Bai Tou Weng Jia Gan Cao E Jiao Tang

Pulsatilla Decoction plus Licorice and Ass-Hide Gelatin · 白頭翁加甘草阿膠湯

Also known as: Bai Tou Weng Jia Gan Cao E Jiao Tang, Augmented Pulsatilla Decoction, Pulsatilla Decoction plus Licorice and Donkey-Hide Gelatin

A classical formula for treating hot dysentery (bloody diarrhea with intestinal inflammation) in people who are physically weakened, especially after childbirth, during old age, or after prolonged illness. It combines strong intestinal heat-clearing herbs with blood-nourishing and protective ingredients, making it gentler than the standard Pulsatilla Decoction while still effectively fighting the infection and inflammation causing the bloody stool.

Origin Jin Gui Yao Lue (金匮要略, Essential Prescriptions of the Golden Cabinet) by Zhang Zhongjing, Chapter 21: Pulse, Patterns, and Treatment of Postpartum Diseases (妇人产后病脉证治) — Eastern Hàn dynasty, ~200 CE
Composition 6 herbs
Bai Tou Weng
King
Bai Tou Weng
Huang Lian
Deputy
Huang Lian
Huang Qi
Deputy
Huang Qi
E Jiao
Assistant
E Jiao
Gan Cao
Assistant
Gan Cao
Qin Pi
Envoy
Qin Pi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bai Tou Weng Jia Gan Cao E Jiao Tang is designed to correct these specific patterns.

Why Bai Tou Weng Jia Gan Cao E Jiao Tang addresses this pattern

This is the formula's primary and defining pattern. When heat-toxin lodges in the intestines and causes dysentery, the continuous loss of blood and fluids in the stool gradually depletes the body's blood and yin reserves. In patients who are already blood-deficient (as after childbirth, in the elderly, or after prolonged illness), the situation is particularly dangerous because the standard approach of using only bitter-cold herbs risks further depleting the body.

Bai Tou Weng Jia Gan Cao E Jiao Tang addresses both sides of this problem simultaneously. The Bai Tou Weng, Huang Lian, Huang Bai, and Qin Pi core clears the heat-toxin and damp-heat driving the dysentery, while E Jiao nourishes blood and stops bleeding, and Gan Cao protects the middle burner and moderates the harsh cold nature of the other herbs. This makes it suitable where Bai Tou Weng Tang alone would be too aggressive.

A practitioner would look for one or more of these signs

Bloody Stool

Dysentery with blood and pus in stool, often more blood than pus

Abdominal Pain

Lower abdominal cramping pain with urgency

Tenesmus

Rectal heaviness and incomplete evacuation (li ji hou zhong)

Eye Fatigue

Extreme weakness and exhaustion, especially postpartum

Dry Mouth

Mouth and throat dryness from yin and fluid depletion

Dull Pale Complexion

Pallor indicating blood deficiency

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bai Tou Weng Jia Gan Cao E Jiao Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands ulcerative colitis as a condition where the disease is located in the Large Intestine but rooted in the Spleen. In its acute active phase, damp-heat accumulates in the intestines, damaging the intestinal lining (the 'collaterals' of the gut), causing the blood and fluids to putrefy into pus and blood in the stool. Over time, repeated flares and chronic blood loss weaken both the blood and yin of the body. The Spleen's ability to generate new blood is compromised, creating a vicious cycle: the patient is too deficient to fight off the lingering heat, and the lingering heat continues to consume yin and blood.

This formula directly addresses the combined picture of active intestinal damp-heat alongside underlying blood and yin deficiency, which is a very common presentation in UC patients who have been ill for months or years.

Why Bai Tou Weng Jia Gan Cao E Jiao Tang Helps

Bai Tou Weng Jia Gan Cao E Jiao Tang combines aggressive intestinal heat-clearing with gentle blood nourishment. Bai Tou Weng, Huang Lian, and Huang Bai directly target the damp-heat driving the active inflammation and bloody stool. Qin Pi adds an astringent quality that helps reduce the frequency of bowel movements. Meanwhile, E Jiao nourishes the blood that has been lost through repeated bloody stools and helps repair the intestinal lining from a TCM perspective. Gan Cao protects the digestive system from the harsh cold nature of the heat-clearing herbs, which is especially important in patients whose Spleen function is already compromised by chronic illness. This balanced approach makes it more suitable for UC patients than the plain Bai Tou Weng Tang, which can be too aggressive for patients with significant underlying weakness.

