Ge Xia Zhu Yu Tang

Drive Out Stasis Below the Diaphragm Decoction · 膈下逐瘀汤

A classical formula for fixed abdominal pain, masses, or bloating caused by blood stasis and Qi stagnation below the diaphragm. It works by vigorously moving stagnant blood while also promoting the smooth flow of Qi in the abdomen and flanks, and is commonly used for conditions such as liver enlargement, uterine fibroids, endometriosis, and chronic pelvic pain.

Origin Yi Lin Gai Cuo (医林改错, Correcting the Errors in the Forest of Medicine) by Wang Qing-Ren — Qīng dynasty, 1830 CE
Composition 12 herbs
Tao Ren
King
Tao Ren
Hong Hua
King
Hong Hua
Wu Ling Zhi
Deputy
Wu Ling Zhi
Dang Gui
Deputy
Dang Gui
Chuan Xiong
Deputy
Chuan Xiong
Chi Shao
Deputy
Chi Shao
Mu Dan Pi
Deputy
Mu Dan Pi
Xiang Fu
Assistant
Xiang Fu
+4
more
Explore composition
Available in our store
View in Store
From $23.00

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ge Xia Zhu Yu Tang is designed to correct these specific patterns.

Why Ge Xia Zhu Yu Tang addresses this pattern

This formula was specifically designed for blood stasis lodged below the diaphragm. When blood stasis accumulates in the abdominal region, it can form palpable masses, cause fixed stabbing pain, and create a sensation of heaviness or dragging in the abdomen when lying down. The formula's large contingent of blood-moving herbs (Tao Ren, Hong Hua, Wu Ling Zhi, Chi Shao, Mu Dan Pi, Chuan Xiong, Dang Gui) directly breaks up stagnant blood and restores normal circulation, while Dang Gui simultaneously nourishes new blood to replace what has been dispersed.

A practitioner would look for one or more of these signs

Abdominal Masses

Palpable masses or lumps in the abdomen, flanks, or below the ribs

Stabbing Fixed Pain

Fixed, stabbing pain in the abdomen that does not move

Abdominal Distention

Sensation of abdominal heaviness or dragging, worse when lying down

Dark Complexion

Dark or purplish complexion

Pale Tongue

Dark purple tongue with stasis spots

Choppy Pulse

Choppy or wiry-choppy pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ge Xia Zhu Yu Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, endometriosis is understood as a form of blood stasis (referred to as 'stasis masses' or 'zheng jia') in the lower abdomen and pelvic cavity. The Liver's failure to maintain smooth Qi flow allows blood to pool and congeal outside its normal pathways. Over time, this stagnant blood forms fixed, painful deposits that worsen with the menstrual cycle. The pain is characteristically fixed in location, stabbing in quality, and accompanied by dark menstrual blood with clots. Emotional stress further constrains the Liver, creating a vicious cycle of Qi stagnation feeding blood stasis.

Why Ge Xia Zhu Yu Tang Helps

Ge Xia Zhu Yu Tang directly targets both aspects of endometriosis pathology. Tao Ren and Hong Hua break up the congealed blood deposits, while Wu Ling Zhi and Yan Hu Suo disperse stasis and provide strong pain relief. Mu Dan Pi and Chi Shao cool and move blood, addressing any heat from chronic stasis. Critically, the four Qi-regulating herbs (Xiang Fu, Wu Yao, Zhi Ke, Yan Hu Suo) address the Liver Qi constraint that drives the condition, while Dang Gui nourishes the blood to prevent the strong stasis-breaking herbs from depleting the body. Clinical studies have shown this formula effective for endometriosis-related dysmenorrhea.

Also commonly used for

Chronic Pelvic Inflammatory Disease

Chronic pelvic inflammatory disease with fixed lower abdominal pain

Hepatomegaly

Liver enlargement with blood stasis

Uterine Fibroids

Uterine fibroids presenting with pain and blood stasis

Ovarian Cysts

Ovarian cysts due to blood stasis and Qi stagnation

Chronic Hepatitis

Chronic active hepatitis with hypochondriac pain

Acute Pancreatitis

Acute pancreatitis (combined with other formulas)

Dyspepsia

Dyspepsia with epigastric fullness and blood stasis signs

Infertility

Infertility due to blood stasis obstructing the uterus

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ge Xia Zhu Yu Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ge Xia Zhu Yu Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ge Xia Zhu Yu Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ge Xia Zhu Yu Tang works at the root level.

