Guo Qi Yin

Delayed Menstruation Drink · 過期飲

Also known as: 过期饮

A classical women's health formula designed to nourish Blood and gently move Blood stasis while regulating Qi flow, primarily used for delayed or absent menstruation caused by underlying Blood deficiency combined with Qi stagnation. It is built on the foundation of Si Wu Tang (Four Substances Decoction) with added herbs to invigorate Blood circulation and move Qi.

Origin Zhèng Zhì Zhǔn Shéng · Nǚ Kē (证治准绳·女科), Volume 1, by Wáng Kěntáng (王肯堂) — Míng dynasty, 1602 CE
Composition 11 herbs
Dang Gui
King
Dang Gui
Shu Di Huang
King
Shu Di Huang
Bai Shao
Deputy
Bai Shao
Xiang Fu
Deputy
Xiang Fu
Chuan Xiong
Deputy
Chuan Xiong
Hong Hua
Assistant
Hong Hua
Tao Ren
Assistant
Tao Ren
E Zhu
Assistant
E Zhu
+3
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Guo Qi Yin is designed to correct these specific patterns.

Why Guo Qi Yin addresses this pattern

This is the primary pattern this formula was designed for. Blood deficiency leaves insufficient Blood to fill the Chong and Ren vessels that govern menstruation, while concurrent Qi stagnation further impedes whatever Blood remains from flowing properly. The formula addresses this with Si Wu Tang (Shu Di Huang, Dang Gui, Bai Shao, Chuan Xiong) as its core to nourish Blood, supplemented by Xiang Fu to regulate Qi, and Tao Ren, Hong Hua, and E Zhu to break up Blood stasis. Rou Gui warms the channels to aid circulation, and Mu Tong opens the vessels. This comprehensive approach replenishes the Blood while removing the stagnation that blocks its flow, restoring the menstrual cycle.

A practitioner would look for one or more of these signs

Late Menstruation

Menstruation arrives later than expected or not at all

Amenorrhea

Absence of menstruation

Abdominal Pain

Lower abdominal distension and pain that worsens before period is expected

Scanty Menstruation

Very light menstrual flow when period does arrive

Dull Pale Complexion

Pallor reflecting underlying Blood deficiency

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Guo Qi Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Deficiency

TCM Interpretation

In TCM, menstruation depends on sufficient Blood filling the Chong (Penetrating) and Ren (Conception) vessels, and on the smooth flow of Qi and Blood through these channels. When Blood is deficient, there is simply not enough material to produce a menstrual flow. When Qi stagnates on top of this, the Liver's role in ensuring smooth flow is compromised, and whatever Blood exists cannot move freely. The combination of these two factors, not enough Blood and obstructed flow, leads to amenorrhea. The Liver, Spleen, and Kidney organ systems are all involved: the Liver stores Blood and governs smooth Qi flow, the Spleen produces Blood, and the Kidney provides the foundation for the reproductive cycle.

Why Guo Qi Yin Helps

Guo Qi Yin directly addresses both sides of this problem. The Si Wu Tang core (Shu Di Huang, Dang Gui, Bai Shao, Chuan Xiong) replenishes the Blood supply so the Chong and Ren vessels can gradually fill again. Simultaneously, Xiang Fu regulates Liver Qi to restore smooth flow, while Tao Ren, Hong Hua, and E Zhu break through the Blood stasis that has accumulated during the months without menstruation. Rou Gui adds warmth to the lower abdomen and uterus, which helps activate Blood circulation in these areas. Clinical studies have reported a total effectiveness rate of 90% in treating amenorrhea-related infertility with this formula.

Also commonly used for

Scanty Menstruation

Abnormally light menstrual flow (hypomenorrhea)

Infertility

When related to menstrual irregularity from Blood deficiency and stasis

What This Formula Does

Every TCM formula has a specific set of actions — here's what Guo Qi Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Guo Qi Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Guo Qi Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Guo Qi Yin works at the root level.

This formula addresses a pattern where the body's Blood is insufficient and its Qi flow has become stagnant, leading to delayed or absent menstruation. In TCM, the Liver stores Blood and governs the smooth flow of Qi, while the Chong and Ren vessels (the two extraordinary vessels most closely tied to menstruation) depend on adequate Blood to fill and timely Qi movement to discharge. When Blood is deficient, there is simply not enough substance to fill the uterus on schedule. When Qi stagnates (often from emotional stress or constitutional tendency), what little Blood there is cannot flow freely, and mild stasis begins to form in the vessels that serve the uterus.

