Formula Pill (Wan)

Liang Fu Wan

Galangal and Cyperus Pill · 良附丸

Also known as: Zhǐ Tòng Liáng Fù Wán (止痛良附丸)

A simple two-herb classical formula used to warm the stomach and move stagnant Qi, relieving cold-type stomach pain, bloating, acid regurgitation, and menstrual cramps. It is especially suited to pain that feels better with warmth and is triggered by cold exposure or emotional stress.

Origin Liáng Fāng Jí Yè (良方集腋) by Xiè Yuánqìng — Qīng dynasty, 1842 CE
Composition 2 herbs
Gao Liang Jiang
King
Gao Liang Jiang
Xiang Fu
Deputy
Xiang Fu
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Liang Fu Wan is designed to correct these specific patterns.

Why Liang Fu Wan addresses this pattern

When Cold pathogen lodges in the Stomach, it congeals Qi and obstructs the free flow of warming Yang in the Middle Burner. This creates sharp or cramping epigastric pain that improves with warmth and pressure, often accompanied by vomiting of clear fluid and a preference for warm drinks. Gao Liang Jiang directly warms the Stomach and expels Cold, while Xiang Fu moves the stagnant Qi that inevitably develops when Cold blocks the normal flow. The formula's simple but targeted design makes it the representative formula for Cold-type stomach pain with a Qi stagnation component.

A practitioner would look for one or more of these signs

Stomach Pain

Epigastric pain relieved by warmth and pressure

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting clear or watery fluid

Acid Reflux

Spitting up sour or clear acidic fluid

Post-Surgical Constipation And Bloating

Fullness and distension in the chest and abdomen

Sensitivity to Cold

Aversion to cold, preference for warmth

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Liang Fu Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic gastritis often maps to the pattern of Stomach Cold with Qi stagnation. The Stomach requires warmth to "ripen and rot" (digest) food. When Cold either invades from outside (eating cold foods, exposure to cold weather) or accumulates due to a constitutional weakness in Stomach Yang, the digestive function slows and Qi movement in the Middle Burner stalls. This produces the chronic dull or cramping epigastric pain, bloating, poor appetite, and nausea characteristic of the condition. The pain characteristically improves after warm food or drinks and worsens after cold intake.

Why Liang Fu Wan Helps

Liang Fu Wan addresses chronic gastritis by warming the Stomach (Gao Liang Jiang) and restoring free Qi movement (Xiang Fu). Modern pharmacological research shows that its components promote gastric motility, protect the gastric mucosa, and have analgesic and anti-inflammatory effects. The formula's ability to both warm the digestive environment and move stagnant Qi makes it well-suited for chronic gastritis where cold-type pain and bloating are the dominant symptoms.

Also commonly used for

Stomach Pain

Cold-type epigastric pain

Peptic Ulcer

Peptic or gastric ulcers with cold pattern

Acid Reflux

Acid regurgitation from stomach cold

Post-Surgical Constipation And Bloating

Abdominal distension from cold and Qi stagnation

Intercostal Neuralgia

Rib pain with cold-stagnation pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Liang Fu Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Liang Fu Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Liang Fu Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Liang Fu Wan works at the root level.

Liang Fu Wan addresses a condition where two pathological forces converge in the middle body region: Cold congealing in the Stomach and Liver Qi stagnation. Understanding how these two factors interact is key to grasping why this formula works.

The Stomach needs warmth to function properly. When Cold invades it, whether from eating cold food, exposure to cold weather, or internal Yang deficiency, it causes the Qi and Blood in the Stomach region to congeal and stagnate. Think of it like pipes freezing in winter: the normal flow grinds to a halt. This produces sharp, cramping pain in the upper abdomen (epigastrium) that feels better with warmth and pressure, along with vomiting of clear watery fluid. Meanwhile, the Liver is responsible for ensuring Qi flows smoothly throughout the body. Emotional stress, frustration, or anger can cause the Liver's Qi to become knotted and stagnant. Because the Liver channel runs through the flanks and has a close relationship with the Stomach, stagnant Liver Qi easily "invades" the Stomach, compounding the blockage. This adds chest tightness, rib-side discomfort, and in women, painful menstruation (since the same Qi stagnation affects the uterus).