This formula addresses a pattern where Blood stasis has become lodged in the area below the diaphragm, which in TCM encompasses the upper abdomen, the region around the Liver and Spleen organs, and the hypochondria (the area under the ribs on both sides). In TCM theory, the Liver is responsible for ensuring the smooth flow of Qi throughout the body, and when the Liver's Qi-moving function stagnates, Blood circulation in this region slows and eventually congeals. Over time, this stagnant Blood solidifies into fixed, palpable masses.

The disease logic unfolds in stages: emotional frustration, chronic illness, or physical trauma causes Liver Qi to stagnate. Since "Qi is the commander of Blood" (气为血之帅), when Qi stops flowing freely, Blood follows suit and becomes stuck. The resulting Blood stasis in the sub-diaphragmatic region manifests as fixed, stabbing pain that does not shift location, palpable masses in the abdomen or under the ribs, and a sensation of heaviness or dragging when lying down. Because the Liver and its paired organ the Gallbladder govern the flanks, pain often radiates to the hypochondriac region. The tongue typically shows a dark or purplish color with possible stasis spots, and the pulse is choppy or wiry, all hallmarks of combined Qi stagnation and Blood stasis.

Wang Qingren's insight was that many stubborn abdominal conditions previously attributed to other causes were in fact rooted in Blood stasis. He emphasized that "where there are formed masses, there must be tangible Blood" (结块者,必有形之血), and that the only effective approach was to directly dispel the stasis while simultaneously moving Qi to prevent it from re-forming. The formula therefore works by powerfully invigorating Blood to break up the stasis, while strongly regulating Liver Qi to address the root cause of stagnation, restoring normal circulation to the sub-diaphragmatic region.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter with a sweet undertone. The acrid flavor moves Qi and Blood, the bitter flavor directs downward and disperses stasis, while the sweet taste of Gan Cao harmonizes and moderates.

Ingredients

12 herbs

The herbs that make up Ge Xia Zhu Yu Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Tao Ren

Tao Ren

Peach kernel

Dosage 9g
Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Preparation Crush to a paste (研泥) before decocting

Role in Ge Xia Zhu Yu Tang

Breaks blood stasis and dispels congealed masses below the diaphragm. As the primary stasis-breaking herb used at a high dose, it directly addresses the core pathology of blood stasis accumulation.
Hong Hua

Hong Hua

Safflower flower

Dosage 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver

Role in Ge Xia Zhu Yu Tang

Invigorates blood circulation and dispels stasis, working together with Tao Ren as the core blood-moving pair to dissolve masses and relieve pain.
Deputies — Assists and enhances the King
Wu Ling Zhi

Wu Ling Zhi

Flying squirrel feces

Dosage 6g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Liver, Spleen
Preparation Dry-fried (炒) before use

Role in Ge Xia Zhu Yu Tang

Disperses congealed blood and stops pain, reinforcing the King herbs in their stasis-breaking action. Particularly effective for fixed, stabbing abdominal pain due to blood stasis.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Ge Xia Zhu Yu Tang

Nourishes and invigorates blood simultaneously. It supports the stasis-dispelling action while preventing the aggressive blood-moving herbs from depleting healthy blood, ensuring that the formula dispels stasis without damaging the body's resources.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Ge Xia Zhu Yu Tang

Moves both blood and Qi, bridging the formula's two strategies. Known as the 'Qi herb within the blood', it enhances the power of all the blood-moving ingredients while also helping the Qi-regulating herbs work more effectively.
Chi Shao

Chi Shao

Red peony root

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver

Role in Ge Xia Zhu Yu Tang

Cools the blood and disperses stasis, complementing the warming Qi-moving herbs and helping to clear any heat that may have developed from prolonged blood stasis.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Ge Xia Zhu Yu Tang

Clears heat from the blood and activates blood circulation. Works alongside Chi Shao to cool and move stagnant blood, addressing any heat generated by chronic stasis.
Assistants — Supports or moderates other herbs
Xiang Fu

