Dark Menstrual Clots

Dark-coloured menstrual blood with clots

Postmenstrual Bleeding

Heavy or prolonged periods with dark-red blood

Abdominal Pain

Lower abdominal pain and distension before or during menstruation

Red Tongue

Red tongue with yellow coating, wiry-rapid pulse

How It Addresses the Root Cause

This formula addresses a pattern where Heat lodges in the Blood level of the Uterus (Chong and Ren channels), causing the Blood to become both agitated and stagnant. In TCM theory, Heat in the Blood has a paradoxical effect: it makes the Blood "reckless" (forcing it to move erratically) while simultaneously "scorching" it into thick, sluggish clots. This combination of Heat and stasis creates a vicious cycle. As the menstrual period approaches, Qi and Blood naturally surge downward toward the Uterus. When they encounter the existing obstruction of Heat and stasis in the lower abdomen, the flow is blocked, producing the characteristic intermittent cramping pain described in the classical indication.

Emotional frustration or chronic stress can compound this mechanism. When Liver Qi becomes constrained, it generates internal Heat (Qi stagnation transforming into Fire), and this Heat is readily transmitted into the Blood level via the Liver's close relationship with Blood storage and the Chong channel. The stagnant Qi also impairs Blood circulation directly, worsening the stasis. This is why the original text specifies "Qi and Blood both in excess" — it is not a deficiency problem but rather an excess condition of Heat congesting the Blood combined with Qi stagnation driving the pain.

In modern clinical practice, this pathomechanism is commonly seen in conditions such as endometriosis-related dysmenorrhea, chronic pelvic inflammatory disease, and uterine fibroids where the presenting pattern involves Heat signs (dark red or purplish menstrual blood with clots, burning sensations, yellow tongue coating) alongside stasis signs (fixed stabbing pain, clotted flow).

Formula Properties

Temperature

Cool

Taste Profile

Predominantly bitter and pungent — bitter to clear Heat and drain Fire downward, pungent to move Qi and Blood and dispel stasis, with a secondary sour-sweet note from the Blood-nourishing herbs.

Target Organs
Liver Uterus Heart
Channels Entered
Liver Heart Spleen Chong Mai (冲脉) Penetrating Vessel

Formula Origin

万病回春 (Wàn Bìng Huí Chūn) by Gong Tingxian (龚廷贤)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Qing Re Tiao Xue Tang

Detailed information about each herb in Qing Re Tiao Xue Tang and their roles

Kings
Deputies
Assistants
Envoys
Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 9 - 12g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Qing Re Tiao Xue Tang

Clears Heat from the Blood level, cools the Blood, and activates Blood circulation to dispel stasis. As King herb it directly addresses the core pathomechanism of Heat accumulating in the Blood layer of the uterus.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qing Re Tiao Xue Tang

Clears Heat, cools the Blood, and nourishes Yin. Works alongside Mu Dan Pi to clear Heat from the Blood level while protecting Yin fluids from being consumed by Heat.

Huang Lian
Huang Lian

Coptis rhizome

Dosage: 5 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Re Tiao Xue Tang

Clears Heat and dries Dampness, particularly in the Lower Burner. Powerfully drains excess Fire-Heat that has accumulated alongside Blood stasis, reinforcing the Heat-clearing action of the King herbs from a different angle.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 6 - 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Qing Re Tiao Xue Tang

Nourishes and harmonizes the Blood while also gently activating Blood circulation. Prevents the cold, bitter Heat-clearing herbs from damaging the Blood and ensures that new Blood is generated as stasis is resolved.

Bai Shao
Bai Shao

White peony root

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Qing Re Tiao Xue Tang

Nourishes the Blood, softens the Liver, and alleviates pain. Works with Dang Gui to nourish Blood while its sour-astringent quality helps contain Blood within the vessels.

Chuan Xiong
Chuan Xiong

Szechuan lovage rhizome

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Re Tiao Xue Tang

Invigorates Blood and promotes the movement of Qi within the Blood. As the key 'Qi-within-Blood' herb, it ensures that Blood circulates freely and does not stagnate, amplifying the stasis-resolving effect of the formula.

Tao Ren
Tao Ren

Peach kernel

Dosage: 6 - 9g

Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Qing Re Tiao Xue Tang

Breaks up Blood stasis and promotes Blood circulation. Directly targets established Blood stasis in the lower abdomen, working with Hong Hua to form the classical Blood-moving pair.

Hong Hua
Hong Hua

Safflower

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver
Parts Used Flower (花 huā)
Role in Qing Re Tiao Xue Tang

Invigorates Blood, dispels stasis, and unblocks the channels. Pairs with Tao Ren to provide powerful stasis-dispelling action directed at menstrual Blood stagnation.

E Zhu
E Zhu

Zedoary rhizome

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Re Tiao Xue Tang

Breaks Blood stasis and promotes the movement of Qi. Particularly effective for stubborn, fixed abdominal masses or severe menstrual clotting where Blood stasis has become entrenched.

Yan Hu Suo
Yan Hu Suo

Corydalis tuber

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qing Re Tiao Xue Tang

Moves both Qi and Blood and is one of Chinese medicine's most important pain-relieving herbs. Directly addresses the menstrual pain that is the primary symptom this formula targets.

