Formula Pill (Wan)

Ju He Wan

Tangerine Seed Pill · 橘核丸

Also known as: Ju He Shan Qi Wan (橘核疝气丸), Tangerine Seed Pill for Hernia

A classical formula designed to relieve testicular and scrotal swelling, hardness, and pain caused by Cold and Dampness accumulating in the lower body. It works by promoting the smooth flow of Qi and Blood through the groin area, warming the body to expel Cold, draining excess Dampness, and softening hard masses. Commonly used for conditions such as hernia, epididymitis, orchitis, and hydrocele.

Origin Ji Sheng Fang (济生方, Formulas to Aid the Living) by Yan Yong-He (严用和) — Sòng dynasty, 1253 CE
Composition 12 herbs
Ju He
King
Ju He
Chuan Lian Zi
Deputy
Chuan Lian Zi
Mu Xiang
Deputy
Mu Xiang
Tao Ren
Deputy
Tao Ren
Yan Hu Suo
Deputy
Yan Hu Suo
Hai Zao
Assistant
Hai Zao
Kun Bu
Assistant
Kun Bu
Hai Zao
Assistant
Hai Zao
+4
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ju He Wan is designed to correct these specific patterns.

Why Ju He Wan addresses this pattern

This is the primary pattern Ju He Wan was designed to treat. When Cold and Dampness invade and lodge in the Liver channel (which passes through the genitalia), they cause Qi and Blood to stagnate, leading to testicular swelling, heaviness, hardness, and pain that often radiates to the lower abdomen. The formula directly addresses every aspect of this pattern: Ju He, Chuan Lian Zi, and Mu Xiang move the stagnant Liver Qi; Tao Ren and Yan Hu Suo invigorate the stagnant Blood; Rou Gui warms the Liver and Kidney to dispel Cold at the root level; Hou Po and Mu Tong dry and drain the Dampness; and the seaweed trio softens the hard masses that form when Cold-Damp congeals over time.

A practitioner would look for one or more of these signs

Testicular Pain

Pain in one or both testicles, often radiating to the navel and lower abdomen

Testicular Swelling

Swelling of the scrotum or testicle, with unilateral enlargement or asymmetry

Genital Swelling

Scrotal heaviness, hardness described as 'hard as stone'

Hernia

Inguinal or scrotal hernia with sensation of downward dragging

Lower Abdominal Pain

Colicky or pulling pain in the lower abdomen connected to the groin

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ju He Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Cold-Damp Stagnation in the Liver Channel Qi Stagnation

TCM Interpretation

In TCM, the epididymis and testicle fall within the territory of the Liver channel, which encircles the external genitalia. When Cold and Dampness invade this channel (through exposure to cold environments, sitting on cold surfaces, or internal Cold from Kidney Yang deficiency), they obstruct the flow of Qi and Blood. Over time, this stagnation produces swelling, induration, and pain in the epididymis and surrounding tissues. The condition is located at the junction of the Liver and Kidney organ systems, with the Liver governing the smooth flow of Qi through the region and the Kidney governing the reproductive organs. Chronic cases often involve both Qi stagnation and Blood stasis, explaining why the tissue becomes hard and nodular rather than simply swollen.

Why Ju He Wan Helps

Ju He Wan addresses epididymitis from multiple angles that match the TCM understanding of the condition. The King herb Ju He specifically enters the Liver channel to disperse Qi stagnation in the genital region. The Deputies Chuan Lian Zi and Mu Xiang further promote Qi flow, while Tao Ren and Yan Hu Suo invigorate Blood to reduce the induration that characterizes chronic epididymitis. Rou Gui warms the Liver and Kidney to expel the Cold at the root of the problem, while Mu Tong drains Dampness through urination. The seaweed trio (Hai Zao, Kun Bu, Hai Dai) softens the hardened, fibrotic tissue that develops in chronic cases. This multi-layered approach addresses not only the pain but also the underlying stagnation that perpetuates the condition.

Also commonly used for

Hydrocele

Testicular hydrocele (water shan) of the Cold-Damp type

Testicular Pain

Chronic testicular or scrotal pain with hardness

Male Infertility

Male infertility related to Liver channel Qi stagnation and Blood stasis

Endometriosis

Endometriosis with lower abdominal masses and pain (modified use in women)

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ju He Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ju He Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ju He Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ju He Wan works at the root level.