Also commonly used for

Chronic Diarrhea

Chronic bloody diarrhea with underlying deficiency

Diarrhea

The formula's classical primary indication

Inflammatory Bowel Disease

When presenting with damp-heat pattern and concurrent blood deficiency

Hemorrhoids

Bleeding hemorrhoids with heat pattern and blood deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bai Tou Weng Jia Gan Cao E Jiao Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bai Tou Weng Jia Gan Cao E Jiao Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bai Tou Weng Jia Gan Cao E Jiao Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bai Tou Weng Jia Gan Cao E Jiao Tang works at the root level.

This formula addresses a condition where Heat toxin has lodged in the Large Intestine, causing bloody dysentery, but the patient's underlying constitution is already depleted, specifically from postpartum Blood loss or prolonged illness. The core disease logic involves two intertwined problems occurring simultaneously.

First, Heat toxin scorches the intestinal blood vessels and disrupts the Qi mechanism in the lower abdomen, producing the hallmark signs of hot dysentery: bloody and mucoid stools, burning sensation at the anus, abdominal pain, tenesmus (a painful urgency to pass stool), thirst, and a red tongue with yellow coating. The Heat drives Blood out of the vessels and damages the intestinal lining.

Second, the patient is already in a state of Blood deficiency and Yin depletion. In the postpartum context, delivery itself consumes large amounts of Blood, and continued dysenteric bleeding further exhausts the body's Yin and Blood reserves. This creates a dangerous situation: a purely bitter-cold approach (as in the original Bai Tou Weng Tang) would clear the Heat but risk further damaging an already fragile constitution. The Yin and Blood cannot be left unnourished, yet the Heat toxin cannot be left untreated. The formula must therefore walk a fine line, clearing Heat toxin from the intestines while simultaneously replenishing Blood and protecting Yin from further depletion.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter with underlying sweet notes. The bitter flavor from Huang Lian, Huang Bai, Qin Pi, and Bai Tou Weng clears Heat and dries Dampness, while the sweetness of Gan Cao and E Jiao moderates the harshness and nourishes the Blood.

Ingredients

6 herbs

The herbs that make up Bai Tou Weng Jia Gan Cao E Jiao Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Bai Tou Weng

Bai Tou Weng

Chinese Pulsatilla Roots

Dosage 6 - 15g
Temperature Cold
Taste Bitter
Organ Affinity Stomach, Large Intestine, Liver

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

The chief herb, bitter and cold, enters the Stomach, Large Intestine, and Liver channels. Clears heat-toxin from the blood level and intestines, cools the blood, and stops dysentery. It directly addresses the core pathomechanism of toxic heat lodged in the intestines damaging the blood vessels.
Deputies — Assists and enhances the King
Huang Lian

Huang Lian

Goldthread rhizomes

Dosage 3 - 9g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Liver, Spleen, Stomach

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

Bitter and cold, powerfully clears heat and drains dampness from the Stomach and intestines. As a premier herb for treating dysentery, it reinforces the King herb's ability to clear heat-toxin while also drying dampness that contributes to the formation of pus in the stool.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 6 - 12g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

Bitter and cold, specializes in clearing damp-heat from the lower burner, including the Large Intestine and Bladder. It assists both the King herb and Huang Lian in resolving intestinal heat-toxin, and helps quell ministerial fire that can aggravate bleeding in the lower body.
Assistants — Supports or moderates other herbs
E Jiao

E Jiao

Donkey-hide gelatin

Dosage 6 - 9g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver, Lungs
Preparation Dissolve separately in the strained hot decoction (烊化, yang hua). Do not decoct together with the other herbs.

