Di Gu Pi Yin

Lycium Root Bark Decoction · 地骨皮飲

Also known as: 地骨皮饮

A classical formula that combines the famous blood-nourishing Four Substances Decoction with two cooling bark herbs. It is designed for people experiencing low-grade fevers, night sweats, and feelings of heat in the palms and soles caused by a deficiency of Blood and Yin with internal Heat. It is particularly noted in classical texts for addressing fevers during pregnancy and nighttime fevers that worsen when the body is at rest.

Origin 《醫壘元戎》(Yī Lěi Yuán Róng) by Wang Haogu (王好古), commentary in《醫宗金鑒·刪補名醫方論》(Yī Zōng Jīn Jiàn) by Wu Qian (吳謙) — Yuán dynasty (元朝), circa 13th century
Composition 6 herbs
Shu Di Huang
King
Shu Di Huang
Di Gu Pi
Deputy
Di Gu Pi
Mu Dan Pi
Deputy
Mu Dan Pi
Dang Gui
Assistant
Dang Gui
Bai Shao
Assistant
Bai Shao
Chuan Xiong
Envoy
Chuan Xiong
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Di Gu Pi Yin is designed to correct these specific patterns.

Why Di Gu Pi Yin addresses this pattern

When Yin and Blood in the Liver become depleted, they can no longer anchor Yang, allowing deficiency Heat to flare. This manifests as bone-steaming fever (a deep, smoldering heat sensation), tidal fevers that worsen at night, heat in the palms and soles, irritability, and a red tongue with little coating. Di Gu Pi Yin addresses this by using Si Wu Tang to replenish the depleted Blood and Yin, while Di Gu Pi and Mu Dan Pi clear the resulting deficiency Heat. The classical commentary emphasizes that this formula specifically targets deficiency Heat in the Liver (Jue Yin) level, using a 'cool supplementation' (凉补) strategy rather than aggressive purging of Fire.

A practitioner would look for one or more of these signs

Bone Steaming

Deep smoldering heat sensation, especially at night

Tidal Fever

Low-grade fever that worsens in the evening or at night

Night Sweats

Sweating during sleep from Yin deficiency

Five Palm Heat

Heat sensation in palms, soles, and chest

Irritability

Restlessness and irritability from deficiency Heat disturbing the spirit

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Di Gu Pi Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, menopause represents a natural decline in the Kidney's Yin and Essence, which normally keeps the body's warming Yang in balance. As Yin weakens, Yang rises unchecked, producing waves of heat (hot flashes), night sweats, and emotional restlessness. Because the Liver depends on Kidney Yin and Blood for nourishment, the Liver is often affected too, leading to irritability, mood swings, and disturbed sleep. This explains why menopausal symptoms frequently involve both Kidney Yin deficiency and Liver Blood deficiency generating internal Heat.

Why Di Gu Pi Yin Helps

Di Gu Pi Yin nourishes the Blood through its Si Wu Tang base (Shu Di Huang, Dang Gui, Bai Shao, Chuan Xiong), which supports the Liver and indirectly benefits the Kidneys. Di Gu Pi specifically clears deficiency Heat from the Liver and Kidney levels, targeting the bone-steaming, smoldering heat characteristic of menopausal hot flashes. Mu Dan Pi cools the Blood and calms upward-flaring Heat. Together, the formula replenishes what has been lost while clearing the excess Heat that results from the deficiency, offering a gentler approach than formulas that rely on intensely cold herbs.

Also commonly used for

Abnormal Uterine Bleeding

Early or heavy menstruation from Blood Heat

Threatened Miscarriage

Fever during pregnancy with signs of Blood Heat

Urticaria

Papular urticaria from Blood Heat

Eczema

Acute eczema with red, hot skin lesions

Henoch-Schonlein Purpura

Allergic purpura in children with Blood Heat

Purpura

Bleeding from Blood Heat with underlying deficiency

Neurodermatitis

From Blood deficiency generating Wind and Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Di Gu Pi Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Di Gu Pi Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Di Gu Pi Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Di Gu Pi Yin works at the root level.