The combination of insufficient Blood and obstructed Qi creates a self-reinforcing cycle: deficient Blood fails to nourish the Liver, which then cannot regulate Qi smoothly, and stagnant Qi further impedes the generation and movement of Blood. Additionally, Blood deficiency often carries an element of internal Cold, since Blood and warmth travel together. This mild Cold further congeals what Blood remains in the Chong and Ren channels, making menstruation even more reluctant to arrive. The result is menstruation that comes late, is scanty, or stops altogether, often accompanied by lower abdominal distension and a sense that the period "wants to come but cannot." The pale tongue, white coating, and wiry-thin pulse all reflect this interplay of Blood deficiency, Qi stagnation, and mild Cold.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and acrid with mild bitterness — sweet to nourish Blood, acrid to move Qi and Blood, with a slight bitter note to direct downward and resolve stasis.

Channels Entered

Ingredients

11 herbs

The herbs that make up Guo Qi Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Guo Qi Yin

Nourishes and invigorates Blood, warms the channels and alleviates pain. As the primary herb, it addresses the core Blood deficiency while also gently moving Blood to resolve stasis, making it the ideal lead herb for this pattern of deficiency and stagnation coexisting.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 6g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Guo Qi Yin

Strongly tonifies Blood and nourishes Yin, providing the substantial material foundation needed to replenish depleted Blood. As the heaviest nourishing herb in the formula, it works alongside Dang Gui to address the root Blood deficiency.
Deputies — Assists and enhances the King
Bai Shao

Bai Shao

White peony root

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Guo Qi Yin

Nourishes Blood, softens the Liver, and alleviates pain. Supports the King herbs by preserving Yin and Blood while harmonizing the Liver to ease menstrual discomfort.
Xiang Fu

Xiang Fu

Nutgrass rhizome

Dosage 6g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)

Role in Guo Qi Yin

The primary Qi-regulating herb in this formula, known as a key herb for gynaecological conditions. It smooths Liver Qi, regulates menstruation, and alleviates pain caused by Qi stagnation, directly addressing the Qi stagnation component of the pattern.
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 3g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Guo Qi Yin

Invigorates Blood and promotes Qi movement. Bridges the Blood-nourishing and Blood-moving actions of the formula, ensuring that newly nourished Blood flows freely through the vessels and channels.
Assistants — Supports or moderates other herbs
Hong Hua

Hong Hua

Safflower

Dosage 2g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver

Role in Guo Qi Yin

Invigorates Blood and dispels stasis, unblocking the channels and vessels to promote menstrual flow. Used at a moderate dose to activate Blood circulation without being overly drastic.
Tao Ren

Tao Ren

Peach kernel

Dosage 2g
Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Preparation Crushed to paste (桃仁泥)

Role in Guo Qi Yin

Breaks up Blood stasis and promotes menstrual flow. Works synergistically with Hong Hua to form the classical Tao Ren-Hong Hua pair for resolving Blood stasis in the uterus.
E Zhu

E Zhu

Zedoary rhizome

Dosage 1.5g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Spleen

Role in Guo Qi Yin

Strongly breaks Blood stasis and promotes Qi movement, targeting more stubborn or deep-seated stagnation. Its inclusion at a small dose strengthens the formula's ability to dispel entrenched Blood stasis without being too aggressive.
Mu Tong

Mu Tong

Akebia stem

Dosage 1.5g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Small Intestine, Urinary Bladder

Role in Guo Qi Yin

Promotes the movement of Blood through the channels and opens the vessels, helping to direct the formula's Blood-moving action to the uterine network vessels and supporting menstrual flow.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 1g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys

Role in Guo Qi Yin

Warms the channels, disperses Cold, and promotes Blood circulation. Adds a warming dynamic to the formula that helps Cold-stagnated Blood flow freely, particularly important when Cold is contributing to the menstrual blockage.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 1g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Guo Qi Yin

Harmonizes all the herbs in the formula, moderates the strong Blood-moving herbs, and tonifies the Spleen to support the production of new Blood.

Why This Combination Works

How the herbs in Guo Qi Yin complement each other

Overall strategy

This formula addresses the dual problem of Blood deficiency and Qi-Blood stagnation causing delayed or absent menstruation. The strategy is to simultaneously nourish Blood (to treat the root) and invigorate Blood circulation while regulating Qi (to treat the branch), so that the menstrual cycle can resume naturally.

King herbs

Dang Gui (Chinese Angelica) and Shu Di Huang (Prepared Rehmannia) serve as the King herbs. Shu Di Huang is the strongest Blood-nourishing herb in the formula, providing the material basis to replenish depleted Blood. Dang Gui both nourishes and invigorates Blood, bridging the formula's tonifying and moving strategies. Together they address the fundamental Blood deficiency that underlies the delayed menstruation.