The core principle at work is "when there is no free flow, there is pain" (不通则痛, bù tōng zé tòng). Cold congeals and contracts, while Qi stagnation blocks and binds. Together they create a double obstruction. The treatment strategy therefore needs to address both problems simultaneously: warm away the Cold to restore flow, and move the stagnant Qi to unblock the channels. Neither warming alone nor Qi-moving alone would fully resolve the pain.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly pungent (acrid) and slightly bitter. The pungent taste disperses Cold and moves Qi, while the mild bitterness helps direct Qi downward and resolve stagnation.

Channels Entered

Ingredients

2 herbs

The herbs that make up Liang Fu Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Gao Liang Jiang

Gao Liang Jiang

Lesser galangal rhizome

Dosage 6 - 9g
Temperature Hot
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach
Preparation Wine-washed (酒洗) seven times, then baked dry

Role in Liang Fu Wan

Warms the Middle Burner, disperses Cold, and stops pain. As the primary warming herb, it directly addresses the core pathomechanism of Cold congealing in the Stomach. Wine-washing enhances its ability to disperse Cold and move through the channels.
Deputy — Assists and enhances the King
Xiang Fu

Xiang Fu

Nutgrass rhizome

Dosage 6 - 9g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Preparation Vinegar-washed (醋洗) seven times, then baked dry

Role in Liang Fu Wan

Soothes the Liver, unblocks Qi stagnation, and stops pain. Addresses the Qi stagnation component of the pathomechanism, complementing Gao Liang Jiang's warming action. Vinegar-washing strengthens its ability to enter the Liver channel and relieve pain.

Why This Combination Works

How the herbs in Liang Fu Wan complement each other

Overall strategy

The pathomechanism involves Cold congealing in the Stomach with Liver Qi stagnation, causing pain through obstruction of both warmth and Qi flow. The prescription pairs one herb that warms and disperses Cold with one that moves and unblocks Qi, addressing both causes of the obstruction simultaneously.

King herbs

Gao Liang Jiang (Lesser Galangal) is acrid and very hot in nature, entering the Spleen and Stomach channels. It powerfully warms the Middle Burner and disperses accumulated Cold, directly restoring the warm environment the Stomach needs to function. Its wine-washing enhances its ability to penetrate and disperse, increasing its Cold-scattering power.

Deputy herbs

Xiang Fu (Cyperus) is acrid, slightly bitter, and slightly sweet, entering the Liver and Triple Burner channels. It is classically described as the "commander-in-chief of Qi diseases" for its unsurpassed ability to move stagnant Qi, soothe the Liver, and relieve pain. Its vinegar-processing strengthens its affinity for the Liver channel, enhancing its capacity to relieve pain caused by constrained Liver Qi invading the Stomach.

Notable synergies

The pairing of Gao Liang Jiang and Xiang Fu is the defining synergy of this formula. One disperses Cold congelation, the other breaks through Qi stagnation. Together they address both the Cold and the stagnation that cause the "not free, therefore pain" (不通则痛) mechanism. The rice porridge, ginger juice, and salt used in pill preparation also play supporting roles: ginger juice reinforces the warming and anti-nausea action, rice porridge protects the Stomach, and salt guides the formula downward.

How to Prepare

Traditional preparation instructions for Liang Fu Wan

The two herbs must be ground separately and stored separately. When it is time to take the formula, combine the powders and form into pills using a thin rice porridge (米饮汤) with a spoonful of fresh ginger juice and a pinch of salt as the binding liquid. Take on an empty stomach.

The original text specifies dosage ratios based on the cause of pain: if pain is mainly from Cold exposure, use Gao Liang Jiang 6g and Xiang Fu 3g; if mainly from emotional upset (anger), use Gao Liang Jiang 3g and Xiang Fu 6g; if both causes are present, use equal amounts (4.5g each). This formula can also be prepared as a decoction.

Common Modifications

How practitioners adapt Liang Fu Wan for specific situations

Double the dose of Gao Liang Jiang relative to Xiang Fu (e.g. 6g to 3g). This is specified in the original text for pain caused primarily by Cold exposure, increasing the warming and Cold-dispersing power of the formula.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Liang Fu Wan should not be used or requires extra caution

Avoid

Heat patterns in the Liver and Stomach: epigastric burning pain, bitter taste in the mouth, constipation, or other signs of Heat. Gao Liang Jiang is very hot in nature and will worsen Heat conditions.