This formula addresses a pattern where the body's Yin (the cooling, nourishing, and anchoring aspect) has become depleted, particularly in the Liver system. When Liver Yin and Blood are insufficient, they can no longer anchor and control the body's Yang and warmth. The uncontrolled Yang rises and flares as pathological Fire, a condition sometimes called "Yin deficiency with effulgent Fire."

The Liver stores Blood and governs the smooth flow of Qi. When Liver Blood is depleted, the organ dries out and heats up. This deficiency Heat characteristically worsens at night, because nighttime is when Yin should be dominant. With insufficient Yin to take charge, floating Yang produces symptoms such as bone-steaming sensation (a deep, smoldering heat felt in the bones), hot palms and soles, irritability, night sweats, a red tongue with little coating, and a thin, rapid pulse. In women, this Liver Blood deficiency with Heat readily disturbs the Chong and Ren vessels, causing fever during pregnancy ("Heat entering the Blood Chamber") or menstrual irregularities.

The classical commentator Ke Qin specifically positioned this formula for deficiency Heat localized to the Jue Yin Liver, distinguishing it from Spleen-level deficiency Heat (addressed by Bu Zhong Yi Qi Tang) and Kidney-level deficiency Heat (addressed by Liu Wei Di Huang Wan). When Yin is deficient in the Liver, the therapeutic approach must simultaneously replenish the Blood that the Liver stores while gently clearing the floating Fire that has arisen from that deficiency.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and slightly bitter, with mild pungent notes. The sweet taste (from Shu Di Huang, Dang Gui, Bai Shao) nourishes and tonifies, while the slight bitterness (from Di Gu Pi, Mu Dan Pi) clears Heat and directs downward.

Channels Entered

Ingredients

6 herbs

The herbs that make up Di Gu Pi Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Preparation Wine-steamed (酒蒸)

Role in Di Gu Pi Yin

The chief blood-nourishing herb in this formula. Its sweet, warm, and rich nature powerfully supplements Blood and nourishes Yin in the Liver and Kidneys, directly addressing the root deficiency that gives rise to internal Heat.
Deputies — Assists and enhances the King
Di Gu Pi

Di Gu Pi

Lycium root bark

Dosage 9 - 12g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Lungs, Liver, Kidneys

Role in Di Gu Pi Yin

Clears deficiency Heat from the Liver and Kidneys and cools the Blood. As Ke Qin's commentary explains, it clears 'the fire within the will' (志中之火) to settle the Kidneys, supporting the mother organ of the Liver. Its cool nature directly quenches the bone-steaming Heat that arises from Yin deficiency.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Di Gu Pi Yin

Cools the Blood, clears Heat, and activates Blood circulation to resolve stasis. According to the classical commentary, it clears 'the fire within the spirit' (神中之火) to cool the Heart, draining the child organ of the Liver. Together with Di Gu Pi, these two barks cool without being overly drying, clearing Liver Fire without harming the Spleen and Stomach.
Assistants — Supports or moderates other herbs
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Preparation Wine-washed and dry-fried (酒浸炒)

Role in Di Gu Pi Yin

Nourishes and invigorates the Blood. As the primary blood-tonifying herb in Si Wu Tang, it supplements Blood while gently promoting its circulation, ensuring that the newly nourished Blood moves freely rather than becoming stagnant.
Bai Shao

Bai Shao

White peony root

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Preparation Wine-fried (酒炒)

Role in Di Gu Pi Yin

Nourishes the Blood and preserves Yin, softens the Liver and harmonizes the nutritive level. Its sour and cool nature helps collect and store the Blood that has been tonified by the other herbs, ensuring it stays properly housed in the Liver.
Envoy — Directs the formula to its target
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 4.5 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Di Gu Pi Yin

Moves Qi and activates Blood circulation. Its acrid and warm nature counterbalances the rich, cloying quality of Shu Di Huang, preventing stagnation. It guides the Blood-nourishing herbs throughout the body, reaching upward to the head and downward to the Blood chamber (血海), ensuring the formula's effects are broadly distributed.