Ju He Wan addresses a condition the classics call tui shan (颓疝), a type of hernia or testicular disorder rooted in two interacting problems: Qi stagnation and Blood stasis in the Liver channel, combined with Cold-Dampness lodging in the lower body around the Kidneys.

The Liver channel wraps around the external genitalia. When Cold-Damp pathogenic factors invade or accumulate in this region, they obstruct the smooth flow of Qi and Blood through the Liver channel. This stagnation causes the characteristic symptoms: testicular swelling (often more on one side), a hard mass that can feel like stone, and pain that radiates upward toward the navel and abdomen. As Qi stagnation persists, Blood circulation also becomes impaired, leading to further hardening and nodule formation. In severe or prolonged cases, the combined stagnation of Qi, Blood, and Dampness can produce local tissue breakdown, with the scrotum oozing yellow fluid or even developing abscesses.

The formula's strategy therefore must work on multiple fronts simultaneously: move Qi through the Liver channel to relieve distension, activate Blood to resolve masses, warm the Kidneys and Liver to expel Cold, drain Dampness downward through urination, and soften and dissolve the hardened nodules that have already formed. This multi-layered approach reflects the complexity of the underlying pathology, where Cold, Dampness, Qi stagnation, and Blood stasis all reinforce each other.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly bitter and pungent with a salty component — bitter and pungent to move Qi and Blood and dispel stagnation, salty (from the seaweeds) to soften hardness and dissolve nodules.

Channels Entered

Liver Kidney Bladder Spleen

Ingredients

12 herbs

The herbs that make up Ju He Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Ju He

Ju He

Bitter orange seeds

Dosage 9 - 12g
Temperature Neutral
Taste Bitter
Organ Affinity Kidneys, Liver
Preparation Salt-fried (盐炒)

Role in Ju He Wan

The chief herb of the formula, Ju He enters the Liver channel to move Qi, disperse stagnation, and relieve pain. It specifically targets swelling and hardness of the testicles and is the defining herb for treating hernia-type disorders (shan qi).
Deputies — Assists and enhances the King
Chuan Lian Zi

Chuan Lian Zi

Sichuan chinaberries

Dosage 9 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Spleen, Liver, Small Intestine
Preparation Dry-roasted and flesh removed (煨,去肉)

Role in Ju He Wan

Enters the Liver channel Qi level to promote Qi movement and relieve pain. Assists the King herb in unblocking Liver Qi stagnation in the lower abdomen and groin.
Mu Xiang

Mu Xiang

Costus roots

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Gallbladder, Large Intestine, Liver, Lungs, Spleen, Stomach
Preparation Not exposed to fire (不见火)

Role in Ju He Wan

A powerful Qi-moving herb that enters the Liver channel's Qi level. Works alongside the King to promote the smooth flow of Qi through the Liver channel and relieve distension and pain.
Tao Ren

Tao Ren

Peach kernels

Dosage 9 - 12g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Heart, Large Intestine, Liver
Preparation Bran-fried (麸炒)

Role in Ju He Wan

Enters the Liver channel's Blood level to activate Blood circulation, dispel Blood stasis, and reduce swelling. Complements the Qi-moving herbs by addressing the Blood stagnation component of the pathology.
Yan Hu Suo

Yan Hu Suo

Corydalis tubers

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Heart, Liver, Lungs
Preparation Stir-fried with skin removed (炒,去皮)

Role in Ju He Wan

Enters the Liver channel's Blood level to invigorate Blood and powerfully relieve pain. Paired with Tao Ren, it addresses Blood stasis that accompanies Qi stagnation in the Liver channel.
Assistants — Supports or moderates other herbs
Hai Zao

Hai Zao

Sargassum

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Washed (洗)

Role in Ju He Wan

Salty and cold, it softens hardness and disperses nodules. Targets the hard, stone-like swelling of the testicles by breaking down pathological accumulations.
Kun Bu

Kun Bu

Kombu

Dosage 9 - 12g
Temperature Cold
Taste Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Washed (洗)

Role in Ju He Wan

Salty and cold, it works synergistically with Hai Zao and Hai Dai to soften hardness, dissipate nodules, and promote the drainage of pathological fluids.
Hai Zao

Hai Zao

Sargassum

Dosage 9 - 12g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Washed (洗)