Xiang Fu

Nutgrass Galingale Rhizome

Dosage 4.5g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)

Role in Ge Xia Zhu Yu Tang

Spreads Liver Qi and relieves constraint. As the chief Qi-regulating herb in this formula, it addresses the underlying Liver Qi stagnation that contributes to blood stasis below the diaphragm.
Wu Yao

Wu Yao

Lindera root

Dosage 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Kidneys, Urinary Bladder

Role in Ge Xia Zhu Yu Tang

Warms and moves Qi, disperses cold, and stops pain. Particularly effective for distending pain in the lower abdomen and flanks, it complements Xiang Fu in regulating Qi flow.
Yan Hu Suo

Yan Hu Suo

Corydalis rhizome

Dosage 3g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen

Role in Ge Xia Zhu Yu Tang

One of the strongest pain-relieving herbs in the Chinese materia medica, it moves both blood and Qi to stop pain. It is the formula's key analgesic ingredient.
Zhi Ke

Zhi Ke

Bitter orange fruit

Dosage 4.5g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine, Lungs

Role in Ge Xia Zhu Yu Tang

Regulates Qi and reduces distention, helping to relieve the sense of fullness and bloating in the epigastrium and abdomen that accompanies Qi stagnation.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Ge Xia Zhu Yu Tang

Harmonizes all other herbs in the formula. Used at a relatively high dose here to moderate the strong dispersing action of the blood-moving herbs, and to assist in relieving pain through its antispasmodic properties.

Why This Combination Works

How the herbs in Ge Xia Zhu Yu Tang complement each other

Overall strategy

This formula targets blood stasis lodged below the diaphragm (in the abdominal region) complicated by Liver Qi stagnation. Because Qi drives blood and stagnant Qi leads to stagnant blood, the prescription pairs vigorous blood-moving herbs with a strong contingent of Qi-regulating herbs to break up masses, relieve pain, and restore normal circulation in the abdomen.

King herbs

Tao Ren (Peach Kernel) and Hong Hua (Safflower) are the core stasis-breaking pair. Tao Ren is powerful at breaking through congealed blood and dissolving masses, while Hong Hua vigorously moves blood and unblocks the vessels. Together at high doses, they directly attack the root cause of sub-diaphragmatic blood stasis.

Deputy herbs

Wu Ling Zhi reinforces the Kings by dispersing congealed blood and stopping pain, especially in the abdomen. Chuan Xiong is uniquely positioned as the "Qi herb within the blood" and amplifies both the blood-moving and Qi-regulating functions of the formula. Chi Shao and Mu Dan Pi cool the blood while dispersing stasis, preventing heat from developing due to chronic stagnation. Dang Gui nourishes the blood alongside its stasis-dispersing action, ensuring that the formula does not deplete healthy blood while aggressively targeting pathological stasis.

Assistant herbs

Xiang Fu, Wu Yao, Zhi Ke, and Yan Hu Suo form the Qi-regulating wing of the formula. Xiang Fu is the premier herb for soothing constrained Liver Qi. Wu Yao warms and disperses Qi in the lower abdomen. Zhi Ke breaks up Qi stagnation and relieves distention. Yan Hu Suo treats both Qi and blood stasis simultaneously and is one of the most potent analgesic herbs available, directly targeting the pain that defines this pattern. These four herbs embody the principle that "when Qi moves, blood moves" and ensure the blood-moving herbs can work to their full potential.

Envoy herbs

Gan Cao harmonizes and moderates the entire prescription. Its relatively high dose here is deliberate: it tempers the powerful dispersing action of the formula so that it attacks stasis without recklessly scattering, and its natural antispasmodic quality helps relieve cramping pain.

Notable synergies

The Tao Ren and Hong Hua pair is the classical blood-stasis-breaking combination found across all five of Wang Qing-Ren's Zhu Yu Tang formulas. What distinguishes this formula is the addition of four strong Qi-moving herbs (Xiang Fu, Wu Yao, Zhi Ke, Yan Hu Suo) that give it unmatched pain-relieving and Qi-regulating power for the sub-diaphragmatic region. Chuan Xiong acts as a bridge between the blood-moving and Qi-moving teams, enhancing both. Dang Gui paired with the stasis-breaking herbs ensures that healthy blood is generated even as pathological blood is dispersed.