Why This Combination Works

How the herbs in Di Gu Pi Yin complement each other

Overall strategy

Di Gu Pi Yin addresses the root cause (Blood and Yin deficiency in the Liver) and the branch symptom (deficiency Heat flaring upward) simultaneously. It nourishes Blood using the classical Si Wu Tang base while adding two cooling bark herbs to clear the pathological Heat that arises when Yin is insufficient to anchor Yang.

King herbs

Shu Di Huang (prepared Rehmannia) is the King herb. Its sweet, warm, and deeply nourishing nature makes it the strongest blood-tonifying substance in the formula. It fills the depleted Blood and Yin of the Liver and Kidneys, addressing the fundamental deficiency that allows Heat to flare.

Deputy herbs

Di Gu Pi and Mu Dan Pi serve as co-Deputies. Together they clear deficiency Heat and cool the Blood from two complementary angles. The classical commentary by Ke Qin explains that Di Gu Pi clears Heat in the Kidneys (the Liver's mother organ), while Mu Dan Pi clears Heat in the Heart (the Liver's child organ). By addressing both the mother and child of the Liver, these two barks ensure that pathological Heat is drained from above and below. Crucially, both are described as cooling without being harsh or overly bitter, so they clear Liver Fire without damaging the Spleen and Stomach, a key advantage over alternatives like Zhi Mu and Huang Bai.

Assistant herbs

Dang Gui (reinforcing assistant) works alongside Shu Di Huang to tonify and invigorate the Blood. Bai Shao (reinforcing assistant) nourishes Blood, preserves Yin, and softens the Liver, helping the replenished Blood return to its proper storage in the Liver.

Envoy herbs

Chuan Xiong acts as the Envoy, moving Qi and Blood to prevent the rich, cloying blood-tonifying herbs from causing stagnation. Its ascending and dispersing nature distributes the formula's effects throughout the body.

Notable synergies

The pairing of Di Gu Pi and Mu Dan Pi is central to this formula's identity. Both are bark herbs that are cool and mild, clearing Heat without the harshness of mineral or intensely bitter herbs. The Si Wu Tang base (Shu Di Huang, Dang Gui, Bai Shao, Chuan Xiong) creates a balanced dynamic of nourishing, storing, and moving Blood, to which the two bark Deputies add a heat-clearing layer, transforming a pure blood-tonifying formula into one that simultaneously treats deficiency Heat.

How to Prepare

Traditional preparation instructions for Di Gu Pi Yin

Combine all six herbs in a ceramic or clay pot. Add approximately 400 ml of water and soak for 30 minutes. Bring to a boil over high heat, then reduce to a gentle simmer and decoct for 20 to 25 minutes. Strain and drink warm. Take one dose per day, divided into two servings (morning and evening). The herbs should be decocted fresh for each day's dose.

Common Modifications

How practitioners adapt Di Gu Pi Yin for specific situations

Added
15 - 30g, clears Heat and resolves toxins
Bai Jiang Cao

15 - 30g, clears Heat, resolves toxins and expels pus

Yu Xing Cao

15 - 30g, clears Heat-toxins, especially in the Lungs

When Heat signs are pronounced with possible infection, adding Heat-toxin clearing herbs strengthens the formula's ability to combat active inflammatory processes while the base formula continues to nourish Blood and Yin.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Di Gu Pi Yin should not be used or requires extra caution

Avoid

Fever or Heat conditions caused by external pathogens (Wind-Cold or Wind-Heat invasion). This formula treats internal deficiency Heat, not externally contracted febrile disease. Using it for external Heat patterns may trap the pathogen inside the body.

Caution

Spleen and Stomach deficiency with loose stools or poor appetite. The formula contains cooling herbs (Di Gu Pi, Mu Dan Pi) and the rich, cloying Shu Di Huang, which can further burden a weak digestive system.