Role in Ju He Wan

Completes the trio of salty, softening seaweed herbs. Together they form a powerful group for resolving hard masses and reducing scrotal swelling.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 3 - 6g
Temperature Hot
Taste Pungent, Sweet
Organ Affinity Heart, Kidneys, Liver, Spleen
Preparation Not exposed to fire (不见火)

Role in Ju He Wan

Warms the Liver and Kidney, expels Cold from the lower body, and supplements the Fire of the Ming Men (life gate). Addresses the root Cold component of the condition that allows dampness to congeal.
Hou Pu

Hou Pu

Houpu Magnolia bark

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen, Stomach
Preparation Skin removed, stir-fried with ginger juice (去皮,姜汁炒)

Role in Ju He Wan

Descends Qi, dries Dampness, and helps break up accumulations of fluid and stagnant Blood in the lower abdomen. Reinforces the formula's ability to address Dampness.
Zhi Shi

Zhi Shi

Immature Bitter Oranges

Dosage 3 - 6g
Temperature Cool
Taste Bitter, Pungent, Sour
Organ Affinity Spleen, Stomach, Large Intestine
Preparation Bran-fried (麸炒)

Role in Ju He Wan

Strongly moves Qi and breaks through stagnation. Helps disperse hardened accumulations and complements the Qi-regulating action of the formula.
Envoy — Directs the formula to its target
Mu Tong

Mu Tong

Akebia stems

Dosage 3 - 6g
Temperature Cold
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine

Role in Ju He Wan

Opens the water passages and drains Dampness downward through the urine. Directs the pathological Dampness out of the lower body via the Bladder, serving as a channel guide for the formula.

Why This Combination Works

How the herbs in Ju He Wan complement each other

Overall strategy

The formula targets a condition rooted in Cold-Damp invading the Liver channel, leading to Qi and Blood stagnation that manifests as testicular swelling, hardness, and pain. The prescription strategy simultaneously moves Qi, activates Blood, expels Cold-Damp, and softens hardened masses, directly addressing every layer of the pathology.

King herbs

Ju He (Tangerine Seed) is the sole King herb. It enters the Liver channel to powerfully move Qi, disperse accumulations, and relieve pain in the lower abdomen and groin. It has a specific affinity for hernia-type disorders and testicular swelling, making it the ideal lead herb for this condition.

Deputy herbs

The Deputies work in two complementary pairs. Chuan Lian Zi and Mu Xiang enter the Liver channel's Qi level to reinforce the King's Qi-moving and pain-relieving action. Tao Ren and Yan Hu Suo enter the Liver channel's Blood level to invigorate Blood circulation and break up stasis. Together, these four Deputies ensure that both the Qi and Blood stagnation in the Liver channel are thoroughly addressed.

Assistant herbs

The Assistants tackle several secondary dimensions of the pathology. Hai Zao, Kun Bu, and Hai Dai form a trio of salty, softening herbs that dissolve hardened nodules and reduce firm scrotal swelling (reinforcing Assistants). Rou Gui warms the Liver and Kidney to expel the underlying Cold that allows Dampness to congeal (reinforcing Assistant targeting the root cause). Hou Po descends Qi and dries Dampness, while Zhi Shi breaks through Qi stagnation and hardened accumulations (reinforcing Assistants addressing the Dampness and stagnation).

Envoy herbs

Mu Tong serves as the Envoy by opening the water passages and directing Dampness downward through urination. It provides a drainage route for the pathological fluids trapped in the lower body, ensuring the other herbs' actions do not simply mobilize Dampness without eliminating it.

Notable synergies

The pairing of Qi-level herbs (Ju He, Chuan Lian Zi, Mu Xiang) with Blood-level herbs (Tao Ren, Yan Hu Suo) reflects the classical principle that "where Qi goes, Blood follows." By moving both simultaneously, the formula prevents either from re-stagnating. The trio of seaweed herbs (Hai Zao, Kun Bu, Hai Dai) creates a powerful softening effect that no single herb could achieve alone, specifically targeting the stone-hard quality of the swelling. Rou Gui paired with Mu Tong balances warming and draining: Rou Gui warms the interior to prevent further Cold accumulation, while Mu Tong ensures Dampness is channeled out rather than lingering.

How to Prepare

Traditional preparation instructions for Ju He Wan

Grind all ingredients into a fine powder. Form into pills using wine-based paste (酒糊), making each pill roughly the size of a Chinese parasol tree seed (about 6mm diameter). Take approximately 70 pills (about 9g) per dose, 1 to 2 times daily on an empty stomach, swallowed with warm salted wine or warm lightly salted water.