Avoid

Yin deficiency with Fire signs (dry mouth, flushed cheeks, hot palms and soles). The warm-hot nature of this formula will further damage Yin fluids.

Avoid

Active bleeding conditions, including peptic ulcer with active hemorrhage. The warming and Qi-moving properties may aggravate bleeding.

Caution

Individuals with severe chronic conditions such as hypertension, heart disease, liver disease, diabetes, or kidney disease should use this formula only under professional guidance.

Caution

Elderly or constitutionally weak individuals may find the formula's hot nature too strong. Dosage reduction and professional monitoring are advised.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Xiang Fu (Cyperus) is a strong Qi-moving herb that enters the Liver and the extraordinary vessels, and vigorous Qi movement can potentially stimulate uterine activity. Gao Liang Jiang (Lesser Galangal) is intensely hot in nature. While neither herb is classified among the strongest abortifacient substances, the combination's strong Qi-moving and warming properties mean it should only be used during pregnancy under the direct supervision of a qualified practitioner, and only when clearly indicated.

Breastfeeding

Generally considered acceptable for short-term use during breastfeeding under professional guidance. Gao Liang Jiang's volatile oils and Xiang Fu's active compounds may transfer in small amounts through breast milk. The formula's intensely warm and pungent nature could theoretically affect the infant, potentially causing irritability or digestive upset. If breastfeeding, use the lowest effective dose for the shortest duration necessary, and monitor the infant for any changes in feeding behavior or stool pattern. Discontinue and consult a practitioner if concerns arise.

Children

Children should only take Liang Fu Wan under the supervision of a qualified practitioner. The formula's hot nature (from Gao Liang Jiang) requires careful dose adjustment. Children's digestive systems are considered delicate in TCM, and excessive warming can easily generate Heat. Typical pediatric doses are reduced to one-third to one-half of the adult dose depending on age and body weight. Not generally recommended for children under 3 years of age. For older children, the patent pill form may be more convenient than decoction. Duration should be kept short, and symptoms should be reassessed promptly.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Liang Fu Wan

Anticoagulant and antiplatelet drugs: Xiang Fu (Cyperus) has demonstrated Qi-moving and Blood-activating properties. Although mild, when combined with blood-thinning medications (warfarin, aspirin, clopidogrel), there is a theoretical risk of increased bleeding tendency. Monitor for unusual bruising or bleeding.

Antacids, proton pump inhibitors, and H2 blockers: The formula's mechanism involves warming the Stomach and promoting gastric motility. Concurrent use with acid-suppressing medications may produce unpredictable interactions with gastric acid regulation. Coordinate timing of administration with a practitioner.

Prokinetic agents (domperidone, mosapride): Since Liang Fu Wan itself promotes gastric emptying and intestinal motility, concurrent use with pharmaceutical prokinetics could have additive effects. Use together with caution to avoid excessive gastrointestinal stimulation.

General note: As with any herbal formula, allow at least 1 to 2 hours between taking Liang Fu Wan and pharmaceutical medications to minimize potential interactions.

Usage Guidance

Practical advice for getting the most out of Liang Fu Wan

Best time to take

30 minutes before meals, twice daily, with warm water. Taking on an empty stomach improves absorption and directs the formula's warming action to the Stomach.

Typical duration

Acute pain episodes: 3-7 days. For recurring cold-type stomach pain, may be used for up to 2 weeks, then reassessed by a practitioner.

Dietary advice

While taking this formula, avoid cold and raw foods (salads, iced drinks, raw fruits in excess, cold dairy products) as these directly counteract the warming action of the formula. Also avoid greasy, heavy, and hard-to-digest foods that burden the Stomach. Spicy, pungent seasonings in moderate amounts (ginger, scallion, cinnamon) can complement the formula's warming action. Alcohol and strong-flavored stimulants (coffee, strong tea) should be limited. Warm, easily digested foods such as congee, soups, and lightly cooked vegetables are ideal. The original preparation method itself includes fresh ginger juice and a pinch of salt, reflecting the classical understanding that ginger synergizes with the formula's warming effect.