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

Sweet, neutral, enriches yin and nourishes blood. This is a key addition to the base Bai Tou Weng Tang, specifically addressing the blood deficiency and yin damage that results from prolonged dysentery or from the patient's pre-existing weakness (as in postpartum). It also helps stop bleeding by nourishing and stabilizing the blood.
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

Sweet, neutral to cool, tonifies the middle burner Qi and harmonizes the formula. It moderates the intensely bitter and cold nature of the other herbs to protect the Stomach, while its sweet flavour helps generate fluids and supports the body's recuperation. As noted in classical commentary, Gan Cao's gentle sweetness 'clears the middle while tonifying it' without the cloying nature of stronger tonics.
Envoy — Directs the formula to its target
Qin Pi

Qin Pi

Ash Barks

Dosage 6 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Stomach, Large Intestine, Liver

Role in Bai Tou Weng Jia Gan Cao E Jiao Tang

Bitter, astringent, and cold, clears heat and dries dampness while its astringent quality helps bind the intestines and check the diarrhea. It directs the formula's action to the Large Intestine, complementing the heat-clearing herbs with a consolidating effect that helps stop the discharge without trapping pathogenic factors.

Why This Combination Works

How the herbs in Bai Tou Weng Jia Gan Cao E Jiao Tang complement each other

Overall strategy

This formula addresses the challenging clinical scenario where heat-toxin dysentery occurs in a patient who is already blood-deficient and yin-depleted, most classically after childbirth. The strategy is to clear intestinal heat-toxin vigorously while simultaneously nourishing blood and yin, preventing the bitter-cold herbs from further damaging an already weakened body.

King herb

Bai Tou Weng (Pulsatilla Root) serves as King because it directly enters the blood level and the intestines to clear heat-toxin and cool the blood. It is the definitive herb for hot dysentery with bloody stool, targeting the root cause of the intestinal bleeding and inflammation.

Deputy herbs

Huang Lian and Huang Bai jointly reinforce the King's heat-clearing action. Huang Lian focuses on draining fire and drying dampness in the middle and lower digestive tract, making it indispensable for dysentery. Huang Bai specializes in clearing damp-heat from the lower burner, complementing Huang Lian's action and addressing the ministerial fire that can worsen lower body bleeding.

Assistant herbs

E Jiao (reinforcing type) is the formula's distinguishing addition. It nourishes blood and enriches yin, directly replenishing what the dysentery has consumed and what the patient lacked to begin with. It also helps arrest bleeding. Gan Cao (restraining type) moderates the intensely bitter-cold properties of the three heat-clearing herbs, protecting the Stomach and Spleen from damage. Its sweet, gentle nature supports middle burner Qi and harmonizes the entire prescription.

Envoy herb

Qin Pi directs the formula's action to the Large Intestine. Its astringent quality provides a binding effect that checks diarrhea, while its cold and bitter nature adds to the overall heat-clearing power. It ensures that the formula consolidates the intestines without prematurely trapping pathogenic heat.

Notable synergies

The pairing of the four bitter-cold herbs (Bai Tou Weng, Huang Lian, Huang Bai, Qin Pi) with the sweet-nourishing pair (E Jiao and Gan Cao) exemplifies the classical principle of combining attack and support. The bitter-cold herbs clear the pathogen, while E Jiao and Gan Cao protect and rebuild the body's resources. As the Jin Gui Yao Lue Lun Zhu commentary noted, for dysentery, bitter-cold herbs are indispensable to eliminate damp-heat, but just one measure of Gan Cao and E Jiao is sufficient to harmonize the blood and settle the middle.

How to Prepare

Traditional preparation instructions for Bai Tou Weng Jia Gan Cao E Jiao Tang

Decoct Bai Tou Weng, Huang Lian, Huang Bai, Qin Pi, and Gan Cao together in approximately 1400ml of water. Bring to a boil, then simmer until the liquid is reduced to approximately 400ml. Strain and remove the dregs.

Dissolve E Jiao (Donkey-Hide Gelatin) separately in the hot strained decoction, stirring until fully melted (this method is called yang hua 烊化). Divide into two portions and take warm, one portion per dose, twice daily. If symptoms do not improve after the first dose, take the second dose.