In modern clinical use, the formula may also be prepared as a decoction. When used as a decoction, the ingredients should be adjusted to standard decoction dosages (the gram amounts listed reflect decoction-form dosing) and simmered in water for approximately 30 minutes.

Common Modifications

How practitioners adapt Ju He Wan for specific situations

Added
Xiao Hui Xiang

6-9g, warms the Liver and disperses Cold in the lower abdomen

Wu Zhu Yu

3-6g, warms the Liver channel and stops pain from Cold stagnation

When Cold predominates with the scrotum feeling icy cold and the pain worsening markedly in cold weather, adding these strongly warming Liver-channel herbs enhances the formula's ability to dispel Cold and relieve pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ju He Wan should not be used or requires extra caution

Avoid

Pregnancy. This formula contains Tao Ren (peach kernel), which has Blood-moving properties and may stimulate uterine contractions, as well as other strongly Qi-moving herbs. It should not be used during pregnancy.

Caution

Yin deficiency with Heat signs. This formula is designed for Cold-Damp patterns. If the scrotal swelling or hernia involves redness, hot sensation, and signs of Damp-Heat, Rou Gui (cinnamon bark) should be removed and cooling, Heat-clearing herbs added instead.

Caution

Qi and Blood deficiency without excess. The formula relies heavily on Qi-moving and Blood-activating herbs, which can further weaken those who are constitutionally depleted. The classical text Ben Jing Feng Yuan warns that Ju He (tangerine seed) is suitable only for excess patterns and is contraindicated in deficiency because its bitter flavor damages the Stomach's harmonious Qi.

Caution

Active bleeding disorders or patients on anticoagulant therapy. The Blood-moving herbs Tao Ren and Yan Hu Suo may increase bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. This formula contains Tao Ren (peach kernel), which is a recognized Blood-moving herb with documented potential to stimulate uterine contractions and induce labor. Chuan Lian Zi (Melia fruit) is also classified as a pregnancy caution herb. Additionally, the formula's overall strategy of vigorously moving Qi and Blood makes it unsuitable for pregnant women. The combination of multiple Qi-moving and Blood-activating ingredients poses a clear risk of miscarriage or premature labor.

Breastfeeding

Use with caution during breastfeeding. While not absolutely contraindicated, several ingredients deserve attention. Chuan Lian Zi (Melia toosendan fruit) contains potentially toxic alkaloids (such as toosendanin) that could theoretically transfer through breast milk in small amounts. Tao Ren also has active pharmacological compounds. There is no established safety data for this formula in breastfeeding women. If use is clinically necessary, it should be under close practitioner supervision with the shortest possible course.

Children

This formula was historically used for pediatric inguinal hernia, which the classical texts noted was common in children. However, dosages must be significantly reduced — typically to one-third to one-half of the adult dose depending on the child's age and weight. The formula contains strong Qi-moving and Blood-activating herbs that can be harsh on a child's immature digestive system. For children under age 5, this formula should only be used under close practitioner supervision. Mu Tong in particular requires careful dosing in children due to potential nephrotoxicity concerns with certain Mu Tong species (Aristolochia-derived varieties should be strictly avoided; only Akebia-derived Mu Tong should be used).

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ju He Wan

Anticoagulants and antiplatelet drugs (e.g. warfarin, aspirin, clopidogrel): Tao Ren (peach kernel) and Yan Hu Suo (corydalis) both have documented Blood-activating and analgesic properties. They may potentiate anticoagulant effects and increase bleeding risk when taken alongside blood-thinning medications.

Hepatotoxic medications: Chuan Lian Zi (Melia toosendan fruit) contains toosendanin, which has known hepatotoxic potential at higher doses. Concurrent use with other liver-burdening drugs (e.g. acetaminophen/paracetamol, statins, certain antibiotics) may increase the risk of liver damage.

Mu Tong species caution: If the formula uses traditional Mu Tong derived from Aristolochia species (now banned in many countries due to aristolochic acid nephrotoxicity), there is serious risk of kidney injury. Only Akebia-derived Mu Tong (Caulis Akebiae) should be used. This is a safety concern rather than a drug interaction per se, but it becomes especially important if the patient is taking any nephrotoxic drugs.