Liang Fu Wan originates from Liáng Fāng Jí Yè (良方集腋) by Xiè Yuánqìng Qīng dynasty, 1842 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Liang Fu Wan and its clinical use

《良方集腋・气痹门》(Liáng Fāng Jí Yè, Qi Impediment chapter):

「治心口一点痛,乃胃脘有滞或有虫,多因恼怒及受寒而起,遂致终身为痰。俗云心头痛者非也。」

Translation: "Treats a focal pain at the pit of the heart [epigastrium], which is due to stagnation or parasites in the stomach region, most often arising from anger or exposure to cold, ultimately becoming a chronic affliction. What common people call 'heart pain' is not [true cardiac pain]."


Original dosage instructions from the source text:

「上两味须要各研各贮,用时以米饮汤加入生姜汁一匙,盐一撮为丸,服之立止。」

Translation: "The two herbs must each be ground and stored separately. When needed, combine with rice water, add a spoonful of fresh ginger juice and a pinch of salt, form into pills, and the pain will stop immediately upon taking them."


Dosage modification principle from the original text:

「如病因寒而得者,用高良姜二钱、香附末一钱;如病因怒而得者,用高良姜一钱、香附末三钱;如因寒怒兼有者,高良姜一钱五分、香附一钱五分。」

Translation: "If the condition arose from cold, use 2 qian of Gao Liang Jiang and 1 qian of Xiang Fu. If it arose from anger, use 1 qian of Gao Liang Jiang and 3 qian of Xiang Fu. If both cold and anger are present, use equal amounts of 1.5 qian each."

Historical Context

How Liang Fu Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Liang Fu Wan originates from the Liáng Fāng Jí Yè (《良方集腋》, "Small Collection of Fine Formulas"), a Qing dynasty medical compendium compiled in the mid-19th century. The formula appears in the Qi Impediment (气痹门) section. Its name simply combines the key character from each herb: "Liang" (良) from Gao Liang Jiang (galangal), and "Fu" (附) from Xiang Fu (cyperus).

Despite its relatively late compilation date, the pairing of galangal and cyperus has deeper roots. The Ming dynasty physician Sun Yikui (孙一奎) used equal parts of Gao Liang Jiang and Xiang Fu under the name Li Ying San (立应散, "Immediately Effective Powder") to treat cold-type, Qi-type, and abdominal pain. The Liang Fang Ji Ye version is notable for its elegant flexibility: the original text instructs practitioners to adjust the ratio of the two herbs based on whether the patient's pain is primarily caused by cold, by anger (emotional Qi stagnation), or a combination of both. This built-in dose modification principle makes it a remarkably adaptable two-herb formula. The formula also has an alias, Zhi Tong Liang Fu Wan (止痛良附丸, "Pain-Stopping Galangal and Cyperus Pill"). It remains widely available today as a Chinese patent medicine (中成药) listed in the Chinese Pharmacopoeia, prescribed for cold-stagnation type stomach pain.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Liang Fu Wan

1

Pharmacodynamic study of Liang Fu Wan on cold-type functional dyspepsia in rats (Preclinical, 2022)

Wei Q, et al. China Pharmacy (中国药房), 2022, Vol. 41(9), pp. 1324-1329

This animal study investigated Liang Fu Wan's effects on a cold-type functional dyspepsia rat model. The formula significantly reduced pain responses in acetic acid and formaldehyde pain models, promoted gastric emptying and small intestinal transit in mice, and improved food intake, sucrose preference, and open-field activity in cold-type FD rats. The mechanism appeared related to regulation of brain-gut peptides, particularly increasing 5-HT (serotonin) expression in gastric and intestinal tissues.

2

Network pharmacology study of Liang Fu Wan for gastric ulcer treatment with animal validation (Preclinical, 2021)

Wei Q, Liang SS, Jiang SS, et al. China Pharmacy (中国药房), 2021, Vol. 32(9)

Using network pharmacology analysis combined with animal experiments, this study identified 9 active compounds in Liang Fu Wan (including isorhamnetin, beta-sitosterol, and kaempferol) and 166 therapeutic targets related to gastric ulcer. In an ethanol-induced gastric ulcer mouse model, Liang Fu Wan significantly reduced ulcer index scores and downregulated inflammatory proteins (TP53, c-Jun, p38 MAPK, TNF-alpha). The therapeutic mechanism involves suppression of MAPK, NF-kB, TNF, and PI3K/Akt signaling pathways.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.