Common Modifications

How practitioners adapt Bai Tou Weng Jia Gan Cao E Jiao Tang for specific situations

Added
Di yu

9 - 15g, cools blood and stops intestinal bleeding

Huai Hua

9 - 12g, cools blood and stops bleeding in the Large Intestine

Di Yu and Huai Hua both specifically target bleeding in the lower digestive tract, reinforcing E Jiao's hemostatic action while adding direct cooling of the blood vessels in the intestinal wall.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bai Tou Weng Jia Gan Cao E Jiao Tang should not be used or requires extra caution

Avoid

Dysentery caused by Cold or Spleen Yang deficiency (diarrhea with clear watery stools, absence of thirst, cold limbs). This formula is strongly cooling and would further damage Spleen Yang.

Avoid

Chronic diarrhea due to pure Spleen Qi deficiency without Heat signs. The bitter-cold herbs in this formula would further weaken the Spleen's transportive function.

Caution

Patients with significant Blood stagnation. E Jiao (Donkey-hide Gelatin) is cloying and sticky in nature, which may obstruct circulation in the presence of significant stasis. Modify the formula accordingly.

Caution

Patients with poor appetite or significant Dampness with thick greasy tongue coating. The sticky, nourishing quality of E Jiao and the cloying nature of Gan Cao may worsen Dampness and impair digestion.

Caution

Patients taking potassium-depleting diuretics, cardiac glycosides, or corticosteroids, due to the glycyrrhizin content in Gan Cao (Licorice).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. While this formula was originally designed for postpartum use, several of its herbs warrant care during pregnancy. Huang Lian (Coptis) and Huang Bai (Phellodendron) are strongly bitter and cold, which classical texts warn may injure the fetus or Spleen Qi if used excessively. Gan Cao (Licorice) in larger doses has been associated with fluid retention and potential hormonal effects. E Jiao (Donkey-hide Gelatin) is generally considered safe in pregnancy and is used in traditional formulas to calm the fetus. Overall, this formula should only be used during pregnancy under the close supervision of a qualified practitioner, and only when a clear pattern of Heat-toxin dysentery with Blood deficiency is present.

Breastfeeding

This formula may be used cautiously during breastfeeding under professional supervision. The bitter-cold herbs (Huang Lian, Huang Bai) could theoretically affect breast milk quality or reduce milk supply in sensitive individuals, as extremely cold herbs are traditionally considered to potentially impair Spleen function and thereby affect lactation. E Jiao and Gan Cao are generally considered compatible with breastfeeding. Since the original classical indication is specifically for postpartum dysentery, Zhang Zhongjing implicitly anticipated use in breastfeeding women. Monitor the nursing infant for any signs of digestive upset. Use for the shortest duration necessary to resolve the acute dysentery.

Children

This formula can be adapted for pediatric use, particularly for acute bacterial or amoebic dysentery presenting with Heat-toxin pattern and underlying deficiency. Dosages should be reduced to approximately one-third to one-half of the adult dose for children aged 6 to 12 years, and one-quarter for children under 6, adjusted by body weight and the severity of the condition. The bitter taste of Huang Lian and Huang Bai may cause difficulty with compliance in young children. E Jiao should be dissolved separately and stirred in after decoction. Because children's Spleen and Stomach functions are delicate and easily damaged by bitter-cold herbs, treatment duration should be kept short and the child monitored for signs of appetite loss or loose stools from cold damage. Not recommended for infants without specialist guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bai Tou Weng Jia Gan Cao E Jiao Tang

Gan Cao (Licorice / Glycyrrhiza): The glycyrrhizin in Gan Cao may interact with several classes of pharmaceutical drugs. It can cause potassium depletion (hypokalemia), which may potentiate the effects of cardiac glycosides such as digoxin, increasing the risk of arrhythmia. It may counteract the effects of antihypertensive medications due to its mineralocorticoid-like activity (sodium and water retention). Concurrent use with potassium-depleting diuretics (thiazides, loop diuretics) may compound potassium loss. Caution is also warranted with corticosteroids, as glycyrrhizin inhibits the enzyme that metabolizes cortisol, potentially enhancing corticosteroid effects and side effects.