Usage Guidance

Practical advice for getting the most out of Ju He Wan

Best time to take

On an empty stomach (空心, kōng xīn), traditionally in the morning, with warm salted wine or warm lightly salted water to guide the formula's action downward to the lower body.

Typical duration

Often taken for 2–4 weeks as a course, then reassessed by a practitioner. Chronic or stubborn cases may require multiple courses with modifications.

Dietary advice

Avoid cold and raw foods, iced drinks, and excessive dairy, as these can generate further Cold-Dampness in the lower body and counteract the formula's warming, Dampness-dispelling action. Reduce greasy, fried, and heavy foods that contribute to Dampness and Phlegm accumulation. Alcohol in small amounts (particularly warm rice wine) is traditionally considered compatible and was in fact part of the original administration method. Favor lightly warming, easy-to-digest foods such as cooked vegetables, soups, and mild spices like fresh ginger.

Ju He Wan originates from Ji Sheng Fang (济生方, Formulas to Aid the Living) by Yan Yong-He (严用和) Sòng dynasty, 1253 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ju He Wan and its clinical use

《济生方》 (Jì Shēng Fāng, Yan Yonghe):
「治四种颓病,卵核肿胀,偏有大小;或坚硬如石;或引脐腹绞痛,甚则肤囊肿胀;或成疮毒,轻则时出黄水,甚则成痈溃烂。」
"Treats four types of tui-hernia: testicular swelling with uneven size on each side; or hardness like stone; or colicky pain radiating to the navel and abdomen, with severe cases causing scrotal swelling; or developing into sores and toxins — in mild cases oozing yellow fluid, in severe cases forming abscesses and ulceration."

《医方集解》 (Yī Fāng Jí Jiě, Wang Ang):
「此足厥阴药也。橘核、木香能入厥阴气分而行气;桃仁、延胡能入厥阴血分而活血;川楝、木通能导小肠膀胱之热,由小便下行,所以去湿;官桂能平肝暖肾,补肾命之火,所以祛寒;厚朴、枳实,并能行结水而破宿血;昆布、藻、带,咸润下而软坚。」
"This is a formula for the Foot Jue Yin [Liver] channel. Ju He and Mu Xiang enter the Qi aspect of Jue Yin to move Qi; Tao Ren and Yan Hu Suo enter the Blood aspect of Jue Yin to invigorate Blood; Chuan Lian Zi and Mu Tong guide the heat of the Small Intestine and Bladder downward via urination, thereby eliminating Dampness; Guan Gui warms the Kidneys and supplements the fire of the life gate, thereby expelling Cold; Hou Po and Zhi Shi can move accumulated fluids and break up old stagnant Blood; Kun Bu, Hai Zao, and Hai Dai are salty to moisten, descend, and soften hardness."

《汤头歌诀》 (Tāng Tóu Gē Jué, Wang Ang):
「橘核丸中川楝桂,朴实延胡藻带昆,桃仁木香于木通,颓疝痛丸盐酒吞。」
"Ju He Wan contains Chuan Lian Zi and Gui, Hou Po, Zhi Shi, Yan Hu Suo, Hai Zao, Hai Dai, and Kun Bu; Tao Ren, Mu Xiang, and Mu Tong — pills for tui-hernia pain, swallowed with salted wine."

Historical Context

How Ju He Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ju He Wan was created by Yan Yonghe (严用和, c. 1199–1267), a prominent physician of the Southern Song dynasty from Lushan in Jiangxi province. It was published in his major work, the Ji Sheng Fang (《济生方》, "Formulas to Aid the Living"), completed in 1253 CE. Yan was a celebrated clinical innovator who studied under the physician Liu Kai, and whose many formulas — including Gui Pi Tang and Shi Pi Yin — remain foundational in Chinese medicine today.

The formula gained even wider recognition when the Qing dynasty physician Wang Ang (汪昂) included it in his influential Tang Tou Ge Jue (《汤头歌诀》, "Rhyming Guide to Formulas"), composing a memorable verse to help students learn its composition and indications. Wang Ang also provided a detailed analysis of the formula in his Yi Fang Ji Jie (《医方集解》), explaining how each herb targets either the Qi aspect or Blood aspect of the Liver (Jue Yin) channel. After the publication of Ju He Wan, tangerine seeds (Ju He) became almost synonymous with hernia treatment in Chinese medicine, and later practitioners expanded its application to conditions like orchitis, epididymitis, and even breast lumps.