How to Prepare

Traditional preparation instructions for Ge Xia Zhu Yu Tang

Add all 12 herbs to approximately 600 ml of water. Bring to a boil, then simmer on low heat for 25 to 30 minutes until reduced to roughly 300 ml. Strain and divide into two portions. Take one portion warm in the morning and one in the evening, ideally on an empty stomach or between meals.

Wang Qing-Ren noted in the original text: for mild cases, take fewer doses; for severe cases, take more doses. Stop when symptoms resolve and do not continue unnecessarily. If the patient is weak and cannot tolerate vigorous blood-moving, add Dang Shen (党参) 9 to 15 g to support the Qi.

Common Modifications

How practitioners adapt Ge Xia Zhu Yu Tang for specific situations

Added
Dang Shen

9 - 15g, to supplement Qi and support the body's tolerance of the stasis-breaking herbs

Wang Qing-Ren himself recommended adding Dang Shen when the patient is weak and cannot withstand strong dispersing action, ensuring the formula resolves stasis without exhausting the body's vitality.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ge Xia Zhu Yu Tang should not be used or requires extra caution

Avoid

Pregnancy. This formula contains multiple strong Blood-moving herbs (Tao Ren, Hong Hua, Dan Pi, Wu Ling Zhi) that can stimulate uterine contractions and risk miscarriage.

Avoid

Active hemorrhage or bleeding disorders. The formula's powerful Blood-moving action can worsen active bleeding from any cause, including heavy menstrual bleeding not caused by Blood stasis.

Caution

Blood deficiency without stasis. In patients who are primarily Blood-deficient (pale complexion, dizziness, thin pulse) without clear signs of Blood stasis, this formula's strong dispersing action can further deplete Blood.

Caution

Patients on anticoagulant or antiplatelet therapy. The Blood-invigorating herbs may potentiate the effects of blood-thinning medications and increase bleeding risk.

Caution

Qi deficiency-predominant patterns. In significantly Qi-deficient patients, the moving and dispersing nature of this formula may further exhaust the body's Qi. If used, tonifying herbs such as Huang Qi should be added.

Caution

Pre-surgical and post-surgical patients. Should be discontinued at least 1-2 weeks before scheduled surgery due to its Blood-moving properties, and not resumed until adequate post-surgical healing.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. This formula contains several herbs with strong Blood-moving and stasis-breaking actions that pose serious risks during pregnancy. Tao Ren (Peach Kernel) and Hong Hua (Safflower) are well-known for their ability to stimulate uterine contractions and promote menstrual flow, making them potentially abortifacient. Dan Pi (Moutan Bark) cools and moves Blood and is also classified as cautioned or contraindicated in pregnancy. Wu Ling Zhi (Trogopterus Dung) has strong Blood-dispersing action. The combined effect of these herbs creates a formula with significant potential to cause uterine bleeding, threatened miscarriage, or premature labor. This formula should not be used at any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While there are no classical prohibitions specifically regarding lactation, several herbs in this formula have potent Blood-moving properties (Tao Ren, Hong Hua, Wu Ling Zhi, Dan Pi) whose active compounds may transfer into breast milk in small amounts. The potential effects on a nursing infant are not well studied. Yan Hu Suo (Corydalis) contains alkaloids (including tetrahydropalmatine) with analgesic and sedative properties that could theoretically affect an infant through breast milk. If the formula is clinically necessary for the mother, a qualified practitioner should weigh the benefits against potential risks and monitor both mother and infant. It may be advisable to use reduced dosages and to time feedings to minimize infant exposure.