Xiang Fu
Xiang Fu

Nutgrass rhizome

Dosage: 6 - 9g

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Re Tiao Xue Tang

Moves Liver Qi and alleviates pain, particularly in gynaecological conditions. Known as the 'commander of Qi within Blood-level disorders,' it directs the formula's action to the Liver channel and uterus, and ensures smooth Qi flow so that Blood can circulate freely.

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes to 1 hour after meals, twice daily (morning and evening), beginning 5-7 days before the expected menstrual period and continuing through the menstrual phase.

Typical Duration

Typically prescribed for 3-6 menstrual cycles, taken during the premenstrual and menstrual phases, with reassessment by a practitioner after each cycle.

Dietary Advice

Avoid spicy, greasy, and fried foods, which generate internal Heat and Dampness and may worsen the underlying condition. Reduce consumption of alcohol and coffee, as both can agitate Blood Heat. Cold and raw foods should also be limited, as they can impair Spleen function and hinder the formula's ability to regulate Blood effectively. Favor lightly cooked vegetables, whole grains, and foods that gently support Blood circulation without generating excess Heat, such as small amounts of hawthorn berry, celery, and dark leafy greens. Adequate hydration with warm or room-temperature water is recommended.

Special Populations

Pregnancy

Contraindicated during pregnancy. The formula contains multiple herbs that strongly move Blood and break stasis: - Tao Ren (Peach Kernel) and Hong Hua (Safflower) are well-known for promoting Blood circulation and are traditionally contraindicated in pregnancy due to risk of uterine stimulation. - E Zhu (Curcuma Zedoary) is a powerful stasis-breaking herb that can stimulate uterine contractions. - Mu Dan Pi (Moutan Bark) activates Blood and is traditionally listed among pregnancy-caution herbs. The combined effect of these ingredients poses a significant risk of miscarriage or premature labor. This formula must not be used during any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While none of the individual herbs are specifically documented as toxic through breast milk, the formula contains potent Blood-moving herbs (Tao Ren, Hong Hua, E Zhu) whose effects on the nursing infant have not been well studied. Huang Lian (Coptis) is very bitter and cold, and its alkaloids (particularly berberine) are known to pass into breast milk in small amounts, potentially causing digestive upset in the infant. If the formula is clinically necessary, a practitioner should monitor for signs of loose stools or fussiness in the nursing infant and consider reducing the Huang Lian dosage.

Pediatric Use

This formula is designed for gynecological conditions in adult women and is not indicated for pediatric use. The Blood-moving and stasis-breaking herbs (Tao Ren, Hong Hua, E Zhu) are generally too strong for children. Adolescent girls experiencing severe dysmenorrhea with clear Heat-stasis signs may be prescribed a modified version by an experienced practitioner, with significantly reduced dosages (typically one-third to one-half of adult doses) and with E Zhu either reduced or removed. Not suitable for children under 12.

Drug Interactions

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): The formula contains multiple Blood-activating herbs — Tao Ren (Peach Kernel), Hong Hua (Safflower), Chuan Xiong (Ligusticum), Dan Pi (Moutan Bark), and E Zhu (Curcuma Zedoary) — all of which have demonstrated antiplatelet or anticoagulant activity in pharmacological studies. Concurrent use may significantly increase the risk of bleeding. Coagulation parameters (INR, PT) should be monitored closely if concurrent use is unavoidable.

NSAIDs (e.g. ibuprofen, naproxen): Since both the formula and NSAIDs are commonly used for dysmenorrhea, concurrent use is likely in practice. The combined antiplatelet effects may increase gastrointestinal bleeding risk, particularly given the cold nature of Huang Lian which can already stress the stomach lining.

Antihypertensive medications: Yan Hu Suo (Corydalis) contains alkaloids (notably tetrahydropalmatine) with mild sedative and hypotensive properties. Combined use with antihypertensive drugs could theoretically potentiate blood pressure-lowering effects.

Sedatives and CNS depressants: Yan Hu Suo's analgesic alkaloids have mild sedative properties and could potentially enhance the effects of benzodiazepines or other sedating medications.

Contraindications

Avoid

Pregnancy. The formula contains several strong Blood-moving and stasis-breaking herbs (Tao Ren, Hong Hua, E Zhu, Mu Dan Pi) that may stimulate uterine contractions and risk miscarriage.

Avoid

Heavy menstrual bleeding (menorrhagia) without Blood stasis. The formula's Blood-invigorating herbs can increase bleeding volume when there is no underlying stasis pattern.

Avoid

Cold-deficiency type dysmenorrhea (pain improved by warmth, pale complexion, cold limbs, pale tongue). This formula is cooling in nature and designed for Heat patterns; using it for Cold patterns would worsen the condition.

Caution

Qi and Blood deficiency patterns without Heat or stasis signs. The formula's cooling and moving nature may further deplete Qi and Blood in already weakened patients.

Caution

Spleen and Stomach deficiency with poor digestion. Several herbs (Huang Lian, Sheng Di Huang, Mu Dan Pi) are cold in nature and may impair digestive function. Dosage reduction or addition of Spleen-supporting herbs may be needed.

Cautions & Warnings

Qing Re Tiao Xue Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Qing Re Tiao Xue Tang.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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