Avoid

Yang deficiency patterns with cold limbs, aversion to cold, and pale tongue. The formula's cooling and Yin-nourishing strategy is inappropriate and may further damage Yang.

Caution

Excessive menstrual bleeding or active hemorrhage without clear Blood-Heat signs. Mu Dan Pi and Chuan Xiong have mild Blood-moving properties that could theoretically worsen uncontrolled bleeding if the cause is not Blood Heat.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. This formula was historically indicated for prenatal fever (胎前发热) caused by Blood-Heat, suggesting classical practitioners did use it during pregnancy for specific conditions. However, Mu Dan Pi (Moutan Bark) has mild Blood-invigorating properties that could theoretically stimulate uterine activity, and Chuan Xiong is a Blood-moving herb. Use should be guided by a qualified practitioner who can confirm that the pattern of Yin deficiency with Blood-Heat is present and that the benefits outweigh any risks. Not suitable for casual or unsupervised use in pregnancy.

Breastfeeding

Generally considered compatible with breastfeeding when used under professional guidance for confirmed Yin deficiency Heat patterns. The ingredients are mostly mild Blood-tonifying and cooling herbs without known lactation-suppressing effects. However, the cooling nature of Di Gu Pi and Mu Dan Pi could theoretically affect digestion in sensitive infants through breast milk. A practitioner should monitor both mother and infant. Not recommended for long-term unsupervised use during breastfeeding.

Children

This formula can be adapted for pediatric use in older children with confirmed Yin deficiency Heat patterns, such as persistent low-grade fever after illness. Dosages should be reduced to approximately one-third to one-half of adult doses depending on the child's age and weight. Shu Di Huang (prepared Rehmannia) is heavy and cloying, which can be difficult for children's immature digestive systems. A practitioner may reduce the Shu Di Huang dose or add digestive-supporting herbs like Sha Ren. Not generally suitable for infants or very young children (under 3 years) without specific professional guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Di Gu Pi Yin

Anticoagulants and antiplatelet medications (e.g. warfarin, aspirin, clopidogrel): Dang Gui and Chuan Xiong both have Blood-invigorating properties, and Mu Dan Pi has mild anticoagulant activity. Concurrent use with blood-thinning drugs may increase bleeding risk. Coagulation parameters should be monitored.

Antihypertensive medications: Di Gu Pi (Lycium root bark) has documented mild blood-pressure-lowering effects. Combined use with antihypertensives could theoretically potentiate the hypotensive effect.

Hypoglycemic agents: Di Gu Pi contains guanidine derivatives that have been shown to lower blood glucose levels. Patients on insulin or oral hypoglycemics should monitor blood sugar more closely, as additive effects could lead to hypoglycemia.

Iron supplements: The tannins in several herbs in this formula may reduce iron absorption if taken simultaneously. Separate dosing by at least two hours is advisable.

Usage Guidance

Practical advice for getting the most out of Di Gu Pi Yin

Best time to take

30 minutes to 1 hour after meals, twice daily (morning and evening). Taking after meals reduces the risk of digestive upset from the rich, cloying Shu Di Huang.

Typical duration

Typically taken for 1 to 4 weeks, with reassessment by a practitioner. May be extended for chronic Yin deficiency patterns under professional supervision.

Dietary advice

Avoid spicy, greasy, deep-fried, or heavily warming foods (lamb, chili, alcohol, coffee) while taking this formula, as these can aggravate internal Heat and counteract the cooling, Yin-nourishing strategy. Cold and raw foods should also be limited, since Shu Di Huang is heavy on the digestion. Favor lightly prepared, nourishing foods such as congee, steamed vegetables, pears, lily bulb, black sesame, and small amounts of lean protein. Adequate hydration with room-temperature water supports the formula's Yin-nourishing effect.