Deputy herbs

Bai Shao (White Peony Root) reinforces Blood nourishment while softening the Liver and relieving pain. These first three herbs together form the core of Si Wu Tang (Four Substances Decoction), the foundational Blood-tonifying formula. Xiang Fu (Cyperus) is the primary Qi-regulating herb, often called the "commander of Qi among gynaecological herbs." It directly targets the Qi stagnation that is preventing Blood from flowing. Chuan Xiong (Sichuan Lovage) completes the Si Wu Tang base and uniquely moves both Qi and Blood, acting as a bridge between the nourishing and moving functions.

Assistant herbs

Hong Hua (Safflower) and Tao Ren (Peach Kernel) form a classical Blood-invigorating pair that specifically breaks up stasis and promotes menstrual flow (reinforcing assistants). E Zhu (Zedoary) adds stronger stasis-breaking power for more stubborn blockages (reinforcing assistant). Mu Tong (Akebia Stem) opens the channels and network vessels, helping to direct the Blood-moving action toward the uterus (reinforcing assistant). Rou Gui (Cinnamon Bark) warms the channels and interior, addressing any Cold that may be contributing to the stagnation, and helps activate Blood circulation (reinforcing assistant).

Envoy herbs

Zhi Gan Cao (Honey-prepared Licorice) harmonizes the entire formula, moderating the potentially harsh Blood-moving herbs to prevent them from damaging what is already deficient. It also gently supports the Spleen's role in generating new Blood.

Notable synergies

The Tao Ren and Hong Hua pairing is one of the most well-known Blood-invigorating combinations in Chinese medicine, creating a stronger stasis-resolving effect than either herb alone. The Dang Gui and Chuan Xiong pair (known as "Xiong Gui") is a classical combination that simultaneously nourishes and moves Blood. Xiang Fu paired with the Blood-moving herbs ensures that Qi movement supports Blood movement, reflecting the principle that "when Qi moves, Blood moves."

How to Prepare

Traditional preparation instructions for Guo Qi Yin

Use approximately 400 mL of water. Bring to a boil, then simmer until reduced to approximately 200 mL. Strain and take warm on an empty stomach. One dose per day, divided into two servings if needed.

Common Modifications

How practitioners adapt Guo Qi Yin for specific situations

Added
Chai Hu

6g, to spread Liver Qi and relieve constraint

Qing Pi

6g, to break stagnant Qi and reduce distension

When Qi stagnation is more dominant than Blood stasis, adding Chai Hu and Qing Pi strengthens the Qi-moving action, helping to unblock the Liver and release the constraint that is preventing menstrual flow.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Guo Qi Yin should not be used or requires extra caution

Avoid

Pregnancy. This formula contains multiple Blood-moving and stasis-breaking herbs (Tao Ren, Hong Hua, E Zhu) that can stimulate uterine contractions and risk miscarriage.

Avoid

Heavy menstrual bleeding (menorrhagia) or any active uterine hemorrhage. The Blood-invigorating herbs in this formula would worsen excessive bleeding.

Caution

Delayed menstruation due to Blood Heat or Yin deficiency with Heat signs. This formula is warming in nature and would aggravate Heat-pattern amenorrhea.

Caution

Patients without Blood deficiency and Cold. This formula is designed specifically for Blood deficiency with Qi stagnation and mild Cold; using it when these conditions are absent is inappropriate.

Caution

Patients with bleeding disorders or those on anticoagulant therapy, as the Blood-moving herbs may increase bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. This formula contains several herbs that strongly move and break Blood stasis: Tao Ren (Peach Kernel), Hong Hua (Safflower), and E Zhu (Curcuma Rhizome) all have documented ability to stimulate uterine contractions and promote blood flow to the uterus. Rou Gui (Cinnamon Bark) also warms and moves Blood powerfully. These combined actions pose a significant risk of miscarriage or premature labor. This formula must not be used during any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. The Blood-moving herbs (Tao Ren, Hong Hua, E Zhu) may pass active compounds into breast milk, and their effects on the nursing infant are not well studied. Mu Tong (Akebia Stem) has been associated with nephrotoxicity when aristolochic acid-containing species are used, and any transfer through breast milk could pose a risk to the infant. If this formula is considered necessary during lactation, a qualified practitioner should supervise, and the specific species of Mu Tong used should be confirmed as a safe variety (e.g., Akebia trifoliata, not Aristolochia).