Children

Wang Qingren himself noted that Ge Xia Zhu Yu Tang could be used for childhood abdominal masses (小儿痞块), making it one of the few Blood-moving formulas with a classical pediatric indication. However, in children, dosages must be significantly reduced according to age and body weight, typically to one-third to one-half of the adult dose for school-age children, and further reduced for younger children. The formula's strong Blood-moving nature means it should only be used in pediatric cases where clear signs of Blood stasis and abdominal masses are present, and only under the supervision of an experienced practitioner. Duration of use in children should be shorter and closely monitored. This formula is not suitable for infants or toddlers.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ge Xia Zhu Yu Tang

Anticoagulant and antiplatelet medications: Multiple herbs in this formula (Tao Ren, Hong Hua, Dan Pi, Chi Shao, Dang Gui, Chuan Xiong, Wu Ling Zhi) have demonstrated antiplatelet aggregation and blood-activating effects. Combined use with warfarin, heparin, aspirin, clopidogrel, or direct oral anticoagulants (DOACs) may increase bleeding risk. INR and bleeding time should be monitored if concurrent use is unavoidable.

Gan Cao (Licorice) interactions: Gan Cao (甘草) in this formula contains glycyrrhizin, which can cause pseudoaldosteronism with prolonged use. It may interact with antihypertensive medications (by promoting sodium retention and potassium loss), corticosteroids (potentiating hypokalemic effects), digoxin and cardiac glycosides (hypokalemia increases toxicity risk), and diuretics (compounding electrolyte imbalances).

Yan Hu Suo (Corydalis) interactions: Contains tetrahydropalmatine and other alkaloids with analgesic and mild sedative properties. It may potentiate the effects of CNS depressants, sedatives, or opioid analgesics, and may interact with dopaminergic medications.

Hepatically metabolized drugs: Given the formula's strong action on liver circulation and its use in liver conditions, it may theoretically alter hepatic drug metabolism. Patients taking medications with narrow therapeutic windows that are liver-metabolized should use caution.

Usage Guidance

Practical advice for getting the most out of Ge Xia Zhu Yu Tang

Best time to take

30 minutes to 1 hour after meals, twice daily (morning and evening). Taking it after meals reduces potential gastrointestinal irritation from the Blood-moving herbs.

Typical duration

Typically prescribed for 2-8 weeks depending on condition severity, then reassessed. For acute pain with stasis, shorter courses of 1-2 weeks may suffice. For chronic masses or liver conditions, longer courses of 1-3 months with periodic reassessment are common.

Dietary advice

Avoid cold, raw, and frozen foods and beverages, as these can constrict blood vessels and counteract the formula's Blood-moving action. Reduce greasy, fatty, and fried foods, which can generate Dampness and impede Qi flow in the Liver and Spleen. Avoid excessive alcohol, which produces Damp-Heat and can worsen Liver stagnation. Favor lightly cooked, warm foods that support smooth Qi circulation, such as leafy greens, small amounts of vinegar-dressed dishes, and foods with gentle Blood-moving properties like hawthorn, turmeric, and dark leafy vegetables. Avoid overeating, as an overly full Stomach burdens the sub-diaphragmatic region where this formula is directed.

Ge Xia Zhu Yu Tang originates from Yi Lin Gai Cuo (医林改错, Correcting the Errors in the Forest of Medicine) by Wang Qing-Ren Qīng dynasty, 1830 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ge Xia Zhu Yu Tang and its clinical use

Wang Qingren (王清任), Yi Lin Gai Cuo (《医林改错》, Corrections of Errors in Medicine), 1830:

Original text describing the formula's indications:
「瘀在膈下,形成积块,或小儿痞块,痛处不移,卧则腹坠者。」
Translation: "When Blood stasis accumulates below the diaphragm, forming masses; or in children with abdominal lumps; or when pain is fixed and does not move; or when lying down the abdomen feels heavy as though something is dragging downward."

Wang Qingren, on the rationale for creating the formula (方叙, Formula Preface):

「立膈下逐瘀汤治肚腹血瘀之症。」
Translation: "I established Ge Xia Zhu Yu Tang to treat Blood stasis conditions of the belly and abdomen."

Wang Qingren, on using the formula for childhood wasting disease (疳症):

「用膈下逐瘀汤,消化积块。三方轮服,未有不愈者。」
Translation: "Use Ge Xia Zhu Yu Tang to dissolve accumulated masses. Rotating the three formulas in turn, there have been none who did not recover."

Formula song (方歌):

「膈下逐瘀桃牡丹,赤芍乌药元胡甘,归芎灵脂红花壳,香附开郁血亦安。」
Translation: "Below-the-diaphragm stasis-chasing: Peach Kernel, Moutan, and Peony Root, Red Peony, Lindera, Corydalis, Licorice; Dang Gui, Chuan Xiong, Trogopterus, Safflower, Bitter Orange, Cyperus opens constraint so the Blood finds peace."