Di Gu Pi Yin originates from 《醫壘元戎》(Yī Lěi Yuán Róng) by Wang Haogu (王好古), commentary in《醫宗金鑒·刪補名醫方論》(Yī Zōng Jīn Jiàn) by Wu Qian (吳謙) Yuán dynasty (元朝), circa 13th century

Classical Texts

Key passages from the classical Chinese medical texts that first described Di Gu Pi Yin and its clinical use

From the Shan Bu Ming Yi Fang Lun (删补名医方论), commentary by Ke Qin (柯琴):

Original: 「阴虚者阳往乘之,发热也。当分三阴而治之……乘入厥阴肝部,当地骨皮饮以凉补之,血有所藏而火自安也。」

Translation: "When Yin is deficient, Yang takes advantage and invades, producing fever. One should differentiate and treat according to the three Yin [organs]… When [pathological Yang] invades the Jue Yin Liver, one should use Di Gu Pi Yin to cool and supplement it. When Blood has a place to be stored, the Fire will naturally settle."


From the same commentary by Ke Qin:

Original: 「四物汤为肝家滋阴调血之剂,加地骨皮清志中之火以安肾,补其母也;加牡丹皮清神中之火以凉心,泻其子也。二皮凉而不润,但清肝火不伤脾胃。」

Translation: "Si Wu Tang is a formula that nourishes Yin and regulates Blood for the Liver. Adding Di Gu Pi clears the Fire within the Will [Zhi] to calm the Kidneys, supplementing the [Liver's] mother. Adding Mu Dan Pi clears the Fire within the Spirit [Shen] to cool the Heart, draining the [Liver's] child. Both bark herbs are cooling but not moistening. They merely clear Liver Fire without injuring the Spleen and Stomach."


From the same commentary, comparing with Xiao Yao San:

Original: 「逍遥散治肝火之郁于本脏者也,木郁达之,顺其性也;地骨皮饮,治阳邪之乘于肝脏者也,客者除之,勿纵寇以遗患也。二方皆肝家得力之剂。」

Translation: "Xiao Yao San treats Liver Fire that is constrained within the organ itself, unblocking Wood stagnation and following its nature. Di Gu Pi Yin treats pathological Yang that has invaded the Liver organ, removing the intruder, lest letting the enemy linger cause lasting harm. Both formulas are powerful tools for the Liver."

Historical Context

How Di Gu Pi Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Di Gu Pi Yin originates from the Yi Lei Yuan Rong (医垒元戎, "The Vanguard of the Medical Rampart"), written by the Yuan Dynasty physician Wang Haogu (王好古, c. 1200–1264). Wang Haogu was a student of the great Li Dongyuan (李东垣) and a key figure in the Yi Shui (易水) school of medical thought. He was known for integrating Zhang Zhongjing's classical approaches with the organ-based theories of his teachers.

The formula later gained broader recognition when it was included in the Yi Zong Jin Jian (医宗金鉴, "Golden Mirror of the Medical Tradition"), the monumental Qing Dynasty medical compendium commissioned by Emperor Qianlong and completed in 1742. The celebrated Qing physician and Shang Han Lun scholar Ke Qin (柯琴, also known by the courtesy name Yunbo 韵伯) provided an influential commentary on this formula in his contributions to the Shan Bu Ming Yi Fang Lun (删补名医方论) section. Ke Qin's analysis elegantly positioned Di Gu Pi Yin within a framework of three-Yin differential treatment for deficiency Heat, comparing it directly with Xiao Yao San as complementary strategies for treating the Liver. His insight that the two bark herbs "cool without being moistening" and "clear Liver Fire without harming the Spleen and Stomach" distinguished this formula from harsher cold-bitter approaches such as adding Zhi Mu and Huang Bai to Si Wu Tang.

Structurally, the formula is a modification of Si Wu Tang (Four Substances Decoction), one of the most foundational Blood-nourishing formulas in Chinese medicine. By adding Di Gu Pi and Mu Dan Pi to this classic base, Wang Haogu created an elegant tool that simultaneously addresses both the root (Blood deficiency) and the branch (deficiency Heat) of Liver Yin-Blood deficiency patterns.