Children

This formula is designed specifically for menstrual disorders in adult women and is not indicated for pediatric use. It should not be given to children. In rare cases where an adolescent girl has begun menstruating and presents with the exact pattern of Blood deficiency with Qi stagnation causing delayed menses, a practitioner may consider a significantly reduced dose under close supervision, but this would be an exceptional situation requiring professional judgment.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Guo Qi Yin

Anticoagulants and antiplatelet agents (e.g., warfarin, heparin, aspirin, clopidogrel): This formula contains multiple Blood-invigorating herbs (Tao Ren, Hong Hua, E Zhu, Chuan Xiong) that have demonstrated antiplatelet and anticoagulant activity in pharmacological studies. Concurrent use may increase the risk of bleeding.

Gan Cao (Licorice) interactions: The Zhi Gan Cao in this formula may interact with corticosteroids (potentiating their effects), digoxin and other cardiac glycosides (through its effect on potassium levels), antihypertensive medications (licorice can cause sodium retention and raise blood pressure), and diuretics (compounding potassium loss).

Rou Gui (Cinnamon Bark): Contains cinnamaldehyde, which has mild hypoglycemic properties. Patients on diabetes medications (insulin, sulfonylureas) should be monitored for potential additive blood sugar-lowering effects.

Mu Tong (Akebia Stem): If an aristolochic acid-containing species is mistakenly used, it poses serious nephrotoxicity risk and may interact with any medication metabolized through the kidneys. Only confirmed safe species should be dispensed.

Usage Guidance

Practical advice for getting the most out of Guo Qi Yin

Best time to take

On an empty stomach, taken warm — traditionally recommended as a warm decoction before meals (空腹温服).

Typical duration

Typically taken for 1 to 3 menstrual cycles (roughly 4 to 12 weeks), reassessed each cycle based on menstrual response.

Dietary advice

While taking this formula, favor warm, nourishing, easy-to-digest foods such as soups, congee, red dates, longan, and lightly cooked dark leafy greens that support Blood production. Avoid cold and raw foods (salads, iced drinks, raw fruits in excess), as these may counteract the formula's warming action and further obstruct the flow of Qi and Blood. Also limit greasy, heavy, or overly rich foods that burden the Spleen and impede Qi movement. Avoid excessive sour foods, which have an astringent quality that may counteract the formula's Blood-moving effects.

Guo Qi Yin originates from Zhèng Zhì Zhǔn Shéng · Nǚ Kē (证治准绳·女科), Volume 1, by Wáng Kěntáng (王肯堂) Míng dynasty, 1602 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Guo Qi Yin and its clinical use

Source text indication from Zheng Zhi Zhun Sheng, Women's Section (《证治准绳·女科》卷一):

治血虚气滞,经水过期不行。
"Treats Blood deficiency with Qi stagnation, where menstrual flow is overdue and does not come."

Classical formula song (方歌):

过期饮含四物汤,香附桃仁红花匡,木通莪术肉桂草,血瘀经闭了后康。
"Guo Qi Yin contains Si Wu Tang [as its base], assisted by Xiang Fu, Tao Ren, and Hong Hua; with Mu Tong, E Zhu, Rou Gui, and Gan Cao — Blood stasis and amenorrhea are thus resolved and health restored."

Historical Context

How Guo Qi Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Guo Qi Yin was first recorded in the gynecology section of Zheng Zhi Zhun Sheng (《证治准绳·女科》), compiled by the Ming Dynasty physician Wang Kentang (王肯堂) and published in 1602. Wang Kentang was one of the most encyclopedic medical compilers of his era, and the Zheng Zhi Zhun Sheng (also known as the Six Departments of Pattern Identification and Treatment Standards) is a massive six-part work covering internal medicine, surgery, gynecology, pediatrics, ophthalmology, and febrile disease. Its gynecology volume drew extensively on earlier authorities including Zhang Zhongjing, Zhu Danxi, and Xue Ji, organizing their insights into a systematic clinical reference.

The formula's name, "Guo Qi Yin" (过期饮, literally "Overdue Drink"), directly describes its clinical target: menstruation that is overdue. Its design builds on the classical Si Wu Tang (Four Substances Decoction) as a Blood-nourishing foundation and adds Qi-regulating and Blood-moving herbs to address the combined deficiency-stagnation pattern. A separately named formula also called Guo Qi Yin appears in the later text Yi Lue Liu Shu (《医略六书》) with a quite different composition emphasizing warming herbs like Fu Zi (Aconite), Pao Jiang (Blast-fried Ginger), and Ai Ye (Mugwort Leaf). That variant targets menstrual delay due to pronounced Cold, whereas the Zheng Zhi Zhun Sheng version focuses more on Blood stasis with deficiency. Clinicians must distinguish the two versions carefully.