Historical Context

How Ge Xia Zhu Yu Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ge Xia Zhu Yu Tang was created by Wang Qingren (王清任, 1768-1831), one of the most innovative and controversial physicians of the Qing Dynasty. Wang was from Yutian County in Zhili Province (modern-day Hebei). He published this formula in his landmark work Yi Lin Gai Cuo (《医林改错》, Corrections of Errors in Medicine), which was first printed in 1830, just one year before his death.

Wang Qingren is often called the founder of the Blood stasis (瘀血) school of thought. His most famous contribution was the creation of five "stasis-chasing decoctions" (逐瘀汤), each targeting Blood stasis in a different body region: Xue Fu Zhu Yu Tang for the chest, Tong Qiao Huo Xue Tang for the head and face, Ge Xia Zhu Yu Tang for below the diaphragm, Shao Fu Zhu Yu Tang for the lower abdomen, and Shen Tong Zhu Yu Tang for the limbs and body. All five share a common core of Blood-moving herbs (Tao Ren, Hong Hua, Chuan Xiong, Chi Shao, Dang Gui) but are differentiated by region-specific additions. Ge Xia Zhu Yu Tang is distinguished by its strong Qi-regulating herbs (Xiang Fu, Yan Hu Suo, Wu Yao, Zhi Ke) that target Liver Qi stagnation in the sub-diaphragmatic region.

Wang Qingren was remarkable for his empirical spirit. He personally examined over 300 corpses during epidemic outbreaks and at execution grounds to study human anatomy, and he was not afraid to challenge classical authorities when his observations contradicted received wisdom. In modern clinical practice, Ge Xia Zhu Yu Tang has found widespread use far beyond its original indications, particularly in hepatology (chronic hepatitis, liver cirrhosis, fatty liver disease), gynecology (endometriosis, ovarian cysts), and oncology as an adjunctive treatment.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Ge Xia Zhu Yu Tang

1

Gexia-Zhuyu Tang prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cell proliferation (Animal study, 2012)

Chen JY, Chen HL, Cheng JC, Lin HJ, Tung YT, Lin CF, Chen CM. Journal of Ethnopharmacology, 2012, 142(3): 811-818.

This preclinical study in rats investigated GZT's effects on chemically-induced liver fibrosis. Oral administration of GZT significantly decreased liver enzyme levels (GOT and GPT) and reduced the expression of fibrosis markers including collagen alpha-1(I) and alpha-smooth muscle actin. The researchers concluded that GZT exhibited both hepatoprotective and antifibrogenic effects, suggesting it may be useful in preventing the development of liver fibrosis.

Link
2

Pharmacodynamic evaluation of Gexia Zhuyu Decoction in the treatment of NAFLD and the molecular mechanism underlying the TRPM4 pathway regulation (Animal study, 2021)

Zhao T, Yang S, Liu CH, Wang YH, Tao H, Zhou H, Liu CH. Canadian Journal of Gastroenterology and Hepatology, 2021, Article ID 6668498.

Using mouse models of nonalcoholic fatty liver disease (NAFLD) at various progression stages, this study found that the Gexia Zhuyu decoction reduced serum ALT, AST, and liver triglyceride levels while increasing HDL and SOD levels. Fatty changes, inflammation, and fibrous tissue proliferation in liver tissue were all relieved. The mechanism appeared to involve regulation of the TRPM4 protein pathway via miRNA-24 expression changes.

PubMed
3

Modified Gexia-Zhuyu Tang inhibits gastric cancer progression by restoring gut microbiota and regulating pyroptosis (Animal study, 2024)

Zhao T, Yu Z. Cancer Cell International, 2024, 24: 21.

This preclinical study used mouse xenograft models of gastric cancer to investigate a modified version of GZT. The study found that the modified formula inhibited tumor growth, altered gut microbiota composition (assessed by 16S rRNA sequencing), and regulated pyroptosis (a form of programmed cell death). The researchers suggested this provided a theoretical basis for clinical use of modified GZT in gastric cancer treatment.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.