Huang Lian (Coptis) and Huang Bai (Phellodendron): Both contain berberine, which has been shown to inhibit certain cytochrome P450 enzymes (particularly CYP2D6 and CYP3A4). This may affect the metabolism of drugs processed through these pathways, including cyclosporine, certain statins, and anticoagulants like warfarin. Berberine has documented blood-glucose-lowering effects, so caution is advised with hypoglycemic agents (metformin, sulfonylureas, insulin), as additive hypoglycemia may occur.

Usage Guidance

Practical advice for getting the most out of Bai Tou Weng Jia Gan Cao E Jiao Tang

Best time to take

On an empty stomach or between meals, served warm. Traditionally taken in two divided doses per day (morning and evening). E Jiao should be dissolved separately and stirred into the warm decoction before drinking.

Typical duration

Acute use: typically 3 to 7 days, reassessed as symptoms resolve. May be continued up to 10 to 14 days in cases of severe postpartum dysentery with marked deficiency, with ongoing practitioner monitoring.

Dietary advice

While taking this formula, avoid spicy, greasy, and fried foods, which can generate further Heat and Dampness in the intestines. Alcohol is strictly prohibited, as it produces Damp-Heat and aggravates dysentery. Cold and raw foods (such as salads, ice-cold drinks, and raw seafood) should also be avoided, as they can injure the already weakened Spleen and Stomach. Favor easily digestible, bland, and warming foods: plain rice congee (porridge), steamed vegetables, and light soups. Small, frequent meals are better than large ones. As the condition improves, foods that gently nourish Blood such as well-cooked dark leafy greens, red dates, and black sesame may be gradually introduced.

Bai Tou Weng Jia Gan Cao E Jiao Tang originates from Jin Gui Yao Lue (金匮要略, Essential Prescriptions of the Golden Cabinet) by Zhang Zhongjing, Chapter 21: Pulse, Patterns, and Treatment of Postpartum Diseases (妇人产后病脉证治) Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bai Tou Weng Jia Gan Cao E Jiao Tang and its clinical use

Jin Gui Yao Lue (金匮要略), Chapter 21: Postpartum Diseases (妇人产后病脉证治)

「产后下利虚极,白头翁加甘草阿胶汤主之。」

"For postpartum diarrhea [dysentery] with extreme deficiency, Bai Tou Weng Jia Gan Cao E Jiao Tang governs."


Qian Jin Fang Yan Yi (《千金方衍义》) commentary:

「《伤寒》厥阴例中白头翁汤治热痢下重,《金匮》加甘草、阿胶治下痢虚极。」

"In the Shang Han Lun, under the Jue Yin section, Bai Tou Weng Tang treats hot dysentery with tenesmus. In the Jin Gui [Yao Lue], adding Gan Cao and E Jiao treats dysentery with extreme deficiency."

Historical Context

How Bai Tou Weng Jia Gan Cao E Jiao Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

This formula originates from Zhang Zhongjing's Jin Gui Yao Lue (Esserta from the Golden Cabinet, c. 3rd century CE), appearing in the chapter on postpartum diseases (妇人产后病脉证治第二十一). It is a modification of the well-known Bai Tou Weng Tang from the Shang Han Lun, which treats Heat-toxin dysentery in patients of normal constitution. Zhang Zhongjing recognized that postpartum women could develop the same type of hot dysentery but with a critical difference: their bodies were already severely weakened from childbirth and Blood loss. Simply applying bitter-cold herbs would clear Heat but potentially collapse an already deficient patient.

His solution was elegant: he kept the original four-herb core of Bai Tou Weng Tang (Bai Tou Weng, Huang Lian, Huang Bai, Qin Pi) and added two herbs: Gan Cao to moderate the harsh bitterness and protect the Stomach, and E Jiao to nourish the Blood and enrich Yin. This exemplifies a key principle in Zhang Zhongjing's clinical method: adapting a formula to the patient's constitutional state. The commentary tradition, including the Qian Jin Fang Yan Yi, praised this modification as the definitive approach for dysentery complicated by deficiency. Later practitioners extended its application beyond postpartum cases to include anyone suffering from Heat-toxin dysentery complicated by Blood deficiency or Yin depletion, such as elderly patients or those weakened by chronic illness.